2020
Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep.
Zeng C, Motta-Ribeiro G, Hinoshita T, Lessa M, Winkler T, Grogg K, Kingston N, Hutchinson J, Sholl L, Fang X, Varelas X, Layne M, Baron R, Vidal Melo M. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology 2020, 133: 1060-1076. PMID: 32796202, PMCID: PMC7572680, DOI: 10.1097/aln.0000000000003491.Peer-Reviewed Original ResearchConceptsAlveolar-capillary barrier functionInterferon-stimulated genesImmune responseLung atelectasisAerated lungBarrier functionAerated lung regionsPulmonary transcriptomeSystemic lipopolysaccharideYes-associated protein signalingPulmonary atelectasisGene Set Enrichment AnalysisSystemic inflammationBronchial blockerLung injuryRight lungBarrier dysfunctionComputed tomographyLipopolysaccharide exposureAtelectasisLipopolysaccharide infusionAbsolute fold changeYes-Associated ProteinAtelectatic lungLung
2018
Local Clonal Diversification and Dissemination of B Lymphocytes in the Human Bronchial Mucosa
Ohm-Laursen L, Meng H, Chen J, Zhou JQ, Corrigan CJ, Gould HJ, Kleinstein SH. Local Clonal Diversification and Dissemination of B Lymphocytes in the Human Bronchial Mucosa. Frontiers In Immunology 2018, 9: 1976. PMID: 30245687, PMCID: PMC6137163, DOI: 10.3389/fimmu.2018.01976.Peer-Reviewed Original ResearchConceptsHumoral immune responseBronchial mucosaB cell repertoireHealthy subjectsAsthmatic patientsImmune responseCell repertoireAdaptive humoral immune responseB cell antibody productionFeatures of atopyB cell clonesHuman bronchial mucosaMucosal migrationAdaptive immune receptor repertoire sequencingAtopic asthmaAsthmatic individualsBronchial biopsiesRight lungPeripheral bloodDistal biopsiesAdjacent biopsiesLarge cohortB cellsB lymphocytesAntibody production
2013
Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer
Isobe T, Onn A, Morgensztern D, Jacoby JJ, Wu W, Shintani T, Itasaka S, Shibuya K, Koo PJ, O'Reilly MS, Herbst RS. Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer. Journal Of Thoracic Oncology 2013, 8: 140-146. PMID: 23328546, DOI: 10.1097/jto.0b013e3182725ff9.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerHuman small cell lung cancerLymph nodesLung cancerMurine modelOrthotopic nude mouse modelHuman SCLC tumorsAxillary lymph nodesOrthotopic murine modelNovel therapeutic strategiesSubcutaneous xenograft modelTumor growth patternNude mouse modelEffective murine modelLeft lungRight lungTumor sizeSolitary massSCLC tumorsOrthotopic modelMouse modelNew therapiesTherapeutic strategiesXenograft modelNude mice
2011
Shifting Pneumothorax
Bassily-Marcus A, Oropello J, Shaik A, Kohli-Seth R, Manasia A, DelGiudice R, Benjamin E. Shifting Pneumothorax. ICU Director 2011, 2: 158-162. DOI: 10.1177/1944451611419156.Peer-Reviewed Original ResearchConsistent with pneumothoraxStress dose steroidsBilateral spontaneous pneumothoraxBilateral polycystic kidneysPostoperative day 4Left thoracic cavityChest X-rayAbsence of air leaksLung ultrasound scanDose steroidsLeft pneumothoraxSpontaneous pneumothoraxChest tubeRight pneumothoraxCrystalloid bolusBilateral nephrectomySonographic evaluationPostoperative periodMechanical ventilationPleural fluidUltrasound scanRight lungAir leakLung ultrasoundPneumothorax
2005
Of Buffaloes, Horseshoes, and Having No Connections
Parsons AM, Detterbeck FC. Of Buffaloes, Horseshoes, and Having No Connections. The Annals Of Thoracic Surgery 2005, 80: 1521-1523. PMID: 16181911, DOI: 10.1016/j.athoracsur.2004.04.054.Peer-Reviewed Original ResearchConceptsUnilateral pulmonary artery agenesisCongenital pulmonary anomaliesPulmonary artery agenesisDouble lung transplantationRight middle lobeRight upper lobeBuffalo chestHorseshoe lungLung transplantationPulmonary anomaliesLeft lungUpper lobeLower lobeRight chestRight lungAnatomic anomaliesMiddle lobeLeft chestLungChestLobePatientsTransplantationAgenesisHemithoraces
1998
Pulmonary Immunocytoma With Massive Crystal Storing Histiocytosis
Prasad M, Charney D, Sarlin J, Keller S. Pulmonary Immunocytoma With Massive Crystal Storing Histiocytosis. The American Journal Of Surgical Pathology 1998, 22: 1148-1153. PMID: 9737249, DOI: 10.1097/00000478-199809000-00015.Peer-Reviewed Case Reports and Technical NotesConceptsImmunoglobulin M antibodiesLymphoid tissue lymphomaMarginal zone lymphomaB-cell originCrystal-storing histiocytesLymphoplasmacytic aggregatesLymph nodesLymphoplasmacytoid cellsTissue lymphomaReactive histiocytesRight lungAltered intraBronchial mucosaM antibodiesCrystal-Storing HistiocytosisLymphoplasmacytic disordersExcessive productionMore casesSame antibodyHistiocytesLymphomaImmunocytomaLungIgMType I
1997
Metastatic Adenocarcinoma Involving a Mesothelial/Monocytic Incidental Cardiac Excrescence (Cardiac MICE)
Argani P, Sternberg S, Burt M, Adsay N, Klimstra D. Metastatic Adenocarcinoma Involving a Mesothelial/Monocytic Incidental Cardiac Excrescence (Cardiac MICE). The American Journal Of Surgical Pathology 1997, 21: 970-974. PMID: 9255262, DOI: 10.1097/00000478-199708000-00013.Peer-Reviewed Original ResearchConceptsMesothelial/monocytic incidental cardiac excrescenceMesothelial cellsAdenocarcinoma cellsEpithelial membrane antigenMetastatic adenocarcinoma cellsClusters of histiocytesMetastatic adenocarcinomaMetastatic carcinomaCardiac instrumentationMembrane antigenRight lungIntracellular mucinCarcinoembryonic antigenClinical circumstancesNo historyPericardial spacePleomorphic cellsNon-neoplasticUnique caseAdenocarcinomaHistiocytesMicroscopic findingsPericardial cavityMicroscopic examinationCell clusters
1975
The Influence of Cortisol on the Enzymes of Fatty Acid Synthesis in Developing Mammalian Lung and Brain
Gross I, Rooney S, Warshaw J. The Influence of Cortisol on the Enzymes of Fatty Acid Synthesis in Developing Mammalian Lung and Brain. Pediatric Research 1975, 9: 752-755. PMID: 648, DOI: 10.1203/00006450-197509000-00014.Peer-Reviewed Original ResearchConceptsDe novo fatty acid synthesisNovo fatty acid synthesisFatty acid synthesisRabbit lungsFatty acid synthetaseAcetyl-CoA carboxylase activityAccelerated lung maturationCortisol-induced inhibitionHyaline membrane diseaseAdministration of cortisolFetal rabbit lungInfluence of cortisolFatty acid synthetase activityAcid synthesisFatty acid elongation activityAntenatal administrationNumber of inhibitoryMembrane diseaseRight lungLung maturationLung growthCortisol exposureElectron microscopic examinationFetal rabbitsFetal brain
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