2024
Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever
Kotliar D, Raju S, Tabrizi S, Odia I, Goba A, Momoh M, Sandi J, Nair P, Phelan E, Tariyal R, Eromon P, Mehta S, Robles-Sikisaka R, Siddle K, Stremlau M, Jalloh S, Gire S, Winnicki S, Chak B, Schaffner S, Pauthner M, Karlsson E, Chapin S, Kennedy S, Branco L, Kanneh L, Vitti J, Broodie N, Gladden-Young A, Omoniwa O, Jiang P, Yozwiak N, Heuklom S, Moses L, Akpede G, Asogun D, Rubins K, Kales S, Happi A, Iruolagbe C, Dic-Ijiewere M, Iraoyah K, Osazuwa O, Okonkwo A, Kunz S, McCormick J, Khan S, Honko A, Lander E, Oldstone M, Hensley L, Folarin O, Okogbenin S, Günther S, Ollila H, Tewhey R, Okokhere P, Schieffelin J, Andersen K, Reilly S, Grant D, Garry R, Barnes K, Happi C, Sabeti P. Genome-wide association study identifies human genetic variants associated with fatal outcome from Lassa fever. Nature Microbiology 2024, 9: 751-762. PMID: 38326571, PMCID: PMC10914620, DOI: 10.1038/s41564-023-01589-3.Peer-Reviewed Original ResearchMeSH KeywordsFeverGenome-Wide Association StudyHuman GeneticsHumansLassa FeverLassa virusSeroepidemiologic StudiesConceptsGenome-wide association studiesAssociation studiesSignatures of positive selectionHuman genetic variationFatal outcomeNigerian cohortLassa feverLassa virusFunctional characterization assaysVariant associationsGenetic variationHuman leukocyte antigen typingPositive selectionAssociated with decreased riskSevere Lassa feverCases of Lassa feverViral pathogenesisEntry factorsLASV infectionCharacterization assaysMild symptomsFeverAntigenic typesSeroprevalence surveyCohort
2020
Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response
van den Pol A, Zhang X, Lima E, Pitruzzello M, Albayrak N, Alvero A, Davis J, Mor G. Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response. Virology 2020, 555: 44-55. PMID: 33453650, PMCID: PMC8451984, DOI: 10.1016/j.virol.2020.10.009.Peer-Reviewed Original ResearchConceptsOvarian cancer cellsHuman ovarian cancer cellsLong-term survivalOvarian cancerCancer cellsTreatment of immunocompetent miceKill ovarian cancer cellsMouse ovarian cancer cellsTreatment of ovarian cancerAnti-tumor responsesImmunocompromised nude miceOncolytic actionImmunocompetent miceMetastatic spreadChemotherapeutic paclitaxelFemale cancersPoor survivalNude miceIntraperitoneal injectionCancer growthSurvival extensionVesicular stomatitis virusVSV glycoproteinCancerReduced neurotropism
2015
Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors
Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors. Journal Of Virology 2015, 89: 6711-6724. PMID: 25878115, PMCID: PMC4468483, DOI: 10.1128/jvi.00709-15.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusBrain tumorsVesicular stomatitis virusChimeric virusesBrain cancerLassa virusEbola virusMarburg virusRabies virusAdverse neurologic consequencesExquisite tumor specificityHigh-grade tumorsPromising oncolytic virusLassa virus glycoprotein precursorAdverse side effectsTumor-bearing miceMetastatic cancer modelsStomatitis virusNovel chimeric virusHigh-grade glioblastomaEbola virus glycoproteinMultiple cancer typesNoninjected tumorNeurologic consequencesOncolytic potential
1997
A survey for antibodies to Lassa virus among health workers in Nigeria
Bajani M, Tomori O, Rollin P, Harry T, Bukbuk N, Wilson L, Childs J, Peters C, Ksiazek T. A survey for antibodies to Lassa virus among health workers in Nigeria. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 1997, 91: 379-381. PMID: 9373625, DOI: 10.1016/s0035-9203(97)90247-9.Peer-Reviewed Original ResearchConceptsHealth workersAntibody prevalenceHealth facilitiesSecondary health facilitiesVirus IgM antibodiesImmunoglobulin G antibodiesEnzyme-linked immunosorbentTertiary centerSpecific IgMIgM antibodiesRecent infectionHealth centersG antibodiesLassa feverLassa virusDifferent occupational groupsPrevalenceAntibodiesOccupational groupsFeverSeroprevalenceIgMInfectionWorkersNurses
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply