2003
Invasion and survival strategies of Anaplasma phagocytophilum
Carlyon JA, Fikrig E. Invasion and survival strategies of Anaplasma phagocytophilum. Cellular Microbiology 2003, 5: 743-754. PMID: 14531890, DOI: 10.1046/j.1462-5822.2003.00323.x.Peer-Reviewed Original ResearchConceptsAnaplasma phagocytophilumA. phagocytophilumHuman granulocytic ehrlichiosisHostile intracellular environmentTick-borne zoonosisObligate intracellular bacteriumHost neutrophilsNeutrophil adhesionInnate immunityPolymorphonuclear leucocytesAetiological agentGranulocytic ehrlichiosisIntracellular bacteriumNeutrophilsMicrobicidal activityPhagocytophilumHost cellsProteolytic compoundsAcidic lysosomesBacteria-containing phagosomesKey playersLeucocytesImmunityEhrlichiosisPhagocytesSuccessful Treatment of Human Granulocytic Ehrlichiosis in Children Using Rifampin
Krause PJ, Corrow CL, Bakken JS. Successful Treatment of Human Granulocytic Ehrlichiosis in Children Using Rifampin. 2003, 112: e252-e253. PMID: 12949322, DOI: 10.1542/peds.112.3.e252.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisYears of ageSuccessful treatmentGranulocytic ehrlichiosisTick-borne infectious diseaseFlu-like illnessTreatment of choiceHospital admissionClinical featuresSerious infectionsInfectious diseasesPhagocytophilum infectionRifampinAnaplasma phagocytophilumPermanent stainingChildrenInfectionTreatmentEhrlichiosisAgeYearsAdmissionIllnessDiseaseDoxycyclineMurine neutrophils require α1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum
Carlyon JA, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings RD, McEver RP, Fikrig E. Murine neutrophils require α1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood 2003, 102: 3387-3395. PMID: 12869507, DOI: 10.1182/blood-2003-02-0621.Peer-Reviewed Original ResearchConceptsWild-type miceP-selectin glycoprotein ligand-1Murine neutrophilsCommon tick-borne diseaseAnaplasma phagocytophilumFuc-TIVHuman granulocytic ehrlichiosisPSGL-1 expressionTick-borne diseaseNeutrophil expressionInfection burdenMurine infectionNeutrophilsGranulocytic ehrlichiosisPhagocytophilum infectionMiceHuman neutrophilsSimilar molecular featuresInfectionProductive infectionSialidase treatmentLigand 1PhagocytophilumMolecular featuresFuc-TVIIStructurally Distinct Requirements for Binding of P-selectin Glycoprotein Ligand-1 and Sialyl Lewis x to Anaplasma phagocytophilum and P-selectin*
Yago T, Leppänen A, Carlyon JA, Akkoyunlu M, Karmakar S, Fikrig E, Cummings RD, McEver RP. Structurally Distinct Requirements for Binding of P-selectin Glycoprotein Ligand-1 and Sialyl Lewis x to Anaplasma phagocytophilum and P-selectin*. Journal Of Biological Chemistry 2003, 278: 37987-37997. PMID: 12847092, DOI: 10.1074/jbc.m305778200.Peer-Reviewed Original ResearchHuman Immunodeficiency Virus Infection with Human Granulocytic Ehrlichiosis Complicated by Symptomatic Lactic Acidosis
Springer SA, Altice FL. Human Immunodeficiency Virus Infection with Human Granulocytic Ehrlichiosis Complicated by Symptomatic Lactic Acidosis. Clinical Infectious Diseases 2003, 36: e162-e164. PMID: 12802782, DOI: 10.1086/374930.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisSymptomatic hyperlactatemiaLactic acidosisNormal serum lactate levelsHuman immunodeficiency virus (HIV) infectionNucleoside reverse transcriptase inhibitorSymptomatic lactic acidosisImmunodeficiency virus infectionSerum lactate levelsHuman immunodeficiency virusReverse transcriptase inhibitorAcute coinfectionAntiretroviral therapyHIV infectionHepatic insultImmunodeficiency virusAppropriate treatmentVirus infectionLactate levelsFirst presentationGranulocytic ehrlichiosisPatientsHyperlactatemiaAcidosisInfection
2002
Repression of rac2 mRNA Expression by Anaplasma phagocytophila Is Essential to the Inhibition of Superoxide Production and Bacterial Proliferation
Carlyon JA, Chan WT, Galán J, Roos D, Fikrig E. Repression of rac2 mRNA Expression by Anaplasma phagocytophila Is Essential to the Inhibition of Superoxide Production and Bacterial Proliferation. The Journal Of Immunology 2002, 169: 7009-7018. PMID: 12471136, DOI: 10.4049/jimmunol.169.12.7009.Peer-Reviewed Original ResearchConceptsInfected HL-60 cellsHL-60 cellsAnaplasma phagocytophilaMRNA expressionNADPH oxidaseRetinoic acid-differentiated HL-60 cellsBacterial intracellular survivalHuman granulocytic ehrlichiosisNADPH oxidase activityNADPH oxidase activationQuantitative RT-PCRCMV immediate-early promoterInfected neutrophilsEtiologic agentGranulocytic ehrlichiosisRT-PCR analysisA. phagocytophilaIntracellular survivalSuperoxide productionOxidase activationNeutrophilsProtein expressionRT-PCRImmediate early promoterH postinfectionEhrlichiosis in children
Lantos P, Krause PJ. Ehrlichiosis in children. Seminars In Pediatric Infectious Diseases 2002, 13: 249-256. PMID: 12491230, DOI: 10.1053/spid.2002.127200.Peer-Reviewed Original ResearchDifferential Expression of the p44 Gene Family in the Agent of Human Granulocytic Ehrlichiosis
IJdo JW, Wu C, Telford SR, Fikrig E. Differential Expression of the p44 Gene Family in the Agent of Human Granulocytic Ehrlichiosis. Infection And Immunity 2002, 70: 5295-5298. PMID: 12183586, PMCID: PMC128253, DOI: 10.1128/iai.70.9.5295-5298.2002.Peer-Reviewed Original ResearchConceptsP44 geneDifferential expressionHuman granulocytic ehrlichiosisGene familyAntigenic variationHGE bacteriaTransmission feedingGranulocytic ehrlichiosisGenesHypervariable regionInfected C3H miceP44 expressionTick transmissionExpressionSCID miceC3H miceHGE infectionMurine modelInfected ticksSalivary glandsNymphal ticksMiceTicksEhrlichiosisBacteriaSpatial Analysis of Human Granulocytic Ehrlichiosis near Lyme, Connecticut - Volume 8, Number 9—September 2002 - Emerging Infectious Diseases journal - CDC
Chaput EK, Meek JI, Heimer R. Spatial Analysis of Human Granulocytic Ehrlichiosis near Lyme, Connecticut - Volume 8, Number 9—September 2002 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2002, 8: 943-948. PMID: 12194771, PMCID: PMC2732548, DOI: 10.3201/eid0809.020103.Peer-Reviewed Original ResearchComparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis
Magnarelli LA, Lawrenz M, Norris SJ, Fikrig E. Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis. Journal Of Medical Microbiology 2002, 51: 649-655. PMID: 12171295, DOI: 10.1099/0022-1317-51-8-649.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayIgG antibodiesErythema migransIgM antibodiesLyme borreliosisPhysician-diagnosed erythema migransOnset of illnessVlsE antigenB. burgdorferi infectionBorrelia burgdorferi antigensEnzyme-linked immunosorbentHuman granulocytic ehrlichiosisHuman serumOuter surface protein CRheumatoid arthritisBorrelia burgdorferi sensu strictoOral infectionBurgdorferi infectionFalse-positive reactionsBurgdorferi sensu strictoSera crossLouse-borneLaboratory diagnosisNormal serumGranulocytic ehrlichiosisDisease-Specific Diagnosis of Coinfecting Tickborne Zoonoses: Babesiosis, Human Granulocytic Ehrlichiosis, and Lyme Disease
Krause PJ, McKay K, Thompson CA, Sikand VK, Lentz R, Lepore T, Closter L, Christianson D, Telford SR, Persing D, Radolf JD, Spielman A, Group A. Disease-Specific Diagnosis of Coinfecting Tickborne Zoonoses: Babesiosis, Human Granulocytic Ehrlichiosis, and Lyme Disease. Clinical Infectious Diseases 2002, 34: 1184-1191. PMID: 11941544, DOI: 10.1086/339813.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisLyme diseaseImmunoglobulin M antibody testGranulocytic ehrlichiosisPolymerase chain reaction testingShort-term complicationsComplete blood countDisease-specific diagnosisFlulike illnessThin blood smearsLaboratory manifestationsAcute manifestationsBlood countBlood samplesAntibody testReaction testingBlood smearsTickborne zoonosesDiseaseHuman babesiosisLaboratory test resultsPatientsStructured questionnaireSymptomsBabesiosis
2001
Diagnosis of Babesiosis Using an Immunoblot Serologic Test
Ryan R, Krause P, Radolf J, Freeman K, Spielman A, Lenz R, Levin A. Diagnosis of Babesiosis Using an Immunoblot Serologic Test. MSphere 2001, 8: 1177-1180. PMID: 11687460, PMCID: PMC96246, DOI: 10.1128/cdli.8.6.1177-1180.2001.Peer-Reviewed Original ResearchConceptsB. microti antigenAntibody testHuman babesiosisB. microtiReactivity of seraDiagnostic antibody testsHuman granulocytic ehrlichiosisDiagnosis of babesiosisImmunoblot stripsRoutine clinical diagnosisSerologic testsAcute babesiosisIFA testLaboratory evidenceClinical diagnosisImmunoblot assayGranulocytic ehrlichiosisLyme diseaseAntigenSerumGI strainsInterpretive criteriaReactive bandsTest sensitivityHuman subjectsExploitation of Interleukin-8-Induced Neutrophil Chemotaxis by the Agent of Human Granulocytic Ehrlichiosis
Akkoyunlu M, Malawista S, Anguita J, Fikrig E. Exploitation of Interleukin-8-Induced Neutrophil Chemotaxis by the Agent of Human Granulocytic Ehrlichiosis. Infection And Immunity 2001, 69: 5577-5588. PMID: 11500432, PMCID: PMC98672, DOI: 10.1128/iai.69.9.5577-5588.2001.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisInterleukin-8Granulocytic ehrlichiosisHGE bacteriaUpregulation of CXCR2IL-8 receptorsIL-8 productionIL-8 secretionSite of infectionInfected HL-60 cellsObligate intracellular bacteriumChemotaxis chamber assayNeutrophils migrateNeutrophil migrationNeutrophil chemotaxisImmunodeficient miceControl animalsBacterial disseminationHost defensePromyelocytic cell lineChamber assayIntracellular bacteriumHL-60 cellsRetinoic acidNeutrophil lineageClinical and Serological Follow-Up of Patients with Human Granulocytic Ehrlichiosis in Slovenia
Lotrič-Furlan S, Avsic-Zupanc T, Petrovec M, Nicholson W, Sumner J, Childs J, Strle F. Clinical and Serological Follow-Up of Patients with Human Granulocytic Ehrlichiosis in Slovenia. MSphere 2001, 8: 899-903. PMID: 11527800, PMCID: PMC96168, DOI: 10.1128/cdli.8.5.899-903.2001.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisAntibody titersTick biteLong-term clinical consequencesGranulocytic ehrlichiosisIFA antibody titersOnset of feverSerological Follow-UpHigh antibody titersMost time pointsSeronegative patientsSeropositive patientsAdult patientsFebrile illnessPatients 6Initial presentationClinical outcomesAntibody responseClinical evaluationFollow-upReciprocal titersClinical consequencesSerum collectionFirst presentationPatientsCoinfecting Deer-Associated Zoonoses: Lyme Disease, Babesiosis, and Ehrlichiosis
Goldstein E, Thompson C, Spielman A, Krause P. Coinfecting Deer-Associated Zoonoses: Lyme Disease, Babesiosis, and Ehrlichiosis. Clinical Infectious Diseases 2001, 33: 676-685. PMID: 11486290, DOI: 10.1086/322681.Peer-Reviewed Original ResearchConceptsLyme diseaseDuration of symptomsHuman granulocytic ehrlichiosisTickborne infectionClinical managementHealth burdenHuman coinfectionsDiagnostic proceduresGranulocytic ehrlichiosisDisease syndromeHuman babesiosisRodent reservoirsHuman hostInfectionDiseaseEhrlichiosisDiversity of pathogensBabesiosisPathogensCoinfectionSyndromeSymptomsIncidenceVector hostRecombinant Protein-44-Based Class-Specific Enzyme-Linked Immunosorbent Assays for Serologic Diagnosis of Human Granulocytic Ehrlichiosis
Magnarelli L, IJdo J, Wu C, Fikrig E. Recombinant Protein-44-Based Class-Specific Enzyme-Linked Immunosorbent Assays for Serologic Diagnosis of Human Granulocytic Ehrlichiosis. European Journal Of Clinical Microbiology & Infectious Diseases 2001, 20: 482-485. PMID: 11561804, DOI: 10.1007/s100960100542.Peer-Reviewed Original ResearchConceptsPolyvalent enzyme-linked immunosorbent assaysClass-specific enzyme-linked immunosorbent assaysEnzyme-linked immunosorbent assayIndirect fluorescent-antibody analysisFluorescent antibody analysisImmunosorbent assaySpecificity testsIgG antibodiesHigh sensitivityHuman granulocytic ehrlichiosisHuman serumGranulocytic ehrlichiosisWhole cell antigenAntibody analysisImmunoglobulin M antibodiesOnset of illnessSerologic diagnosisSerum samplesHuman granulocytic ehrlichiosis (HGE) agentPatient 3False-positive resultsIgM antibodiesM antibodiesTotal immunoglobulinTotal antibodyInterference Between the Agents of Lyme Disease and Human Granulocytic Ehrlichiosis in a Natural Reservoir Host
Levin M, Fish D. Interference Between the Agents of Lyme Disease and Human Granulocytic Ehrlichiosis in a Natural Reservoir Host. Vector-Borne And Zoonotic Diseases 2001, 1: 139-148. PMID: 12653144, DOI: 10.1089/153036601316977741.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisE. phagocytophilaB. burgdorferiGranulocytic ehrlichiosisLyme diseaseB. burgdorferi challengeGroups of miceB. burgdorferi-infected miceBurgdorferi-infected miceXenodiagnostic larvaeI. scapularis larvaeUninfected miceNatural reservoir hostsControl miceInfectious challengePrimary infectionXenodiagnostic ticksControl groupMiceInfectionMixed infectionsI. scapularis nymphsBurgdorferiWeekly intervalsSecond agentInfection of Mice with the Agent of Human Granulocytic Ehrlichiosis after Different Routes of Inoculation
Hodzic E, Feng S, Fish D, Leutenegger C, Freet K, Barthold S. Infection of Mice with the Agent of Human Granulocytic Ehrlichiosis after Different Routes of Inoculation. The Journal Of Infectious Diseases 2001, 183: 1781-1786. PMID: 11372031, DOI: 10.1086/320735.Peer-Reviewed Original ResearchConceptsBone marrow samplesReal-time polymerase chain reactionPolymerase chain reactionHuman granulocytic ehrlichiosisMarrow samplesDay 20Granulocytic ehrlichiosisInfection of miceRate of infectionKinetics of infectionLymph nodesGene targetsInfected miceC3H miceEarly disseminationVascular perfusionDay 10Experimental infectionInfectionMiceNeedle inoculationChain reactionBloodEhrlichiosisInoculationCoinfection with Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis Alters Murine Immune Responses, Pathogen Burden, and Severity of Lyme Arthritis
Thomas V, Anguita J, Barthold S, Fikrig E. Coinfection with Borrelia burgdorferi and the Agent of Human Granulocytic Ehrlichiosis Alters Murine Immune Responses, Pathogen Burden, and Severity of Lyme Arthritis. Infection And Immunity 2001, 69: 3359-3371. PMID: 11292759, PMCID: PMC98295, DOI: 10.1128/iai.69.5.3359-3371.2001.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisLyme arthritisDual infectionBacterial burdenImmune responseTumor necrosis factor-alpha levelsB. burgdorferiElevated IL-6 levelsNecrosis factor-alpha levelsGranulocytic ehrlichiosisIL-6 levelsAgent of HGEMurine immune responseBorrelia burgdorferiTick-borne illnessMurine Lyme arthritisSevere Lyme arthritisCoinfection of miceIFN-gamma receptor expressionInfected miceInterleukin-12Receptor expressionGamma interferonArthritisPathogen burdenEffect of Tick Removal on Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Nymphs
Vignes F, Piesman J, Heffernan R, Schulze T, Stafford K, Fish D. Effect of Tick Removal on Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Nymphs. The Journal Of Infectious Diseases 2001, 183: 773-778. PMID: 11181154, DOI: 10.1086/318818.Peer-Reviewed Original ResearchConceptsEhrlichia phagocytophilaBorrelia burgdorferiLyme disease endemic areaHuman granulocytic ehrlichiosisDisease-endemic areasScapularis nymphsPolymerase chain reaction analysisSerologic testingField strainsChain reaction analysisSpirochete Borrelia burgdorferiIxodes scapularis nymphsTick removalProbability of infectionHuman infectionsE. phagocytophilaGranulocytic ehrlichiosisInfectionI. scapularis nymphsB. burgdorferiBurgdorferiMiceLyme disease spirochete Borrelia burgdorferiNymphal Ixodes scapularisFed ticks
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