2024
Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy
Khan W, Chopra S, Zheng X, Liu S, Paszkowski P, Valcarce-Aspegren M, Sieu L, Mcgill S, Mccafferty C, Blumenfeld H. Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy. Experimental Neurology 2024, 381: 114925. PMID: 39151596, PMCID: PMC12020870, DOI: 10.1016/j.expneurol.2024.114925.Peer-Reviewed Original ResearchExtracellular single unit recordingsSingle unit recordingsMouse modelNeuronal firingAbsence epilepsyFiring patternsRat modelSeizure initiationMouse model of absence epilepsyIn vivo extracellular single unit recordingNeuronal activityUnit recordingsModel of absence epilepsySomatosensory barrel cortexC3H/HeJ mouse modelNeuronal firing rateHuman absence epilepsyDiverse firing patternsNeuronal rhythmicityArousal stateC3H/HeJ miceBarrel cortexStudy of neuronal activityCortical electroencephalographyFiring rate
2022
Babesia duncani in Culture and in Mouse (ICIM) Model for the Advancement of Babesia Biology, Pathogenesis, and Therapy.
Kumari V, Pal A, Singh P, Mamoun C. Babesia duncani in Culture and in Mouse (ICIM) Model for the Advancement of Babesia Biology, Pathogenesis, and Therapy. Bio-protocol 2022, 12 PMID: 36620533, PMCID: PMC9795036, DOI: 10.21769/bioprotoc.4549.Peer-Reviewed Original ResearchMouse modelHuman red blood cellsRed blood cellsC3H/HeJ miceBlood cellsHuman babesiosisMalaria-like illnessB. duncaniImportant health impactsTick-borne diseaseBlood transfusionTick biteLethal infectionHeJ miceRare caseBabesia duncaniImmunocompromised miceAnimal modelsHuman infectionsParasitic diseasesBabesia microtiDiseaseElderly peopleIntraerythrocytic parasitesB. microtiVaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney
Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.Peer-Reviewed Original ResearchConceptsLethal challenge infectionChallenge infectionBacterial loadC3H/HeJ miceKey target organClinical pathogenesisSevere leptospirosisOrgan infectionProtein immunizationHeJ miceSerovar CanicolaTarget organsAnimal modelsLeptospirosis pathogenesisCellular pathogenesisMicePathogenesisInfectionLeptospira interrogansVirulence factorsModifying proteinsImmunizationKidneyLeptospirosisLiverAn Alternative Culture Medium for Continuous In Vitro Propagation of the Human Pathogen Babesia duncani in Human Erythrocytes
Singh P, Pal AC, Mamoun CB. An Alternative Culture Medium for Continuous In Vitro Propagation of the Human Pathogen Babesia duncani in Human Erythrocytes. Pathogens 2022, 11: 599. PMID: 35631120, PMCID: PMC9146245, DOI: 10.3390/pathogens11050599.Peer-Reviewed Original ResearchBabesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo
Pal AC, Renard I, Singh P, Vydyam P, Chiu JE, Pou S, Winter RW, Dodean R, Frueh L, Nilsen AC, Riscoe MK, Doggett JS, Mamoun C. Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo. The Journal Of Infectious Diseases 2022, 226: 1267-1275. PMID: 35512141, PMCID: PMC10233494, DOI: 10.1093/infdis/jiac181.Peer-Reviewed Original ResearchConceptsLethal infectionC3H/HeJ miceMalaria-like illnessB. duncaniMouse genetic backgroundSurvival outcomesHeJ miceSevere diseaseBabesia duncaniMouse modelDifferent mouse genetic backgroundsDrug susceptibilityBabesia microtiHuman babesiosisIntraerythrocytic parasitesUnique pathogenParasite loadMiceSpecies of BabesiaApicomplexa phylumInfectionBabesia parasitesFree merozoitesHuman erythrocytesGenetic background
2021
Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure
Lee AM, Mansuri MS, Wilson RS, Lam TT, Nairn AC, Picciotto MR. Sex Differences in the Ventral Tegmental Area and Nucleus Accumbens Proteome at Baseline and Following Nicotine Exposure. Frontiers In Molecular Neuroscience 2021, 14: 657064. PMID: 34335180, PMCID: PMC8317211, DOI: 10.3389/fnmol.2021.657064.Peer-Reviewed Original ResearchVentral tegmental areaC3H/HeJ miceGlial fibrillary acidic proteinChronic nicotine administrationNicotine administrationProtein abundanceProteomeIsobaric labelingNicotine exposureFemale miceTegmental areaHeJ miceNucleus accumbensNicotine addictionProteinSex differencesSample fractionationPathwayFibrillary acidic proteinTandem mass spectrometryNetwork analysisMouse strainsChronic nicotineMesolimbic systemNicotine rewardOral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations
Gertie JA, Zhang B, Liu EG, Hoyt LR, Yin X, Xu L, Long LL, Soldatenko A, Gowthaman U, Williams A, Eisenbarth SC. Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations. Journal Of Allergy And Clinical Immunology 2021, 149: 262-274. PMID: 34051223, PMCID: PMC8626534, DOI: 10.1016/j.jaci.2021.05.015.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsArachisDisease Models, AnimalFemaleGastrointestinal MicrobiomeGenetic Predisposition to DiseaseGuanine Nucleotide Exchange FactorsIntestinal MucosaMaleMice, Inbred C3HMice, Inbred C57BLMutationPassive Cutaneous AnaphylaxisPeanut HypersensitivityPermeabilitySpecies SpecificityToll-Like Receptor 4ConceptsC3H/HeJ miceGut permeabilityHeJ miceOral anaphylaxisPeanut challengeFood allergyMouse modelToll-like receptor 4BALB/c miceCytokinesis 8 (DOCK8) mutationsEnhanced gut permeabilityOral peanut challengesDOCK8 functionIngested allergenImmunologic mechanismsAnaphylaxis responsesImmunologic pathwaysAllergic diseasesC57BL/6 micePeanut allergyAntibody responseC miceReceptor 4DOCK8 mutationsIntraperitoneal challenge
2016
Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy
Srivastava KD, Siefert A, Fahmy TM, Caplan MJ, Li XM, Sampson HA. Investigation of peanut oral immunotherapy with CpG/peanut nanoparticles in a murine model of peanut allergy. Journal Of Allergy And Clinical Immunology 2016, 138: 536-543.e4. PMID: 27130858, DOI: 10.1016/j.jaci.2016.01.047.Peer-Reviewed Original ResearchConceptsPeanut oral immunotherapyOral peanut challengesPeanut-specific immunotherapyPeanut allergyOral immunotherapyPeanut challengeSymptom scoresRecall responsesMurine modelSplenocyte culturesHistamine levelsPeanut-specific serum IgEC3H/HeJ miceIFN-γ levelsPlasma histamine levelsVehicle control animalsCytokine recall responsesLower symptom scoresBody temperatureCurrent clinical approachesOral sensitizationWeekly gavageIgG2a levelsSublingual immunotherapySerum IgE
2014
Secreted Phosphoprotein 1 Is a Determinant of Lung Function Development in Mice
Ganguly K, Martin TM, Concel VJ, Upadhyay S, Bein K, Brant KA, George L, Mitra A, Thimraj TA, Fabisiak JP, Vuga LJ, Fattman C, Kaminski N, Schulz H, Leikauf GD. Secreted Phosphoprotein 1 Is a Determinant of Lung Function Development in Mice. American Journal Of Respiratory Cell And Molecular Biology 2014, 51: 637-651. PMID: 24816281, PMCID: PMC4224082, DOI: 10.1165/rcmb.2013-0471oc.Peer-Reviewed Original ResearchMeSH KeywordsAlveolar Epithelial CellsAnimalsAnimals, NewbornCore Binding Factor Alpha 1 SubunitFemaleGene Expression Regulation, DevelopmentalLung ComplianceMaleMice, Inbred C3HMice, Inbred C57BLMice, KnockoutOligonucleotide Array Sequence AnalysisOsteopontinPromoter Regions, GeneticPulmonary AlveoliPulmonary Disease, Chronic ObstructiveReceptor, Notch1ConceptsMicroarray analysisPhosphoprotein 1Quantitative trait lociLung functionQuantitative RT-PCR analysisDNA-protein bindingRunt-related transcription factor 2Transcription factor 2Developmental transcriptsLung developmentTrait lociNumerous genesSecreted Phosphoprotein 1Notch1 transcriptsRT-PCR analysisInsulin-like growth factor-1C3H/HeJ miceDiminished lung functionLung function developmentSPP1 promoterSPP1Growth factor-1Mean airspace chord lengthC3H/HeJGenetic variants
2010
Immunization with Adenoviral-expressed salivary gland proteins (SALPs) decreases spirochete load in a murine model of Lyme borreliosis (52.2)
Ullmann A, Dolan M, Fikrig E, Piesman J, Zeidner N. Immunization with Adenoviral-expressed salivary gland proteins (SALPs) decreases spirochete load in a murine model of Lyme borreliosis (52.2). The Journal Of Immunology 2010, 184: 52.2-52.2. DOI: 10.4049/jimmunol.184.supp.52.2.Peer-Reviewed Original ResearchBurgdorferi infectionMurine modelTick salivary proteinsC3H/HeJ miceDendritic cell expressionCellular immune responsesBorrelia burgdorferi infectionB. burgdorferi infectionLeast partial protectionSalivary proteinsSalivary gland proteinsImmunized miceSpecific immunitySpirochete burdenImmunomodulatory factorsHeJ miceVaccination techniqueImmune responseI. scapularis ticksTarget organsProtein antibodiesCell expressionSpirochete loadTick salivaLyme borreliosis
2007
A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair
Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ. A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair. The Journal Of Immunology 2007, 179: 4808-4820. PMID: 17878380, DOI: 10.4049/jimmunol.179.7.4808.Peer-Reviewed Original ResearchConceptsDevelopment of NECNEC developmentTLR4 activationEnterocyte apoptosisEnterocyte migrationTLR4-mutant C3H/HeJ miceC3H/HeOuJ miceC3H/HeJ miceTranslocation of LPSExpression of TLR4Cause of deathMurine intestinal epitheliumFocal adhesion kinaseNEC severityCritical roleIntestinal injuryMucosal injuryPreterm infantsNecrotizing enterocolitisEnterocyte injuryInflamed intestineIntestinal healingGastrointestinal diseasesHeJ miceIntestinal repairMarginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection
Belperron AA, Dailey CM, Booth CJ, Bockenstedt LK. Marginal Zone B-Cell Depletion Impairs Murine Host Defense against Borrelia burgdorferi Infection. Infection And Immunity 2007, 75: 3354-3360. PMID: 17470546, PMCID: PMC1932939, DOI: 10.1128/iai.00422-07.Peer-Reviewed Original ResearchConceptsT-cell-independent antibodiesCell-depleted miceSplenic CD4Cell depletionPathogen burdenSplenic T cell responsesHost defenseT-cell activation markersC3H/HeJ miceImmunoglobulin M titersInfected control miceMurine host defensePathogen-specific IgMT cell responsesMarginal zone B cellsBlood-borne antigensBlood-borne pathogensWeeks of infectionB cell subsetsImmune mouse serumBorrelia burgdorferi infectionImportant host defenseSevere arthritisActivation markersControl mice
2000
Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL‐2 and IFNγ production and promotes an IL‐4 response in C3H/HeJ mice
Zeidner N, Dolan M, Massung R, Piesman J, Fish D. Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL‐2 and IFNγ production and promotes an IL‐4 response in C3H/HeJ mice. Parasite Immunology 2000, 22: 581-588. PMID: 11116438, DOI: 10.1046/j.1365-3024.2000.00339.x.Peer-Reviewed Original ResearchConceptsIL-4 productionIL-2Human granulocytic ehrlichiosisT cellsB. burgdorferiGranulocytic ehrlichiosisC3H/HeJ miceSplenic IL-4Systemic IL-2Th2 cytokine responsesIL-4 responsesIFN-gamma productionSplenic T cellsIFN-gamma responsesTick infestationHuman granulocytic ehrlichiosis (HGE) agentBorrelia burgdorferi transmissionIFNγ productionCytokine responsesIL-4HeJ miceGamma productionB cellsCoinfectionDay 10
1999
Population Dynamics of a Naturally Occurring Heterogeneous Mixture of Borrelia burgdorferiClones
Hofmeister E, Glass G, Childs J, Persing D. Population Dynamics of a Naturally Occurring Heterogeneous Mixture of Borrelia burgdorferiClones. Infection And Immunity 1999, 67: 5709-5716. PMID: 10531219, PMCID: PMC96945, DOI: 10.1128/iai.67.11.5709-5716.1999.Peer-Reviewed Original ResearchConceptsC3H/HeJ miceC.B-17 miceLarval Ixodes scapularis ticksMajority of miceB. burgdorferiInfected nymphal ticksIxodes scapularis ticksBurgdorferi antibodiesSecondary challengeHeJ micePrimary isolatesSequential isolatesC3H miceSequential infectionMiceMonoclonal antibodiesBorrelia burgdorferiC expressionScapularis ticksClonal dominanceUnique isolatesMacrorestriction analysisOspC proteinsClonal groupsEnzootic site
1997
The Early Humoral Response in Human Granulocytic Ehrlichiosis
IJdo J, Zhang Y, Hodzic E, Magnarelli L, Wilson M, Telford S, Barthold S, Fikrig E. The Early Humoral Response in Human Granulocytic Ehrlichiosis. The Journal Of Infectious Diseases 1997, 176: 687-692. PMID: 9291316, DOI: 10.1086/514091.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisAntibody responseGranulocytic ehrlichiosisHGE agentC3H/HeJ miceEarly humoral responseEarly antibody responseStrong antibody responseHumoral responseHeJ miceClinical infectionPatientsAntigenHL-60 cellsMiceInfectionIgGEhrlichiosisSerumWeeksResponseIgMAgentsDiseaseDiagnosis
1996
Suppression of Acute Ixodes scapularis-Induced Borrelia burgdorferi Infection using Tumor Necrosis Factor-α, Interleukin-2, and Interferon-γ
Zeidner N, Dreitz M, Belasco D, Fish D. Suppression of Acute Ixodes scapularis-Induced Borrelia burgdorferi Infection using Tumor Necrosis Factor-α, Interleukin-2, and Interferon-γ. The Journal Of Infectious Diseases 1996, 173: 187-195. PMID: 8537658, DOI: 10.1093/infdis/173.1.187.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsAntibodies, BacterialArachnid VectorsBlotting, WesternBorrelia burgdorferi GroupDNA, BacterialDrug Therapy, CombinationElectrophoresis, Polyacrylamide GelFluorescent Antibody TechniqueImmune ToleranceImmunity, CellularInjections, IntraperitonealInterferon-gammaInterleukin-2IxodesLyme DiseaseMiceMice, Inbred C3HPolymerase Chain ReactionRandom AllocationTumor Necrosis Factor-alphaConceptsTumor necrosis factorNecrosis factorBurgdorferi infectionB. burgdorferiC3H/HeJ miceTick feedingBorrelia burgdorferi infectionB. burgdorferi infectionImmune containmentPolymerase chain reaction analysisCellular immunityCytokine productionIL-2TNF-alphaHeJ miceInterleukin-2IFN-gammaChain reaction analysisDay 21Infection rateWestern blotEar biopsiesProtection rateInfectionBorrelia burgdorferi
1992
Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens
de Souza M, Fikrig E, Smith A, Flavell R, Barthold SW. Nonspecific Proliferative Responses of Murine Lymphocytes to Borrelia burgdorferi Antigens. The Journal Of Infectious Diseases 1992, 165: 471-478. PMID: 1531672, DOI: 10.1093/infdis/165.3.471.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial ProteinsBacterial VaccinesBorrelia burgdorferi GroupDose-Response Relationship, ImmunologicFlow CytometryImmunoglobulin GImmunoglobulin MLipopolysaccharidesLipoproteinsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C3HRecombinant ProteinsSpecific Pathogen-Free OrganismsConceptsBorrelia burgdorferi antigensNaive splenocytesNonspecific proliferationProliferative responseB. burgdorferiC3H/HeNCrlBR miceRecombinant outer surface proteinB cell-enriched fractionC3H/HeJ miceNonspecific proliferative responseAntigen-specific proliferationStrains of miceCell-enriched fractionB. burgdorferi spirochetesIgG synthesisHeJ miceB cellsMitogenic effectOuter surface proteinsMurine lymphocytesLyme borreliosisMiceSplenocytesBurgdorferiAntigen
1990
Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA
Fikrig E, Barthold S, Kantor F, Flavell R. Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA. Science 1990, 250: 553-556. PMID: 2237407, DOI: 10.1126/science.2237407.Peer-Reviewed Original ResearchConceptsRecombinant OspALyme borreliosisC3H/HeJ miceProtection of miceTick-borne illnessB. burgdorferi strain N40Recombinant OspA proteinSurface protein AOuter surface protein AHeJ miceLyme disease agentStrain N40Borrelia burgdorferiB. burgdorferiMiceOspABorreliosisOspA proteinBurgdorferiDisease agentsProtein AVaccineIllnessAntibodies
1989
Disparate Effects of In Vitro Low-Dose UVB Irradiation on Intravenous Immunization with Purified Epidermal Cell Subpopulations for the Induction of Contact Hypersensitivity
Cruz P, Nixon-Fulton J, Tigelaar R, Bergstresser P. Disparate Effects of In Vitro Low-Dose UVB Irradiation on Intravenous Immunization with Purified Epidermal Cell Subpopulations for the Induction of Contact Hypersensitivity. Journal Of Investigative Dermatology 1989, 92: 160-165. PMID: 2918229, DOI: 10.1111/1523-1747.ep12276682.Peer-Reviewed Original ResearchConceptsIntravenous immunizationCH responsesLow-dose UVB irradiationUVB irradiationLow-dose UVB radiationC3H/HeJ miceLow-dose ultraviolet B irradiationModel of immunosuppressionAntigen-presenting functionContact hypersensitivity reactionCapacity of ECUltraviolet B irradiationContact hypersensitivityEffects of UVBSubsequent immunizationHypersensitivity reactionsHeJ miceLeft earEpidermal cell subpopulationsSyngeneic miceRight earPanel of miceDay 14Day 0Abdominal skin
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