2015
Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial
Lindesmith LC, Ferris MT, Mullan CW, Ferreira J, Debbink K, Swanstrom J, Richardson C, Goodwin RR, Baehner F, Mendelman PM, Bargatze RF, Baric RS. Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial. PLOS Medicine 2015, 12: e1001807. PMID: 25803642, PMCID: PMC4371888, DOI: 10.1371/journal.pmed.1001807.Peer-Reviewed Original ResearchConceptsTime of vaccinationAb responsesVLP vaccineHuman volunteersProtective immunityAb titersCandidate vaccinesEffective NoV vaccinesPhase I ClinicalCross-strain protectionSurrogate neutralization assayBlockade antibodiesAb blockadeNoV infectionBlockade assayAcute gastroenteritisImmune responseNeutralization assaysNoV vaccinesVaccine componentsPredominant GIIMultiple epitopesVaccinationPrevious exposure historyAntigenic drift
2014
Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors
Chernova I, Jones DD, Wilmore JR, Bortnick A, Yucel M, Hershberg U, Allman D. Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors. The Journal Of Immunology 2014, 193: 4971-4979. PMID: 25326027, PMCID: PMC4234148, DOI: 10.4049/jimmunol.1401264.Peer-Reviewed Original ResearchConceptsBM plasma cellsPlasma cellsLong-term Ab responsesLong-term humoral responseBone marrow plasma cellsT cell-dependent AgSerum Ab titersIgG-secreting cellsRole of subpopulationsMarrow plasma cellsActivated B cellsPC poolAb titersHumoral responseAntibody responseIgG AbsAb responsesL chain usageIgM AbsB cellsHapten-protein conjugatesPC subsetsChain usageIgM
2013
Novel Biopanning Strategy To Identify Epitopes Associated with Vaccine Protection
Bachler B, Humbert M, Palikuqi B, Siddappa N, Lakhashe S, Rasmussen R, Ruprecht R. Novel Biopanning Strategy To Identify Epitopes Associated with Vaccine Protection. Journal Of Virology 2013, 87: 4403-4416. PMID: 23388727, PMCID: PMC3624354, DOI: 10.1128/jvi.02888-12.Peer-Reviewed Original ResearchConceptsSimian-human immunodeficiency virusRhesus macaquesHIV-1Vaccinated rhesus macaquesHIV-1 vaccineVaccine protectionScreen plasma samplesHIV-1 TatMucosal challengeImmune correlatesImmunodeficiency virusNT AbsAb responsesVaccine recipientsAb titersAb epitopesVaccine failurePlasma samplesMulticomponent vaccineProtective effectIn vivoDetection AbVaccineFunctional assaysDisease models
2009
Chlamydia trachomatis Native Major Outer Membrane Protein Induces Partial Protection in Nonhuman Primates: Implication for a Trachoma Transmission-Blocking Vaccine
Kari L, Whitmire W, Crane D, Reveneau N, Carlson J, Goheen M, Peterson E, Pal S, de la Maza L, Caldwell H. Chlamydia trachomatis Native Major Outer Membrane Protein Induces Partial Protection in Nonhuman Primates: Implication for a Trachoma Transmission-Blocking Vaccine. The Journal Of Immunology 2009, 182: 8063-8070. PMID: 19494332, PMCID: PMC2692073, DOI: 10.4049/jimmunol.0804375.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntibody SpecificityBacterial Outer Membrane ProteinsBacterial VaccinesChlamydia InfectionsChlamydia trachomatisCytokinesDisease Models, AnimalEnzyme-Linked Immunosorbent AssayHeLa CellsHumansKineticsLeukocytesMacaca fascicularisMaleProtein DenaturationTitrimetryConceptsMuridarum major outer membrane proteinChlamydia muridarum major outer membrane proteinInfectious burdenAg-specific IFN-gamma responseBlinding inflammatory diseaseReduces infectious burdenProgression of ocular diseaseNonhuman primatesInfection of childrenTransmission-blocking vaccinesIFN-gamma responseHuman chlamydial infectionsHigher serum IgGDuration of infectionMajor Outer Membrane ProteinOcular sheddingOcular diseasesChlamydial infectionImmunized monkeysAb titersCynomolgus monkeysNeutralizing activityPrimary infectionChlamydial challengeInflammatory diseases
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