2023
HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal
Pierce C, Loh L, Steach H, Cheshenko N, Preston-Hurlburt P, Zhang F, Stransky S, Kravets L, Sidoli S, Philbrick W, Nassar M, Krishnaswamy S, Herold K, Herold B. HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal. Journal Of Clinical Investigation 2023, 133: e164317. PMID: 37079384, PMCID: PMC10232005, DOI: 10.1172/jci164317.Peer-Reviewed Original ResearchConceptsHIV-1 reactivationHIV latency reversalT cellsLatency reversalHuman CD4HIV-1 viral loadHIV-1 restriction factorsHSV-2 recurrencesHSV-2 infectionHIV-1 latencyUpregulation of MALAT1Primary human CD4HSV-2 proteinsViral loadHIV replicationPeripheral bloodMALAT1 expressionHSV-2Tissue reservoirsCD4Viral replicationExpression of transcriptsBystander cellsRestriction factorsMALAT1Epidemiological Survey of Human Alphaherpesvirus 2 (HSV-2) Infection in Indigenous People of Dourados Municipality, Central Brazil
de Oliveira Bonfim F, Villar L, Croda J, da Silva S, Gonçalves C, de Castro V, de Rezende Romeira G, Cesar G, dos Santos Weis-Torres S, Horta M, Simionatto S, Motta-Castro A, de Paula V. Epidemiological Survey of Human Alphaherpesvirus 2 (HSV-2) Infection in Indigenous People of Dourados Municipality, Central Brazil. Tropical Medicine And Infectious Disease 2023, 8: 197. PMID: 37104324, PMCID: PMC10143357, DOI: 10.3390/tropicalmed8040197.Peer-Reviewed Original ResearchHSV-2 IgMHSV-2 transmissionHSV-2 infectionHealth access barriersIllicit drug abuseAdult Brazilian populationPublic health policyAppropriate intervention programsGenital ulcersGenital wartsUrethral dischargeExact prevalenceUrinary problemsHSV-2Used needlesSerologic testsContraceptive methodsActive adolescentsEpidemiological surveyBrazilian indigenous populationDrug usersCondom useDrug abuseHealth policyIndigenous populations
2022
HSV-2 increases replication of HIV in human T cells
Pierce C, Preston-Hurlburt P, Loh L, Steach H, Sidoli S, Zhang F, Philbrick W, Nassar M, Krishnaswamy S, Herold K, Herold B. HSV-2 increases replication of HIV in human T cells. The Journal Of Immunology 2022, 208: 182.40-182.40. DOI: 10.4049/jimmunol.208.supp.182.40.Peer-Reviewed Original ResearchCD4 cellsHSV-2HIV reactivationHIV PVLT cellsHerpes simplex virus 2 infectionLncRNA MALAT1Simplex virus 2 infectionHIV-LTR expressionHSV-2 lesionsMALAT1 gene expressionUninfected CD4 cellsFollicular helper cellsHSV-2 infectionCD4 T cellsHIV restriction factorsVirus 2 infectionGlobal HIV epidemicHSV-2 glycoprotein BHIV latent reservoirHuman T cellsInterferon response genesMucosal responsesHSV infectionLatent reservoir
2021
Endogenous retroviruses mediate IFN-independent protection against vaginal HSV-2 infection
Tokuyama M, Jayewickreme R, Mao T, Philbrick W, Kong Y, Dong H, Treger R, Rakib T, Iwasaki A. Endogenous retroviruses mediate IFN-independent protection against vaginal HSV-2 infection. The Journal Of Immunology 2021, 206: 20.39-20.39. DOI: 10.4049/jimmunol.206.supp.20.39.Peer-Reviewed Original ResearchHSV-2 infectionVaginal HSV-2 infectionTight junction proteinsB6 miceVaginal epitheliumHerpes simplex virus type 2 infectionSimplex virus type 2 infectionEnhanced type I interferonIntravaginal HSV-2 infectionVirus type 2 infectionToll-like receptor 7Epithelial tight junction proteinsEndogenous retrovirusesReceptor-deficient miceJunction proteinsType 2 infectionHigh systemic levelsWildtype C57BL/6 miceType I interferonDisease courseC57BL/6 miceInfectious endogenous retrovirusReceptor 7Disease burdenHSV-2Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus–Seronegative Recipients of the HSV529 Vaccine
Wang K, Dropulic L, Bozekowski J, Pietz H, Jegaskanda S, Dowdell K, Vogel J, Garabedian D, Oestreich M, Nguyen H, Ali M, Lumbard K, Hunsberger S, Reifert J, Haynes W, Sawyer J, Shon J, Daugherty P, Cohen J. Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus–Seronegative Recipients of the HSV529 Vaccine. The Journal Of Infectious Diseases 2021, 224: 1509-1519. PMID: 33718970, PMCID: PMC8599754, DOI: 10.1093/infdis/jiab139.Peer-Reviewed Original ResearchConceptsVaccine recipientsHSV-2Genital tractNatural killer (NK) cell activityCell activationHerpes simplex virus type 2Replication-defective vaccinesNK cell activitySerum neutralizing antibody responsesNeutralizing antibody responsesAntibodies to epitopesCervicovaginal fluidGenital infectionGenital herpesAntibody profilesNeutralization titersHSV529Antibody responseSerum antibodiesHerpesType 2GD antibodiesAntibodiesSerumVaccine
2020
RUNX Binding Sites Are Enriched in Herpesvirus Genomes, and RUNX1 Overexpression Leads to Herpes Simplex Virus 1 Suppression
Kim DJ, Khoury-Hanold W, Jain PC, Klein J, Kong Y, Pope SD, Ge W, Medzhitov R, Iwasaki A. RUNX Binding Sites Are Enriched in Herpesvirus Genomes, and RUNX1 Overexpression Leads to Herpes Simplex Virus 1 Suppression. Journal Of Virology 2020, 94: 10.1128/jvi.00943-20. PMID: 32878886, PMCID: PMC7592204, DOI: 10.1128/jvi.00943-20.Peer-Reviewed Original ResearchConceptsDorsal root gangliaHSV-1 infectionNumerous viral genesHSV-2Sensory neuronsHost transcription factorsHSV-1 genomeHSV-1Dorsal root ganglion neuronsViral gene expressionMouse DRG neuronsLifelong latent infectionViral genesKnockdown of RUNX1Herpes simplex virus 1Simplex virus 1DRG neuronsGanglion neuronsRoot gangliaOverall infectionViral gene transcriptionLatent infectionHSV-2 genomeInfectionNeuroblastoma cellsHSV-2 infects T follicular helper cells to promote HIV reactivation
Pierce C, Loh L, Preston-Hurlburt P, Herold K, Herold B. HSV-2 infects T follicular helper cells to promote HIV reactivation. The Journal Of Immunology 2020, 204: 247.24-247.24. DOI: 10.4049/jimmunol.204.supp.247.24.Peer-Reviewed Original ResearchCD4 T cellsFollicular helper cellsHIV reactivationHSV-2T cellsTfh cellsIL-32Helper cellsSystemic effectsCD4 T-cell subpopulationsT Follicular Helper CellsHSV-2 recurrencesHSV-2 seropositiveT cell subpopulationsGlobal HIV epidemicPotential systemic effectsT cell linesSeronegative womenIL-32γHigh HIVViral loadHIV transmissionLatent HIVProinflammatory cytokinesHIV epidemicChapter 43 Mucosal Vaccines for Genital Herpes
Oh J, Iwasaki A. Chapter 43 Mucosal Vaccines for Genital Herpes. 2020, 723-734. DOI: 10.1016/b978-0-12-811924-2.00043-2.Peer-Reviewed Original ResearchGenital herpesMucosal vaccinesHSV-2Immune responseSensory neuronsHerpes simplex virus type 2Simplex virus type 2Genital mucosal epitheliaLocal immune responseDorsal root gangliaHSV type 1Host immune responseVirus type 2Painful ulcersGenital mucosaMucosal immunityAsymptomatic sheddingHIV transmissionRoot gangliaRisk factorsSystemic immunityClinical trialsLifelong infectionMucosal epitheliumAntiviral drugs
2016
Role of Interleukin 32 in Human Immunodeficiency Virus Reactivation and Its Link to Human Immunodeficiency Virus–Herpes Simplex Virus Coinfection
Mesquita PM, Preston-Hurlburt P, Keller MJ, Vudattu N, Espinoza L, Altrich M, Anastos K, Herold KC, Herold BC. Role of Interleukin 32 in Human Immunodeficiency Virus Reactivation and Its Link to Human Immunodeficiency Virus–Herpes Simplex Virus Coinfection. The Journal Of Infectious Diseases 2016, 215: 614-622. PMID: 28007920, PMCID: PMC5388286, DOI: 10.1093/infdis/jiw612.Peer-Reviewed Original ResearchMeSH KeywordsAdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoinfectionCore Binding Factor Alpha 2 SubunitCross-Sectional StudiesDNA, ViralFemaleHerpes GenitalisHerpesvirus 2, HumanHIV InfectionsHIV-1HumansInterleukinsLeukocytes, MononuclearMiddle AgedRecombinant ProteinsRNA, ViralViral LoadYoung AdultConceptsHuman immunodeficiency virus type 1T cellsIL-32HSV-2HIV reactivationHIV reservoirHIV DNACell-associated HIV DNAHuman Immunodeficiency Virus ReactivationHerpes simplex virus type 2Peripheral blood mononuclear cellsSimplex virus type 2Immunodeficiency virus type 1Frequency of CCR5Higher HIV DNARecombinant IL-32γSystemic T cellsRUNX1 inhibitorT-cell phenotypeBlood mononuclear cellsSubpopulation of CD4Virus type 1Virus type 2Interleukin-32γAntiretroviral therapyCommercial sex and risk of HIV, syphilis, and herpes simplex virus-2 among men who have sex with men in six Chinese cities
Zheng C, Xu JJ, Hu QH, Yu YQ, Chu ZX, Zhang J, Han XX, Lu L, Wang Z, Fu JH, Chen X, Yan HJ, Jiang YJ, Geng WQ, Vermund SH, Qian HZ, Shang H. Commercial sex and risk of HIV, syphilis, and herpes simplex virus-2 among men who have sex with men in six Chinese cities. BMC Infectious Diseases 2016, 16: 765. PMID: 28003032, PMCID: PMC5178086, DOI: 10.1186/s12879-016-2130-x.Peer-Reviewed Original ResearchConceptsHIV/STIsHigh prevalenceHigh riskSex partnersHIV/STI surveillanceSimplex virus type 2HSV-2 infectionHIV/STISubgroups of MSMSimplex virus 2Male sex partnersCommercial sexRisk of HIVUnprotected anal intercourseVirus type 2Cross-sectional surveyHIV prevalenceSTI surveillanceHSV-2Overall prevalenceAnal intercourseHIVType 2Serological testsGreater riskCD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
Shin H, Kumamoto Y, Gopinath S, Iwasaki A. CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2. Nature Communications 2016, 7: 13346. PMID: 27827367, PMCID: PMC5105190, DOI: 10.1038/ncomms13346.Peer-Reviewed Original ResearchConceptsCD8 TRM cellsAntigen-presenting cellsGenital HSV-2 infectionTissue-resident memory CD8HSV-2 infectionTRM cellsDendritic cellsMemory CD8Protective immunityT cellsPopulations of APCsGenital HSV-2Protective immune responseFemale genital tractMHC class IHSV-2Genital tractAntigen presentationImmune responseLamina propriaViral infectionConfer protectionBarrier tissuesClass IInfectionHSV‐2 enhances ZIKV infection of the placenta and induces apoptosis in first‐trimester trophoblast cells
Aldo P, You Y, Szigeti K, Horvath TL, Lindenbach B, Mor G. HSV‐2 enhances ZIKV infection of the placenta and induces apoptosis in first‐trimester trophoblast cells. American Journal Of Reproductive Immunology 2016, 76: 348-357. PMID: 27613665, DOI: 10.1111/aji.12578.Peer-Reviewed Original ResearchConceptsHSV-2 infectionZIKV infectionZika virusTrophoblast cellsHSV-2First-trimester human trophoblast cellsFirst trimester trophoblast cellsZIKV-infected mothersSimplex virus 2First trimester trophoblastsHuman trophoblast cellsPlacental sensitivityFirst trimesterPregnant micePlacental barrierTAM receptorsFetal protectionHigh riskTeratogenic effectsViral titersInfectionPlacental formationRT-PCRVirus 2Fetuses
2014
Recreational drug use and risks of HIV and sexually transmitted infections among Chinese men who have sex with men: Mediation through multiple sexual partnerships
Xu JJ, Zhang C, Hu QH, Chu ZX, Zhang J, Li YZ, Lu L, Wang Z, Fu JH, Chen X, Yan HJ, Zhuang MH, Jiang YJ, Geng WQ, Vermund SH, Shang H, Qian HZ. Recreational drug use and risks of HIV and sexually transmitted infections among Chinese men who have sex with men: Mediation through multiple sexual partnerships. BMC Infectious Diseases 2014, 14: 642. PMID: 25443542, PMCID: PMC4272794, DOI: 10.1186/s12879-014-0642-9.Peer-Reviewed Original ResearchConceptsMultiple sexual partnershipsUnprotected sexDrug useSexual partnersSexual partnershipsSimplex virus type 2Multiple logistic regression modelHSV-2 infectionHSV-2 prevalenceCross-sectional studyRisk of HIVMultiple sexual partnersVirus type 2Last sexual encounterRecreational drug useLogistic regression modelsHIV infectionActive MSMHSV-2HIV riskSexual disinhibitionChinese MSMHigh riskHIVChinese menA local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells
Iijima N, Iwasaki A. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science 2014, 346: 93-98. PMID: 25170048, PMCID: PMC4254703, DOI: 10.1126/science.1257530.Peer-Reviewed Original ResearchConceptsMemory lymphocyte clustersMemory T cellsT cellsCD8 tissue-resident memory T cellsTissue-resident memory CD4 T cellsHerpes simplex virus 2 infectionTissue-resident memory T cellsSimplex virus 2 infectionMemory CD4 T cellsEfficient local controlPool of CD4Role of CD4CD4 T cellsVirus 2 infectionVaginal CD4Parabiotic miceGenital mucosaVaccine strategiesChemokine networkLymphocyte clustersHSV-2Viral infectionCD4Local controlInfection
2009
Herpes Simplex Type-2 Meningitis: Presentation and Lack of Standardized Therapy
Landry ML, Greenwold J, Vikram HR. Herpes Simplex Type-2 Meningitis: Presentation and Lack of Standardized Therapy. The American Journal Of Medicine 2009, 122: 688-691. PMID: 19559173, DOI: 10.1016/j.amjmed.2009.02.017.Peer-Reviewed Original ResearchConceptsHSV-2 meningitisGenital herpesHerpes simplex type 2Evidence of meningoencephalitisOral antiviral therapyRecurrent lymphocytic meningitisRetrospective observational studyTime of presentationSimplex type 2Optimal patient managementCerebrospinal fluid samplesSteroid injectionCesarean sectionLymphocytic meningitisOral therapyStandardized therapyAntiviral treatmentGenital symptomsIntravenous therapyRecurrent meningitisAntiviral therapySpinal stenosisGenital lesionsHSV-2Medical recordsPreventing HIV in Developing Countries: Status of Biomedical Interventions
Vermund S. Preventing HIV in Developing Countries: Status of Biomedical Interventions. The FASEB Journal 2009, 23: 199.1-199.1. DOI: 10.1096/fasebj.23.1_supplement.199.1.Peer-Reviewed Original ResearchHIV Prevention Trials NetworkPrevention of motherHIV drug resistanceNeedle exchange programsDNA boostBehavior changeHIV seroconversionHIV seroincidenceEarly therapyPregnant womenHSV-2Clinical trialsHIVMale circumcisionDrug addiction treatmentDrug resistanceTrials NetworkAddiction treatmentBiomedical interventionsSeroincidenceInfantsRisk reductionTherapyPrevention challengesEfficacy
2007
Vaginal epithelial dendritic cells renew from bone marrow precursors
Iijima N, Linehan MM, Saeland S, Iwasaki A. Vaginal epithelial dendritic cells renew from bone marrow precursors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 19061-19066. PMID: 18006657, PMCID: PMC2141908, DOI: 10.1073/pnas.0707179104.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAnimals, CongenicAntigens, CDAntigens, SurfaceBone Marrow CellsCell LineageDiestrusEpidermal CellsEpithelial CellsFemaleHerpes GenitalisLectins, C-TypeLymph NodesMannose-Binding LectinsMiceMice, Inbred C57BLMice, TransgenicMucous MembraneMultipotent Stem CellsOrgan SpecificityRadiation ChimeraVaginaConceptsEpithelial dendritic cellsDendritic cellsLangerhans cellsKey professional antigen-presenting cellsProfessional antigen-presenting cellsSkin Langerhans cellsAntigen-presenting cellsPrimary immune responseEpidermal Langerhans cellsMucosal epithelial liningBone marrow precursorsSquamous epithelial layerStratified squamous epithelial layerHSV-2Sex hormonesImmune responseOral cavityVaginal mucosaEpithelial liningMarrow precursorsActivation statusSpecialized subsetCytometric analysisEpithelial layerCells
2006
Anatomical mapping of human herpesvirus reservoirs of infection
Chen T, Hudnall SD. Anatomical mapping of human herpesvirus reservoirs of infection. Modern Pathology 2006, 19: 726-737. PMID: 16528368, DOI: 10.1038/modpathol.3800584.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnal CanalAutopsyCytomegalovirusDNA, ViralFemaleHerpesviridaeHerpesviridae InfectionsHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 7, HumanHerpesvirus 8, HumanHumansIntestinesMaleMiddle AgedNasal MucosaNervous SystemThyroid GlandConceptsHHV-6Whole blood specimensHSV-1Lymph nodesHHV-7Nasal mucosaAnatomic sitesHuman herpesvirusesHIV-AIDSActive herpesvirus infectionHSV-1 positivitySalivary glandsMajor anatomic sitesMiddle-aged malesTime of deathCardiac arrestHHV-8Adrenal glandElderly malesPrimary infectionHSV-2Urinary bladderHerpesvirus infectionAnatomical mappingBone marrow
2005
Parents’/guardians’ willingness to vaccinate their children against genital herpes
Liddon N, Pulley L, Cockerham WC, Lueschen G, Vermund SH, Hook EW. Parents’/guardians’ willingness to vaccinate their children against genital herpes. Journal Of Adolescent Health 2005, 37: 187-193. PMID: 16109337, DOI: 10.1016/j.jadohealth.2005.05.030.Peer-Reviewed Original ResearchConceptsHSV-2Type 2 vaccineLogistic regression modelsParents/guardiansInfluenza shotSTD vaccinesCorrelates of intentionGenital herpesMajority of parentsVaccine acceptanceDisease vaccineVaccinationLogistic regressionOptimal timingFuture interventionsVaccineAppropriate timingSexual activityTelephone surveyChildrenParents' acceptanceInterventionOne-thirdDescriptive statisticsOverall attitudeHerpes simplex virus Type 2 Acute Retinal Necrosis 9 Years after Neonatal Herpes
Landry ML, Mullangi P, Nee P, Klein BR. Herpes simplex virus Type 2 Acute Retinal Necrosis 9 Years after Neonatal Herpes. The Journal Of Pediatrics 2005, 146: 836-838. PMID: 15973328, DOI: 10.1016/j.jpeds.2005.02.025.Peer-Reviewed Original Research
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