2025
A ventilated perfused lung model platform to dissect the response of the lungs to viral infection
Derman I, Alioglu M, Moses J, Chroneos Z, Yilmaz Y, Banerjee D, Koff J, Rizvi S, Klunk D, Celik N, Pochareddy S, Umstead T, Namli I, Holton S, Mikacenic C, Thompson J, Castaneda D, Hickey D, Nagamine M, Warang P, Schotsaert M, Chen P, Peeples M, Palucka K, Ozbolat I. A ventilated perfused lung model platform to dissect the response of the lungs to viral infection. Trends In Biotechnology 2025, 43: 1714-1742. PMID: 40280814, PMCID: PMC12226239, DOI: 10.1016/j.tibtech.2025.03.012.Peer-Reviewed Original ResearchRespiratory syncytial virusViral infectionEpithelial barrier functionAir-liquid interfaceResponse to ventilationResponse to viral infectionTight-junction formationResponse to infectionViral responseProinflammatory chemokinesSyncytial virusRespiratory infectionsPulmonary physiologyViral recognitionLung physiologyEpithelial layerRespiratory cyclePerfusion modelBarrier functionAlveolar epithelial layerVascular componentInfectionViral spreadLung modelVentilation
2018
Cellular Dynamics Driving Elongation of the Gut
Sumigray K, Lechler T. Cellular Dynamics Driving Elongation of the Gut. Developmental Cell 2018, 46: 127-128. PMID: 30016614, DOI: 10.1016/j.devcel.2018.06.027.Peer-Reviewed Original Research
2014
Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas
Shahrabi-Farahani S, Wang L, Zwaans B, Santana J, Shimizu A, Takashima S, Kreuter M, Coultas L, D'Amore P, Arbeit J, Akslen L, Bielenberg D. Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas. Laboratory Investigation 2014, 94: 752-765. PMID: 24791743, PMCID: PMC4074450, DOI: 10.1038/labinvest.2014.66.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCarcinoma, Squamous CellCell DifferentiationCell Line, TumorCells, CulturedEpidermal CellsEpidermisFemaleGene ExpressionHumansImmunohistochemistryKeratin-1KeratinocytesMiceMice, Inbred BALB CMice, NudeMice, TransgenicNeuropilin-1Receptors, Vascular Endothelial Growth FactorReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsTransplantation, HeterologousVascular Endothelial Growth Factor AConceptsSquamous cell carcinomaVascular endothelial growth factorExpression of NRP1Epithelial cellsCell carcinomaVascular endothelial growth factor ligandCutaneous squamous cell carcinomaGrowth factorSuprabasal epithelial cellsNeuropilin-1 expressionProliferating Cell Nuclear AntigenSuprabasal epithelial layersEndothelial growth factorHuman SCC xenograftsCell nuclear antigenEpidermal growth factor-family growth factorsEpithelial compartmentVEGF-ADegree of differentiationCell surface receptorsNuclear antigenKeratin 14Epithelial layerDifferentiation statusPrimary keratinocytes
2013
Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye
Nabili M, Patel H, Mahesh SP, Liu J, Geist C, Zderic V. Ultrasound-Enhanced Delivery of Antibiotics and Anti-Inflammatory Drugs Into the Eye. Ultrasound In Medicine & Biology 2013, 39: 638-646. PMID: 23415283, PMCID: PMC3770302, DOI: 10.1016/j.ultrasmedbio.2012.11.010.Peer-Reviewed Original ResearchConceptsOphthalmic drugsLong-term survival studiesSodium fluoresceinAnti-inflammatory drugsTreatment parameter combinationUltrasound-enhanced deliveryTopical administrationHistologic analysisSurvival studiesCorneaCorneal permeabilityDexamethasoneEpithelial layerTherapeutic drugsRabbit corneaStatistical significanceDrug dexamethasoneDrugsTobramycinUltrasoundEyesDeliveryFuture investigationsAdministrationDrug delivery
2007
Vaginal epithelial dendritic cells renew from bone marrow precursors
Iijima N, Linehan MM, Saeland S, Iwasaki A. Vaginal epithelial dendritic cells renew from bone marrow precursors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 19061-19066. PMID: 18006657, PMCID: PMC2141908, DOI: 10.1073/pnas.0707179104.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAnimals, CongenicAntigens, CDAntigens, SurfaceBone Marrow CellsCell LineageDiestrusEpidermal CellsEpithelial CellsFemaleHerpes GenitalisLectins, C-TypeLymph NodesMannose-Binding LectinsMiceMice, Inbred C57BLMice, TransgenicMucous MembraneMultipotent Stem CellsOrgan SpecificityRadiation ChimeraVaginaConceptsEpithelial dendritic cellsDendritic cellsLangerhans cellsKey professional antigen-presenting cellsProfessional antigen-presenting cellsSkin Langerhans cellsAntigen-presenting cellsPrimary immune responseEpidermal Langerhans cellsMucosal epithelial liningBone marrow precursorsSquamous epithelial layerStratified squamous epithelial layerHSV-2Sex hormonesImmune responseOral cavityVaginal mucosaEpithelial liningMarrow precursorsActivation statusSpecialized subsetCytometric analysisEpithelial layerCells
2004
Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells
Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S. Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells. Blood 2004, 104: 166-169. PMID: 15026310, DOI: 10.1182/blood-2003-09-3293.Peer-Reviewed Original ResearchConceptsVascular progenitor cellsAll-Trans Retinoic AcidChicken chorioallantoic membraneEndothelial cellsTie2 signalingProgenitor cellsBlood vessel formationMural cellsEpithelial layerExpression of angiopoietin-2Vessel formationRetinoic acidImpaired vascular remodelingImpaired branchingAngiopoietin-2Ang-1Vascular remodelingRo41-5253Cell interactionsMural cell interactions
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply