2024
Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity
Niemeyer C, Merle L, Bubak A, Baxter B, Polese A, Colon-Reyes K, Vang S, Hassell J, Bruce K, Nagel M, Restrepo D. Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity. Journal Of Virology 2024, 98: e00968-24. PMID: 39475273, PMCID: PMC11575344, DOI: 10.1128/jvi.00968-24.Peer-Reviewed Original ResearchCentral nervous systemHerpes simplex virus type 1Trigeminal ganglionVirus type 1Olfactory epitheliumHSV-1Locus coeruleusHSV-1 CNS infectionBrain regionsImmune responseResponse to HSV-1Microglial activationType 1Spread of HSV-1Absence of viral antigenHSV-1 antigenHSV-1 spreadHSV-1 infectionC57BL/6 mouse modelCranial nerve nucleiResponse of macrophagesInflammatory response of macrophagesCNS infectionRaphe nucleusNasal epitheliaHigh silent prevalence of human herpesvirus 1 (HSV-1) infection affecting the indigenous reservation of the municipality of Dourados, Central-West Brazil
de Oliveira Bonfim F, Villar L, Croda J, Pereira J, Guimarães A, da Silva S, Maymone Gonçalves C, Leonardo L, de Rezende Romeira G, Cesar G, Weis-Torres S, de Oliveira Landgraf de Castro V, Horta M, Simionatto S, Motta-Castro A, de Paula V. High silent prevalence of human herpesvirus 1 (HSV-1) infection affecting the indigenous reservation of the municipality of Dourados, Central-West Brazil. BMC Infectious Diseases 2024, 24: 700. PMID: 39020287, PMCID: PMC11253429, DOI: 10.1186/s12879-024-09497-5.Peer-Reviewed Original ResearchConceptsAnti-HSV-1 antibodiesHSV-1 DNAAnti-HSV-1HSV-1Viral loadReal-time PCRDetection of HSV-1 DNAHSV-1 viral loadSeroprevalence of HSV-1HSV-1 transmissionControl of HSV-1 infectionHSV-1 infectionAdult Brazilian populationIgM-positive samplesNeonatal infectionHerpetic keratitisGenital wartsUrethral dischargeHerpes encephalitisHuman herpesvirus 1IgM antibodiesRisk factorsSevere diseaseUrinary problemsHuman alphaherpesvirus
2020
RUNX Binding Sites Are Enriched in Herpesvirus Genomes, and RUNX1 Overexpression Leads to Herpes Simplex Virus 1 Suppression
Kim DJ, Khoury-Hanold W, Jain PC, Klein J, Kong Y, Pope SD, Ge W, Medzhitov R, Iwasaki A. RUNX Binding Sites Are Enriched in Herpesvirus Genomes, and RUNX1 Overexpression Leads to Herpes Simplex Virus 1 Suppression. Journal Of Virology 2020, 94: 10.1128/jvi.00943-20. PMID: 32878886, PMCID: PMC7592204, DOI: 10.1128/jvi.00943-20.Peer-Reviewed Original ResearchConceptsDorsal root gangliaHSV-1 infectionNumerous viral genesHSV-2Sensory neuronsHost transcription factorsHSV-1 genomeHSV-1Dorsal root ganglion neuronsViral gene expressionMouse DRG neuronsLifelong latent infectionViral genesKnockdown of RUNX1Herpes simplex virus 1Simplex virus 1DRG neuronsGanglion neuronsRoot gangliaOverall infectionViral gene transcriptionLatent infectionHSV-2 genomeInfectionNeuroblastoma cells
2019
The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers
Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host & Microbe 2019, 26: 369-384.e8. PMID: 31513772, DOI: 10.1016/j.chom.2019.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesAnimalsAntiviral AgentsChromosomal Proteins, Non-HistoneDNA Topoisomerases, Type IDNA VirusesHEK293 CellsHeLa CellsHerpesvirus 1, HumanHeterogeneous-Nuclear Ribonucleoprotein UHost-Pathogen InteractionsHumansImmunity, InnateInterferon Regulatory Factor-3Interferon Regulatory Factor-7MiceNuclear Matrix-Associated ProteinsProtein Serine-Threonine KinasesReceptors, Pattern RecognitionRNA VirusesRNA, Double-StrandedRNA, ViralVirusesConceptsImmune gene transcriptionViral RNAViral RNA sensorsChromatin remodelingTrigger innate immune responsesSuper enhancersGene transcriptionExtranuclear localizationRNA virusesInnate immune responseAntiviral genesDsRNA sensorsRNA sensorsViral dsRNAAntiviral stateAntiviral responseType I IFNDsRNAVSV infectionRobust antiviral responseRNAEnhancerI IFNImmune responseHSV-1The viral protein corona directs viral pathogenesis and amyloid aggregation
Ezzat K, Pernemalm M, Pålsson S, Roberts T, Järver P, Dondalska A, Bestas B, Sobkowiak M, Levänen B, Sköld M, Thompson E, Saher O, Kari O, Lajunen T, Sverremark Ekström E, Nilsson C, Ishchenko Y, Malm T, Wood M, Power U, Masich S, Lindén A, Sandberg J, Lehtiö J, Spetz A, EL Andaloussi S. The viral protein corona directs viral pathogenesis and amyloid aggregation. Nature Communications 2019, 10: 2331. PMID: 31133680, PMCID: PMC6536551, DOI: 10.1038/s41467-019-10192-2.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBronchoalveolar Lavage FluidCell Line, TumorChlorocebus aethiopsDisease Models, AnimalFemaleHealthy VolunteersHerpes SimplexHerpesvirus 1, HumanHost-Pathogen InteractionsHumansMaleMiceMice, TransgenicPeptide FragmentsProtein AggregatesProtein CoronaRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanVero CellsConceptsProtein coronaRespiratory syncytial virusArtificial nanoparticlesProtein corona layerBiological fluidsDifferent biological fluidsImmune cell activationCorona layerSyncytial virusAmyloid plaquesObligate intracellular parasitesSimplex virusAmyloid β-peptideAnimal modelsViral-host interactionsHSV-1Cell activationViral pathogenesisAlzheimer's diseaseNanoparticlesType 1Viral infectivityIntracellular parasitesVirusDisease
2018
Herpes simplex virus 1 infection and valacyclovir treatment in schizophrenia: Results from the VISTA study
Breier A, Buchanan RW, D'Souza D, Nuechterlein K, Marder S, Dunn W, Preskorn S, Macaluso M, Wurfel B, Maguire G, Kakar R, Highum D, Hoffmeyer D, Coskinas E, Litman R, Vohs JL, Radnovich A, Francis MM, Metzler E, Visco A, Mehdiyoun N, Yang Z, Zhang Y, Yolken RH, Dickerson FB. Herpes simplex virus 1 infection and valacyclovir treatment in schizophrenia: Results from the VISTA study. Schizophrenia Research 2018, 206: 291-299. PMID: 30478008, DOI: 10.1016/j.schres.2018.11.002.Peer-Reviewed Original ResearchConceptsHSV-1Double-blind efficacy trialHerpes simplex virus 1 (HSV-1) infectionEarly phase schizophreniaSimplex virus 1 infectionVirus-1 infectionPathophysiology of schizophreniaPrimary endpointValacyclovir treatmentNegative subjectsRecent trialsVISTA studyEfficacy trialsLetter-Number Sequencing TestNegative groupPositive groupSevere formHerpes virusPositive symptomsMore impairmentTreatment resultsUS sitesCognitive deficitsNon-activated stateSchizophreniaUBXN3B positively regulates STING-mediated antiviral immune responses
Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P. UBXN3B positively regulates STING-mediated antiviral immune responses. Nature Communications 2018, 9: 2329. PMID: 29899553, PMCID: PMC5998066, DOI: 10.1038/s41467-018-04759-8.Peer-Reviewed Original ResearchConceptsUbiquitin regulatory X domain-containing proteinAntiviral immune responseImmune responseDeficient immune responseDomain-containing proteinsInterferon genes (STING) signalingVesicular stomatitis virus infectionDiverse biological processesStomatitis virus infectionPhosphorylation of TBK1Physiological evidenceHerpes simplex virus 1Cre-loxP approachSimplex virus 1Virus infectionAdult miceGene signalingHSV-1Biological processesPhysiological functionsVirus 1MicePrimary cellsConsequent recruitmentResponse39.4 A DOUBLE-BLIND TRIAL OF VALACYCLOVIR TO IMPROVE COGNITION IN EARLY PHASE SCHIZOPHRENIA: RESULTS FROM THE VISTA STUDY
Breier A, Dickerson F, Buchanan R, Marder S, Neuchterlein K, D’Souza D, Francis M, Radnovich A, Yolken R, Preskorn S, Macaluso M, Yang Z, Mehdyoun N, Kakar R, Dunn W, Hoffmeyer D, Maguire G. 39.4 A DOUBLE-BLIND TRIAL OF VALACYCLOVIR TO IMPROVE COGNITION IN EARLY PHASE SCHIZOPHRENIA: RESULTS FROM THE VISTA STUDY. Schizophrenia Bulletin 2018, 44: s63-s63. PMCID: PMC5888721, DOI: 10.1093/schbul/sby014.162.Peer-Reviewed Original ResearchEarly phase schizophreniaHSV-1 seropositiveHSV-1Cognitive impairmentNegative subjectsHerpes virusPrevious small clinical trialsDuration of psychosisEfficacy of valacyclovirDouble-blind trialSmall clinical trialsHerpes virus infectionHerpes simplex virus type 1Treatment of schizophreniaSimplex virus type 1Life-long infectionVirus type 1Treatment outcome analysisMemory scoresFull therapeutic potentialPlacebo groupAdjunctive placeboInflammatory markersPrimary outcomeHuman CNS
2016
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality
Khoury-Hanold W, Yordy B, Kong P, Kong Y, Ge W, Szigeti-Buck K, Ralevski A, Horvath TL, Iwasaki A. Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. Cell Host & Microbe 2016, 19: 788-799. PMID: 27281569, PMCID: PMC4902295, DOI: 10.1016/j.chom.2016.05.008.Peer-Reviewed Original ResearchConceptsGenital HSV-1 infectionEnteric nervous systemHSV-1 infectionSensory nervous systemNervous systemGenital herpesToxic megacolonHSV-1Genital mucosal epithelial cellsPeripheral sensory nervous systemDorsal root gangliaPathological inflammatory responsesMucosal epithelial cellsHerpes simplex virus 1Simplex virus 1Urinary retentionEnteric neuronsLaxative treatmentAutonomic gangliaRoot gangliaInflammatory responseViral gene transcriptionMouse modelInfectionEpithelial cells
2013
Cell type-dependent requirement of autophagy in HSV-1 antiviral defense
Yordy B, Iwasaki A. Cell type-dependent requirement of autophagy in HSV-1 antiviral defense. Autophagy 2013, 9: 236-238. PMID: 23095715, PMCID: PMC3552887, DOI: 10.4161/auto.22506.Peer-Reviewed Original ResearchConceptsDRG neuronsAntiviral programI interferonHSV-1Dorsal root ganglion neuronsRobust type I IFN responseType I IFN responseMost viral infectionsAntiviral immune mechanismsAntiviral defenseHSV-1 infectionI IFN responseType I interferonInnate antiviral responseType IGanglion neuronsImmune mechanismsViral controlLess cell deathViral infectionAntiviral responseIFN responseInfection modelAntiviral defense mechanismNeurons
2009
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection
Lee HK, Zamora M, Linehan MM, Iijima N, Gonzalez D, Haberman A, Iwasaki A. Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. Journal Of Experimental Medicine 2009, 206: 359-370. PMID: 19153243, PMCID: PMC2646574, DOI: 10.1084/jem.20080601.Peer-Reviewed Original ResearchConceptsResident dendritic cellsCD8 T cellsDendritic cellsHSV-1 infectionT cellsEpicutaneous infectionAntigen presentationLymph node-resident dendritic cellsHSV-specific T cellsCD4 T cell responsesNeedle injectionHerpes simplex virus 1 (HSV-1) infectionSimplex virus 1 infectionT cell primingT cell responsesVirus-1 infectionMode of infectionDC populationsCell primingVaginal infectionsImmune responseMucosal tissuesMucosal surfacesHSV-1Cell responses
2006
Anatomical mapping of human herpesvirus reservoirs of infection
Chen T, Hudnall SD. Anatomical mapping of human herpesvirus reservoirs of infection. Modern Pathology 2006, 19: 726-737. PMID: 16528368, DOI: 10.1038/modpathol.3800584.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnal CanalAutopsyCytomegalovirusDNA, ViralFemaleHerpesviridaeHerpesviridae InfectionsHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 7, HumanHerpesvirus 8, HumanHumansIntestinesMaleMiddle AgedNasal MucosaNervous SystemThyroid GlandConceptsHHV-6Whole blood specimensHSV-1Lymph nodesHHV-7Nasal mucosaAnatomic sitesHuman herpesvirusesHIV-AIDSActive herpesvirus infectionHSV-1 positivitySalivary glandsMajor anatomic sitesMiddle-aged malesTime of deathCardiac arrestHHV-8Adrenal glandElderly malesPrimary infectionHSV-2Urinary bladderHerpesvirus infectionAnatomical mappingBone marrow
2004
In Vivo Role of Nectin-1 in Entry of Herpes Simplex Virus Type 1 (HSV-1) and HSV-2 through the Vaginal Mucosa
Linehan MM, Richman S, Krummenacher C, Eisenberg RJ, Cohen GH, Iwasaki A. In Vivo Role of Nectin-1 in Entry of Herpes Simplex Virus Type 1 (HSV-1) and HSV-2 through the Vaginal Mucosa. Journal Of Virology 2004, 78: 2530-2536. PMID: 14963155, PMCID: PMC369262, DOI: 10.1128/jvi.78.5.2530-2536.2004.Peer-Reviewed Original ResearchConceptsHSV-2HSV-1Viral entryNectin-1Genital herpesGenital mucosaVaginal epitheliumVaginal mucosaHerpes simplex virus type 2Simplex virus type 2Primary genital herpesHerpes simplex virus type 1Mouse vaginal epitheliumFemale genital tractSimplex virus type 1Virus type 1Virus type 2Intravaginal inoculationHSV infectionMenstrual cycleVaginal infectionsGenital tractMouse modelEstrous cycleType 2
2002
HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons
White BH, Cummins TR, Wolf DH, Waxman SG, Russell DS, Kaczmarek LK. HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons. Journal Of Neurophysiology 2002, 87: 2149-2157. PMID: 11929932, DOI: 10.1152/jn.00498.2001.Peer-Reviewed Original ResearchConceptsSodium currentAnti-HSV antibodiesAverage spike frequencyWild-type HSV-1Helper virusViral-based strategiesDays of transductionCultured neuronsHSV-1Spike frequencyGene deliveryNeuronsMammalian neuronsAmplicon systemSimilar suppressionHSV-1 genesVirusTherapeutic purposesViral proteinsAmplicon preparationsCellsCoinfectionSuppressionPreparation resultsTiters
1992
Recurrent Genital Infection in the Guinea Pig: Differences between Herpes Simplex Types 1 and 2
Landry M, Myerson D, Bull C. Recurrent Genital Infection in the Guinea Pig: Differences between Herpes Simplex Types 1 and 2. Intervirology 1992, 34: 169-179. PMID: 1339184, DOI: 10.1159/000150279.Peer-Reviewed Original ResearchConceptsHSV-2 strainsHSV-2HSV-1Genital infectionRecurrence rateHSV-1 McKrae strainType 1Herpes simplex virus type 2Simplex virus type 2Recurrent genital infectionsHerpes simplex type 1Guinea pig modelHSV type 1Simplex type 1HSV-1 strainsVirus type 2Vaginal virusAcute infectionLesion recurrenceOcular infectionsMcKrae strainGenital tractNervous systemType 2Guinea pigs
1991
Advantages of multiple cell culture systems for detection of mixed-virus infections
Fong C, Landry M. Advantages of multiple cell culture systems for detection of mixed-virus infections. Journal Of Virological Methods 1991, 33: 283-289. PMID: 1783674, DOI: 10.1016/0166-0934(91)90027-w.Peer-Reviewed Original ResearchConceptsMRC-5 cellsHSV-1MRC-5CMV-positive casesA549 cellsHSV-1 isolatesCell culturesRhesus monkey kidney cell culturesMonkey kidney cell culturesHuman continuous cell lineImmunosuppressed patientsCytomegalovirus antigenFibroblast cell strainsCentrifugation cultureKidney cell culturesViral agentsSimultaneous infectionContinuous cell linesCulture systemShell vialsMore virusesAdenovirus isolatesEmbryo cell culturesCell culture systemMixed virus infections
1988
Ability of Herpes Simplex Virus (HSV) Types 1 and 2 To Induce Clinical Disease and Establish Latency Following Previous Genital Infection with the Heterologous HSV Type
Landry M, Zibello T. Ability of Herpes Simplex Virus (HSV) Types 1 and 2 To Induce Clinical Disease and Establish Latency Following Previous Genital Infection with the Heterologous HSV Type. The Journal Of Infectious Diseases 1988, 158: 1220-1226. PMID: 2848899, DOI: 10.1093/infdis/158.6.1220.Peer-Reviewed Original ResearchConceptsHerpes simplex virus type 1Simplex virus type 1Virus type 1Clinical diseaseHSV typesSuperinfecting virusType 1Heterologous virus typesPrevious genital infectionsLevels of serumHSV antibodiesGenital infectionHSV-2Prior infectionLatent infectionHSV-1Type 2Months postinoculationGuinea pigsVirus typeInitial virusLatent virusSuperinfectionInfectionDisease
1982
Effect of acyclovir on genital infection with herpes simplex virus types 1 and 2 in the guinea pig
Landry M, Lucia H, Hsiung GD, Pronovost A, Dann P, August M, Mayo D. Effect of acyclovir on genital infection with herpes simplex virus types 1 and 2 in the guinea pig. The American Journal Of Medicine 1982, 73: 143-150. PMID: 6285705, DOI: 10.1016/0002-9343(82)90080-8.Peer-Reviewed Original ResearchConceptsHSV-2 infectionHerpes simplex virus type 1Simplex virus type 1Genital infectionVirus type 1Lumbosacral gangliaHSV-2Clinical diseaseLatent infectionHSV-1Guinea pigsHSV-1-infected animalsHSV-2-infected animalsType 1Herpes simplex virus type 2Simplex virus type 2Acyclovir-treated groupEffect of acyclovirHSV-1 strainsVirus type 2Systemic treatmentAcute infectionMild diseaseSpinal cordChronic changes
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