2024
‘Case of the Month’ from The University of Texas MD Anderson Cancer Center, Houston, Texas, USA: ependymoma of the urinary bladder
Myers A, Tan W, de Groot J, Westney O, Kamat A. ‘Case of the Month’ from The University of Texas MD Anderson Cancer Center, Houston, Texas, USA: ependymoma of the urinary bladder. BJU International 2024, 134: 45-47. PMID: 38379218, DOI: 10.1111/bju.16302.Peer-Reviewed Original ResearchConceptsUniversity of Texas MD Anderson Cancer CenterMD Anderson Cancer CenterUrinary bladderCancer Center
2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal modelsBiodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1
Rischka L, Murgaš M, Pichler V, Vraka C, Rausch I, Winkler D, Nics L, Rasul S, Silberbauer LR, Reed MB, Godbersen GM, Unterholzner J, Handschuh P, Gryglewski G, Mindt T, Mitterhauser M, Hahn A, Ametamey SM, Wadsak W, Lanzenberger R, Hacker M. Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1. EJNMMI Research 2022, 12: 53. PMID: 36018389, PMCID: PMC9418393, DOI: 10.1186/s13550-022-00925-8.Peer-Reviewed Original ResearchExtrasynaptic NMDA receptorsStandardized uptake valueNMDA receptorsUrinary bladderEffective dose coefficientsPET radioligandNeuropsychiatric disordersTreatment monitoringSynaptic NMDA receptorsTime-integrated activity coefficientsCentral nervous systemUrinary bladder contentsDrug developmentDose coefficientsAdverse eventsExcitotoxic processTRIAL REGISTRATIONBladder contentsHealthy subjectsSynaptic transmissionSide effectsBone marrowNervous systemUptake valueEffective doseLong-Term Survival and Causes of Death After Diagnoses of Common Cancers in 3 Cohorts of U.S. Health Professionals
Cheng E, Lee DH, Tamimi RM, Hankinson SE, Willett WC, Giovannucci EL, Eliassen AH, Stampfer MJ, Mucci LA, Fuchs CS, Spiegelman D. Long-Term Survival and Causes of Death After Diagnoses of Common Cancers in 3 Cohorts of U.S. Health Professionals. JNCI Cancer Spectrum 2022, 6: pkac021-. PMID: 35603853, PMCID: PMC8973409, DOI: 10.1093/jncics/pkac021.Peer-Reviewed Original ResearchConceptsCancer-specific mortalityHealth Study IIUterine corpusCause of deathCommon cancerThyroid cancerPrimary cancerCancer survivorsLung cancerCumulative mortalityHealth StudyColorectal cancer-specific mortalityLong-term overall survivalNurses' Health Study IICancer-specific mortality ratesU.S. health professionalsHealth Professionals FollowNurses' Health StudyMale cancer survivorsFemale cancer survivorsProfessionals FollowMost patientsOverall survivalExcess riskUrinary bladder
2021
Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A
Li S, Naganawa M, Pracitto R, Najafzadeh S, Holden D, Henry S, Matuskey D, Emery PR, Cai Z, Ropchan J, Nabulsi N, Carson RE, Huang Y. Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 1327-1338. PMID: 33416954, DOI: 10.1007/s00259-020-05149-3.Peer-Reviewed Original ResearchConceptsTest-retest reproducibilityTime-activity curvesBPND valuesNonhuman primatesAbsolute test-retest variabilitySynaptic vesicle glycoprotein 2AHigh brain uptakeNon-displaceable binding potentialExcellent test-retest reproducibilityGray matter areasHealthy human subjectsHigh uptakeTest-retest variabilityDynamic PET scanningTest-retest reliabilityBrain uptakeDistribution volume valuesCentrum semiovaleUrinary bladderOne-tissue compartment modelMaximum SUVPET scanningPET scansTracer uptakeBrain disorders
2020
Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J
Bini J, Holden D, Fontaine K, Mulnix T, Lu Y, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Carson RE. Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J. EJNMMI Research 2020, 10: 83. PMID: 32666239, PMCID: PMC7359974, DOI: 10.1186/s13550-020-00670-w.Peer-Reviewed Original ResearchDose-limiting organUrinary bladderTime-activity curvesSynaptic densityOLINDA/EXM 1.0 softwareWhole-body PET scansWhole-body scanHuman adultsDose limitTotal radiation doseGastrointestinal tractPET scansHealthy adultsInjected activityRegion of interestLarge intestineNeuropsychiatric disordersEffective doseRelevant disordersBladderLiverRadiation doseAdultsMBqHigh uptake
2019
Extrahepatic Malignancies After Treatment with Direct Antiviral Agents for Chronic HCV Infection
Khoury J, Nassar G, Kramsky R, Saadi T. Extrahepatic Malignancies After Treatment with Direct Antiviral Agents for Chronic HCV Infection. Journal Of Gastrointestinal Cancer 2019, 51: 584-590. PMID: 31407252, DOI: 10.1007/s12029-019-00293-y.Peer-Reviewed Original ResearchConceptsHepatitis C virusExtrahepatic malignanciesAntiviral agentsParitaprevir/ritonavir/ombitasvirChronic hepatitis C virusRecurrent metastatic breast cancerRecurrent transitional cell carcinomaMethodsFour hundred thirtyChronic HCV infectionDirect antiviral agentsMetastatic breast cancerTreatment of choiceTransitional cell carcinomaPossible relationshipDAA treatmentResultsNine patientsHCV infectionCommon regimenCell carcinomaC virusLaryngeal carcinomaPancreatic adenocarcinomaLung carcinomaBreast cancerUrinary bladderBiodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO
Watanabe S, Shiga T, Hirata K, Magota K, Okamoto S, Toyonaga T, Higashikawa K, Yasui H, Kobayashi J, Nishijima KI, Iseki K, Matsumoto H, Kuge Y, Tamaki N. Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO. EJNMMI Research 2019, 9: 60. PMID: 31278504, PMCID: PMC6611855, DOI: 10.1186/s13550-019-0525-6.Peer-Reviewed Original ResearchPositron emission tomographyPreliminary clinical studyUrinary systemClinical studiesSequential whole-body scansTumor hypoxiaHypoxia tracerAbnormal clinical findingsΜSv/MBqDiagnostic abilityExcretion of radioactivityMean effective doseWhole-body scanGood inter-observer reproducibilityHealthy male adultsInter-observer reproducibilityMedical Internal Radiation Dose (MIRD) schemaAdverse eventsMulticenter trialClinical findingsSingle administrationMalignant tumorsUrinary bladderHealthy subjectsEmission tomography
2018
Composite Paraganglioma: Pioneering in the Head and Neck
Delgado S, Smith SM, Mehra S, Prasad ML. Composite Paraganglioma: Pioneering in the Head and Neck. International Journal Of Surgical Pathology 2018, 27: 282-289. PMID: 30222023, DOI: 10.1177/1066896918799940.Peer-Reviewed Original Research
2016
Hydronephrosis and Urinary Bladder Hypertrophy in ROMK Bartter's Mouse
Kim J, Guo X, Hu H, Xu S, Wang T. Hydronephrosis and Urinary Bladder Hypertrophy in ROMK Bartter's Mouse. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1224.30.Peer-Reviewed Original ResearchThickness of urotheliumKO miceROMK expressionBladder capacityBladder weightWT miceKnockout miceRenal outer medullary potassium channelLuminal membraneROMK knockout miceUrinary bladder hypertrophyLow K intakeWestern blottingLow potassium dietSmooth muscle layerMonths of ageNormal KBladder hypertrophyDetrusor muscleMouse bladderBartter's syndromePotassium dietK intakeROMKUrinary bladder
2014
Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation
Sinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. Journal Of Nuclear Medicine 2014, 55: 1445-1451. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.Peer-Reviewed Original ResearchConceptsAdministered activityBlood-pool standardized uptake valuesPhase 1 clinical trialCardiac nerve terminalsCardiac imagingMSv/MBqMean effective doseStandardized uptake valueRadiation doseOLINDA/EXMPatient radiation doseRadiation dose estimatesAdverse eventsBlood pressureWhole-body imagesClinical trialsBlood radioactivityMyocardial innervationNerve terminalsUrinary bladderHealthy subjectsLiver ratioHeart rateLung activityMyocardial uptakeWhole-body biodistribution and dosimetry estimates of a novel radiotracer for imaging of serotonin 4 receptors in brain: [18F]MNI-698
Tavares AA, Caillé F, Barret O, Papin C, Lee H, Morley TJ, Fowles K, Holden D, Seibyl JP, Alagille D, Tamagnan GD. Whole-body biodistribution and dosimetry estimates of a novel radiotracer for imaging of serotonin 4 receptors in brain: [18F]MNI-698. Nuclear Medicine And Biology 2014, 41: 432-439. PMID: 24674817, DOI: 10.1016/j.nucmedbio.2014.02.005.Peer-Reviewed Original ResearchConceptsSerotonin 4 receptorWhole-body biodistributionUrinary bladderDosimetry estimatesOLINDA/EXM 1.0 softwareNovel radiotracersEffective doseMSv/MBqIntravenous bolus injectionWhole-body positron emission tomography (PET) imagesHuman clinical trialsFuture clinical protocolsMain elimination routeAdult rhesus monkeysUrinary bladder modelWhole body weightClinical trialsBolus injectionClinical protocolsNew radiotracersRhesus monkeysCritical organsEffective dosesEmission tomography imagesBladder model
2013
Colovesical Fistula Caused by an Ingested Chicken Bone
Clements MB, Hedrick TL, Colen DL, Schenkman NS. Colovesical Fistula Caused by an Ingested Chicken Bone. Urology 2013, 82: e37-e38. PMID: 24295267, DOI: 10.1016/j.urology.2013.08.054.Peer-Reviewed Original ResearchConceptsIngested chicken boneColovesical fistulaSigmoid colonForeign bodyInflammatory bowel diseaseFistulous communicationHospital dischargeBowel diseaseColonic diverticulaIatrogenic injuryUrinary bladderGastrointestinal tractRadiation therapyChicken boneFistulaBladderColonTractDirect visualizationBoneDiverticulitisColonoscopyPatientsNeoplasmsUrethra
2012
Cell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder cancer
YUN S, JEONG P, KIM W, KIM T, LEE Y, SONG P, CHOI Y, KIM I, MOON S, KIM W. Cell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder cancer. International Journal Of Oncology 2012, 41: 1871-1878. PMID: 22961325, DOI: 10.3892/ijo.2012.1622.Peer-Reviewed Original ResearchConceptsBladder cancerCell-free miRNAsMiR-200aMiR-145Transitional cell carcinomaBladder cancer patientsNon-cancer controlsHealthy normal controlsMiR-145 levelsMiR-200a levelsCell-free microRNAsNMIBC recurrenceIndependent predictorsClinicopathological featuresCell carcinomaCancer patientsPrognostic biomarkerUrinary bladderHigh riskNoninvasive biomarkersNormal controlsAccurate biomarkersMultivariate analysisPatientsCancer
2006
BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder
Soung Y, Lee J, Park W, Nam S, Lee J, Yoo N, Lee S. BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder. Pathology 2006, 38: 33-34. PMID: 16484005, DOI: 10.1080/00313020500455811.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingApoptosisbcl-Associated Death ProteinBH3 Interacting Domain Death Agonist ProteinCarcinoma, Transitional CellDNA, NeoplasmHumansMutationPolymerase Chain ReactionPolymorphism, Single-Stranded ConformationalProto-Oncogene Proteins c-bcl-2Urinary Bladder NeoplasmsConceptsBH3 domain of BADBcl-GBH3 domainTransitional cell carcinomaSomatic mutationsSingle strand conformation polymorphism assayBcl-2 family proteinsDetection of somatic mutationsIntrinsic apoptosis pathwayDeregulation of apoptosisProapoptotic genes BadPathogenesis of transitional cell carcinomaDevelopment of human cancersFamily proteinsTransitional cell carcinoma samplesApoptosis pathwayCell carcinomaUrinary bladderBcl-2Development of urinary bladder cancerBH3GenesHuman cancersUrinary bladder cancerDomain mutationsAnatomical mapping of human herpesvirus reservoirs of infection
Chen T, Hudnall SD. Anatomical mapping of human herpesvirus reservoirs of infection. Modern Pathology 2006, 19: 726-737. PMID: 16528368, DOI: 10.1038/modpathol.3800584.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnal CanalAutopsyCytomegalovirusDNA, ViralFemaleHerpesviridaeHerpesviridae InfectionsHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHerpesvirus 4, HumanHerpesvirus 6, HumanHerpesvirus 7, HumanHerpesvirus 8, HumanHumansIntestinesMaleMiddle AgedNasal MucosaNervous SystemThyroid GlandConceptsHHV-6Whole blood specimensHSV-1Lymph nodesHHV-7Nasal mucosaAnatomic sitesHuman herpesvirusesHIV-AIDSActive herpesvirus infectionHSV-1 positivitySalivary glandsMajor anatomic sitesMiddle-aged malesTime of deathCardiac arrestHHV-8Adrenal glandElderly malesPrimary infectionHSV-2Urinary bladderHerpesvirus infectionAnatomical mappingBone marrow
2005
Skeletal metastases from recurrent paraganglioma of the urinary bladder.
Goyal S, Puri T, Gunabushanam G, Das A, Julka P. Skeletal metastases from recurrent paraganglioma of the urinary bladder. Indian Journal Of Urology 2005, 21: 122-124. DOI: 10.4103/0970-1591.19637.Peer-Reviewed Case Reports and Technical NotesUrinary bladderRecurrent paragangliomaPatient's general conditionYears male patientPalliative chemotherapySurgical resectionSystemic treatmentAggressive courseMale patientsSkeletal metastasesVertebral metastasesRegional nodesGeneral conditionParagangliomaBladderDistant sitesPatientsMetastasisResectionChemotherapyCarboplatinZoledronateRadiotherapyEtoposideDisease
2004
Protective Niche for Borrelia burgdorferi to Evade Humoral Immunity
Liang FT, Brown EL, Wang T, Iozzo RV, Fikrig E. Protective Niche for Borrelia burgdorferi to Evade Humoral Immunity. American Journal Of Pathology 2004, 165: 977-985. PMID: 15331421, PMCID: PMC1618599, DOI: 10.1016/s0002-9440(10)63359-7.Peer-Reviewed Original ResearchConceptsChronic infectionHumoral immunityProtective nicheB. burgdorferiDecorin expressionLower decorin expressionDecorin-deficient miceWild-type miceStrong immune responseDecorin-binding protein ASpirochete burdenUrinary bladderImmune responsePersistent infectionMurine infectionEarly infectionInfectionExtracellular microbesDbpA expressionLyme disease spirocheteBorrelia burgdorferiC expressionTargeted disruptionBurgdorferiMice
2003
Inactivating mutations of CASPASE-7 gene in human cancers
Soung Y, Lee J, Kim H, Park W, Kim S, Lee J, Park J, Cho Y, Kim C, Park Y, Nam S, Jeong S, Kim S, Lee J, Yoo N, Lee S. Inactivating mutations of CASPASE-7 gene in human cancers. Oncogene 2003, 22: 8048-8052. PMID: 12970753, DOI: 10.1038/sj.onc.1206727.Peer-Reviewed Original ResearchConceptsCaspase-7 geneCaspase-7Inactivating mutationsSplice siteWild-type caspase-7Human solid cancersGenetic alterationsDetection of somatic mutationsHuman cancersT cellsSolid cancersDevelopment of human cancersApoptotic functionCoding regionSomatic mutationsGenesMutationsEsophageal carcinomaHead/neck carcinomasGene mutationsColon carcinomaHuman malignanciesUrinary bladderCarcinomaApoptosis
2001
Predictive value of expression of transforming growth factor‐β1 and its receptors in transitional cell carcinoma of the urinary bladder
Kim J, Shariat S, Kim I, Menesses‐Diaz A, Tokunaga H, Wheeler T, Lerner S. Predictive value of expression of transforming growth factor‐β1 and its receptors in transitional cell carcinoma of the urinary bladder. Cancer 2001, 92: 1475-1483. PMID: 11745225, DOI: 10.1002/1097-0142(20010915)92:6<1475::aid-cncr1472>3.0.co;2-x.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaBladder transitional cell carcinomaInvasive tumor stageOverexpression of TGFDisease progressionIndependent predictorsCell carcinomaTumor stageLoss of expressionTGF betaGrowth factorDisease-specific survivalAltered expressionExpression of TGFGrowth factor-β1Lymphovascular invasionRadical cystectomySpecific survivalClinical outcomesCystectomy specimensUrinary bladderImmunohistochemical stainingBlinded fashionFactor-β1Predictive value
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