2024
Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT
Korem N, Duek O, Ben-Zion Z, Spiller T, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. Psychiatry Research Neuroimaging 2024, 343: 111864. PMID: 39111111, DOI: 10.1016/j.pscychresns.2024.111864.Peer-Reviewed Original ResearchReduced resting-state functional connectivityPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional connectivityPost-treatment changesReducing PTSD symptom severityFollow-up changesResting-state functional connectivityIntensive exposure therapyExposure-based psychotherapyVentromedial prefrontal cortexPTSD symptom severityReduced structural connectivityFunctional connectivity patternsPost-treatmentWhite matter integrityPrefrontal cortexExposure therapyPTSD symptomsStress disorderSymptom severityUncinate fasciculusLimbic systemSecondary analysisAssociated with sustained changesGenetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes
Pathak G, Singh K, Choi K, Fang Y, Kouakou M, Lee Y, Zhou X, Fritsche L, Wendt F, Davis L, Polimanti R. Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes. JAMA Psychiatry 2024, 81: 34-44. PMID: 37910111, PMCID: PMC10620678, DOI: 10.1001/jamapsychiatry.2023.4127.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderBody mass indexMass General BrighamPTSD symptom severityElectronic health recordsSymptom severityRespiratory outcomesMass indexRisk factorsMedical outcomesHealth outcomesMendelian randomizationDisease categoriesGenetic liabilityMeta-analyzed associationsSignificant medical outcomesNonspecific chest painC-reactive proteinMental health disordersUK BiobankMultivariable Mendelian randomizationPosttraumatic stress disorder (PTSD) symptomsChest painCardiac dysrhythmiasTobacco smoking
2023
Perceptions of psychedelic-assisted therapy among Black Americans
Carter S, Packard G, Coghlan C, George J, Brown A, Ching T, Julian J, Maples-Keller J. Perceptions of psychedelic-assisted therapy among Black Americans. Journal Of Mood And Anxiety Disorders 2023, 4: 100023. DOI: 10.1016/j.xjmad.2023.100023.Peer-Reviewed Original ResearchPsychedelic-assisted therapySymptom severityPTSD symptom severityDepressive symptom severityPsilocybin-assisted therapyBlack American participantsStudy investigated differencesBlack AmericansMental health carePositive viewWhite AmericansPTSD symptomsPsychological treatmentPsychedelic therapyPsychedelic researchTrauma historyPerceived stressPsychoeducationAmerican participantsWhite participantsDepressionBlack participantsPTSDParticipantsBaseline viewsExamining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods
Yang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderStructural covariance networksCortical thicknessPTSD diagnosisInsular cortexPTSD patientsCingulate cortexSymptom severityBilateral superior frontal cortexStress disorderGreater cortical thicknessLower cortical thicknessChildhood trauma severitySuperior frontal cortexRegression analysisAnterior cingulate cortexTrauma-exposed controlsPosterior cingulate cortexPrefrontal regulatory regionsPTSD symptom severityComorbid depressionMotor cortexHealthy controlsFrontal cortexAlcohol abusePosttraumatic Growth in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study
Kang H, Fischer I, Dickinson S, Na P, Tsai J, Tedeschi R, Pietrzak R. Posttraumatic Growth in U.S. Military Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatric Quarterly 2023, 95: 17-32. PMID: 37938492, DOI: 10.1007/s11126-023-10061-8.Peer-Reviewed Original ResearchPosttraumatic growthU.S. military veteransPTSD symptomsTraumatic eventsPosttraumatic stress disorder (PTSD) symptomsPositive psychological changesVeterans StudyMilitary veteransGreater posttraumatic growthTrauma-exposed veteransIntrinsic religiosityPTSD symptom severitySevere PTSD symptomsHigh-risk sampleIntrusive symptomsDisorder symptomsPsychological changesPTG levelsTraumatic experiencesPTSD ChecklistVeteran samplePsychosocial characteristicsSymptom clustersDSM-5Symptom severityAn examination of relationship satisfaction as a predictor of outcomes of brief couple therapy for posttraumatic stress disorder
Sippel L, Knopp K, Wachsman T, Khalifian C, Glynn S, Morland L. An examination of relationship satisfaction as a predictor of outcomes of brief couple therapy for posttraumatic stress disorder. Journal Of Traumatic Stress 2023, 36: 1115-1125. PMID: 37898980, DOI: 10.1002/jts.22984.Peer-Reviewed Original ResearchConceptsRelationship satisfactionBaseline relationship satisfactionPsychosocial functioningCouple therapyCognitive-behavioral conjoint therapyBehavioral Conjoint TherapyPTSD symptom severityPosttraumatic stress disorderBrief Couple TherapyRelationship distressDyadic treatmentPTSD symptomsConjoint therapyStress disorderDistressed individualsDistressed rangeCAPS-5Military veteransSymptom severityPTSDSatisfactionIntimate relationshipsFunctioningTreatment conditionsFamily educationExpressive writing treatments to reduce PTSD symptom severity and negative alcohol-related outcomes among trauma-exposed sexual minority women and transgender/nonbinary people: Study protocol for a mixed-method pilot trial
Scheer J, Behari K, Schwarz A, Cascalheira C, Helminen E, Pirog S, Jaipuriyar V, Sullivan T, Batchelder A, Jackson S. Expressive writing treatments to reduce PTSD symptom severity and negative alcohol-related outcomes among trauma-exposed sexual minority women and transgender/nonbinary people: Study protocol for a mixed-method pilot trial. Contemporary Clinical Trials Communications 2023, 35: 101197. PMID: 37671246, PMCID: PMC10475481, DOI: 10.1016/j.conctc.2023.101197.Peer-Reviewed Original ResearchNegative alcohol-related outcomesAlcohol-related outcomesExpressive writing treatmentsPTSD symptom severitySexual minority womenTNB individualsWriting sessionsWriting treatmentPosttraumatic stress disorder (PTSD) symptomsSymptom severityWeb-based treatmentDisorder symptomsTNB peoplePilot trialEffective treatment approachNonbinary individualsCisgender peopleMinority womenMixed-methods pilotNonbinary peopleIndividualsTreatment approachesHeterosexual womenThree monthsTreatment outcomesProbable PTSD, PTSD symptom severity, and comorbid PTSD and hazardous drinking among sexual minority women compared to heterosexual women: A meta-analysis
Scheer J, Helminen E, Cascalheira C, Jaipuriyar V, Shaw T, Zabelski S, Behari K, Pirog S, Batchelder A, Possemato K, Hughes T, Sullivan T. Probable PTSD, PTSD symptom severity, and comorbid PTSD and hazardous drinking among sexual minority women compared to heterosexual women: A meta-analysis. Clinical Psychology Review 2023, 102: 102283. PMID: 37150043, PMCID: PMC10205673, DOI: 10.1016/j.cpr.2023.102283.Peer-Reviewed Original ResearchConceptsProbable posttraumatic stress disorderPosttraumatic stress disorderHazardous drinkingSexual minority womenPTSD symptom severitySymptom severityPTSD riskComorbid posttraumatic stress disorderMinority womenHeterosexual womenEligible publicationsReference listsPeer-reviewed publicationsElectronic databasesPronounced riskGreater riskTrauma-related sequelaeStress disorderSystematic searchWomenDemographic characteristicsRiskGender diverse peopleRelevant papersSeverityUnderstanding veteran barriers to specialty outpatient PTSD clinical care
Rozek D, Steigerwald V, Baker S, Gross G, Maieritsch K, Hoff R, Harpaz-Rotem I, Smith N. Understanding veteran barriers to specialty outpatient PTSD clinical care. Journal Of Anxiety Disorders 2023, 95: 102675. PMID: 36854224, DOI: 10.1016/j.janxdis.2023.102675.Peer-Reviewed Original ResearchConceptsSpecialty outpatient clinicsPosttraumatic stress disorderOutpatient clinicPTSD specialty clinicClinical characteristicsMale sexPTSD symptom severitySpecialty clinicWhite raceClinical careClinical concernTreatment engagementSymptom severityStress disorderClinicGreater likelihoodVeteransSignificant minorityTreatmentImpact of demographicsMulti-faceted barriersCareFiscal year 2019DemographicsNational samplePosttraumatic Stress as a Moderator of the Association Between HPA-Axis Functioning and Alcohol Use Disorder Among a Community Sample of Women Currently Experiencing Intimate Partner Violence
Goldstein SC, Schick MR, Weyandt LL, Sullivan TP, Cadely H, Weiss NH. Posttraumatic Stress as a Moderator of the Association Between HPA-Axis Functioning and Alcohol Use Disorder Among a Community Sample of Women Currently Experiencing Intimate Partner Violence. Experimental And Clinical Psychopharmacology 2023, 31: 163-173. PMID: 35113644, PMCID: PMC10829849, DOI: 10.1037/pha0000543.Peer-Reviewed Original ResearchConceptsHPA axis functioningAlcohol use disorderHPA axis recoveryHigher PTSD symptom severityPTSD symptom severitySymptom severityMeeting criteriaUse disordersLog oddsMaintenance of AUDCurrent male partnerPosttraumatic stress disorder (PTSD) symptomsSaliva cortisol samplesAmount of alcoholAxis functioningInduction protocolCortisol samplesIntimate partner violence experiencesMale partnersCommunity womenSeverityHeightened prevalenceWomenDisorder symptomsIntimate partner violence
2022
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records
Polimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, PMCID: PMC10986859, DOI: 10.1038/s41380-022-01735-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePosttraumatic stress disorderElectronic health recordsMillion Veteran ProgramArtery diseaseTotal scoreCAD diagnosisPlatelet amyloid precursor proteinHealth recordsPosttraumatic stress severityAmyloid precursor proteinEarly CAD diagnosisUK BiobankBidirectional relationshipTwo-sample Mendelian randomization (MR) analysisMendelian randomization analysisCAD riskHigh morbidityPTSD symptom severityCARDIoGRAMplusC4D consortiumPleiotropic mechanismsSymptom severityLongitudinal changesDiscordant effectsStress disorderComparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans
Spiller TR, Duek O, Buta E, Gross G, Smith NB, Harpaz-Rotem I. Comparative effectiveness of group v. individual trauma-focused treatment for posttraumatic stress disorder in veterans. Psychological Medicine 2022, 53: 4561-4568. PMID: 35959560, PMCID: PMC10388318, DOI: 10.1017/s0033291722001441.Peer-Reviewed Original ResearchConceptsGroup cognitive processing therapyCognitive processing therapyPosttraumatic stress disorderIndividual cognitive processing therapyPTSD symptom severitySymptom severityStress disorderReal-world effectivenessComparative effectiveness studiesResidential treatmentEffective treatmentComparative effectivenessVeterans AffairsEffectiveness studiesPTSD ChecklistPTSD severityGroup therapySeverityVeteransTreatmentDSM-5Group V.TherapyDisordersSmall reductionStructural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis
Harnett NG, Finegold KE, Lebois LAM, van Rooij SJH, Ely TD, Murty VP, Jovanovic T, Bruce SE, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Chang AM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O’Neil B, Sergot P, Sanchez LD, Miller MW, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Nickerson LD, Ressler KJ, Stevens JS. Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis. Translational Psychiatry 2022, 12: 321. PMID: 35941117, PMCID: PMC9360028, DOI: 10.1038/s41398-022-02085-8.Peer-Reviewed Original ResearchConceptsVentral visual streamPosttraumatic stress disorderVisual streamTrauma memoriesStructural covariance networksPTSD symptomsDevelopment of PTSDVisual componentsHigher PTSD symptom severityMultimodal magnetic resonance imaging (MRI) dataPTSD symptom severityFunctional covariance networkInferior temporal gyrusAdverse posttraumatic neuropsychiatric sequelaeCovariance networksPosttraumatic intrusionsTrauma exposureIntrusion symptomsStress disorderTemporal gyrusMagnetic resonance imaging dataNegative alterationsAffective disturbancesNightmare symptomsSymptom severityPosttraumatic Stress Disorder Symptom Severity Modulates Avoidance of Positive Emotions Among Trauma-Exposed Military Veterans in the Community
Weiss N, Schick M, Contractor A, Goncharenko S, Raudales A, Forkus S. Posttraumatic Stress Disorder Symptom Severity Modulates Avoidance of Positive Emotions Among Trauma-Exposed Military Veterans in the Community. Psychological Trauma Theory Research Practice And Policy 2022, 14: 446-452. PMID: 34197172, PMCID: PMC8720112, DOI: 10.1037/tra0001048.Peer-Reviewed Original ResearchConceptsPositive emotional avoidancePosttraumatic stress disorderPosttraumatic stress disorder symptom severityPositive emotional intensityPTSD symptom severityEmotional avoidanceSymptom severityEmotional intensityMaintenance of posttraumatic stress disorderLevels of PTSD symptom severityPositive emotionsTrauma-exposed military veteransReducing PTSD symptom severityTrauma-exposed veteransSevere PTSD symptomsTrauma-exposedPTSD symptomsStress disorderMilitary veteransModerating RoleAvoidanceVeteransAvoidance strategiesEmotionsSymptomsPolygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events
Wendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events. Neurobiology Of Stress 2022, 17: 100439. PMID: 35242894, PMCID: PMC8881478, DOI: 10.1016/j.ynstr.2022.100439.Peer-Reviewed Original ResearchPosttraumatic stress disorderTraumatic eventsPolygenic scoringGreater emotional sensitivityChildhood neglect/abusePTSD symptom severityCertain traumatic eventsSevere PTSD symptomsPosttraumatic stress severityContext of traumaNeglect/abuseEarly life adversityHigher empathyPTSD symptomsEmotional sensitivityHigh empathizersStress disorderLife eventsEmpathyPotential traumaSymptom severityPolygenic scoresAutismStress severityDepressionAltered gene expression and PTSD symptom dimensions in World Trade Center responders
Marchese S, Cancelmo L, Diab O, Cahn L, Aaronson C, Daskalakis NP, Schaffer J, Horn SR, Johnson JS, Schechter C, Desarnaud F, Bierer LM, Makotkine I, Flory JD, Crane M, Moline JM, Udasin IG, Harrison DJ, Roussos P, Charney DS, Koenen KC, Southwick SM, Yehuda R, Pietrzak RH, Huckins LM, Feder A. Altered gene expression and PTSD symptom dimensions in World Trade Center responders. Molecular Psychiatry 2022, 27: 2225-2246. PMID: 35177824, DOI: 10.1038/s41380-022-01457-2.Peer-Reviewed Original ResearchConceptsPTSD symptom dimensionsPosttraumatic stress disorderCAPS scoresAnxious arousal symptomsSymptom dimensionsWorld Trade Center rescueClinician-Administered PTSD Scale scoresBiomarker of PTSDArousal symptomsCD4 T cellsWorld Trade Center respondersDevelopment of PTSDTotal CAPS scoresCase/control statusTherapeutic target developmentIdentification of biomarkersClinical interview dataResponder cohortPTSD symptom severityPotential biological differencesWTC respondersT cellsGene expressionPTSD studiesPsychiatric disorders
2021
Trauma exposure and mental health outcomes among Central American and Mexican children held in immigration detention at the United States–Mexico border
Sidamon‐Eristoff A, Cohodes EM, Gee DG, Peña CJ. Trauma exposure and mental health outcomes among Central American and Mexican children held in immigration detention at the United States–Mexico border. Developmental Psychobiology 2021, 64: e22227. PMID: 35050507, DOI: 10.1002/dev.22227.Peer-Reviewed Original ResearchConceptsEarly life adversityMental health disordersTrauma exposureHealth disordersPTSD symptomsChild PTSD symptomsLos Angeles Posttraumatic Stress Disorder Reaction IndexMental health outcomesChildren's stress responsesPTSD symptom severityPosttraumatic Stress Disorder Reaction IndexAdditional stress exposureHealth outcomesMexican childrenSymptom severityStress exposureMental healthUnited States-Mexico borderPremigration traumatic eventsPTSD Symptoms and Hazardous Drinking Indicators among Trauma-Exposed Sexual Minority Women during Heightened Societal Stress
Helminen EC, Scheer JR, Jackson SD, Brisbin CD, Batchelder AW, Cascalheira CJ, Sullivan TP. PTSD Symptoms and Hazardous Drinking Indicators among Trauma-Exposed Sexual Minority Women during Heightened Societal Stress. Behavioral Medicine 2021, 49: 183-194. PMID: 34870567, PMCID: PMC9167896, DOI: 10.1080/08964289.2021.2006132.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderHazardous drinking indicatorsSexual minority womenDrinking indicatorsAlcohol useHigher PTSD symptom severityProbable posttraumatic stress disorderCoronavirus disease 2019 (COVID-19) epidemicMinority womenBehavioral health concernsSocietal stressorsAlcohol use preventionPTSD symptom severityOnline self-report questionnaireChi-square analysisSelf-report questionnairesSemi-structured qualitative interviewsElevated riskSocietal stressHazardous drinkingUse preventionSymptom severityFirst epicenterHealth concernStress disorderLongitudinal associations between childhood sexual abuse-related PTSD symptoms and passive and active suicidal ideation among sexual minority men
Scheer JR, Clark KA, Talan A, Cabral C, Pachankis JE, Rendina HJ. Longitudinal associations between childhood sexual abuse-related PTSD symptoms and passive and active suicidal ideation among sexual minority men. Child Abuse & Neglect 2021, 122: 105353. PMID: 34638046, PMCID: PMC8612966, DOI: 10.1016/j.chiabu.2021.105353.Peer-Reviewed Original ResearchConceptsActive suicidal ideationSexual minority menSuicidal ideationChildhood sexual abusePTSD symptomsElevated suicide riskOne-yearPTSD symptom severitySymptom severityMultivariable logistic regression analysisMinority menLogistic regression analysisLow social supportPassive suicidal ideationSocial supportProspective cohortElevated riskSuicide attempt historyProspective associationsBivariate analysisSymptomsSuicidal thoughtsSuicide riskLongitudinal associationsBaselineRisk and resilience factors associated with traumatic loss-related PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Asch RH, Esterlis I, Southwick SM, Pietrzak RH. Risk and resilience factors associated with traumatic loss-related PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry Research 2021, 298: 113775. PMID: 33578060, DOI: 10.1016/j.psychres.2021.113775.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderU.S. military veteransAttachment styleResilience factorsMilitary veteransPTSD symptom severitySomatic symptomsTraumatic eventsStress disorderPsychosocial correlatesPositive screenVeterans StudyNational HealthSudden deathSymptom severityTherapeutic targetU.S. veteransStrongest correlate
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