2019
Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer
Colavito SA, Platt JT, Held MA, Liu Z, Sokup R, Stern DF. Combinatorial drug screening of mammary cells with induced mesenchymal transformation to identify drug combinations for triple-negative breast cancer. Oncotarget 2019, 10: 4822-4839. PMID: 31448050, PMCID: PMC6690678, DOI: 10.18632/oncotarget.27104.Peer-Reviewed Original ResearchBreast cancerDrug combinationsB-cell lymphoma-2 inhibitorTriple-negative breast cancerEffective treatment strategiesBreast cancer cellsEffective drug combinationsCombination regimenPoor prognosisCombination therapyTreatment optionsTreatment strategiesBCL2 inhibitorsEffective treatmentSelf-renewal capabilityCancerTumor cellsDifferent dosesCancer cellsMammary cellsCheckpoint kinase 1 inhibitorsKinase 1 inhibitorMesenchymal characteristicsMesenchymal transformationUntreated cells
2017
Assessment of nicotine withdrawal-induced changes in sucrose preference in mice
Alkhlaif Y, Bagdas D, Jackson A, Park AJ, Damaj IM. Assessment of nicotine withdrawal-induced changes in sucrose preference in mice. Pharmacology Biochemistry And Behavior 2017, 161: 47-52. PMID: 28919072, PMCID: PMC6408212, DOI: 10.1016/j.pbb.2017.08.013.Peer-Reviewed Original ResearchConceptsSucrose preference testNicotine withdrawalSpontaneous nicotine withdrawalLight-dark box testDark box testPositive affective stimuliSucrose preferenceAffective signsSmoking relapse ratesΑ6 KO miceSubcutaneous osmotic minipumpsWithdrawal-induced changesUnderlying neurobiological factorsPreference testRelapse rateOsmotic minipumpsKO miceTobacco useNicotine dependenceKnockout miceAnimal modelsNicotinic subunitsDay 15MiceDifferent dosesExposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice
Wang H, Chang M, Peng T, Yang Y, Li N, Luo T, Cheng Y, Zhou M, Zeng X, Zheng L. Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice. Cellular Physiology And Biochemistry 2017, 42: 44-54. PMID: 28554186, DOI: 10.1159/000477113.Peer-Reviewed Original ResearchConceptsAdult male C57BL/6 miceMale C57BL/6 miceImpair sperm functionAcute cadmium exposureSperm functionSperm-specific Ca2C57BL/6 miceReproductive toxicityCadmium exposureWestern blottingDifferent dosesSperm dysfunctionExpression levelsEnvironmental heavy metalsToxic effectsMiceEndocrine disruptorsCatSperSperm motilityMouse spermatozoaSpecific roleToxicityExposureMotilityDysfunction
2016
Aflibercept in diabetic macular edema: evaluating efficacy as a primary and secondary therapeutic option
Ashraf M, Souka A, Adelman R, Forster SH. Aflibercept in diabetic macular edema: evaluating efficacy as a primary and secondary therapeutic option. Eye 2016, 30: 1531-1541. PMID: 27564719, PMCID: PMC5177746, DOI: 10.1038/eye.2016.174.Peer-Reviewed Original ResearchConceptsDiabetic macular edemaMacular edemaLarge phase 3 trialsBetter baseline VAEfficacy of afliberceptRole of afliberceptSecondary therapeutic optionsPhase 3 trialProtocol TBaseline VABimonthly regimenNata protocolAnatomic outcomesTherapeutic optionsPoor visionTreatment strategiesPrimary drugAfliberceptDifferent dosesDoseRanibizumabRegimenEdemaPatientsRecent dataEfficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Fischer S, Hirche C, Diehm Y, Nuutila K, Kiefer J, Gazyakan E, Bueno E, Kremer T, Kneser U, Pomahac B. Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. PLOS ONE 2016, 11: e0156428. PMID: 27232716, PMCID: PMC4883774, DOI: 10.1371/journal.pone.0156428.Peer-Reviewed Original ResearchConceptsFull-thickness skin graftThickness skin graftBacterium Clostridium histolyticumCapsular contractureSkin graftsBreast sitesSilicone implantsReasonable treatment optionClostridium histolyticumFibrotic capsuleCollagen subtypesEx vivo studyCollagenase doseEx-vivo settingTreatment optionsContracture tissueAcellular tissue matrixOutcome measuresHistological assessmentSubtype 4Capsule tissueClinical utilizationDifferent dosesClinical realityType 4Neemazal ® as a possible alternative control tool for malaria and African trypanosomiasis?
Yerbanga R, Rayaisse J, Vantaux A, Salou E, Mouline K, Hien F, Habluetzel A, Dabiré R, Ouédraogo J, Solano P, Lefèvre T. Neemazal ® as a possible alternative control tool for malaria and African trypanosomiasis? Parasites & Vectors 2016, 9: 263. PMID: 27146309, PMCID: PMC4857419, DOI: 10.1186/s13071-016-1538-x.Peer-Reviewed Original ResearchConceptsAfrican trypanosomiasisEffect of bloodOral dosesBehavioral alterationsConclusionThis studyAnthropophilic rateDifferent dosesMembrane feedingAlternative control toolsDosesCalf odourPromising activityMalariaMiceBloodDoseVector control programsHost stimuliAdditional researchControl programsPlant remediesBehavioral responsesG. palpalis gambiensisTrypanosomiasisBloodmealBisphenol A Impairs Mature Sperm Functions by a CatSper-Relevant Mechanism
Wang H, Liu M, Li N, Luo T, Zheng L, Zeng X. Bisphenol A Impairs Mature Sperm Functions by a CatSper-Relevant Mechanism. Toxicological Sciences 2016, 152: 145-154. PMID: 27125968, DOI: 10.1093/toxsci/kfw070.Peer-Reviewed Original ResearchConceptsToxicity of BPANormal mouse spermSperm functionMature sperm functionVivo administrationEndocrine-disrupting chemicalsWestern blotDifferent dosesSignificant decreaseSperm total motilitySignificant reductionBisphenol AMiceSperm motilityMouse spermMouse spermatozoaMotilityCatSperTotal motilityToxicity
2015
Treated Malaria Does Not Affect Physical Growth And Hemoglobin Concentration of Young Children in Burkina Faso
Some J, Abbeddou S, Jimenez E, Hess S, Ouedraogo Z, Guissou R, Vosti S, Ouedraogo J, Brown K. Treated Malaria Does Not Affect Physical Growth And Hemoglobin Concentration of Young Children in Burkina Faso. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.757.7.Peer-Reviewed Original ResearchLipid-based nutrient supplementationRapid diagnostic testsPhysical growthHemoglobin concentrationZ-scoreYoung Burkinabe childrenLength z-scoreCause of anemiaAssociation of malariaAge z-scoreYoung childrenMo of ageMalaria episodesMorbidity assessmentBurkinabe childrenMean changeMalariaDiagnostic testsDifferent dosesEarly childhoodChildrenDiarrheaFeverEpisodesFrequency categoriesEffects of Interleukin-13 and Montelukast on the Expression of Zonula Occludens-1 in Human Podocytes
Park J, Saleem M, Nam J, Ha T, Shin J. Effects of Interleukin-13 and Montelukast on the Expression of Zonula Occludens-1 in Human Podocytes. Yonsei Medical Journal 2015, 56: 426-432. PMID: 25683991, PMCID: PMC4329354, DOI: 10.3349/ymj.2015.56.2.426.Peer-Reviewed Original ResearchConceptsMinimal-change nephrotic syndromeZonula occludens-1Expression of zonula occludens-1IL-13Human podocytesLevel of ZO-1 proteinInterleukin-13High dosesDistribution of zonula occludens-1Occludens-1Zonula occludens-1 protein levelLeukotriene receptor antagonistsBovine serum albumin-coated platesEffect of interleukin-13ZO-1 proteinTreated with different dosesPathogenesis of proteinuriaDose-dependent mannerCultured human podocytesMontelukast treatmentReceptor antagonistNephrotic syndromeMontelukastDifferent dosesWestern blotting
2014
Radiation-induced Changes in Levels of Selected Proteins in Peripheral Blood Serum of Breast Cancer Patients as a Potential Triage Biodosimeter for Large-scale Radiological Emergencies
Deperas-Kaminska M, Bajinskis A, Marczyk M, Polanska J, Wersäll P, Lidbrink E, Ainsbury EA, Guipaud O, Benderitter M, Haghdoost S, Wojcik A. Radiation-induced Changes in Levels of Selected Proteins in Peripheral Blood Serum of Breast Cancer Patients as a Potential Triage Biodosimeter for Large-scale Radiological Emergencies. Health Physics 2014, 107: 555-563. PMID: 25353241, DOI: 10.1097/hp.0000000000000158.Peer-Reviewed Original ResearchConceptsPeripheral blood serumBreast cancer patientsLarge-scale radiological emergencyCancer patientsApolipoprotein EConsistent dose-response relationshipBlood serumExternal beam radiotherapyIrradiation of skinKinase 4Dose-response relationshipLogistic regression modelsPartial-body exposuresPurpose of triageMultinomial logistic regression modelsBeam radiotherapyBlood samplesFetuin BMultivariate analysisBody exposureDifferent dosesRadiation-induced changesSerumProtein 7Factor X
2007
Positive Effects of Methylphenidate on Inattention and Hyperactivity in Pervasive Developmental Disorders: An Analysis of Secondary Measures
Posey D, Aman M, McCracken J, Scahill L, Tierney E, Arnold L, Vitiello B, Chuang S, Davies M, Ramadan Y, Witwer A, Swiezy N, Cronin P, Shah B, Carroll D, Young C, Wheeler C, McDougle C. Positive Effects of Methylphenidate on Inattention and Hyperactivity in Pervasive Developmental Disorders: An Analysis of Secondary Measures. Biological Psychiatry 2007, 61: 538-544. PMID: 17276750, DOI: 10.1016/j.biopsych.2006.09.028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild Development Disorders, PervasiveChild, PreschoolCross-Over StudiesDiagnostic and Statistical Manual of Mental DisordersDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMethylphenidatePsychiatric Status Rating ScalesSurveys and QuestionnairesConceptsYale-Brown Obsessive Compulsive ScaleOppositional defiant disorderAttention-deficit/hyperactivity disorderPervasive developmental disorderSequence of placeboChildren's Yale-Brown Obsessive Compulsive ScaleSignificant interindividual variabilityDevelopmental disordersObsessive Compulsive ScaleCrossover studyPelham QuestionnaireOutcome measuresRepetitive behaviorsSecondary measuresMethylphenidate dosesSecondary analysisInterindividual variabilityMethylphenidateDSM-IVDifferent dosesSymptom domainsCompulsive ScaleHyperactivity disorderSymptomsDisorders
2006
Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation
Bruscia EM, Price JE, Cheng EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS. Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 2965-2970. PMID: 16481627, PMCID: PMC1413802, DOI: 10.1073/pnas.0510758103.Peer-Reviewed Original ResearchConceptsCftr-/- miceEpithelial cellsNasal epitheliumBM-derived cellsBone marrow transplantationWild-type BMAirway epithelial cellsCystic fibrosis transmembrane conductance regulator (CFTR) activityCystic fibrosis miceRare epithelial cellsCftr-null miceMarrow transplantationBM transplantationFibrosis miceRespiratory tractCFTR activityGI tractBone marrowGastrointestinalChloride secretionCFTR-dependent chloride secretionIndividual miceTransplantationDifferent dosesMice
2003
Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection
Safieh-Garabedian B, Ochoa-Chaar CI, Poole S, Massaad CA, Atweh SF, Jabbur SJ, Saadé NE. Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection. Neuroscience 2003, 121: 865-873. PMID: 14580936, DOI: 10.1016/s0306-4522(03)00500-1.Peer-Reviewed Original ResearchConceptsCytokine levelsEndotoxin injectionDifferent pain testsInjections of thymulinThymic hormone thymulinPain-related behaviorsAnti-inflammatory actionLevels of cytokinesEffect of pretreatmentInjection of endotoxinDose-dependent mannerIntracerebral inflammationPeak hyperalgesiaInflammatory hyperalgesiaPain testsNeuroprotective roleNociceptive thresholdProinflammatory cytokinesConscious ratsRat modelHyperalgesiaThymulinDifferent dosesSignificant decreaseEndotoxinBeneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats1 1This study was supported by NIH grant HL22273, the R.J. Stransky Foundation, and the Women and Children’s Health Research Foundation of the Children’s Hospital of Buffalo.
Khanna A, Rossman J, Caty MG, Fung H. Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats1 1This study was supported by NIH grant HL22273, the R.J. Stransky Foundation, and the Women and Children’s Health Research Foundation of the Children’s Hospital of Buffalo. Journal Of Surgical Research 2003, 114: 15-24. PMID: 13678693, DOI: 10.1016/s0022-4804(03)00329-9.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAnimalsBileHemodynamicsIntestinal DiseasesIntestinal MucosaIntestinesMaleModels, AnimalNeutrophil ActivationNeutrophil InfiltrationNitric OxideNitroglycerinPermeabilityPlatelet Activating FactorRatsRats, Sprague-DawleyReactive Oxygen SpeciesReperfusion InjuryVasodilator AgentsConceptsIntestinal ischemia-reperfusion injuryIschemia-reperfusion injuryHealth Research FoundationBile flowMean arterial pressureAdministration of nitroglycerinIntestinal barrier functionIntestinal ischemiaMucosal injurySystemic hemodynamicsArterial pressureHypotensive effectIntestinal pathologyChildren's HospitalIntestinal IRIntestinal permeabilityRat modelSustained decreaseExperimental diseaseSystemic effectsNitroglycerinBeneficial effectsPhysiologic functionDifferent dosesBarrier function
1999
Assessment of the Safety and Efficacy Data for the Hypnotic Halcion(R): Results of an Analysis by an Institute of Medicine Committee
Gibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion(R): Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993-1002. DOI: 10.1080/01621459.1999.10473852.Peer-Reviewed Original ResearchInstitute of MedicineEfficacy dataCurrent product labelingDuration of treatmentTreatment of insomniaPossible side effectsHypnotic effectivenessChronic insomniaSide effectsLow dosesAdult populationIOM reportMedicine CommitteeLabeling changesDifferent dosesU.S. FoodTask Force ReportDutch psychiatristsInsomniaProduct labelingDosesHalcionForce ReportPossible linkSafety
1997
The effects of age on rabbit MCL fibroblast matrix synthesis in response to TGF-β1 or EGF
Deie M, Marui T, Allen C, Hildebrand K, Georgescu H, Niyibizi C, Woo S. The effects of age on rabbit MCL fibroblast matrix synthesis in response to TGF-β1 or EGF. Mechanisms Of Ageing And Development 1997, 97: 121-130. PMID: 9226631, DOI: 10.1016/s0047-6374(97)00049-3.Peer-Reviewed Original ResearchConceptsMedial collateral ligamentEffect of ageEpidermal growth factorTotal protein synthesisMCL fibroblastsGrowth factorImmature rabbitsProtein synthesisSenescent groupCollateral ligamentTGF-β1Baseline levelsOwn controlDifferent dosesLigament fibroblastsLess collagenCollagen synthesisEGF doseRabbitsAgeSignificant reductionDoseDosesMatrix synthesisFibroblastsTreatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T
Kosten T, Rosen M, McMahon T, Bridge T, O'malley S, Pearsall R, O'connor P. Treatment of Early AIDS Dementia in Intravenous Drug Users: High Versus Low Dose Peptide T. The American Journal Of Drug And Alcohol Abuse 1997, 23: 543-553. PMID: 9366972, DOI: 10.3109/00952999709016894.Peer-Reviewed Original Research
1985
Capsaicin impairs preoptic serotonin-sensitive structures mediating hypothermia in rats
Hajós M, Obál F, Jancsó G, Obál F. Capsaicin impairs preoptic serotonin-sensitive structures mediating hypothermia in rats. Neuroscience Letters 1985, 54: 97-102. PMID: 3974950, DOI: 10.1016/s0304-3940(85)80124-5.Peer-Reviewed Original ResearchConceptsSystemic capsaicin treatmentCapsaicin-treated ratsCapsaicin treatmentSkin vasodilationBody temperatureTail skin vasodilationGroups of animalsIntrapreoptic injectionThermoregulatory disturbancesCisterna magnaPreoptic regionThermoregulatory impairmentDifferent dosesComparable decreaseRatsVasodilationHypothermiaTreatment
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply