2020
Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model
Baptista-de-Souza D, Tavares-Ferreira D, Megat S, Sankaranarayanan I, Shiers S, Flores CM, Ghosh S, Nunes-de-Souza R, Canto-de-Souza A, Price TJ. Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model. Neurobiology Of Pain 2020, 8: 100049. PMID: 32548337, PMCID: PMC7284072, DOI: 10.1016/j.ynpai.2020.100049.Peer-Reviewed Original ResearchHyperalgesic primingPlantar incisionFemale miceBasolateral nucleusHyperalgesic priming modelSucrose splash testSex differencesPain-related behaviorsIntra-BLA microinjectionGluA2-containing AMPA receptorsDistinct brain regionsMechanical hypersensitivityPain mechanismsAberrant behavioral responsesChronic painFacial grimacingBody of evidenceMale miceSplash testPain unpleasantnessProstaglandin EAMPA receptorsGluA2 expressionUnderlying neural mechanismsBrain regions
2018
Memory for the Experience of Physical Pain
Salovey P, Smith A. Memory for the Experience of Physical Pain. 2018, 295-314. DOI: 10.4324/9781315789231-12.Peer-Reviewed Original Research
2014
Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain
Qu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain. Brain 2014, 137: 1039-1050. PMID: 24549959, PMCID: PMC3959553, DOI: 10.1093/brain/awu007.Peer-Reviewed Original ResearchConceptsContact hypersensitivityPruriceptive neuronsEnhanced excitabilityNervous systemNociceptive dorsal root ganglion (DRG) neuronsSodium currentVehicle-treated control animalsDorsal root ganglion neuronsSquaric acid dibutyl esterItch-like behaviorsPain-related behaviorsResistant sodium currentsAllergic contact dermatitisAction potential activityWhole-cell recordingsInflammatory itchPersistent itchPruritic disordersSpontaneous itchSpontaneous scratchingAcute itchNeuronal hyperexcitabilityNociceptive neuronsPruritic diseasesCommon symptoms
2008
Intra‐neural administration of fractalkine attenuates neuropathic pain‐related behaviour
Holmes FE, Arnott N, Vanderplank P, Kerr NC, Longbrake EE, Popovich PG, Imai T, Combadière C, Murphy PM, Wynick D. Intra‐neural administration of fractalkine attenuates neuropathic pain‐related behaviour. Journal Of Neurochemistry 2008, 106: 640-649. PMID: 18410510, PMCID: PMC2726982, DOI: 10.1111/j.1471-4159.2008.05419.x.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsAnimalsBehavior, AnimalChemokine CX3CL1CX3C Chemokine Receptor 1Disease Models, AnimalDose-Response Relationship, DrugGanglia, SpinalGene Expression RegulationMacrophagesMaleMiceMice, Inbred BALB CMice, KnockoutPain MeasurementPain ThresholdReaction TimeReceptors, ChemokineRNA, MessengerSciaticaSpinal CordTime FactorsConceptsDorsal root gangliaNeuropathic pain-related behaviorLumbar dorsal root gangliaBALB/c controlsDevelopment of allodyniaIntra-neural injectionSciatic nerve proximalNeuropathic pain statesNerve injury modelSciatic nerve axotomyPain-related behaviorsExpression of CX3CR1Site of injuryNumber of cytokinesNeuropathic painNerve axotomyPain statesNerve proximalRoot gangliaSciatic nerveInjury modelCX3CR1 mRNAFractalkine mRNAKnockout miceAxotomy
2003
Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection
Safieh-Garabedian B, Ochoa-Chaar CI, Poole S, Massaad CA, Atweh SF, Jabbur SJ, Saadé NE. Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection. Neuroscience 2003, 121: 865-873. PMID: 14580936, DOI: 10.1016/s0306-4522(03)00500-1.Peer-Reviewed Original ResearchConceptsCytokine levelsEndotoxin injectionDifferent pain testsInjections of thymulinThymic hormone thymulinPain-related behaviorsAnti-inflammatory actionLevels of cytokinesEffect of pretreatmentInjection of endotoxinDose-dependent mannerIntracerebral inflammationPeak hyperalgesiaInflammatory hyperalgesiaPain testsNeuroprotective roleNociceptive thresholdProinflammatory cytokinesConscious ratsRat modelHyperalgesiaThymulinDifferent dosesSignificant decreaseEndotoxin
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply