2010
Absence of P-Selectin in Recipients of Allogeneic Bone Marrow Transplantation Ameliorates Experimental Graft-versus-Host Disease
Lu S, Holland A, Na I, Terwey T, Alpdogan O, Bautista J, Smith O, Suh D, King C, Kochman A, Hubbard V, Rao U, Yim N, Liu C, Laga A, Murphy G, Jenq R, Zakrzewski J, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink M. Absence of P-Selectin in Recipients of Allogeneic Bone Marrow Transplantation Ameliorates Experimental Graft-versus-Host Disease. The Journal Of Immunology 2010, 185: 1912-1919. PMID: 20622117, PMCID: PMC3752704, DOI: 10.4049/jimmunol.0903148.Peer-Reviewed Original ResearchConceptsSecondary lymphoid organsDonor T cellsAllogeneic bone marrow transplantationAlloreactive T cellsBone marrow transplantationT cellsWT T cellsP-selectinP-selectin glycoprotein ligand-1P-selectin ligandsMarrow transplantationSmall bowelInflamed tissuesDonor alloreactive T cellsHost disease (GVHD) pathophysiologyGVHD target organsAlloactivated T cellsLigand 1Wild-type recipientsGVHD mortalityGVHD prophylaxisHost diseaseLymphoid organsPeyer's patchesExperimental disease
2009
Depletion of CD4+CD25+ T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens
Akirav EM, Bergman CM, Hill M, Ruddle NH. Depletion of CD4+CD25+ T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens. Journal Of Neuroscience Research 2009, 87: 3511-3519. PMID: 19125411, PMCID: PMC4429897, DOI: 10.1002/jnr.21981.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAutoantigensAutoimmunityBiomarkersCD4 AntigensCD4-Positive T-LymphocytesCells, CulturedCentral Nervous SystemChemotaxis, LeukocyteDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleInterferon-gammaInterleukin-10Interleukin-17Interleukin-2 Receptor alpha SubunitLymphocyte ActivationMiceMice, Inbred C57BLMultiple SclerosisMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinRatsT-Lymphocytes, RegulatoryConceptsExperimental autoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinAutoimmune encephalomyelitisT cellsIL-10-producing cellsRegulatory T cellsTissue-restricted antigensCentral nervous systemField of autoimmunityT cell activationTreg depletionEAE severitySelf antigensOligodendrocyte glycoproteinForeign antigensExperimental diseaseNervous systemRelated antigensMiceSelf-antigen specificityAntigenTregsEncephalomyelitisAutoimmunityRats
2003
Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats1 1This study was supported by NIH grant HL22273, the R.J. Stransky Foundation, and the Women and Children’s Health Research Foundation of the Children’s Hospital of Buffalo.
Khanna A, Rossman J, Caty MG, Fung H. Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats1 1This study was supported by NIH grant HL22273, the R.J. Stransky Foundation, and the Women and Children’s Health Research Foundation of the Children’s Hospital of Buffalo. Journal Of Surgical Research 2003, 114: 15-24. PMID: 13678693, DOI: 10.1016/s0022-4804(03)00329-9.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAnimalsBileHemodynamicsIntestinal DiseasesIntestinal MucosaIntestinesMaleModels, AnimalNeutrophil ActivationNeutrophil InfiltrationNitric OxideNitroglycerinPermeabilityPlatelet Activating FactorRatsRats, Sprague-DawleyReactive Oxygen SpeciesReperfusion InjuryVasodilator AgentsConceptsIntestinal ischemia-reperfusion injuryIschemia-reperfusion injuryHealth Research FoundationBile flowMean arterial pressureAdministration of nitroglycerinIntestinal barrier functionIntestinal ischemiaMucosal injurySystemic hemodynamicsArterial pressureHypotensive effectIntestinal pathologyChildren's HospitalIntestinal IRIntestinal permeabilityRat modelSustained decreaseExperimental diseaseSystemic effectsNitroglycerinBeneficial effectsPhysiologic functionDifferent dosesBarrier function
1996
Experimental Bacillus cereus post-traumatic endophthalmitis and treatment with ciprofloxacin.
Alfaro D, Davis J, Kim S, Bia F, Bogard J, Briggs J, Liggett P. Experimental Bacillus cereus post-traumatic endophthalmitis and treatment with ciprofloxacin. British Journal Of Ophthalmology 1996, 80: 755. PMID: 8949723, PMCID: PMC505595, DOI: 10.1136/bjo.80.8.755.Peer-Reviewed Case Reports and Technical NotesConceptsPost-traumatic endophthalmitisRetinal necrosisVisual lossRetinal detachmentPermanent visual lossIntraocular infectionSurgical repairDevelopment of diseaseHistological findingsInflammatory cellsScleral lacerationExperimental diseaseHistological examinationEndophthalmitisHistological evaluationSubretinal spaceImportant causeDiseaseCiprofloxacinNecrosisRabbitsHuman diseasesHoursLacerationInjury
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