2021
The Effect of Interleukin-4 and Dexamethasone on RNA-Seq-Based Transcriptomic Profiling of Human Podocytes: A Potential Role in Minimal Change Nephrotic Syndrome
Lee J, Ko Y, Lee C, Jeon N, Lee K, Oh J, Kronbichler A, Saleem M, Lim B, Shin J. The Effect of Interleukin-4 and Dexamethasone on RNA-Seq-Based Transcriptomic Profiling of Human Podocytes: A Potential Role in Minimal Change Nephrotic Syndrome. Journal Of Clinical Medicine 2021, 10: 496. PMID: 33535372, PMCID: PMC7866993, DOI: 10.3390/jcm10030496.Peer-Reviewed Original ResearchGene OntologyHuman podocytesRNA-seq-based transcriptome profilingIL-4-induced changesWhole-transcriptome sequencingRelevant biological pathwaysCytoskeleton organizationGO analysisInterleukin-4 treatmentCell signalingTranscriptome profilingPodocyte genesBiological pathwaysGenesTranscriptomeInterleukin-4Pathogenic effectsExpression levelsNephrotic syndromeDEGsEffect of interleukin-4PathwayPodocytesMinimal change nephrotic syndromePathogenesis of nephrotic syndrome
2018
SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts
Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC. SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. Journal Of The American Society Of Nephrology 2018, 29: 2641-2657. PMID: 30341149, PMCID: PMC6218856, DOI: 10.1681/asn.2018060573.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonAdolescentAdultAgedAlbuminuriaAllograftsAnimalsChildChild, PreschoolEnhancer Elements, GeneticFemaleGene Knockdown TechniquesGlomerular Filtration RateHomozygoteHumansKidneyKidney TransplantationMaleMembrane ProteinsMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMiddle AgedPhosphorylationPodocytesPolymorphism, Single NucleotideProto-Oncogene Proteins c-fynRenal Insufficiency, ChronicRNA, Small InterferingSignal Transductionsrc Homology DomainsYoung AdultConceptsDiffuse foot process effacementKnockdown miceFoot process effacementReduced albuminuriaAllograft fibrosisRenal functionDonor kidneysLower GFRRenal fibrosisTGF-b signalingHuman allograftsNephroseq databaseBiopsy samplesProcess effacementProtective roleAlbuminuriaAdult glomeruliHuman podocytesKnockdown podocytesCKDHuman dataPodocytesAllograftsActin cytoskeleton pathwayFibrosis
2017
Montelukast improves the changes of cytoskeletal and adaptor proteins of human podocytes by interleukin-13
Ha T, Nam J, Seong S, Saleem M, Park S, Shin J. Montelukast improves the changes of cytoskeletal and adaptor proteins of human podocytes by interleukin-13. Inflammation Research 2017, 66: 793-802. PMID: 28608180, DOI: 10.1007/s00011-017-1058-y.Peer-Reviewed Original ResearchConceptsMinimal-change nephrotic syndromePathogenesis of minimal-change nephrotic syndromeTargeting IL-13IL-13Human podocytesIL-13-induced changesUpregulation of B7Human podocytes in vitroConcentrations of IL-13Slit diaphragmConditionally immortalized podocytesPermeability in vitroAssociated with podocyte dysfunctionPodocytes in vitroConcentration-dependent mannerPotential therapeutic strategyNephrotic syndromeA-actininInterleukin-13Potential cytokinesHigh dosesZO-1Therapeutic strategiesB-cateninMontelukast
2015
Effects of Interleukin-13 and Montelukast on the Expression of Zonula Occludens-1 in Human Podocytes
Park J, Saleem M, Nam J, Ha T, Shin J. Effects of Interleukin-13 and Montelukast on the Expression of Zonula Occludens-1 in Human Podocytes. Yonsei Medical Journal 2015, 56: 426-432. PMID: 25683991, PMCID: PMC4329354, DOI: 10.3349/ymj.2015.56.2.426.Peer-Reviewed Original ResearchConceptsMinimal-change nephrotic syndromeZonula occludens-1Expression of zonula occludens-1IL-13Human podocytesLevel of ZO-1 proteinInterleukin-13High dosesDistribution of zonula occludens-1Occludens-1Zonula occludens-1 protein levelLeukotriene receptor antagonistsBovine serum albumin-coated platesEffect of interleukin-13ZO-1 proteinTreated with different dosesPathogenesis of proteinuriaDose-dependent mannerCultured human podocytesMontelukast treatmentReceptor antagonistNephrotic syndromeMontelukastDifferent dosesWestern blotting
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