2024
Safety Profile Comparison of 2 Smooth Tissue Expander Types
Almeida M, Alper D, Williams M, Shah R, Ihnat J, Hu K, Parikh N, Alperovich M. Safety Profile Comparison of 2 Smooth Tissue Expander Types. Annals Of Plastic Surgery 2024, 93: 178-182. PMID: 38980932, DOI: 10.1097/sap.0000000000004019.Peer-Reviewed Original ResearchConceptsBody mass indexComplication rateDrain durationMass indexAcellular dermal matrix useRetrospective review of patientsReview of patientsHigher Body Mass IndexSmooth tissue expandersPain scoresChemotherapy exposureRetrospective reviewCapsular contractureSmooth implantsSafety profileWound breakdownFilling volumePatient comorbiditiesPerioperative informationCancer characteristicsMultivariate analysisComplicationsTissue expanderRadiation exposureMatrix use
2023
Exploring Factors Associated with Implant Removal Satisfaction in Breast Implant Illness Patients: A PRO BREAST-Q Study
Bascone C, McGraw J, Couto J, Sulkar R, Broach R, Butler P, Kovach S. Exploring Factors Associated with Implant Removal Satisfaction in Breast Implant Illness Patients: A PRO BREAST-Q Study. Plastic & Reconstructive Surgery Global Open 2023, 11: e5273. PMID: 37753329, PMCID: PMC10519512, DOI: 10.1097/gox.0000000000005273.Peer-Reviewed Original ResearchBreast implant illnessImplant removalCapsular contractureResidual symptomsPsychiatric illnessSatisfaction scoresPatient-reported symptomsOverall patient satisfactionPatient-associated factorsMultivariable logistic regressionBreast implant removalImplant removal proceduresAcademic medical centerChest discomfortMuscle painSymptomatic improvementRetrospective reviewPreoperative counselingIllness patientsPatient satisfactionMedical CenterImplant ruptureSelf payPatientsResponse ratePrepectoral versus Submuscular Implant-Based Breast Reconstruction: A Matched-Pair Comparison of Outcomes
Talwar A, Lanni M, Ryan I, Kodali P, Bernstein E, McAuliffe P, Broach R, Serletti J, Butler P, Fosnot J. Prepectoral versus Submuscular Implant-Based Breast Reconstruction: A Matched-Pair Comparison of Outcomes. Plastic & Reconstructive Surgery 2023, 153: 281e-290e. PMID: 37159266, DOI: 10.1097/prs.0000000000010618.Peer-Reviewed Original ResearchBreast reconstructionPrepectoral ImplantSecondary reconstructionSubmuscular reconstructionClinical outcomesSubmuscular implantsCapsular contracturePrepectoral reconstructionImplant-based breast reconstructionSurgical site infectionLarge academic medical centerSurgical site occurrenceAcademic medical centerMean followDeep infectionSite infectionNegative infectionsPostoperative differencesAntibiotic managementAnimation deformityMedical CenterCohort analysisExplantationInfectionPropensity scoreExploring the Financial, Psychological, and Operative Factors Associated With Implant Removal Satisfaction in Breast Implant Illness Patients
Bascone C, Couto J, McGraw J, Sulkar R, Broach R, Butler P, Kovach S. Exploring the Financial, Psychological, and Operative Factors Associated With Implant Removal Satisfaction in Breast Implant Illness Patients. Aesthetic Surgery Journal Open Forum 2023, 5: ojad027.015. PMCID: PMC10320688, DOI: 10.1093/asjof/ojad027.015.Peer-Reviewed Original ResearchBreast implant illnessImplant removalCapsular contractureResidual symptomsPsychiatric illnessSatisfaction scoresPatient-reported symptomsOverall patient satisfactionPatient-associated factorsMultivariable logistic regressionBreast implant removalChest discomfortMuscle painSymptomatic improvementRetrospective reviewPreoperative counselingIllness patientsPatient satisfactionOperative factorsImplant ruptureSelf payPatientsResponse ratePhysical symptomsSymptoms
2018
The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture
Diehm Y, Hirche C, Berger M, Heil J, Golatta M, Kotsougiani D, Pomahac B, Kneser U, Fischer S. The Collagenase of the Bacterium Clostridium histolyticum in the Treatment of Irradiation-Induced Capsular Contracture. Aesthetic Plastic Surgery 2018, 43: 836-844. PMID: 30456640, DOI: 10.1007/s00266-018-1267-y.Peer-Reviewed Original ResearchConceptsBacterium Clostridium histolyticumCapsular fibrosisHematoma formationTreatment optionsImplant pocketClostridium histolyticumSilicone implantsMiniature silicone implantsNovel treatment optionsPotential treatment optionInjection of collagenaseVessel wall architectureMethodsThirty-six ratsVessel wall thicknessCollagenase injectionSignificant complicationsBreast reconstructionCapsular contractureClinical safetyBreast cancerDay 1Application of collagenaseDay 120Implant sitesThin capsule
2016
Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Fischer S, Hirche C, Diehm Y, Nuutila K, Kiefer J, Gazyakan E, Bueno E, Kremer T, Kneser U, Pomahac B. Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. PLOS ONE 2016, 11: e0156428. PMID: 27232716, PMCID: PMC4883774, DOI: 10.1371/journal.pone.0156428.Peer-Reviewed Original ResearchConceptsFull-thickness skin graftThickness skin graftBacterium Clostridium histolyticumCapsular contractureSkin graftsBreast sitesSilicone implantsReasonable treatment optionClostridium histolyticumFibrotic capsuleCollagen subtypesEx vivo studyCollagenase doseEx-vivo settingTreatment optionsContracture tissueAcellular tissue matrixOutcome measuresHistological assessmentSubtype 4Capsule tissueClinical utilizationDifferent dosesClinical realityType 4
2015
The Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis after Silicone Implants
Fischer S, Hirsch T, Diehm Y, Kiefer J, Bueno E, Kueckelhaus M, Kremer T, Hirche C, Kneser U, Pomahac B. The Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis after Silicone Implants. Plastic & Reconstructive Surgery 2015, 136: 981-989. PMID: 26171751, DOI: 10.1097/prs.0000000000001698.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsy, NeedleBreast ImplantsClostridium histolyticumDisease Models, AnimalFemaleFibrosisImmunohistochemistryImplant Capsular ContractureMagnetic Resonance ImagingMicrobial CollagenaseRandom AllocationRatsReal-Time Polymerase Chain ReactionReference ValuesSilicone GelsTreatment OutcomeConceptsBacterium Clostridium histolyticumSilicone implantsSkin perforationFibrotic capsuleMiniature silicone implantsClostridium histolyticumMagnetic resonance imagingInflammatory markersDosage-dependent decreasePolymerase chain reaction analysisCapsular fibrosisSafe clinical applicationCapsular contractureDupuytren's contractureMechanical irritationChain reaction analysisControl groupDrug AdministrationResonance imagingHistologic measurementsU.S. FoodThin capsuleVivo studiesSkin digestionCollagen density
2014
Reconstructive Approach for Patients With Augmentation Mammaplasty Undergoing Nipple-Sparing Mastectomy
Alperovich M, Choi M, Frey JD, Karp NS. Reconstructive Approach for Patients With Augmentation Mammaplasty Undergoing Nipple-Sparing Mastectomy. Aesthetic Surgery Journal 2014, 34: 1059-1065. PMID: 25028736, DOI: 10.1177/1090820x14541958.Peer-Reviewed Original ResearchConceptsNipple-sparing mastectomyReconstructive complicationsNipple-areola complexNAC necrosisComplete NAC necrosisPartial NAC necrosisPrevious breast augmentationMastectomy flap necrosisNew York University Langone Medical CenterImplant-based reconstructionMicrovascular free flapsBreast cellulitisNSM reconstructionPrevious augmentationPrior augmentationPatient characteristicsFlap necrosisMedical recordsMinimal complicationsPartial necrosisProphylactic managementCapsular contractureFisher's exactBreast cancerLarge cohortNipple-Sparing Mastectomy in Patients with Prior Breast Irradiation
Alperovich M, Choi M, Frey JD, Lee ZH, Levine JP, Saadeh PB, Shapiro RL, Axelrod DM, Guth AA, Karp NS. Nipple-Sparing Mastectomy in Patients with Prior Breast Irradiation. Plastic & Reconstructive Surgery 2014, 134: 202e-206e. PMID: 25068341, DOI: 10.1097/prs.0000000000000321.Peer-Reviewed Original ResearchConceptsNipple-sparing mastectomyNipple-areola complex necrosisPrior breast irradiationMastectomy flap necrosisHigh-risk procedureBreast irradiationFlap necrosisComplete nipple-areola complex necrosisNipple-sparing mastectomy patientsHigh-risk patientsBody mass indexLatissimus dorsi flapMicrovascular free flapsSignificant differencesMastectomy cohortComplex complicationsImplant explantationMass indexMastectomy patientsCapsular contracturePartial necrosisAutologous reconstructionComplete necrosisIrradiated groupFree flap
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