2025
Activity-Dependent Effects of ERK1/2 on Hepatic Ischemia-Reperfusion Injury
Kim J, Hong S, Lee A, Kumar S, Suchi M, Park J. Activity-Dependent Effects of ERK1/2 on Hepatic Ischemia-Reperfusion Injury. Transplantation Proceedings 2025 PMID: 40796392, DOI: 10.1016/j.transproceed.2025.07.005.Peer-Reviewed Original ResearchHepatic ischemia-reperfusion injuryIschemia-reperfusion injuryERK1/2 activationLiver injuryActivity-dependent effectsResponse to IRIEnd-stage liver diseaseDose of trametinibAnalysis of cell death pathwaysEffect of ERK1/2Extracellular signal-regulated kinaseExpression of ferroptosis markersSignal-regulated kinaseSerum markersModulation of ERK1/2 activityLiver transplantationMEK1/2 inhibitorReperfusion timeMolecular analysisRat modelIschemia-reperfusionLiver ischemiaCell death pathwaysHistological assessmentLiver diseasePatterns of sialyl-Lewis X expression predict gastric histopathology
Vargas N, Quiroga A, Chaves J, Bolaños H, Nalbantoglu I, Astaiza C, Wu Y, Sáenz J. Patterns of sialyl-Lewis X expression predict gastric histopathology. Diagnostic Pathology 2025, 20: 76. PMID: 40551130, PMCID: PMC12183862, DOI: 10.1186/s13000-025-01673-8.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisChronic non-atrophic gastritisGastric pathologyAssociated with chronic atrophic gastritisIntestinal metaplasiaProgression to gastric cancerSLex expressionPre-cancerous lesionsNon-atrophic gastritisGastric pre-cancerous lesionsHistological diagnosisPre-cancerous changesGlandular distributionAntrum biopsiesAdult patientsGastric corpusAtrophic gastritisChronic inflammationGastric cancerHistological markersHistological assessmentGastric histopathologyGastric epitheliumIntroductionGastric cancerBiopsy
2024
Validation of a whole slide image management system for metabolic‐associated steatohepatitis for clinical trials
Pulaski H, Mehta S, Manigat L, Kaufman S, Hou H, Nalbantoglu I, Zhang X, Curl E, Taliano R, Kim T, Torbenson M, Glickman J, Resnick M, Patel N, Taylor C, Bedossa P, Montalto M, Beck A, Wack K. Validation of a whole slide image management system for metabolic‐associated steatohepatitis for clinical trials. The Journal Of Pathology Clinical Research 2024, 10: e12395. PMID: 39294925, PMCID: PMC11410674, DOI: 10.1002/2056-4538.12395.Peer-Reviewed Original ResearchConceptsClinical trialsAssessment of disease activityOverall percent agreementLiver biopsyDisease activityPathological assessmentWashout periodHistological assessmentEndpoint assessmentGold standardPercent agreementScoring systemExpert pathologistsSteatohepatitisAverage agreementDigital scoresPathologistsTrialsProtocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis
Hussain N, Ma C, Hirschfield G, Walmsley M, Hanford P, Vesterhus M, Kowdley K, Bergquist A, Ponsioen C, Levy C, Assis D, Schramm C, Bowlus C, Trauner M, Aiyegbusi O, Jairath V, Trivedi P. Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis. BMJ Open 2024, 14: e080143. PMID: 38926149, PMCID: PMC11216047, DOI: 10.1136/bmjopen-2023-080143.Peer-Reviewed Original ResearchConceptsPrimary sclerosing cholangitisClinical trialsSclerosing cholangitisCore outcome setImmune-mediated liver diseasesPrimary sclerosing cholangitis treatmentOutcome measuresEvaluate novel therapiesSlow disease progressionPatient-reported outcome measuresMedical therapyNovel therapiesLiver fibrosisDisease progressionHistological assessmentLiver diseaseInternational two-round Delphi surveyImaging-based biomarkersIntervention trialsTherapyConsensus meetingHealthcare payersCholangitisSemistructured qualitative interviewsTwo-round Delphi surveyDiandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction?
Nagy A, Niu N, Sun T, Buza N, Hui P. Diandric triploid partial mole versus digynic nonmolar triploidy: is morphological assessment sufficient for the diagnostic distinction? Histopathology 2024, 85: 879-888. PMID: 39031756, DOI: 10.1111/his.15247.Peer-Reviewed Original ResearchPositive predictive valueTriploid gestationsPartial moleTrophoblastic hyperplasiaVillous sizeCistern formationHistological parametersPostmolar gestational trophoblastic neoplasiaTriploid partial molesGenotype-phenotype correlation studiesGestational trophoblastic neoplasiaPartial Hydatidiform MoleModerate interobserver agreementVillous populationsTrophoblastic neoplasiaGestational weeksHydatidiform MoleClinical presentationPatient ageDigynic triploidyAbnormal histologyInterobserver agreementGestationSyncytiotrophoblastHistological assessmentHistological Assessment of the Effectiveness of Microneedling Device-Assisted Filler Delivery
Ugwu N, Xun H, Dover J, Boustany A, Chung H. Histological Assessment of the Effectiveness of Microneedling Device-Assisted Filler Delivery. Dermatologic Surgery 2024, 50: 829-833. PMID: 38691514, DOI: 10.1097/dss.0000000000004206.Peer-Reviewed Original ResearchMicroneedle treatmentMicroneedling penTopical applicationTranscutaneous drug deliveryHuman abdominal skin samplesFiller typeMicroneedle rollerTranscutaneous deliveryHistological assessmentAbdominal skin samplesHistological evaluationTreatment sequenceMicroneedle devicePoly-L-lactic acidTreatmentSkin samples
2021
Mediastinal Mass: An Unusual Location for a Paraganglioma.
Landreth S, Bhamidipati C, Muralidaran A, Sauer D, Goldner B, Fuss C. Mediastinal Mass: An Unusual Location for a Paraganglioma. Radiology Cardiothoracic Imaging 2021, 3: e210063. PMID: 34235449, PMCID: PMC8250414, DOI: 10.1148/ryct.2021210063.Peer-Reviewed Original ResearchRight ventricular outflow tractMaterial-enhanced CTMiddle mediastinal massVentricular outflow tractSymptomatic inguinal herniaLeft coronary arteriesMediastinal massFat planeOutflow tractMediastinal paragangliomaInguinal herniaMediastinal structuresUnusual locationPresurgical workupHistological assessmentCoronary arteryParagangliomaWorkupTumorHerniaArteryAbdomenChestPelvis
2020
Elucidating the role of the AD risk factor Pyk2 in tau‐induced neuronal dysfunction
Brody A, Strittmatter S. Elucidating the role of the AD risk factor Pyk2 in tau‐induced neuronal dysfunction. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.036625.Peer-Reviewed Original ResearchSpatial memory impairmentCell layer thicknessGenetic deletionTau pathologyTau phosphorylationMemory impairmentPharmacological inhibitionAcute hippocampal slice preparationsTau-induced neuronal dysfunctionHippocampal slice preparationPS19 miceNeuronal dysfunctionSlice preparationHistological assessmentMouse modelKnockout micePyk2 activityExacerbationMicePyk2PathologyImpairmentAnimalsTauPhenotype
2016
Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Fischer S, Hirche C, Diehm Y, Nuutila K, Kiefer J, Gazyakan E, Bueno E, Kremer T, Kneser U, Pomahac B. Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. PLOS ONE 2016, 11: e0156428. PMID: 27232716, PMCID: PMC4883774, DOI: 10.1371/journal.pone.0156428.Peer-Reviewed Original ResearchConceptsFull-thickness skin graftThickness skin graftBacterium Clostridium histolyticumCapsular contractureSkin graftsBreast sitesSilicone implantsReasonable treatment optionClostridium histolyticumFibrotic capsuleCollagen subtypesEx vivo studyCollagenase doseEx-vivo settingTreatment optionsContracture tissueAcellular tissue matrixOutcome measuresHistological assessmentSubtype 4Capsule tissueClinical utilizationDifferent dosesClinical realityType 4
2012
Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study.
Attizzani G, Bezerra H, Chamié D, Fujino Y, Spognardi A, Stanley J, Yamamoto H, Mehanna E, Wang W, Carlyle W, McClain J, Costa M. Serial Evaluation of Vascular Response After Implantation of a New Sirolimus-Eluting Stent With Bioabsorbable Polymer (MISTENT): an optical coherence tomography and histopathological study. Journal Of Invasive Cardiology 2012, 24: 560-8. PMID: 23117309.Peer-Reviewed Original ResearchConceptsOptical coherence tomographyBare-metal stentsVascular responsesNormalized optical densitySirolimus-eluting stentsCoherence tomographyHistological evaluationAssessment of vascular responseEvaluation of vascular responsesLowest inflammation scoreBare-metal stent groupYucatan mini-swineAC-SESComplete endothelial coverageSerial OCTPost-procedureInflammation scoreHistological assessmentMinimal inflammationHistological demonstrationSerial evaluationCoronary arteryHistopathological studiesMini-swineNeointimal thickness
2010
The ATP-Binding Cassette Transporter BCRP1/ABCG2 Plays a Pivotal Role in Cardiac Repair After Myocardial Infarction Via Modulation of Microvascular Endothelial Cell Survival and Function
Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M. The ATP-Binding Cassette Transporter BCRP1/ABCG2 Plays a Pivotal Role in Cardiac Repair After Myocardial Infarction Via Modulation of Microvascular Endothelial Cell Survival and Function. Arteriosclerosis Thrombosis And Vascular Biology 2010, 30: 2128-2135. PMID: 20829509, DOI: 10.1161/atvbaha.110.211755.Peer-Reviewed Original ResearchConceptsBreast cancer resistance protein 1BCRP1/ABCG2Myocardial infarctionWT miceCardiac repairEndothelial cellsEndothelial cell survivalAbcg2 knockout micePeri-infarction areaMember 2 expressionTissue defense mechanismsMicrovascular endothelial cellsCell survivalResistance protein 1Cardiac ruptureIntracellular protoporphyrin IXVentricular remodelingKO micePivotal roleHistological assessmentKnockout miceSurvival rateABCG2 inhibitionMiceOxidative stress
2007
Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds
Pomahac B, Zuhaili B, Kudsi Y, Bleiziffer O, Velander P, Eriksson E, Gerner P. Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds. Regional Anesthesia & Pain Medicine 2007, 32: 377-381. DOI: 10.1097/00115550-200709000-00003.Peer-Reviewed Original ResearchFull-thickness woundsPorcine full-thickness woundsSerum levelsWound chambersTopical applicationWound contractionEffects of amitriptylineManagement of painDaily topical applicationHigher serum levelsExcised burn woundsFull-thickness skin biopsiesOvert toxic effectsLevels of amitriptylineTricyclic antidepressant amitriptylineNeuropathic painPain clinicHistopathological findingsNormal salineSkin biopsiesHistological assessmentAntidepressant amitriptylineDay 2Control groupAmitriptylineSafety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds
Pomahac B, Zuhaili B, Kudsi Y, Bleiziffer O, Velander P, Eriksson E, Gerner P. Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds. Regional Anesthesia & Pain Medicine 2007, 32: 377-381. PMID: 17961834, DOI: 10.1016/j.rapm.2007.06.003.Peer-Reviewed Original ResearchConceptsFull-thickness woundsPorcine full-thickness woundsSerum levelsWound chambersTopical applicationWound contractionEffects of amitriptylineManagement of painDaily topical applicationHigher serum levelsExcised burn woundsFull-thickness skin biopsiesOvert toxic effectsLevels of amitriptylineTricyclic antidepressant amitriptylineNeuropathic painPain clinicHistopathological findingsNormal salineSkin biopsiesHistological assessmentAntidepressant amitriptylineDay 2Control groupAmitriptyline
2004
KGF-1 plasmid delivered with electroporation accelerates wound closure in diabetic mice
Marti G, Lin M, Qaiser R, Dieb R, Wang J, Parth S, Bonde P, Duncan M, Harmon J. KGF-1 plasmid delivered with electroporation accelerates wound closure in diabetic mice. Journal Of The American College Of Surgeons 2004, 199: 59. DOI: 10.1016/j.jamcollsurg.2004.05.121.Peer-Reviewed Original ResearchDiabetic miceGrowth factorKGF-1Diabetic mouse modelWound healing deficitsUnmet medical challengeKeratinocyte growth factorFull-thickness woundsImportant growth factorDiabetic individualsHistological assessmentHealing deficitsMouse modelEP groupClosure of woundsGrading scaleMedical challengeDNA expression vectorsThickness woundsWound areaDiminished levelsWoundsUntreated woundsMiceCMV promoter
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