2022
Neural activations to loss anticipation mediates the association between difficulties in emotion regulation and screen media activities among early adolescent youth: A moderating role for depression
Zhang J, Zhou N, Song K, Zou B, Xu L, Fu Y, Geng X, Wang Z, Li X, Potenza M, Nan Y, Zhang J. Neural activations to loss anticipation mediates the association between difficulties in emotion regulation and screen media activities among early adolescent youth: A moderating role for depression. Developmental Cognitive Neuroscience 2022, 58: 101186. PMID: 36516611, PMCID: PMC9764194, DOI: 10.1016/j.dcn.2022.101186.Peer-Reviewed Original ResearchConceptsReward/loss processingDorsolateral prefrontal cortexProcessing of emotionsScreen media activitiesAnterior insulaLoss processingEmotion regulationBrain activationRight dorsolateral prefrontal cortexMonetary incentive delay taskDepressive symptomsNegative emotional situationsEarly adolescent youthIncentive delay taskNegative emotional statesLeft anterior insulaPotential mediating factorsAI activationNeural correlatesFMRI scanningDelay taskEmotional situationsEmotional statesLoss anticipationMediation modelHypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk score
2020
Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group
Rabin RA, Mackey S, Parvaz MA, Cousijn J, Li C, Pearlson G, Schmaal L, Sinha R, Stein E, Veltman D, Thompson PM, Conrod P, Garavan H, Alia‐Klein N, Goldstein RZ. Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group. Human Brain Mapping 2020, 43: 543-554. PMID: 32857473, PMCID: PMC8675419, DOI: 10.1002/hbm.25141.Peer-Reviewed Original ResearchConceptsGray matter volumeCocaine useCocaine-dependent individualsMatter volumeCD individualsWhole-brain linear regressionAnterior insulaHippocampal gray matter volumeSelect brain areasT1-weighted MRI scansGender-specific associationsTotal intracranial volumeENIGMA Addiction Working GroupCue-induced cravingLeft anterior insulaGender-specific mechanismsAge-matched participantsCD menCD womenVoxel-based morphometry dataControl menLimbic regionsClinical dataMRI scansBrain areas
2019
Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder
Diez I, Ortiz-Terán L, Williams B, Jalilianhasanpour R, Ospina J, Dickerson B, Keshavan M, LaFrance W, Sepulcre J, Perez D. Corticolimbic fast-tracking: enhanced multimodal integration in functional neurological disorder. Journal Of Neurology Neurosurgery & Psychiatry 2019, 90: 929. PMID: 30850473, PMCID: PMC6625895, DOI: 10.1136/jnnp-2018-319657.Peer-Reviewed Original ResearchConceptsFunctional neurological disorderLeft anterior insulaRight anterior insulaAnterior insulaSymptom severityWithin-group analysisPathophysiology of functional neurological disorderFunctional neurological disorder cohortsMotor functional neurological disorderRight laterobasal amygdalaMultimodal integration networkBilateral posterior insulaMiddle cingulate cortexMultimodal integration areasLaterobasal amygdalaDisorder subscaleCentromedial amygdalaCingulate cortexInteroceptive processingAffective disturbancesPatient-reported symptom severityPosterior insulaWithin-group associationsAmygdalar nucleiBetween-group differences
2017
Heightened brain response to pain anticipation in high‐functioning adults with autism spectrum disorder
Gu X, Zhou T, Anagnostou E, Soorya L, Kolevzon A, Hof P, Fan J. Heightened brain response to pain anticipation in high‐functioning adults with autism spectrum disorder. European Journal Of Neuroscience 2017, 47: 592-601. PMID: 28452081, PMCID: PMC5659957, DOI: 10.1111/ejn.13598.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAutism spectrum disorderSkin conductance responsesHigh-functioning adultsPain anticipationSpectrum disorderDorsal anterior cingulate cortexAutism spectrum disorder participantsAutism spectrum disorder groupCognitive aspects of pain processingCognitive aspectsAnterior cingulate cortexLeft anterior insulaSocio-communicative difficultiesNo significant group differencesAnticipation of stimulationSignificant group differencesHealthy controlsInteroceptive inferenceAnterior insulaInsular activityAversive stimuliCingulate cortexPain processingNeural mechanisms
2013
Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism
DeVito EE, Meda SA, Jiantonio R, Potenza MN, Krystal JH, Pearlson GD. Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism. Neuropsychopharmacology 2013, 38: 1854-1863. PMID: 23584260, PMCID: PMC3746701, DOI: 10.1038/npp.2013.92.Peer-Reviewed Original ResearchConceptsAlcohol use measuresNeural correlatesFHP individualsImpulse controlHigher self-reported impulsivityGreater BOLD signalFHN groupSelf-reported impulsivityAlcohol useInferior frontal gyrusLeft anterior insulaUse measuresImpulsivity factorsAnterior insulaFrontal gyrusGreater activationImpulsivityAddictive disordersNeural systemsScanner measuresSuccessful inhibitionBOLD signalSex differencesBehavioral traitsAddiction
2008
Time course of regional brain activation associated with onset of auditory/verbal hallucinations
Hoffman RE, Anderson AW, Varanko M, Gore JC, Hampson M. Time course of regional brain activation associated with onset of auditory/verbal hallucinations. The British Journal Of Psychiatry 2008, 193: 424-425. PMID: 18978327, PMCID: PMC2801815, DOI: 10.1192/bjp.bp.107.040501.Peer-Reviewed Original ResearchConceptsVerbal hallucinationsBrain activationRight middle temporal gyrusRegional brain activationLeft anterior insulaFunctional magnetic resonanceMiddle temporal gyrusPrevious case reportsAnterior insulaTemporal gyrusBrain eventsAnterior cingulateDextral patientsTime courseParahippocampal gyrusCase reportHallucinationsGyrusActivationMagnetic resonanceOnsetInsulaCingulate
2001
Functional MR imaging of regional brain activation associated with the affective experience of pain.
Fulbright R, Troche C, Skudlarski P, Gore J, Wexler B. Functional MR imaging of regional brain activation associated with the affective experience of pain. American Journal Of Roentgenology 2001, 177: 1205-10. PMID: 11641204, DOI: 10.2214/ajr.177.5.1771205.Peer-Reviewed Original ResearchConceptsAnterior cingulate gyrusSuperior frontal gyrusCingulate gyrusPain taskRight cuneusFunctional MRFrontal gyrusRight superior frontal gyrusBrain activationPain-related activationCold pressor testLeft anterior insulaExperience of painRegional brain activationFunctional MR imagingMotor-sensory areasPainful temperaturesPain thresholdLeft thalamusPressor testPainful levelsPostcentral gyrusPainFrontal lobeHealthy adults
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