2025
N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder
Engeli E, Preller K, Rieser N, Klar J, Staempfli P, Hulka L, Kirschner M, Seifritz E, Herdener M. N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder. Frontiers In Psychiatry 2025, 15: 1489194. PMID: 40083914, PMCID: PMC11903417, DOI: 10.3389/fpsyt.2024.1489194.Peer-Reviewed Original ResearchCocaine use disorderSuperior frontal gyrusCue reactivityCocaine cuesUse disorderFrontal gyrusPrefrontal regionsResponse to cocaine cuesTreating cocaine use disorderDuration of cocaine useModulation of glutamatergic signalingCue reactivity paradigmCue-induced activationDrug cue reactivityIncreased cue reactivityNeural cue reactivityCue-induced cravingMedial prefrontal regionsRisk of substance usePlacebo-controlled cross-over trialAlleviate cravingCocaine cravingCocaine picturesNucleus accumbensRelapse behavior
2024
Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats
Floris G, Dabrowski K, Zanda M, Daws S. Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats. Molecular Psychiatry 2024, 30: 1801-1816. PMID: 39433903, PMCID: PMC12015112, DOI: 10.1038/s41380-024-02788-y.Peer-Reviewed Original ResearchPrefrontal cortexHeroin seekingHeroin relapseDrug seekingSelf-AdministrationPrefrontal cortex of male ratsPrefrontal cortex of animalsCortex of male ratsHeroin self-administrationHeroin-seeking behaviorDrug-naive ratsOpioid-seeking behaviorSerotonin 2A receptorEfficacy of psilocybinAlcohol seekingHeroin takingForced abstinenceNucleus accumbensRelapse testRelapse behaviorIL-17AMaladaptive behaviorsPsychedelic compoundsAntagonist ketanserinPsilocybin
2022
Mechanistic Effects and Use of N-acetylcysteine in Substance Use Disorders
Greenberg N, Farhadi F, Kazer B, Potenza M, Angarita G. Mechanistic Effects and Use of N-acetylcysteine in Substance Use Disorders. Current Behavioral Neuroscience Reports 2022, 9: 124-143. DOI: 10.1007/s40473-022-00250-3.Peer-Reviewed Original ResearchSubstance use disordersN-acetylcysteineUse disordersEfficacy of NACTreatment of SUDsGlial glutamate transporter-1Glutamate transporter 1Drug-seeking behaviorCue-induced reinstatementNAC useAdjunctive useClinical studiesGlutamate homeostasisGlutamate signalingNeurobiological effectsClinical approachRelapse behaviorSubcortical regionsSynaptic plasticityFunctional connectivity networksPrefrontal cortexBehavioral interventionsTransporter 1Oxidative stressImpulsive behavior
2013
Changes in Smoking for Adults with and without Alcohol and Drug Use Disorders: Longitudinal Evaluation in the US Population
Weinberger AH, Pilver CE, Hoff RA, Mazure CM, McKee SA. Changes in Smoking for Adults with and without Alcohol and Drug Use Disorders: Longitudinal Evaluation in the US Population. The American Journal Of Drug And Alcohol Abuse 2013, 39: 186-193. PMID: 23721534, PMCID: PMC3696891, DOI: 10.3109/00952990.2013.785557.Peer-Reviewed Original ResearchConceptsCurrent drug use disordersDrug use disordersCurrent alcohol use disorderAlcohol use disorderDUD diagnosesUse disordersSmoking cessationDaily smokersSmoking relapsePast alcohol use disordersFormer daily smokersCurrent daily smokersUS adult populationDaily cigarette smokersAssessment 3 yearsNational Epidemiologic SurveyWave 2Gender-specific effectsCigarette smokersEpidemiologic SurveyDiagnosis interactionRelapse behaviorSmokingUS populationAdult population
2008
Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction
Taylor JR, Olausson P, Quinn JJ, Torregrossa MM. Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction. Neuropharmacology 2008, 56: 186-195. PMID: 18708077, PMCID: PMC2635342, DOI: 10.1016/j.neuropharm.2008.07.027.Peer-Reviewed Original ResearchConceptsCue-drug memoriesCue-drug associationsCue exposure therapyMemory reconsolidation processesDisruption of reconsolidationCue-induced relapseDrug-associated cuesInhibitory memoryReconsolidation mechanismsDrug cuesMemory retrievalReconsolidation processMemory processesReconsolidationCompulsive disorderRelapse behaviorMemoryMemory erasureBrief time periodDrug addictionDistinct processesCuesAddictionExtinctionCraving
1987
The Dependence Syndrome Concept as a Psychological Theory of Relapse Behaviour: an empirical evaluation of alcoholic and opiate addicts
BABOR T, COONEY N, LAUERMAN R. The Dependence Syndrome Concept as a Psychological Theory of Relapse Behaviour: an empirical evaluation of alcoholic and opiate addicts. Addiction 1987, 82: 393-405. PMID: 3472584, DOI: 10.1111/j.1360-0443.1987.tb01495.x.Peer-Reviewed Original ResearchConceptsPsychological theoriesPeriod of abstinenceDependence syndrome conceptOpiate usersPsychological explanationsRelapse behaviorReinstatementSyndrome conceptDrug dependenceAlcohol dependence syndromeOpiate addictsEmpirical studyDependence syndromeMeasuresOperational measuresAlcoholicsHypothesis testingAbstinenceEmpirical evaluationTheoryDrug usersAddicts
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