2025
Gamma oscillations and excitation/inhibition imbalance: parallel effects of N-methyl D-aspartate receptor antagonism and psychosis
Roach B, Ford J, Nicholas S, Ferri J, Gunduz-Bruce H, Krystal J, Jaeger J, Mathalon D. Gamma oscillations and excitation/inhibition imbalance: parallel effects of N-methyl D-aspartate receptor antagonism and psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39832734, DOI: 10.1016/j.bpsc.2025.01.008.Peer-Reviewed Original ResearchN-methyl-D-aspartate glutamate receptorAuditory steady-state responsePhase-locking factorBroadband gamma powerGamma powerNMDAR hypofunctionAcute administration of ketamineN-methyl-D-aspartate glutamate receptor antagonistEvoked powerN-methyl-D-aspartate receptor antagonismDrug challenge studiesReplicate previous findingsReplicate prior studiesAdministration of ketamineHealthy control subjectsComparison of patientsSchizophrenia patientsAcute administrationSchizophreniaExcitation/inhibition imbalanceStudy 1Study 2Gamma oscillationsReceptor antagonismEEG studies
2020
Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia
Gu S, Sonkar V, Katare P, Kumar R, Kruger W, Arning E, Bottiglieri T, Lentz S, Dayal S. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia. Journal Of The American Heart Association 2020, 9: e013368. PMID: 32067580, PMCID: PMC7070222, DOI: 10.1161/jaha.119.013368.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierCell DeathCells, CulturedCystathionine beta-SynthaseDisease Models, AnimalDisease ProgressionExcitatory Amino Acid AntagonistsHomocysteineHomocystinuriaHyperhomocysteinemiaInfarction, Middle Cerebral ArteryMemantineMice, KnockoutNeuronsNeuroprotective AgentsReceptors, N-Methyl-D-AspartateSeverity of Illness IndexConceptsN-methyl-D-aspartatePlasma total homocysteineBlood-brain barrier disruptionTotal homocysteineBrain barrier disruptionIschemic strokeN-methyl-D-aspartate receptor antagonismBarrier disruptionCerebrovascular injuryN-methyl-D-aspartate receptor antagonistExpression of NR2B subunitN-methyl-D-aspartate receptor subunitsExpression of N-methyl-D-aspartate receptor subunitsN-methyl-D-aspartate receptor antagonist memantineCystathionine beta-synthaseEffects of memantineCerebral infarct sizeTargeted treatment strategiesAcute ischemic strokeBlood-brain barrierReceptor antagonismNR2B subunitReceptor antagonistSevere elevationHomocysteine levels
2015
N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers
Krishnan‐Sarin S, O'Malley SS, Franco N, Cavallo DA, Morean M, Shi J, Pittman B, Krystal JH. N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers. Alcohol Clinical And Experimental Research 2015, 39: 300-307. PMID: 25664775, PMCID: PMC4331214, DOI: 10.1111/acer.12619.Peer-Reviewed Original ResearchConceptsAlcohol drinkingFamily historyHeavy drinkersAlcohol cravingN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate receptor antagonismAlcohol cue-induced cravingEffects of FHHigher baseline levelsPresence of impulsivityAlcohol use disorderCue-induced cravingAlcohol-induced stimulationReceptor antagonismReceptor antagonistPriming doseNMDA receptorsUse disordersMemantineBaseline levelsModulatory influencePotential efficacyAlcohol accessDrinkersEighth day
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