2023
Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder
Mishra H, Wei H, Rohr K, Ko I, Nievergelt C, Maihofer A, Shilling P, Alda M, Berrettini W, Brennand K, Calabrese J, Coryell W, Frye M, Gage F, Gershon E, McInnis M, Nurnberger J, Oedegaard K, Zandi P, Kelsoe J, McCarthy M. Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. European Neuropsychopharmacology 2023, 74: 1-14. PMID: 37126998, PMCID: PMC11801370, DOI: 10.1016/j.euroneuro.2023.04.009.Peer-Reviewed Original ResearchConceptsCell survival genesCircadian clockSurvival genesCell survivalCircadian clock genesCircadian rhythmGenetic variationClock genesKnockdown studiesCaspase activityCell deathMolecular pathwaysPrimary fibroblastsCellular modelGenesMouse fibroblastsFibroblast modelApoptosisStaurosporinePER1FibroblastsOpposite mannerLithium responsivenessDistinct patternsClock
2015
Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population
White MJ, Kodaman NM, Harder RH, Asselbergs FW, Vaughan DE, Brown NJ, Moore JH, Williams SM. Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. PLOS ONE 2015, 10: e0136379. PMID: 26322636, PMCID: PMC4556460, DOI: 10.1371/journal.pone.0136379.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Genetic variantsCircadian clock genesMost genetic studiesCardiovascular disease susceptibilityImportant genetic variantsActivator inhibitor-1Inhibitor-1Clock genesGenetic studiesGenetic effectsDisease susceptibilityArylsulfatase BMajor modulatorNovel associationsLack of overlapGenesPathway effectsMedian PAI-1European descentVariantsGeneticsPopulationSNPsCaucasian population
2009
Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
So A, Bernal T, Pillsbury M, Yamamoto K, Feldman B. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17582-17587. PMID: 19805059, PMCID: PMC2757402, DOI: 10.1073/pnas.0909733106.Peer-Reviewed Original ResearchConceptsGlucocorticoid response elementClock genesGlucocorticoid regulationGenes in vivoCore clock gene Per2Circadian clock genesGenomic deletionsMultiple clock genesClock gene Per2Response elementRegulatory pathwaysRhythmic expressionGenesPeripheral clocksGlucose homeostasisElevated leptin levelsAction of glucocorticoidsPhysiological consequencesRegulationGlucocorticoid receptorPer2Glucocorticoid treatmentLeptin levelsMuscle wastingGlucose intolerance
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