2024
Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers
Chen Y, Chaudhary S, Li G, Fucito L, Bi J, Li C. Deficient sleep, altered hypothalamic functional connectivity, depression and anxiety in cigarette smokers. Neuroimage Reports 2024, 4: 100200. PMID: 38605733, PMCID: PMC11008573, DOI: 10.1016/j.ynirp.2024.100200.Peer-Reviewed Original ResearchResting state functional connectivitySeverity of depressionPittsburgh Sleep Quality IndexMotivated behaviorNicotine dependenceFunctional connectivityPittsburgh Sleep Quality Index scoreAchenbach Adult Self-ReportSeverity of alcohol useAssociated with greater severityComorbid nicotine dependenceDeficient sleepAdult Self-ReportHypothalamic functional connectivityHuman Connectome ProjectAnxiety disordersAnxiety severityPublished routinesAnxiety symptomsCircuit dysfunctionGreater severityPsychiatric problemsSleep-wake cyclePoor sleep qualityNeural markers
2023
Seizures and electrophysiological features in familial cortical myoclonic tremor with epilepsy 1
Ding Y, Cen Z, Zheng Y, Qiu X, Ye Y, Chen X, Hu L, Wang B, Wang Z, Yin H, Shen C, Ming W, Ge Y, Xie F, Yang D, Ouyang Z, Wang H, Wu S, Ding M, Wang S, Luo W. Seizures and electrophysiological features in familial cortical myoclonic tremor with epilepsy 1. Annals Of Clinical And Translational Neurology 2023, 11: 414-423. PMID: 38059543, PMCID: PMC10863925, DOI: 10.1002/acn3.51961.Peer-Reviewed Original ResearchConceptsInterictal epileptiform dischargesIED indexFamilial cortical myoclonic tremorCortical myoclonic tremorElectrophysiological featuresMyoclonic tremorGeneralized interictal epileptiform dischargesDistribution of interictal epileptiform dischargesFocal interictal epileptiform dischargesThirty-one patientsStage I-IIPositive family historyEpileptic seizuresCourse of epilepsySleep-wake cycleFCMTE patientsOvernight EEGProlonged prodromeBenign courseEpileptiform dischargesFamily historyChinese cohortPhotoparoxysmal responseGenetic testingSAMD12 gene
2020
Crosstalk between circadian rhythms and the microbiota
Pearson JA, Wong FS, Wen L. Crosstalk between circadian rhythms and the microbiota. Immunology 2020, 161: 278-290. PMID: 33090484, PMCID: PMC7692254, DOI: 10.1111/imm.13278.Peer-Reviewed Original ResearchConceptsHost circadian rhythmsMicrobial oscillationsGene/protein expressionAspects of biologyCircadian rhythmMicrobial associationsMolecular oscillationsCircadian oscillationsMicrobial compositionMicrobial influenceCause diseaseMolecular techniquesHost metabolismDisease susceptibilityMicrobial changesProtein expressionPeripheral rhythmsMain inducerMicrobiotaSleep-wake cycleHost immunityCrosstalkClinical successPotential connectionMicrobesThe subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia?
Hasegawa H, Selway R, Gnoni V, Beniczky S, Williams SCR, Kryger M, Ferini-Strambi L, Goadsby P, Leschziner GD, Ashkan K, Rosenzweig I. The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia? Sleep Medicine Reviews 2020, 52: 101317. PMID: 32446196, PMCID: PMC7679363, DOI: 10.1016/j.smrv.2020.101317.Peer-Reviewed Original ResearchConceptsBasal gangliaBasal ganglia disordersFunctional anatomyPhysiology of sleepSlow-wave sleepSleep-wake cycleOptogenetic mappingNeuromodulation strategiesSleep disordersREM sleepGangliaNeural plasticityNeural circuitsSleepFunctional imagingIntracranial recordingsHuman sleep disordersSleep mechanismsDisordersEmotional networkIntegral roleAnatomyBetter understandingNeuromodulation
2010
Medication Effects on Sleep
Roux FJ, Kryger MH. Medication Effects on Sleep. Clinics In Chest Medicine 2010, 31: 397-405. PMID: 20488296, DOI: 10.1016/j.ccm.2010.02.008.Chapters
2008
Influence of Sex on Sleep Regulatory Mechanisms
Paul KN, Turek FW, Kryger MH. Influence of Sex on Sleep Regulatory Mechanisms. Journal Of Women's Health 2008, 17: 1201-1208. PMID: 18710368, DOI: 10.1089/jwh.2008.0841.Peer-Reviewed Original ResearchConceptsSleep regulatory mechanismsRodent studiesSleep-wake disordersReproductive hormonesExtended wakefulnessHomeostatic sleep regulatory mechanismsSleep consolidationSleep-wake amountsActivational influencesBiological sexRapid eye movement (REM) sleepSleep-wake architectureSleep amountSleep-wake cycleEffects of sexFemale reproductive hormonesSleepEye movement sleepSleep-wake statesInfluence of sexSleep disordersSleep statesPositive impactWakefulnessNeonatal exposure
2002
Neuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton J, McCormick D. Neuromodulatory Role of Serotonin in the Ferret Thalamus. Journal Of Neurophysiology 2002, 87: 2124-2136. PMID: 11929930, DOI: 10.1152/jn.00650.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsAction of serotoninDorsal thalamusLocal interneuronsSpontaneous inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusGABAergic synaptic transmissionPrimary sensory nucleiIntracellular recording techniquesPresence of tetrodotoxinTonic firing modesLateral geniculate nucleusModulation of neuronsExtracellular potassium concentrationSleep-wake cycleReversal potential shiftsSerotonergic fibersThalamocortical neuronsAssociative nucleiMedial geniculateNeuromodulatory rolePostsynaptic potentialsSerotonergic inputLateral posteriorSlice preparation
1997
Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study.
Braun AR, Balkin TJ, Wesenten NJ, Carson RE, Varga M, Baldwin P, Selbie S, Belenky G, Herscovitch P. Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain 1997, 120: 1173-1197. PMID: 9236630, DOI: 10.1093/brain/120.7.1173.Peer-Reviewed Original ResearchConceptsSlow-wave sleepSleep-wake cycleHeteromodal association areasREM sleepBasal gangliaSensory cortexState-dependent changesAssociation cortexAssociation areasRegional cerebral blood flowRapid eye movement (REM) sleepActivity of limbicMesial temporal cortexCerebral blood flowEye movement sleepSecondary sensory cortexNormal male volunteersCharacteristics of sleepHeteromodal association cortexFrontoparietal association cortexUnimodal sensory areasREM sleep stateStages of sleepStatistical parametric mappingCentrencephalic structures
1994
Sensory gating mechanisms of the thalamus
McCormick D, Bal T. Sensory gating mechanisms of the thalamus. Current Opinion In Neurobiology 1994, 4: 550-556. PMID: 7812144, DOI: 10.1016/0959-4388(94)90056-6.Peer-Reviewed Original ResearchConceptsCerebral cortexThalamocortical circuitsRole of GABAASleep-wake cycleGABAB receptorsNeurotransmitter systemsThalamocortical activityAbnormal functionThalamusSensory-motor informationDense projectionsCortexAbnormal patternsCellular mechanismsVivo investigationsSensory informationGABAABrainstemReceptors
1992
Neurotransmitter Actions in the Thalamus and Cerebral Cortex
McCormick D. Neurotransmitter Actions in the Thalamus and Cerebral Cortex. Journal Of Clinical Neurophysiology 1992, 9: 212-223. PMID: 1350591, DOI: 10.1097/00004691-199204010-00004.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidCerebral cortexThalamocortical activityInhibitory amino acidsSleep-wake cyclePostsynaptic actionsCortical neuronsNeurotransmitter actionEpileptic seizuresSynaptic informationTransmitter actionThalamusNorepinephrineAcetylcholineCortexNeurotransmittersSeizuresExcitabilityNeocortexHistamineExcitatoryState of activityNeuronsActivity
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