2023
Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder
Mishra H, Wei H, Rohr K, Ko I, Nievergelt C, Maihofer A, Shilling P, Alda M, Berrettini W, Brennand K, Calabrese J, Coryell W, Frye M, Gage F, Gershon E, McInnis M, Nurnberger J, Oedegaard K, Zandi P, Kelsoe J, McCarthy M. Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. European Neuropsychopharmacology 2023, 74: 1-14. PMID: 37126998, PMCID: PMC11801370, DOI: 10.1016/j.euroneuro.2023.04.009.Peer-Reviewed Original ResearchConceptsCell survival genesCircadian clockSurvival genesCell survivalCircadian clock genesCircadian rhythmGenetic variationClock genesKnockdown studiesCaspase activityCell deathMolecular pathwaysPrimary fibroblastsCellular modelGenesMouse fibroblastsFibroblast modelApoptosisStaurosporinePER1FibroblastsOpposite mannerLithium responsivenessDistinct patternsClock
2018
Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity
Edwards A, Deak J, Gizer I, Lai D, Chatzinakos C, Wilhelmsen K, Lindsay J, Heron J, Hickman M, Webb B, Bacanu S, Foroud T, Kendler K, Dick D, Schuckit M. Meta‐Analysis of Genetic Influences on Initial Alcohol Sensitivity. Alcohol Clinical And Experimental Research 2018, 42: 2349-2359. PMID: 30276832, PMCID: PMC6286211, DOI: 10.1111/acer.13896.Peer-Reviewed Original ResearchConceptsCore clock genesClock genesTissue-specific expression dataPopulation-based genome-wide association studiesGenome-wide association studiesGenome-wide significanceGene identification effortsSignificant genetic correlationsMolecular genetic studiesHormone signalingSingle nucleotide polymorphismsIndividual lociGenetic analysisAssociation studiesGenetic studiesExpression dataGenesGenetic componentGenetic correlationsNucleotide polymorphismsHeritabilityAlcohol sensitivityGenetic factorsLow initial sensitivityGenetic influences
2015
Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population
White MJ, Kodaman NM, Harder RH, Asselbergs FW, Vaughan DE, Brown NJ, Moore JH, Williams SM. Genetics of Plasminogen Activator Inhibitor-1 (PAI-1) in a Ghanaian Population. PLOS ONE 2015, 10: e0136379. PMID: 26322636, PMCID: PMC4556460, DOI: 10.1371/journal.pone.0136379.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Genetic variantsCircadian clock genesMost genetic studiesCardiovascular disease susceptibilityImportant genetic variantsActivator inhibitor-1Inhibitor-1Clock genesGenetic studiesGenetic effectsDisease susceptibilityArylsulfatase BMajor modulatorNovel associationsLack of overlapGenesPathway effectsMedian PAI-1European descentVariantsGeneticsPopulationSNPsCaucasian population
2013
Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs
Krueger K, Feldman B. Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs. Hormone Molecular Biology And Clinical Investigation 2013, 14: 15-24. PMID: 25436716, DOI: 10.1515/hmbci-2013-0011.Peer-Reviewed Original ResearchClock genesTranscriptional feedback regulationExpression of metabolic genesSignal energy statusIntricate feedback mechanismMetabolic gene expressionCentral clockEnergy storage organNuclear hormone receptorsGene loopingClock entrainmentMetabolic genesProtein associationAdipose tissueGene expressionMetabolic homeostasisStorage organsFeedback regulationMetabolic rhythmsFeeding activityGenesPeripheral clocksEnergy statusHormone receptorsSteroid hormones
2011
Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells
Silver AC, Arjona A, Hughes ME, Nitabach MN, Fikrig E. Circadian expression of clock genes in mouse macrophages, dendritic cells, and B cells. Brain Behavior And Immunity 2011, 26: 407-413. PMID: 22019350, PMCID: PMC3336152, DOI: 10.1016/j.bbi.2011.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsARNTL Transcription FactorsB-LymphocytesCircadian RhythmCircadian Rhythm Signaling Peptides and ProteinsCLOCK ProteinsDendritic CellsDNA-Binding ProteinsGene ExpressionMacrophagesMiceNuclear Receptor Subfamily 1, Group D, Member 1Period Circadian ProteinsPhotoperiodSpleenTranscription FactorsConceptsMolecular clock mechanismClock genesClock mechanismGene expressionClock-controlled transcription factorsFunctional molecular clockAspects of physiologyConstant environmental conditionsMolecular clockTranscription factorsCircadian expressionB cellsEnvironmental conditionsLight-dark cycleMouse macrophagesDaily rhythmsGenesExpressionCellsDendritic cellsMurine spleenMammalsMacrophagesSplenic NK cellsImmune cells
2009
Glucocorticoid regulation of the circadian clock modulates glucose homeostasis
So A, Bernal T, Pillsbury M, Yamamoto K, Feldman B. Glucocorticoid regulation of the circadian clock modulates glucose homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17582-17587. PMID: 19805059, PMCID: PMC2757402, DOI: 10.1073/pnas.0909733106.Peer-Reviewed Original ResearchConceptsGlucocorticoid response elementClock genesGlucocorticoid regulationGenes in vivoCore clock gene Per2Circadian clock genesGenomic deletionsMultiple clock genesClock gene Per2Response elementRegulatory pathwaysRhythmic expressionGenesPeripheral clocksGlucose homeostasisElevated leptin levelsAction of glucocorticoidsPhysiological consequencesRegulationGlucocorticoid receptorPer2Glucocorticoid treatmentLeptin levelsMuscle wastingGlucose intolerance
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