Frameshift Mutations in a Single Novel Virulence Factor Alter the In Vivo Pathogenicity of Chlamydia trachomatis for the Female Murine Genital Tract
Sturdevant G, Kari L, Gardner D, Olivares-Zavaleta N, Randall L, Whitmire W, Carlson J, Goheen M, Selleck E, Martens C, Caldwell H. Frameshift Mutations in a Single Novel Virulence Factor Alter the In Vivo Pathogenicity of Chlamydia trachomatis for the Female Murine Genital Tract. Infection And Immunity 2010, 78: 3660-3668. PMID: 20547745, PMCID: PMC2937465, DOI: 10.1128/iai.00386-10.Peer-Reviewed Original ResearchConceptsChlamydia trachomatisGenital tractHuman isolatesHuman strainsHuman pathogen of global importanceIn vivo virulence characteristicsSusceptibility of mice to infectionPathogen of global importanceUpper genital tractMurine model of infectionMultiple in vitro passagesNegative selection pressureMice to infectionMurine genital tractIn vivo pathogenicityModel of infectionC3H/HeJ female miceGenome sequenceHost defense mechanismsVirulence genesSusceptibility to infectionVirulence factorsVirulence characteristicsNaive miceClearance phenotype
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