2025
Genomic alterations in normal breast tissues preceding breast cancer diagnosis
Dai J, Rozenblit M, Li X, Shan N, Wang Y, Mane S, Marczyk M, Pusztai L. Genomic alterations in normal breast tissues preceding breast cancer diagnosis. Breast Cancer Research 2025, 27: 60. PMID: 40264151, PMCID: PMC12013151, DOI: 10.1186/s13058-025-02018-5.Peer-Reviewed Original ResearchConceptsHistologically normal breast tissueSomatic mutationsNormal breast tissueGenomic alterationsBreast tissuePre-DiagnosisMethodsWhole exome sequencingCancer diagnosisCancer predisposition genesCOSMIC signature 3Breast cancerCancer hallmark genesBreast tissue of womenBreast cancer diagnosisEvading growth suppressorsVariant burdenMutational signature analysisRegulatory genesAffected genesExome sequencingGermline variantsTissue of womenTissues adjacent to cancerDNA repairGenomic instability
2024
Calcifications
Singh K, Sheiman L, Killelea B, Brownson K, Andrejeva L. Calcifications. 2024, 209-233. DOI: 10.1007/978-3-031-65711-5_8.Peer-Reviewed Original ResearchPost-biopsy mammogramGroups of calcificationsDistribution of calcificationHistological sectionsBreast tissueTarget calcificationMagnification viewsBreast imagingNeoplastic epithelial proliferationCore needle biopsyStereotactic core biopsyTissue levelsRad-path correlationH&E-stained sectionsMilk of calciumAssociation of calcificationMammographic guidanceAmount of calcificationBiopsy planningCore biopsyNeedle biopsyDiagnostic dilemmaBiopsy siteDilated ductsEpithelial proliferationFocal and Developing Asymmetries
Tamayo S, Andrejeva L, Singh K. Focal and Developing Asymmetries. 2024, 159-184. DOI: 10.1007/978-3-031-65711-5_6.Peer-Reviewed Original ResearchFocal asymmetryBreast cancerBreast tissueBenign breast tissueFibroglandular tissue densityLikelihood of malignancyComparison mammogramsFibroadenomatoid changeMalignant causesBaseline mammogramMammographic findingsBenign causesSonographic abnormalitiesNon-palpableFat necrosisImaging findingsScreening mammographyArchitectural distortionPosttreatment changesMammographic viewsBreastMalignancyTissue densityCancerMammograms
2022
Evidence of accelerated epigenetic aging of breast tissues in patients with breast cancer is driven by CpGs associated with polycomb-related genes
Rozenblit M, Hofstatter E, Liu Z, O’Meara T, Storniolo AM, Dalela D, Singh V, Pusztai L, Levine M. Evidence of accelerated epigenetic aging of breast tissues in patients with breast cancer is driven by CpGs associated with polycomb-related genes. Clinical Epigenetics 2022, 14: 30. PMID: 35209953, PMCID: PMC8876160, DOI: 10.1186/s13148-022-01249-z.Peer-Reviewed Original ResearchConceptsNormal breast tissueBreast cancerEpigenetic age accelerationBreast tissuePeripheral bloodAge accelerationStrong risk factorBreast cancer riskTissue/blood samplesGood surrogate markerBreast cancer diagnosisHealthy controlsRisk factorsSurrogate markerCancer riskBlood samplesTumor tissueCancerCancer diagnosisNew scoreTissueUnaffected individualsBloodEpigenetic aging signaturesEpigenetic agingPerceptions of patients and medical oncologists toward biospecimen donation in the setting of abnormal breast imaging findings
Seah DS, Tayob N, Leone JP, Hu J, Yin J, Hughes M, Scott SM, Lederman RI, Frank E, Sohl JJ, Stadler ZK, Erick TK, Peppercorn J, Winer EP, Silverman SG, Come SE, Lin NU. Perceptions of patients and medical oncologists toward biospecimen donation in the setting of abnormal breast imaging findings. Breast Cancer Research And Treatment 2022, 192: 201-210. PMID: 35066788, DOI: 10.1007/s10549-021-06494-z.Peer-Reviewed Original ResearchConceptsAdditional biospecimensMedical oncologistsBreast biopsyBreast tissueBiopsy resultsSingle academic medical centerBreast medical oncologistsPain/discomfortPerceptions of patientsMost medical oncologistsAbnormal breastDiagnostic breast biopsyAcademic medical centerPercutaneous breast biopsyNational Cancer InstituteDonation of bloodCancer CenterDiagnostic biopsyPercutaneous biopsyMedical CenterBiopsyCancer InstitutePatientsOncologistsProcedure risk
2021
Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors.
Dieli-Conwright C, Harrigan M, Cartmel B, Chagpar A, Bai Y, Rimm D, Pusztai L, Lu L, Sanft T, Irwin M. Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors. Journal Of Clinical Oncology 2021, 39: e12501-e12501. DOI: 10.1200/jco.2021.39.15_suppl.e12501.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionSerum insulin levelsCancer survivorsLoss interventionPercent body fatSerum levelsSerum biomarkersTissue biomarkersBody compositionMonth 6Insulin levelsBreast tissueBreast cancerInsulin receptorBody fatStage I breast cancerBreast tissue levelsI breast cancerWeight loss trialBreast tissue markersLevels of CD163Breast tissue biopsiesUsual careLifestyle intervention
2020
MicroRNA‑34a expression affects breast cancer invasion in vitro and patient survival via downregulation of E2F1 and E2F3 expression.
Han R, Zhao J, Lu L. MicroRNA‑34a expression affects breast cancer invasion in vitro and patient survival via downregulation of E2F1 and E2F3 expression. Oncology Reports 2020, 43: 2062-2072. PMID: 32186770, DOI: 10.3892/or.2020.7549.Peer-Reviewed Original ResearchConceptsBreast cancerNormal breast tissueMDA-MB-231 cellsPatient survivalT-47DKaplan-Meier survival curvesBreast tissueCancer-associated mortalityLonger survival timeCommon cancer typesExpression levelsReverse transcription-quantitative PCRPotential therapeutic toolBreast cancer invasionMicroRNA-34a expressionTranscription-quantitative PCRTumor cell proliferationOverall survivalUnderlying molecular mechanismsCaspase-3 activityDownregulation of E2F1Clinical managementExpression of E2F1Survival timeClinical relevance
2018
Increased epigenetic age in normal breast tissue from luminal breast cancer patients
Hofstatter EW, Horvath S, Dalela D, Gupta P, Chagpar AB, Wali VB, Bossuyt V, Storniolo AM, Hatzis C, Patwardhan G, Von Wahlde MK, Butler M, Epstein L, Stavris K, Sturrock T, Au A, Kwei S, Pusztai L. Increased epigenetic age in normal breast tissue from luminal breast cancer patients. Clinical Epigenetics 2018, 10: 112. PMID: 30157950, PMCID: PMC6114717, DOI: 10.1186/s13148-018-0534-8.Peer-Reviewed Original ResearchConceptsNormal breast tissueBreast cancer patientsBreast cancerCancer patientsEpigenetic age accelerationBreast tissueAge accelerationLuminal breast cancer patientsNormal adjacent breast tissueNormal breast tissue samplesIncident breast cancerTissue samplesNon-tumor sitesBreast cancer riskImportant risk factorAdjacent breast tissueKomen Tissue BankChronological ageBreast cancer statusMalignant breast tissueNormal tissue samplesAge-related changesBreast tissue samplesBreast surgeryUnaffected women
2017
Comparison of epigenetic aging in normal breast tissue from women with and without breast cancer.
Hofstatter E, Horvath S, Chagpar A, Wali V, Bossuyt V, Storniolo A, Patwardhan G, Von Wahlde M, Pusztai L. Comparison of epigenetic aging in normal breast tissue from women with and without breast cancer. Journal Of Clinical Oncology 2017, 35: 1522-1522. DOI: 10.1200/jco.2017.35.15_suppl.1522.Peer-Reviewed Original ResearchNormal breast tissueBreast cancerBreast tissueHealthy peersSusan G. Komen Tissue BankIU Simon Cancer CenterNormal breast tissue samplesBreast cancer preventionCohort of womenImportant risk factorKomen Tissue BankLifetime of womenBreast tissue samplesCurrent medicationsTumor characteristicsCancer CenterRisk factorsCancer preventionClinical dataFamily historyReduction mammoplastyHigh riskChronologic ageReproductive historyCancerMammography use in breast cancer survivors: An administrative claims study.
Ruddy K, Sangaralingham L, Neuman H, Greenberg C, Freedman R, Jemal A, Mougalian S, Hunt K, Haddad T, Lemaine V, Ghosh K, Hieken T, Vachon C, Gross C, Shah N. Mammography use in breast cancer survivors: An administrative claims study. Journal Of Clinical Oncology 2017, 35: 6531-6531. DOI: 10.1200/jco.2017.35.15_suppl.6531.Peer-Reviewed Original ResearchBreast cancer survivorsResidual breast tissueCancer survivorsMammography useBreast surgeryBreast cancerEarly-stage breast cancerMetastatic breast cancer diagnosisBreast tissueAnnual surveillance mammographyDefinitive breast surgeryOperable breast cancerCancer diagnosisCommercial insurance databaseProportion of patientsYear of diagnosisMultivariable logistic regressionStage breast cancerAdministrative claims dataYears of ageFirst yearBreast cancer diagnosisInsured cohortUnderwent mammographyRecurrent diseaseA tumor specific antibody to aid breast cancer screening in women with dense breast tissue
Roy LD, Dillon LM, Zhou R, Moore LJ, Livasy C, El-Khoury JM, Puri R, Mukherjee P. A tumor specific antibody to aid breast cancer screening in women with dense breast tissue. Genes & Cancer 2017, 8: 536-549. PMID: 28680538, PMCID: PMC5489651, DOI: 10.18632/genesandcancer.134.Peer-Reviewed Original ResearchBreast cancerDense breast tissueBreast tissueHuman breast cancer tissuesBlinded pilot studyDiagnosis of womenBreast cancer cell linesBreast cancer tissuesTumor-specific antibodiesCancer cell linesCancer immunoeditingEarly diagnosisBreast tissue densitySerial samplesCancer tissuesCancerTumor formGlycoprotein MUC1Tumor cellsPilot studyEarly detectionSpecific antibodiesTAB004DiagnosisTMUC1
2016
Knowledge of Density and Screening Ultrasound
Moothathu NS, Philpotts LE, Busch SH, Gross CP, Staib LH, Hooley RJ. Knowledge of Density and Screening Ultrasound. The Breast Journal 2016, 23: 323-332. PMID: 27943500, DOI: 10.1111/tbj.12734.Peer-Reviewed Original ResearchConceptsBreast density awarenessBreast densityDense breast tissueScreening ultrasoundBreast cancerCaucasian raceBreast tissueBreast ultrasoundSupplemental breast ultrasoundBreast cancer riskBreast density notification lawsNon-Caucasian patientsPercent of participantsPhysician recommendationProvider recommendationAcademic breastSelf-administered surveyUltrasoundWomenPatientsCancerMammography reportsTissueAnxietyHigher incomeThe “Superior Ledge”: a Modification of the Standard Superomedial Pedicle Reduction Mammoplasty to Accentuate Nipple-Areola Complex Projection
Henderson P, Chang M, Taylor E, Weinreb R, Rohde C. The “Superior Ledge”: a Modification of the Standard Superomedial Pedicle Reduction Mammoplasty to Accentuate Nipple-Areola Complex Projection. Aesthetic Plastic Surgery 2016, 40: 733-738. PMID: 27506647, DOI: 10.1007/s00266-016-0687-9.Peer-Reviewed Original ResearchConceptsNipple-areola complexNipple retractionReduction mammaplastyEvidence-Based Medicine ratingsMean follow-upSuperomedial pedicle techniqueWound healing complicationsLevel of Evidence VThis journalBreast reduction techniqueLevel of evidencePlastic surgeon's armamentariumEvidence VThis journalExcess breast tissueIntraoperative detailsPostoperative photographsPatient demographicsPedicle techniqueFollow-upMethodsThe techniqueBreast shapeBreast tissueSurgical teamPatientsSurgeon's armamentariumComplicationsLeptospira in breast tissue and milk of urban Norway rats (Rattus norvegicus)
DE OLIVEIRA D, FIGUEIRA CP, ZHAN L, PERTILE AC, PEDRA GG, GUSMÃO IM, WUNDER EA, RODRIGUES G, RAMOS EA, KO AI, CHILDS JE, REIS MG, COSTA F. Leptospira in breast tissue and milk of urban Norway rats (Rattus norvegicus). Epidemiology And Infection 2016, 144: 2420-2429. PMID: 27019024, PMCID: PMC5437553, DOI: 10.1017/s0950268816000637.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionBreast tissuePresence of leptospiresNorway ratsMajor public health concernMilk-borne transmissionMajor pathological changesReal-time polymerase chain reactionPublic health concernQuantitative real-time polymerase chain reactionPathogenic Leptospira sppBreast tissue samplesChronic carriagePathological changesLactating ratsRatsHealth concernImmunofluorescence assaysLeptospira sppGenus LeptospiraTissue samplesUrban slumsChain reactionLeptospiresLeptospira
2015
The Effect of Menopausal Hormone Therapies on Breast Cancer Avoiding the Risk
Flores VA, Taylor HS. The Effect of Menopausal Hormone Therapies on Breast Cancer Avoiding the Risk. Endocrinology And Metabolism Clinics Of North America 2015, 44: 587-602. PMID: 26316245, PMCID: PMC4555991, DOI: 10.1016/j.ecl.2015.05.007.Peer-Reviewed Original ResearchHigh level PHGDH expression in breast is predominantly associated with keratin 5‐positive cell lineage independently of malignancy
Gromova I, Gromov P, Honma N, Kumar S, Rimm D, Talman ML, Wielenga VT, Moreira JM. High level PHGDH expression in breast is predominantly associated with keratin 5‐positive cell lineage independently of malignancy. Molecular Oncology 2015, 9: 1636-1654. PMID: 26026368, PMCID: PMC5528790, DOI: 10.1016/j.molonc.2015.05.003.Peer-Reviewed Original ResearchConceptsOverexpression of PhgdhPHGDH expressionMammary epithelial cellsTriple-negative breast cancer patientsNegative breast cancer patientsEpithelial cellsBreast cancer patientsNormal breast tissueCell lineagesMammary tissue samplesHigh-level expressionExpression of PHGDHProspective cohortCancer patientsCK5-positive cellsBasal phenotypeProteomic profilingTNBC samplesIHC analysisQuantitative IHC analysisCancer typesBreast tissueMalignancyCandidate oncogeneOncogenic functionFactors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging
O’Connor M, Hruska CB, Tran TD, Swanson T, Conners AL, Jones K, Rhodes DJ. Factors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging. Journal Of Nuclear Medicine Technology 2015, 43: 13-20. PMID: 25613340, DOI: 10.2967/jnmt.114.150128.Peer-Reviewed Original ResearchConceptsMolecular breast imagingBreast tissuePrandial statusOptimal patient preparationPeripheral blood flowBody surface areaCounts/Type of interventionBreast imagingPatient heightPeripheral warmingStudy groupBlood flowSestamibiBreast activityPatient preparationFed stateCount densityMetabolic statusReference groupOblique viewMediolateral oblique viewTissueInterventionBreast thickness
2014
Breast density legislation. Implications for patients and primary care providers.
Rhodes DJ, Conners AL. Breast density legislation. Implications for patients and primary care providers. Minnesota Medicine 2014, 97: 43-8. PMID: 25158436.Peer-Reviewed Original Research
2013
Distinctive lipid profiles of human breast cancer and adjacent normal tissues by desorption electrospray ionization mass spectrometry imaging.
Caragacianu D, Liu X, Norton I, Ide J, Richardson A, Dillon D, Jolesz F, Golshan M, Agar N. Distinctive lipid profiles of human breast cancer and adjacent normal tissues by desorption electrospray ionization mass spectrometry imaging. Journal Of Clinical Oncology 2013, 31: 1132-1132. DOI: 10.1200/jco.2013.31.15_suppl.1132.Peer-Reviewed Original ResearchBreast conserving surgeryAdjacent normal tissuesBreast cancerNormal tissuesCancer tissuesResidual cancer tissueInvasive breast cancer samplesSuccess of surgeryHuman breast cancerNormal breast tissueBreast cancer samplesConserving surgeryLumpectomy bedFatty acidsHuman tissue sectionsLipid profileHistopathology evaluationOperative procedureCancerous human tissuesAnatomical sitesTumor edgeCancer specimenArachidonic acidBreast tissueCancerIntramolecular zero‐quantum‐coherence 2D NMR spectroscopy of lipids in the human breast at 7 T
de Graaf R, Klomp D, Luijten P, Boer V. Intramolecular zero‐quantum‐coherence 2D NMR spectroscopy of lipids in the human breast at 7 T. Magnetic Resonance In Medicine 2013, 71: 451-457. PMID: 23468435, DOI: 10.1002/mrm.24701.Peer-Reviewed Original ResearchConceptsMagnetic field homogeneityZero-quantum coherencesMagnetic field inhomogeneityField homogeneityField inhomogeneityNavigator echo correctionHuman breastEcho correctionSusceptible boundariesSpectra in vivoHuman breast tissueLipid profileInhomogeneityBreast tissueBreastIn vivoIn vitroLipid signalingSpectraNMR spectraMRSSubjectsNMR
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