Genomic alterations in normal breast tissues preceding breast cancer diagnosis
Dai J, Rozenblit M, Li X, Shan N, Wang Y, Mane S, Marczyk M, Pusztai L. Genomic alterations in normal breast tissues preceding breast cancer diagnosis. Breast Cancer Research 2025, 27: 60. PMID: 40264151, PMCID: PMC12013151, DOI: 10.1186/s13058-025-02018-5.Peer-Reviewed Original ResearchConceptsHistologically normal breast tissueSomatic mutationsNormal breast tissueGenomic alterationsBreast tissuePre-DiagnosisMethodsWhole exome sequencingCancer diagnosisCancer predisposition genesCOSMIC signature 3Breast cancerCancer hallmark genesBreast tissue of womenBreast cancer diagnosisEvading growth suppressorsVariant burdenMutational signature analysisRegulatory genesAffected genesExome sequencingGermline variantsTissue of womenTissues adjacent to cancerDNA repairGenomic instability
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