2020
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
Miao K, Lei J, Valecha M, Zhang A, Xu J, Wang L, Lyu X, Chen S, Miao Z, Zhang X, Su S, Shao F, Rajendran B, Bao J, Zeng J, Sun H, Chen P, Tan K, Chen Q, Wong K, Xu X, Deng C. NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications 2020, 11: 3256. PMID: 32591500, PMCID: PMC7320176, DOI: 10.1038/s41467-020-16936-9.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAnimalsAtaxia Telangiectasia Mutated ProteinsBRCA1 ProteinCarcinogenesisCell DeathCell Line, TumorCheckpoint Kinase 1Disease ProgressionDNA Transposable ElementsEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMice, KnockoutMitosisMutationReceptor, Notch1Signal TransductionTriple Negative Breast NeoplasmsConceptsTriple-negative breast cancerEpithelial-mesenchymal transitionHuman breast cancer tissuesBRCA1 mutation carriersBreast cancer tissuesBRCA1-deficient miceActivation of Notch1Breast cancer formationRefractory diseaseForm of Notch1Breast cancerMutation carriersHigh riskCancer tissuesClinical optionG2/M cell cycle checkpointFatal diseaseCell cycle checkpointsM cell cycle checkpointNotch1 activationBRCA1 deficiencyPhosphorylation of ATRNotch1Cancer formationCycle checkpoints
2017
A tumor specific antibody to aid breast cancer screening in women with dense breast tissue
Roy LD, Dillon LM, Zhou R, Moore LJ, Livasy C, El-Khoury JM, Puri R, Mukherjee P. A tumor specific antibody to aid breast cancer screening in women with dense breast tissue. Genes & Cancer 2017, 8: 536-549. PMID: 28680538, PMCID: PMC5489651, DOI: 10.18632/genesandcancer.134.Peer-Reviewed Original ResearchBreast cancerDense breast tissueBreast tissueHuman breast cancer tissuesBlinded pilot studyDiagnosis of womenBreast cancer cell linesBreast cancer tissuesTumor-specific antibodiesCancer cell linesCancer immunoeditingEarly diagnosisBreast tissue densitySerial samplesCancer tissuesCancerTumor formGlycoprotein MUC1Tumor cellsPilot studyEarly detectionSpecific antibodiesTAB004DiagnosisTMUC1Label-free biomolecular characterization of human breast cancer tissue with stimulated Raman scattering (SRS) spectral imaging (Conference Presentation)
Lu F, Calligaris D, Suo Y, Santagata S, Golby A, Xie X, Mallory M, Golshan M, Dillon D, Agar N. Label-free biomolecular characterization of human breast cancer tissue with stimulated Raman scattering (SRS) spectral imaging (Conference Presentation). Proceedings Of SPIE--the International Society For Optical Engineering 2017, 100690r-100690r-1. DOI: 10.1117/12.2253366.Peer-Reviewed Original ResearchHuman breast cancer tissuesBreast cancer tissues
2005
Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In Vivo
Wagner P, Wang B, Clark E, Lee H, Rouzier R, Pusztai L. Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In Vivo. Cell Cycle 2005, 4: 1149-1152. PMID: 16103753, DOI: 10.4161/cc.4.9.2038.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingBreast NeoplasmsCell Line, TumorDown-RegulationDrug Resistance, NeoplasmGene Expression RegulationHumansImmunohistochemistryIn Vitro TechniquesInhibitory Concentration 50Microtubule-Associated ProteinsMicrotubulesModels, BiologicalOligonucleotide Array Sequence AnalysisPaclitaxelRNA, MessengerRNA, Small Interferingtau ProteinsTubulinConceptsPaclitaxel sensitivityHuman breast cancer tissuesBreast cancer tissuesHuman breast cancerRole of tauCell linesRegulation of tauBreast cancerCancer tissuesProtein tauNovel markerLow expressionMicrotubule associated proteinNovel mediatorPaclitaxelTauPhysiological levelsGene expression analysisRecent findingsMediatorsMarkersAssociated proteinsChemotherapyCancerExpression analysis
1998
Expression of Amphiphysin I, an Autoantigen of Paraneoplastic Neurological Syndromes, in Breast Cancer
Floyd S, Butler M, Cremona O, David C, Freyberg Z, Zhang X, Solimena M, Tokunaga A, Ishizu H, Tsutsui K, De Camilli P. Expression of Amphiphysin I, an Autoantigen of Paraneoplastic Neurological Syndromes, in Breast Cancer. Molecular Medicine 1998, 4: 29-39. PMID: 9513187, PMCID: PMC2230265, DOI: 10.1007/bf03401727.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceAmino Acid SubstitutionAnimalsAntibodiesAntibodies, MonoclonalAutoantigensAutoimmunityBlotting, WesternBrainBreastBreast NeoplasmsChromatography, AffinityCloning, MolecularFemaleGene ExpressionHumansIsomerismMolecular Sequence DataNerve Tissue ProteinsNervous System DiseasesPolymerase Chain ReactionProtein BiosynthesisRatsStiff-Person SyndromeTumor Cells, CulturedConceptsBreast cancer tissuesBreast cancerCancer tissuesParaneoplastic sensory neuronopathyHuman breast cancer tissuesParaneoplastic neurological syndromesAutoimmune neurological disordersStiff-man syndromeNormal mammary tissueNon-neuronal tissuesAmphiphysin IForms of cancerSensory neuronopathyNeurological syndromeI antibodiesNerve terminalsDominant autoantigenI expressionNeurological disordersMammary tissueCancerAmino acid insertCancer cellsEnhanced expressionKD isoform
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