2025
Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome
Radhakrishna U, Radhakrishnan R, Uppala L, Trivedi T, Prajapati J, Rawal R, Muvvala S, Bahado-Singh R, Sadhasivam S. Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome. Frontiers In Pain Research 2025, 6: 1497801. PMID: 40313396, PMCID: PMC12043715, DOI: 10.3389/fpain.2025.1497801.Peer-Reviewed Original ResearchNeonatal opioid withdrawal syndromeOpioid-exposed infantsOpioid withdrawal syndromePain-related genesOpioid exposureWithdrawal syndromeChronic painEpigenetic changesMaternal opioid exposurePrenatal opioid exposureImprove pain managementIon channel functionIllumina Infinium Methylation EPIC BeadChipInfinium Methylation EPIC BeadChipAnalyzed DNA methylationUnexposed control subjectsLong-term health risksPain reliefPain perceptionPregnant womenGnRH secretionPlacental tissueMorphine addictionHealth of mothersControl subjectsMake It Happen NOW: Barriers and Inequities in Eat, Sleep, Console Implementation for Neonatal Opioid Withdrawal Syndrome.
Chaudhury N, Zhao S, Ostfeld-Johns S. Make It Happen NOW: Barriers and Inequities in Eat, Sleep, Console Implementation for Neonatal Opioid Withdrawal Syndrome. Hospital Pediatrics 2025, 15: e99-e101. PMID: 39894048, DOI: 10.1542/hpeds.2025-008332.Peer-Reviewed Original Research
2024
Comparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach
Johnson K, Berkwitt A, Yankova L, Osborn R. Comparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach. Seminars In Perinatology 2024, 49: 152021. PMID: 39736490, DOI: 10.1016/j.semperi.2024.152021.Peer-Reviewed Original ResearchHospital sequelae, discharge, and early interventions in infants with Neonatal Opioid Withdrawal Syndrome
Cheng F. Hospital sequelae, discharge, and early interventions in infants with Neonatal Opioid Withdrawal Syndrome. Seminars In Perinatology 2024, 49: 152008. PMID: 39581774, DOI: 10.1016/j.semperi.2024.152008.Peer-Reviewed Original ResearchHospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome
Gaither J, Drago M, Grossman M, Li Y, Shabanova V, Xu X, Leventhal J. Hospital Readmissions Among Infants With Neonatal Opioid Withdrawal Syndrome. JAMA Network Open 2024, 7: e2435074. PMID: 39316398, PMCID: PMC11423163, DOI: 10.1001/jamanetworkopen.2024.35074.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeWithdrawal syndromeCohort studyHospital readmissionLow birth weightReadmission ratesRetrospective cohort studyIncreased risk of readmissionNationwide Readmissions DatabaseClinical Modification codesGestational ageOdds of readmissionMultiple gestationsFull-termInternational Classification of DiseasesRisk of readmissionHospital discharge recordsBirth weightSurvey-weighted logistic regressionType of insuranceIncreased 5-foldIncreased riskReadmissions DatabaseYear of birthPrenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome
Radhakrishna U, Radhakrishnan R, Uppala L, Muvvala S, Prajapati J, Rawal R, Bahado-Singh R, Sadhasivam S. Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome. Frontiers In Neuroscience 2024, 18: 1442915. PMID: 39238930, PMCID: PMC11376091, DOI: 10.3389/fnins.2024.1442915.Peer-Reviewed Original ResearchNeonatal opioid withdrawal syndromeNeonatal opioid withdrawal syndrome treatmentRegulation of drug transportersOpioid use disorderOpioid withdrawal syndromeProtein kinase CDrug transportATP-binding cassetteDrug resistanceWithdrawal syndromeSevere neonatal opioid withdrawal syndromeSolute carrierPrenatal opioid exposureOpioid-exposed infantsATP-binding cassette drug transportersLevels of ATP-binding cassetteIllumina Infinium MethylationEPIC arrayKinase CMethylation changesGastric acid secretionImprove treatment outcomesDrug-drug interactionsMaternal opioidsMaternal relapseInfinium MethylationEPIC arrayAlcohol Use Disorder and Chronic Pain: An Overlooked Epidemic
De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.Peer-Reviewed Original ResearchConceptsAlcohol use disorderChronic painAUD studiesChronic pain disordersChronic pain outcomesRisk of relapseAlcohol withdrawal syndromeAssessment of painHigher levels of alcohol consumptionLevels of alcohol consumptionWithdrawal syndromePain disordersPain outcomesAcute toleranceNeurobiological changesClinical significanceUse disorderPainClinical relevanceSelf-ReportAlcohol intoxicationAlcohol consumptionGeneral populationMedical conditionsNarrative reviewA Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder
Celik M, Gold M, Fuehrlein B. A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder. Brain Sciences 2024, 14: 294. PMID: 38539681, PMCID: PMC10969323, DOI: 10.3390/brainsci14030294.Peer-Reviewed Original ResearchAlcohol use disorderUse disorderTreatment of alcohol use disordersGLP-1 receptor agonistsCurrent treatment landscapeAlcohol withdrawal syndromePhosphodiesterase-4 inhibitorWithdrawal syndromeTreatment landscapeReceptor agonistsTreatment modalitiesGlobal disease burdenPhosphodiesterase-4GLP-1Disease burdenNarrative reviewDisordersAnnual deathsMedicationTreatmentAlcoholPsychotherapyPsychedelicsHealth conditionsPlacental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons
Radhakrishna U, Sadhasivam S, Radhakrishnan R, Forray A, Muvvala S, Metpally R, Patel S, Rawal R, Vishweswaraiah S, Bahado-Singh R, Nath S. Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons. Frontiers In Genetics 2024, 14: 1292148. PMID: 38264209, PMCID: PMC10805101, DOI: 10.3389/fgene.2023.1292148.Peer-Reviewed Original ResearchNeonatal opioid withdrawal syndromeOpioid withdrawal syndromePlacental tissueWithdrawal syndromeLong-term clinical implicationsPrenatal opioid exposureNOWS treatmentPrenatal opioidsOpioid exposureOpioid effectsOpioid usePharmacologic treatmentCYP genesControl mothersMultiple CYP genesValuable biomarkerClinical implicationsInfantsPersonalized treatmentOpioidsCytochrome P450 enzymesInfinium MethylationEPIC BeadChipTreatmentIllumina Infinium MethylationEPIC BeadChipSyndrome
2023
Recognition and Treatment of Wounds in Persons Using Xylazine: A Case Report From New Haven, Connecticut
Dowton A, Doernberg M, Heiman E, Barelli P, Golden M, Wang H, Leventhal J, Morford K, Sue K. Recognition and Treatment of Wounds in Persons Using Xylazine: A Case Report From New Haven, Connecticut. Journal Of Addiction Medicine 2023, 17: 739-741. PMID: 37934550, DOI: 10.1097/adm.0000000000001198.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersDrug useCase report presentsIndex of suspicionInjection drug useDrug supplyCare management strategiesHarm reduction strategiesOverdose presentationsCutaneous manifestationsWithdrawal syndromeClinical complicationsCase reportIntravenous useWound carePatientsTreatment of woundsInfectious diseasesChronic woundsXylazineSkin woundsWoundsMore reportingDiagnosisAlcohol withdrawal syndrome in trauma patients: a study using the Trauma Quality Program Participant User File
Jones T, Bhattacharya B, Schuster K, Becher R, Kodadek L, Davis K, Maung A. Alcohol withdrawal syndrome in trauma patients: a study using the Trauma Quality Program Participant User File. Trauma Surgery & Acute Care Open 2023, 8: e001047. PMID: 37188153, PMCID: PMC10175962, DOI: 10.1136/tsaco-2022-001047.Peer-Reviewed Original ResearchAlcohol withdrawal syndromeAlcohol use disorderPositive blood alcohol concentrationHistory of AUDBlood alcohol concentrationParticipant User FileAdult patientsTrauma patientsWithdrawal syndromeAbbreviated Injury Scale headHigh-risk patient populationInjury scale headAdult trauma patientsPositive toxicology screenMultivariable logistic regressionRetrospective reviewRetrospective studyToxicology screenPatient populationTricyclic antidepressantsMAIN OUTCOMEAmerican CollegePatientsUse disordersUncommon occurrence
2022
Prevention of alcohol withdrawal syndrome in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document
Seshadri A, Appelbaum R, Carmichael S, Farrell M, Filiberto D, Jawa R, Kodadek L, Mandell S, Miles M, Paul J, Robinson B, Michetti C. Prevention of alcohol withdrawal syndrome in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document. Trauma Surgery & Acute Care Open 2022, 7: e001010. PMID: 36425749, PMCID: PMC9680182, DOI: 10.1136/tsaco-2022-001010.Peer-Reviewed Original ResearchClinical consensus documentAlcohol withdrawal syndromeSurgical ICUAlcohol withdrawalWithdrawal syndromeConsensus documentSurgical intensive care unit patientsIntensive care unit patientsCare unit patientsChallenging clinical entityCritical Care CommitteeAmerican AssociationUnit patientsClinical entityProphylactic treatmentPharmacological methodsCare CommitteeScreening toolICUSurgerySyndromeWithdrawalAssociationPatientsTraumaMidwifery Care of Pregnant Individuals Experiencing Opioid use Disorder: Changing Regulations, Complexities, and Call to Action
Bukowski H, Combellick J. Midwifery Care of Pregnant Individuals Experiencing Opioid use Disorder: Changing Regulations, Complexities, and Call to Action. Journal Of Midwifery & Women's Health 2022, 67: 770-776. PMID: 36269042, DOI: 10.1111/jmwh.13415.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersNeonatal opioid withdrawal syndromeCo-occurring mental disordersCo-occurring mental illnessMental Health Services AdministrationProvision of MOUDOpioid withdrawal syndromeAdministration of buprenorphineLong-term sequelaeHealth Services AdministrationDepartment of HealthMultisubstance useMedical comorbiditiesOpioid useWithdrawal syndromePractice guidelinesPregnant individualsMidwifery careMental illnessMental disordersPregnant peopleInterprofessional careSubstance abuseAddiction medicineEarly Weight Loss Percentile Curves and Feeding Practices in Opioid-Exposed Infants.
Cheng FY, Shabanova V, Berkwitt AK, Grossman MR. Early Weight Loss Percentile Curves and Feeding Practices in Opioid-Exposed Infants. Hospital Pediatrics 2022, 12: 857-866. PMID: 36073203, DOI: 10.1542/hpeds.2021-006137.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeFeeding practicesWeight loss patternsBirth weightMedian percent weight lossWeight lossMean gestational ageOpioid withdrawal syndromeMean birth weightPercentile curvesRisk of morbidityHours of lifeHealth care useConfidence intervalsOptimal feeding methodNonpharmacologic treatmentsPharmacologic treatmentWithdrawal syndromeGestational agePercent weight lossSingle centerCare useInclusion criteriaInfantsDelivery typeDelivery timing for the opioid–exposed infant
Sanusi A, Gray M, Xue Y, Mohr S, Curtis P, Dismukes J, Gentle S, Szychowski J, Brocato B, Casey B, Harper L, Sinkey R. Delivery timing for the opioid–exposed infant. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100719. PMID: 35977700, PMCID: PMC10961100, DOI: 10.1016/j.ajogmf.2022.100719.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeOpioid-exposed infantsIncidence of neonatal opioid withdrawal syndromeNeonatal opioid withdrawal syndrome treatmentLate-term periodsEarly term deliveryOpioid-exposed neonatesWithdrawal syndromePrimary composite outcomeOpioid use disorderNeonatal outcomesTerm deliveryMedication-Assisted TreatmentSyndrome treatmentComposite outcomeRisk of neonatal opioid withdrawal syndromeSeverity of neonatal opioid withdrawal syndromeNeonatal intensive care unit admissionAmerican College of Obstetricians and GynecologistsPositive urine toxicology screenPrimary outcomeSecondary outcomesNeonatal intensive care unitPositive urine drug screenAlcohol withdrawal in past‐year drinkers with unhealthy alcohol use: Prevalence, characteristics, and correlates in a national epidemiologic survey
Livne O, Feinn R, Knox J, Hartwell EE, Gelernter J, Hasin DS, Kranzler HR. Alcohol withdrawal in past‐year drinkers with unhealthy alcohol use: Prevalence, characteristics, and correlates in a national epidemiologic survey. Alcohol Clinical And Experimental Research 2022, 46: 422-433. PMID: 35275407, PMCID: PMC8928097, DOI: 10.1111/acer.14781.Peer-Reviewed Original ResearchConceptsAlcohol withdrawal syndromeUnhealthy alcohol useSerious adverse outcomesNational Epidemiologic SurveyAlcohol useHealthcare utilizationAdverse outcomesGeneral populationPsychiatric disordersEpidemiologic SurveyAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnairePast-year alcohol use disorderNausea/vomitingMajor depressive disorderImportant clinical populationAlcohol use disorderRelated Conditions-IIIBorderline personality disorderPast-year prevalenceAlcohol withdrawalWithdrawal syndromeWithdrawal symptomsDepressive disorderUnhealthy drinkersHigher odds
2021
A Review of Phenobarbital for Alcohol Withdrawal Syndrome
Saadatmand H, Ho P. A Review of Phenobarbital for Alcohol Withdrawal Syndrome. Current Psychopharmacologye 2021, 10: 197-207. DOI: 10.2174/2211556010666210810094103.Peer-Reviewed Original ResearchAlcohol withdrawal syndromeAlcohol withdrawalIntensive care unitWithdrawal syndromeEmergency departmentCare unitIntensive care admission rateTrauma surgery serviceClasses of medicationsRetrospective cohort trialGeneral medical unitCommon clinical problemDose of phenobarbitalAlcohol use disorderSerious health problemCohort trialProspective randomizedClinical outcomesSurgery serviceCochrane DatabaseRetrospective trialsAdmission ratesInpatient settingOvid MEDLINESuperior efficacyMaternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome
Radhakrishna U, Nath SK, Vishweswaraiah S, Uppala LV, Forray A, Muvvala SB, Mishra NK, Southekal S, Guda C, Govindamangalam H, Vargas D, Gardella WG, Crist RC, Berrettini WH, Metpally RP, Bahado-Singh RO. Maternal opioid use disorder: Placental transcriptome analysis for neonatal opioid withdrawal syndrome. Genomics 2021, 113: 3610-3617. PMID: 34352367, DOI: 10.1016/j.ygeno.2021.08.001.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeWithdrawal syndromePrenatal opioid exposureOpioid use disorderPlacentas of infantsPlacental tissue samplesP-valueIngenuity Pathway AnalysisOpioid exposureUse disordersUnexposed controlsFDR p-valueGenes CYP1A1Tissue samplesSyndromePathway analysisCYP1A1NewbornsInfantsEtiologyApoBPlacentaGenesGRIN2APlacental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome
Radhakrishna U, Vishweswaraiah S, Uppala LV, Szymanska M, Macknis J, Kumar S, Saleem-Rasheed F, Aydas B, Forray A, Muvvala SB, Mishra NK, Guda C, Carey DJ, Metpally RP, Crist RC, Berrettini WH, Bahado-Singh RO. Placental DNA methylation profiles in opioid-exposed pregnancies and associations with the neonatal opioid withdrawal syndrome. Genomics 2021, 113: 1127-1135. PMID: 33711455, DOI: 10.1016/j.ygeno.2021.03.006.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeIngenuity Pathway AnalysisWithdrawal syndromeOpioid-exposed pregnanciesPlacental tissue samplesOpioid abusePlacental tissueTissue samplesPregnancyMethylation dysregulationGenome-wide methylation analysisSyndromeInfantsPathway analysisAUCDNA methylation profilesMethylation profilesGroupPathophysiologyTherapyStrong evidenceAssociation of Race and Ethnicity with Sedation Management in Pediatric Intensive Care.
Natale J, Asaro L, Joseph J, Ulysse C, Ascenzi J, Bowens C, Wypij D, Curley M, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care. Annals Of The American Thoracic Society 2021, 18: 93-102. PMID: 32776853, PMCID: PMC7780975, DOI: 10.1513/annalsats.201912-872oc.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlack PeopleChildChild, PreschoolCritical CareEthnicityFemaleHealthcare DisparitiesHispanic or LatinoHumansInfantInfant, NewbornIntensive Care Units, PediatricMaleMulticenter Studies as TopicPainPain ManagementRandomized Controlled Trials as TopicRespiration, ArtificialRespiratory InsufficiencyWhite PeopleConceptsSedation managementPain managementClinical trialsU.S. pediatric intensive care unitsPediatric intensive care unitCluster-randomized clinical trialRacial disparitiesIatrogenic withdrawal syndromeAcute respiratory failureEpisodes of painPlanned secondary analysisIntensive care unitPediatric intensive careAssociation of raceEthnicity groupsNon-Hispanic blacksPercentage of daysRespiratory failureUsual careCumulative dosingPediatric patientsWithdrawal syndromeBlack patientsCare unitIntervention arm
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