2025
Rapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes
Lydecker J, Gueorguieva R, Grilo C. Rapid response to behavioral/pharmacological obesity treatments for binge‐eating disorder predicts better clinical outcomes. Obesity 2025, 33: 1067-1075. PMID: 40265670, DOI: 10.1002/oby.24292.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBinge-eating remissionEating-disorder psychopathologyAssociated with greater reductionsObesity treatmentCo-occurring obesityBinge-eating frequencyClinical trial testingBehavioral therapyNon-rapid responseGreater reductionsPercent weight lossNaltrexone/bupropionRandomized clinical trial testingDisordersPrognostic significanceParticipantsPosttreatmentClinical characteristicsPrognostic indicatorClinical outcomesMetabolic outcomesResponse effectMetabolic variablesObesity interventions
2024
Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial
Grilo C, Ivezaj V, Tek C, Yurkow S, Wiedemann A, Gueorguieva R. Cognitive Behavioral Therapy and Lisdexamfetamine, Alone and Combined, for Binge-Eating Disorder With Obesity: A Randomized Controlled Trial. American Journal Of Psychiatry 2024, 182: 209-218. PMID: 39659158, PMCID: PMC11786997, DOI: 10.1176/appi.ajp.20230982.Peer-Reviewed Original ResearchCognitive-behavioral therapyBinge-eating disorderEffectiveness of cognitive-behavioral therapyBinge-eating remission ratesEating-disorder psychopathologyCognitive behavioral therapyEvidence-based treatmentsRemission ratePercent weight lossHigher remission ratesBinge-eating frequencyBehavioral therapyPosttreatment assessmentLisdexamfetamineRandomized Controlled TrialsHeightened ratesCostly public health problemIntention-to-treat ratesFunctional impairmentWeight lossControlled TrialsDisordersPosttreatmentIndividualized treatmentMixed models
2023
Shape discrepancy, weight bias internalization, and eating-disorder psychopathology in patients with loss-of-control eating after bariatric surgery
Dunford A, Ivezaj V, Grilo C. Shape discrepancy, weight bias internalization, and eating-disorder psychopathology in patients with loss-of-control eating after bariatric surgery. Surgery For Obesity And Related Diseases 2023, 20: 291-296. PMID: 37926627, PMCID: PMC10922050, DOI: 10.1016/j.soard.2023.09.028.Peer-Reviewed Original ResearchBariatric surgeryEating Disorder Examination-Bariatric Surgery Version interviewControl eatingCurrent body mass indexWeight lossPoor weight lossBody mass indexED psychopathologyEating-disorder psychopathologyMental health outcomesPostoperative interventionsPostoperative lossEating Disorder PsychopathologyMass indexPercent weight lossResults Most participantsWeight bias internalizationSurgeryYale University SchoolHealth outcomesPatientsSomatic concernsWeight concernsMost participantsMethods ParticipantsPredictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating
Smith C, Dilip A, Ivezaj V, Duffy A, Grilo C. Predictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating. Clinical Obesity 2023, 13: e12603. PMID: 37257889, PMCID: PMC10524670, DOI: 10.1111/cob.12603.Peer-Reviewed Original ResearchConceptsEarly weight lossAdjunctive behavioral treatmentsPost-bariatric surgery patientsEarly weight changeBaseline patient characteristicsSurgery-related variablesMonths of treatmentWeight lossBehavioral treatmentPatient characteristicsSurgery patientsFirst monthWeight changeTime of surgeryWeight gain groupEating-disorder psychopathologyBariatric surgeryMost patientsAdjunctive treatmentBlack patientsPercent weight lossPsychiatric comorbidityClinical variablesTreatment trialsPatients
2022
Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial
Grilo CM, Lydecker JA, Fineberg SK, Moreno JO, Ivezaj V, Gueorguieva R. Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial. American Journal Of Psychiatry 2022, 179: 927-937. PMID: 36285406, PMCID: PMC9722598, DOI: 10.1176/appi.ajp.20220267.Peer-Reviewed Original ResearchConceptsBehavioral weight loss therapyBinge-eating disorderPlacebo groupBupropion groupWeight lossRandomized double-blind placebo-controlled trialDouble-blind placebo-controlled trialLogistic regressionBinge-eating remissionPlacebo-controlled trialWeight loss therapyDouble-blind placeboSerious public health problemPublic health problemEvidence-based treatmentsRate of participantsBinge-eating frequencyBinge Eating DisorderMedical comorbiditiesRemission rateLoss therapyPercent weight lossMixed modelsFunctional impairmentSecondary measuresEarly Weight Loss Percentile Curves and Feeding Practices in Opioid-Exposed Infants.
Cheng FY, Shabanova V, Berkwitt AK, Grossman MR. Early Weight Loss Percentile Curves and Feeding Practices in Opioid-Exposed Infants. Hospital Pediatrics 2022, 12: 857-866. PMID: 36073203, DOI: 10.1542/hpeds.2021-006137.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeFeeding practicesWeight loss patternsBirth weightMedian percent weight lossWeight lossMean gestational ageOpioid withdrawal syndromeMean birth weightPercentile curvesRisk of morbidityHours of lifeHealth care useConfidence intervalsOptimal feeding methodNonpharmacologic treatmentsPharmacologic treatmentWithdrawal syndromeGestational agePercent weight lossSingle centerCare useInclusion criteriaInfantsDelivery type
2019
Getting a head start: identifying pretreatment correlates associated with early weight loss for individuals participating in weight loss treatment
Wiedemann AA, Baumgardt SS, Ivezaj V, Kerrigan SG, Lydecker JA, Grilo CM, Barnes RD. Getting a head start: identifying pretreatment correlates associated with early weight loss for individuals participating in weight loss treatment. Translational Behavioral Medicine 2019, 11: 236-243. PMID: 31816053, PMCID: PMC7877303, DOI: 10.1093/tbm/ibz149.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentUsual careWeight lossLow pretreatmentDepressive symptomsWeek sixMeaningful weight lossPrimary care settingBinge-eating disorder diagnosisEating Disorder Examination interviewGreater weight lossNutrition psychoeducationTreatment cessationPercent weight lossPrimary careNPC groupObesity rangeLoss treatmentEmotional overeatingExamination interviewDisorder diagnosisPretreatment correlatesMotivational interviewingTreatmentPatients' reasons for weight loss and their relations to clinical weight loss outcomes in a comprehensive lifestyle intervention
Boepple L, Cero I, Marek RJ, Coulon S, Lydecker JA, Brown JD, Malcolm R, O'Neil PM. Patients' reasons for weight loss and their relations to clinical weight loss outcomes in a comprehensive lifestyle intervention. Obesity Science & Practice 2019, 5: 548-554. PMID: 31890245, PMCID: PMC6934423, DOI: 10.1002/osp4.372.Peer-Reviewed Original ResearchWeight loss outcomesBody mass indexWeight change outcomesLoss outcomesWeight lossWhite patientsBlack patientsHigher Body Mass IndexComprehensive lifestyle interventionWeight loss trajectoriesCertain patient groupsWeight loss treatmentWeight loss programLifestyle interventionPatient characteristicsMale patientsPatients' reasonsFemale patientsMass indexPercent weight lossLoss programPatient groupWorse outcomesDoctor's recommendationLoss treatmentExamining Race as a Predictor and Moderator of Treatment Outcomes for Binge-Eating Disorder: Analysis of Aggregated Randomized Controlled Trials
Lydecker JA, Gueorguieva R, Masheb R, White MA, Grilo CM. Examining Race as a Predictor and Moderator of Treatment Outcomes for Binge-Eating Disorder: Analysis of Aggregated Randomized Controlled Trials. Journal Of Consulting And Clinical Psychology 2019, 87: 530-540. PMID: 31008634, PMCID: PMC6589831, DOI: 10.1037/ccp0000404.Peer-Reviewed Original ResearchConceptsBinge-eating disorderWhite participantsCognitive behavioral therapySelf-report measuresTreatment outcomesBinge-eating remissionModerate treatment outcomeBinge Eating DisorderBinge-eating episodesMain effectBlack participantsWeight lossBehavioral weight lossEvidence-based treatmentsLower depressionTreatment researchRandomized Controlled TrialsBetter treatment outcomesControl conditionParticipantsControlled TrialsMultimodal treatmentPercent weight lossPatient groupModerator
2017
Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention
Marek RJ, Coulon SM, Brown JD, Lydecker JA, Marek S, Malcolm R, O'Neil PM. Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention. Obesity 2017, 25: 2062-2067. PMID: 29086487, DOI: 10.1002/oby.21942.Peer-Reviewed Original ResearchConceptsWeight loss trajectoriesAverage weight lossWeight lossLifestyle interventionWeight changeWeight gainComprehensive lifestyle interventionLatent class analysisMeal replacement dietMore tailored interventionsLifestyle change counselingWeekly weight changesWeekly weight gainPercent weight lossLess optimal outcomesLifestyle programEfficacy dataGroup 2Group 1Group 3Class analysisPatientsTailored interventionsOptimal outcomesPercent weight gain
2016
Loss-of-control eating following sleeve gastrectomy surgery
Ivezaj V, Kessler EE, Lydecker JA, Barnes RD, White MA, Grilo CM. Loss-of-control eating following sleeve gastrectomy surgery. Surgery For Obesity And Related Diseases 2016, 13: 392-398. PMID: 27913121, PMCID: PMC5357454, DOI: 10.1016/j.soard.2016.09.028.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryGastrectomy surgeryWeight lossEating Disorder Examination-Bariatric Surgery VersionPoorer weight loss outcomesBED criteriaLower percent weight lossPoor weight lossWeight loss outcomesBody mass indexEating-disorder psychopathologyBinge-eating disorderRegular compensatory behaviorsCurrent mean ageUnited States METHODSBariatric surgeryPostoperative lossMass indexPercent weight lossMean ageMonths postsurgeryPoor outcomeLoss outcomesGreater severitySurgeryFood Thought Suppression Inventory: Test–retest reliability and relationship to weight loss treatment outcomes
Barnes RD, Ivezaj V, Grilo CM. Food Thought Suppression Inventory: Test–retest reliability and relationship to weight loss treatment outcomes. Eating Behaviors 2016, 22: 93-95. PMID: 27112114, PMCID: PMC5161461, DOI: 10.1016/j.eatbeh.2016.04.001.Peer-Reviewed Original ResearchConceptsFood Thought Suppression InventoryWeight loss treatmentBinge-eating episodesTest-retest reliabilityLoss treatmentWeight loss treatment outcomesWeight lossWeight loss goalsOriginal body weightWeek test-retest reliabilityPercent weight lossPrimary careTreatment outcomesIntra-class correlationBody weightBaselineTreatmentScoresEpisodesParticipantsPost assessmentHigh levelsBinge
2015
Predicting Meaningful Outcomes to Medication and Self-Help Treatments for Binge-Eating Disorder in Primary Care: The Significance of Early Rapid Response
Grilo CM, White MA, Masheb RM, Gueorguieva R. Predicting Meaningful Outcomes to Medication and Self-Help Treatments for Binge-Eating Disorder in Primary Care: The Significance of Early Rapid Response. Journal Of Consulting And Clinical Psychology 2015, 83: 387-394. PMID: 25622201, PMCID: PMC4380674, DOI: 10.1037/a0038635.Peer-Reviewed Original ResearchConceptsBinge-eating disorderSelf-help cognitive behavioral therapyPrimary care settingObese patientsFourth treatment weekBaseline clinical characteristicsBetter clinical outcomesPrimary care physiciansObese patient groupRandomized clinical trialsStrong prognostic indicatorSelf-help interventionEating-disorder psychopathologyImportant clinical implicationsCognitive behavioral therapyAntiobesity medicationsClinical characteristicsMixed-effects model analysisClinical outcomesPercent weight lossPatient groupPrognostic indicatorTreatment weekClinical trialsResearch clinicians
2014
Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: Randomized placebo-controlled clinical trial of self-help and medication
Grilo CM, Masheb RM, White MA, Gueorguieva R, Barnes RD, Walsh BT, McKenzie KC, Genao I, Garcia R. Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: Randomized placebo-controlled clinical trial of self-help and medication. Behaviour Research And Therapy 2014, 58: 1-9. PMID: 24857821, PMCID: PMC4074556, DOI: 10.1016/j.brat.2014.04.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnti-Obesity AgentsBinge-Eating DisorderBlack or African AmericanBody WeightCognitive Behavioral TherapyCombined Modality TherapyCyclobutanesDouble-Blind MethodFemaleHispanic or LatinoHumansMaleMiddle AgedObesityPrimary Health CareSelf CareTime FactorsTreatment OutcomeWhite PeopleYoung AdultConceptsSelf-help cognitive behavioral therapyDiverse obese patientsAnti-obesity medicationsObese patientsModerate clinical outcomePercent weight lossTime interaction effectsWeight lossClinical outcomesPrimary careRandomized placebo-controlled clinical trialSecond placebo-controlled trialPlacebo-controlled clinical trialAcute weight lossPlacebo-controlled trialDouble-blind fashionDiscontinuation of medicationPrimary care settingWeight loss maintenanceSpecialist treatment centresTreatment of bingeDiverse patient groupsSelf-help CBTBinge-eating frequencyDemographic factors
2010
SU‐GG‐T‐178: Intensity‐Modulated Radiation Therapy (IMRT) in the Treatment of Oropharyngeal Carcinoma: Clinical Outcomes and Relation of Parotid Gland Volume with Xerostomia
Turaka A, Weinberg B, Li T, Nicos N, Burtness B, Lango M, Ridge J, Feigenberg S. SU‐GG‐T‐178: Intensity‐Modulated Radiation Therapy (IMRT) in the Treatment of Oropharyngeal Carcinoma: Clinical Outcomes and Relation of Parotid Gland Volume with Xerostomia. Medical Physics 2010, 37: 3226-3226. DOI: 10.1118/1.3468568.Peer-Reviewed Original ResearchIntensity-modulated radiation therapyParotid gland volumeRT dosesPercent weight lossWeight lossGland volumeMedian percent weight lossUse of IMRTPG volumesFox Chase Cancer CenterGrade 3 xerostomiaAddition of chemotherapyLocoregional control rateOverall survival rateSquamous cell cancerWeeks of treatmentPatterns of failureCurative intentMedian followToxicity scoringDefinitive RTMedian doseNeck dissectionOropharyngeal carcinomaMedian age
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