2025
Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome
Radhakrishna U, Radhakrishnan R, Uppala L, Trivedi T, Prajapati J, Rawal R, Muvvala S, Bahado-Singh R, Sadhasivam S. Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome. Frontiers In Pain Research 2025, 6: 1497801. PMID: 40313396, PMCID: PMC12043715, DOI: 10.3389/fpain.2025.1497801.Peer-Reviewed Original ResearchNeonatal opioid withdrawal syndromeOpioid-exposed infantsOpioid withdrawal syndromePain-related genesOpioid exposureWithdrawal syndromeChronic painEpigenetic changesMaternal opioid exposurePrenatal opioid exposureImprove pain managementIon channel functionIllumina Infinium Methylation EPIC BeadChipInfinium Methylation EPIC BeadChipAnalyzed DNA methylationUnexposed control subjectsLong-term health risksPain reliefPain perceptionPregnant womenGnRH secretionPlacental tissueMorphine addictionHealth of mothersControl subjects
2024
Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome
Radhakrishna U, Radhakrishnan R, Uppala L, Muvvala S, Prajapati J, Rawal R, Bahado-Singh R, Sadhasivam S. Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome. Frontiers In Neuroscience 2024, 18: 1442915. PMID: 39238930, PMCID: PMC11376091, DOI: 10.3389/fnins.2024.1442915.Peer-Reviewed Original ResearchNeonatal opioid withdrawal syndromeNeonatal opioid withdrawal syndrome treatmentRegulation of drug transportersOpioid use disorderOpioid withdrawal syndromeProtein kinase CDrug transportATP-binding cassetteDrug resistanceWithdrawal syndromeSevere neonatal opioid withdrawal syndromeSolute carrierPrenatal opioid exposureOpioid-exposed infantsATP-binding cassette drug transportersLevels of ATP-binding cassetteIllumina Infinium MethylationEPIC arrayKinase CMethylation changesGastric acid secretionImprove treatment outcomesDrug-drug interactionsMaternal opioidsMaternal relapseInfinium MethylationEPIC array
2022
Delivery timing for the opioid–exposed infant
Sanusi A, Gray M, Xue Y, Mohr S, Curtis P, Dismukes J, Gentle S, Szychowski J, Brocato B, Casey B, Harper L, Sinkey R. Delivery timing for the opioid–exposed infant. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100719. PMID: 35977700, PMCID: PMC10961100, DOI: 10.1016/j.ajogmf.2022.100719.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeOpioid-exposed infantsIncidence of neonatal opioid withdrawal syndromeNeonatal opioid withdrawal syndrome treatmentLate-term periodsEarly term deliveryOpioid-exposed neonatesWithdrawal syndromePrimary composite outcomeOpioid use disorderNeonatal outcomesTerm deliveryMedication-Assisted TreatmentSyndrome treatmentComposite outcomeRisk of neonatal opioid withdrawal syndromeSeverity of neonatal opioid withdrawal syndromeNeonatal intensive care unit admissionAmerican College of Obstetricians and GynecologistsPositive urine toxicology screenPrimary outcomeSecondary outcomesNeonatal intensive care unitPositive urine drug screen
2021
Neonatal Abstinence Syndrome: Management Advances and Therapeutic Approaches
Cheng F, McMillan C, Morrison A, Berkwitt A, Grossman M. Neonatal Abstinence Syndrome: Management Advances and Therapeutic Approaches. Current Addiction Reports 2021, 8: 595-604. DOI: 10.1007/s40429-021-00387-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNeonatal abstinence syndromeMaternal-infant dyadsNon-pharmacologic interventionsNumber of infantsDevelopment of NASOpioid crisisLong-term neurodevelopmental outcomesNon-pharmacologic careOpioid-exposed infantsProportion of infantsLength of stayPurpose of ReviewInBirth hospitalizationOutpatient managementInpatient managementNeurodevelopmental outcomesClinical presentationAbstinence syndromeVulnerable infantsPharmacologic agentsStrategy warrantsClinical pathwayTherapeutic approachesFunctional assessmentInfants
2018
A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome
Grossman MR, Lipshaw MJ, Osborn RR, Berkwitt AK. A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome. Hospital Pediatrics 2018, 8: 1-6. PMID: 29263121, DOI: 10.1542/hpeds.2017-0128.Peer-Reviewed Original ResearchConceptsNeonatal abstinence syndromeManagement of infantsTreatment decisionsAbstinence syndromeYale-New Haven Children's HospitalOpioid-exposed infantsLength of stayActual treatment decisionsHealth care systemOpioid treatmentAdverse eventsPharmacologic treatmentPrimary outcomeChildren's HospitalPostnatal treatmentInpatient unitSignificant burdenMorphineInfantsCare systemSyndromeHospitalTreatmentScoresDays
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply