2023
Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring
Ginder C, Li J, Halperin J, Akar J, Martin D, Chattopadhyay I, Upadhyay G. Predicting Malignant Ventricular Arrhythmias Using Real-Time Remote Monitoring. Journal Of The American College Of Cardiology 2023, 81: 949-961. PMID: 36889873, DOI: 10.1016/j.jacc.2022.12.024.Peer-Reviewed Original ResearchConceptsAppropriate device therapyMalignant ventricular arrhythmiasDevice therapyVentricular arrhythmiasImplantable cardioverter-defibrillator therapyLogistic regressionSeparate multivariable logistic regressionsLead impedanceAppropriate ICD therapyCardioverter-defibrillator therapyCardiac resynchronization therapyMultivariable logistic regressionRemote monitoring dataShock lead impedanceAtrial lead impedanceICD therapyHeart failureResynchronization therapyAppropriate therapyAtrial tachyarrhythmiasVentricular tachycardiaVentricular fibrillationDefibrillator devicesHeart ratePatients
2022
Survival Probability and Survival Benefit Associated With Primary Prevention Implantable Cardioverter‐Defibrillator Generator Changes
Bilchick KC, Wang Y, Curtis JP, Shadman R, Dardas TF, Anand I, Lund LH, Dahlström U, Sartipy U, Levy WC. Survival Probability and Survival Benefit Associated With Primary Prevention Implantable Cardioverter‐Defibrillator Generator Changes. Journal Of The American Heart Association 2022, 11: e023743. PMID: 35766293, PMCID: PMC9333379, DOI: 10.1161/jaha.121.023743.Peer-Reviewed Original ResearchConceptsSeattle Heart Failure ModelHeart failure modelHeart failure patientsResynchronization therapyGenerator changeSurvival benefitWorse survivalFailure patientsNational Cardiovascular Data Registry ICD RegistryGC survivalSurvival Benefit AssociatedPrimary prevention indicationVentricular ejection fractionAnnual mortalityICD therapyConclusions PatientsPrevention indicationEjection fractionICD RegistryImproved survivalPrimary preventionPatient deathGreater effect sizeLVEFPatients
2021
Worldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy.
Nauffal V, Marstrand P, Han L, Parikh VN, Helms AS, Ingles J, Jacoby D, Lakdawala NK, Kapur S, Michels M, Owens AT, Ashley EA, Pereira AC, Rossano JW, Saberi S, Semsarian C, Ware JS, Wittekind SG, Day S, Olivotto I, Ho CY. Worldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy. European Heart Journal 2021, 42: 3932-3944. PMID: 36282238, DOI: 10.1093/eurheartj/ehab598.Peer-Reviewed Original ResearchConceptsSudden cardiac deathAppropriate ICD therapyNon-US sitesHypertrophic cardiomyopathyUS sitesICD therapySCD riskICD recipientsImplantation rateImplantable cardioverter-defibrillator (ICD) implantation ratesMultivariable Cox proportional hazards modelsImplantable cardioverter-defibrillator utilizationSarcomeric Human Cardiomyopathy RegistryCox proportional hazards modelHCM Risk-SCD scoreICD implantation ratesPrimary prevention ICDsSCD risk factorsRisk stratification algorithmLong-term outcomesLow-risk populationSignificant differencesSCD/Cardiac deathClinical outcomesWorldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy
Nauffal V, Marstrand P, Han L, Parikh VN, Helms AS, Ingles J, Jacoby D, Lakdawala NK, Kapur S, Michels M, Owens AT, Ashley EA, Pereira AC, Rossano JW, Saberi S, Semsarian C, Ware JS, Wittekind SG, Day S, Olivotto I, Ho CY. Worldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy. European Heart Journal 2021, 42: 3932-3944. PMID: 34491319, PMCID: PMC8497072, DOI: 10.1093/eurheartj/ehab598.Peer-Reviewed Original ResearchConceptsSudden cardiac deathAppropriate ICD therapyNon-US sitesHypertrophic cardiomyopathyUS sitesICD therapySCD riskICD recipientsImplantation rateImplantable cardioverter-defibrillator (ICD) implantation ratesMultivariable Cox proportional hazards modelsImplantable cardioverter-defibrillator utilizationSarcomeric Human Cardiomyopathy RegistryCox proportional hazards modelHCM Risk-SCD scoreICD implantation ratesPrimary prevention ICDsSCD risk factorsRisk stratification algorithmLong-term outcomesLow-risk populationSignificant differencesSCD/Cardiac deathClinical outcomes
2018
Effectiveness of a comprehensive interactive eHealth intervention on patient-reported and clinical outcomes in patients with an implantable cardioverter defibrillator [ACQUIRE-ICD trial]: study protocol of a national Danish randomised controlled trial
Pedersen SS, Skovbakke SJ, Wiil UK, Schmidt T, dePont Christensen R, Brandt CJ, Sørensen J, Vinther M, Larroudé CE, Melchior TM, Riahi S, Smolderen KGE, Spertus JA, Johansen JB, Nielsen JC. Effectiveness of a comprehensive interactive eHealth intervention on patient-reported and clinical outcomes in patients with an implantable cardioverter defibrillator [ACQUIRE-ICD trial]: study protocol of a national Danish randomised controlled trial. BMC Cardiovascular Disorders 2018, 18: 136. PMID: 29969990, PMCID: PMC6029360, DOI: 10.1186/s12872-018-0872-7.Peer-Reviewed Original ResearchMeSH KeywordsDefibrillators, ImplantableDenmarkElectric CountershockHealth StatusHeart FailureHumansMental HealthMulticenter Studies as TopicPatient Reported Outcome MeasuresPredictive Value of TestsProspective StudiesQuality of LifeRandomized Controlled Trials as TopicRemote Sensing TechnologyRisk FactorsTelemedicineTelemetryTime FactorsTreatment OutcomeConceptsImplantable cardioverter defibrillatorQuality of lifeEHealth interventionsUsual careClinical outcomesCardioverter defibrillatorFlorida Patient Acceptance SurveyCardiac synchronization therapyFirst ICD therapyTrial registrationThe trialCare innovationsManagement of patientsPatient-reported outcomesFirst‐time implantable cardioverter defibrillatorsMonitoring of symptomsQuality of carePatient-physician interactionFirst hospitalisationICD therapyPrimary endpointSecondary endpointsMore patientsSuperiority trialDisease management approachClinical effectivenessThe relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients
Friedman DJ, Fudim M, Overton R, Shaw LK, Patel D, Pokorney SD, Velazquez EJ, Al-Khatib SM. The relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients. American Heart Journal 2018, 201: 17-24. PMID: 29910051, PMCID: PMC6309220, DOI: 10.1016/j.ahj.2018.03.017.Peer-Reviewed Original ResearchConceptsLeft ventricular assist devicePrimary prevention ICD patientsAppropriate ICD therapyVentricular ejection fractionImplantable cardioverter defibrillatorICD therapyICD implantationEjection fractionICD patientsMultivariable Cox proportional hazards modelsPrimary prevention implantable cardioverter defibrillatorsCo-primary study endpointsPrimary prevention ICD recipientsFollow-up left ventricular ejection fractionLeft ventricular ejection fractionCox proportional hazards modelComposite of timeLong-term followProportional hazards modelVentricular assist deviceLong-term riskBaseline LVEFLVEF improvementAdverse eventsComposite endpoint
2015
Effectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest
Chan PS, Krumholz HM, Spertus JA, Curtis LH, Li Y, Hammill BG, Nallamothu BK, investigators A. Effectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest. American Heart Journal 2015, 169: 870-878.e1. PMID: 26027626, PMCID: PMC4451609, DOI: 10.1016/j.ahj.2015.02.016.Peer-Reviewed Original ResearchConceptsInhospital cardiac arrestLong-term mortalityHospital cardiac arrestCardiac arrestICD treatmentLower long-term mortalityImplantable cardioverter-defibrillator therapyHigh illness acuityHigher unadjusted mortalityICD-treated patientsCardiac Arrest RegistryCardioverter-defibrillator therapyPulseless ventricular tachycardiaHigh-risk populationComparative effectiveness studiesLong-term survivalPropensity score analysisLower mortality rateArrest etiologyEligible survivorsICD trialsHospital deathICD therapyIndex hospitalizationUntreated patientsOutcomes of patients with definite and suspected isolated cardiac sarcoidosis treated with an implantable cardiac defibrillator
Kron J, Sauer W, Mueller G, Schuller J, Bogun F, Sarsam S, Rosenfeld L, Mitiku TY, Cooper JM, Mehta D, Greenspon AJ, Ortman M, Delurgio DB, Valadri R, Narasimhan C, Swapna N, Singh JP, Danik S, Markowitz SM, Almquist AK, Krahn AD, Wolfe LG, Feinstein S, Ellenbogen KA, Crawford T. Outcomes of patients with definite and suspected isolated cardiac sarcoidosis treated with an implantable cardiac defibrillator. Journal Of Interventional Cardiac Electrophysiology 2015, 43: 55-64. PMID: 25676929, DOI: 10.1007/s10840-015-9978-3.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceImplantable cardiac defibrillatorPositron emission tomographyAppropriate ICD therapyAnti-tachycardia pacingICD therapyCardiac defibrillatorLeft ventricular ejection fractionAppropriate ICD interventionsSecondary prevention indicationTrue natural historyOutcomes of patientsMulticenter retrospective reviewVentricular ejection fractionEnhanced cardiac CTExtracardiac sarcoidosisICD interventionsCardiac sarcoidosisPrevention indicationConsecutive patientsEjection fractionHeart transplantRetrospective reviewSarcoidosis patientsVentricular arrhythmiasA validated risk model for 1-year mortality after primary prevention implantable cardioverter defibrillator placement
Heidenreich PA, Tsai V, Curtis J, Wang Y, Turakhia MP, Masoudi FA, Varosy PD, Goldstein MK. A validated risk model for 1-year mortality after primary prevention implantable cardioverter defibrillator placement. American Heart Journal 2015, 170: 281-289.e2. PMID: 26299225, DOI: 10.1016/j.ahj.2014.12.013.Peer-Reviewed Original ResearchConceptsOne-year mortalityImplantable cardioverter defibrillatorRisk factorsHeart failurePrimary preventionMortality riskRisk scorePrimary prevention implantable cardioverter-defibrillator placementB-type natriuretic peptide valuesImplantable cardioverter-defibrillator placementCardiovascular Disease RegistryPrimary prevention populationNatriuretic peptide valuesChronic lung diseaseSystolic blood pressureSimilar risk factorsBlood urea nitrogenPg/mLLogistic regression modelsPrevention populationICD therapyICD implantationBlood pressureICD RegistryICD placement
2014
Comparative effectiveness of cardiac resynchronization therapy with an implantable cardioverter-defibrillator versus defibrillator therapy alone: a cohort study.
Masoudi FA, Mi X, Curtis LH, Peterson PN, Curtis JP, Fonarow GC, Hammill SC, Heidenreich PA, Al-Khatib SM, Piccini JP, Qualls LG, Hernandez AF. Comparative effectiveness of cardiac resynchronization therapy with an implantable cardioverter-defibrillator versus defibrillator therapy alone: a cohort study. Annals Of Internal Medicine 2014, 160: 603-11. PMID: 24798523, DOI: 10.7326/m13-1879.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac Resynchronization TherapyComparative Effectiveness ResearchDefibrillators, ImplantableElectrocardiographyHeart FailureHumansInfectionsPatient ReadmissionPropensity ScoreRetrospective StudiesRisk FactorsStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftConceptsReduced left ventricular ejection fractionLeft ventricular ejection fractionHeart failure readmissionVentricular ejection fractionCardiac resynchronization therapyICD therapyQRS durationLower riskCohort studyICD RegistryResynchronization therapyEjection fractionNational Cardiovascular Data Registry ICD RegistryImplantable cardioverter-defibrillator therapyLeft bundle branch blockPropensity-matched patientsRetrospective cohort studyCardioverter-defibrillator therapyDevice-related complicationsBundle branch blockDevice-related infectionsCardiovascular readmissionCause readmissionDefibrillator therapyICD implantation
2012
Effectiveness of Implantable Cardioverter Defibrillators and Cardiac Resynchronization Therapy in Heart Failure
Freeman JV, Masoudi FA. Effectiveness of Implantable Cardioverter Defibrillators and Cardiac Resynchronization Therapy in Heart Failure. Heart Failure Clinics 2012, 9: 59-77. PMID: 23168318, DOI: 10.1016/j.hfc.2012.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedCardiac Resynchronization TherapyComparative Effectiveness ResearchDefibrillators, ImplantableDisease ManagementFemaleHeart FailureHumansMaleMeta-Analysis as TopicMiddle AgedObservationOutcome and Process Assessment, Health CarePatient SelectionPractice Guidelines as TopicRandomized Controlled Trials as TopicSecondary PreventionSeverity of Illness IndexSex FactorsSurvival RateConceptsCardiac resynchronization therapyTrial dataResynchronization therapyQRS morphologyNYHA class IV patientsCardiac devicesBenefit of ICDSingle-chamber ICDClass IV patientsHigh-volume hospitalsOptimal medical managementEffective treatment modalityPrior ventricular arrhythmiasProlonged QRS complexRecent trial dataRecent trial resultsImplantable cardioverter defibrillatorQuality of lifeHF hospitalizationSymptomatic HFHF symptomsICD therapySevere comorbiditiesIV patientsMortality benefitElectrophysiology Studies in Patients Undergoing ICD Implantation: Findings from the NCDR®
CHENG A, WANG Y, BERGER RD, CALKINS H, BUXTON AE, CURTIS JP, LAMPERT R. Electrophysiology Studies in Patients Undergoing ICD Implantation: Findings from the NCDR®. Pacing And Clinical Electrophysiology 2012, 35: 912-918. PMID: 22670627, DOI: 10.1111/j.1540-8159.2012.03441.x.Peer-Reviewed Original ResearchConceptsICD implantationElectrophysiology studyEjection fractionSudden deathDe novo ICD implantationSecondary prevention ICD recipientsSudden death risk stratificationLeft ventricular ejection fractionImplantable cardioverter defibrillator implantationNarrow QRS intervalPrimary prevention ICDsDeath risk stratificationCardioverter-defibrillator implantationCongestive heart failureVentricular ejection fractionHigher ejection fractionHistory of syncopeMonomorphic ventricular tachycardiaLogistic regression analysisFuture ICD therapyHierarchical logistic regression analysisICD therapyClinical characteristicsComplication rateDefibrillator implantation
2009
Racial and Gender Trends in the Use of Implantable Cardioverter‐Defibrillators Among Medicare Beneficiaries Between 1997 and 2003
Chan PS, Birkmeyer JD, Krumholz HM, Spertus JA, Nallamothu BK. Racial and Gender Trends in the Use of Implantable Cardioverter‐Defibrillators Among Medicare Beneficiaries Between 1997 and 2003. Congestive Heart Failure 2009, 15: 51-57. PMID: 19379450, PMCID: PMC2921372, DOI: 10.1111/j.1751-7133.2009.00060.x.Peer-Reviewed Original Research
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