2024
Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3
Yrigoin K, Bernard K, Castaño M, Cleaver O, Sumanas S, Davis G. Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3. Frontiers In Cell And Developmental Biology 2024, 12: 1465806. PMID: 39544367, PMCID: PMC11560913, DOI: 10.3389/fcell.2024.1465806.Peer-Reviewed Original ResearchTIMP-3Endothelial cellsHuman pericytesPresence of doxycyclineCollagen type IVCo-culture modelIncreasing tube lengthHuman endothelial cellsStabilization networkTissue inhibitorNetwork assemblyPericyte recruitmentCapillary assemblyCo-assemblyType IVUpregulated expressionPericytesCo-CultureTube lengthDoxycycline additionEC-pericyte interactionsTube widthDoxycyclineNetwork of capillary tubesBiomarkers vs Machines: The Race to Predict Acute Kidney Injury
Ghazi L, Farhat K, Hoenig M, Durant T, El-Khoury J. Biomarkers vs Machines: The Race to Predict Acute Kidney Injury. Clinical Chemistry 2024, 70: 805-819. PMID: 38299927, DOI: 10.1093/clinchem/hvad217.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAcute kidney injuryEarly diagnosisInsulin-like growth factor-binding protein 7Prediction of acute kidney injuryGrowth factor-binding protein 7Detect acute kidney injuryNeutrophil Gelatinase-Associated LipocalinAcute kidney injury detectionClinical practiceIrreversible kidney damageClinical outcome studiesImminent AKISerum creatinineKidney injuryInjury markersPediatric populationCystatin CTissue inhibitorHospitalized patientsClinical useKidney damageRegulatory approvalProtein 7BiomarkersOutcome studies
2023
Biomarkers for acute kidney injury in children – where are we now?
Sandokji I, Greenberg J. Biomarkers for acute kidney injury in children – where are we now? Current Opinion In Pediatrics 2023, 35: 245-250. PMID: 36601976, DOI: 10.1097/mop.0000000000001217.Peer-Reviewed Original ResearchConceptsAcute kidney injuryNeutrophil Gelatinase-Associated LipocalinUrine neutrophil gelatinase-associated lipocalinInsulin-like growth factor binding protein 7AKI biomarkersKidney injuryGrowth factor binding protein 7AKI risk stratificationUrine tissue inhibitorGelatinase-Associated LipocalinBest discriminative valueBinding protein 7Early time pointsTubular injuryRisk stratificationTissue inhibitorDiagnostic biomarkersClinical modelMetalloproteinases 2Discriminative valueBiomarkersInjuryTime pointsProtein 7Modest Improvement
2022
Biomarker Development Trial of Satraplatin in Patients with Metastatic Castration-Resistant Prostate Cancer
Liaw B, Tsao C, Seng S, Jun T, Gong Y, Galsky M, Oh W. Biomarker Development Trial of Satraplatin in Patients with Metastatic Castration-Resistant Prostate Cancer. The Oncologist 2022, 28: 366-e224. PMID: 36519763, PMCID: PMC10078918, DOI: 10.1093/oncolo/oyac224.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerProstate cancerMetastatic castration-resistant prostate cancer patientsImproved time to disease progressionDNA damage repair mutationsTime to disease progressionBlood RNA signatureOral platinum analoguePlatinum-based chemotherapyPhase II studySerum tissue inhibitorAssociated with platinum responseTissue-based biomarkersPeripheral blood samplesMCRPC patientsMedian PSABlood biomarker measurementsII studyPlatinum responseBlood-based biomarkersSPARC trialPlatinum analoguesTissue inhibitorDay 1Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction
Stacy MR, Lin BA, Thorn SL, Lobb DC, Maxfield MW, Novack C, Zellars KN, Freeburg L, Akar JG, Sinusas AJ, Spinale FG. Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction. Heart Rhythm 2022, 19: 847-855. PMID: 35066183, PMCID: PMC9064890, DOI: 10.1016/j.hrthm.2022.01.022.Peer-Reviewed Original ResearchConceptsAtrial fibrillationMyocardial infarctionRight atrial regionsAtrial regionsPost-MIMMP activityMatrix metalloproteinasesMMP/TIMP profilesNew-onset atrial fibrillationLeft atrial regionsMMP/TIMP expressionLeft atrial appendageMatrix remodelingElectrical stimulation protocolFibrillar collagen contentExtracellular matrix remodelingAF vulnerabilityTIMP profilesAtrial appendagePostmyocardial infarctionMyocardial substrateStimulation protocolNoninvasive molecular imagingTIMP expressionTissue inhibitor
2021
AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury
El-Khoury JM, Hoenig MP, Jones GRD, Lamb EJ, Parikh CR, Tolan NV, Wilson FP. AACC Guidance Document on Laboratory Investigation of Acute Kidney Injury. The Journal Of Applied Laboratory Medicine 2021, 6: 1316-1337. PMID: 33973621, DOI: 10.1093/jalm/jfab020.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute kidney injuryKidney injuryNew biomarkersPotential acute kidney injuryInsulin-like growth factor binding protein 7Growth factor binding protein 7Early detectionLong-term complicationsLaboratory investigationsEmergence of biomarkersHealth care costsBinding protein 7AKI alertsKidney damageClinical indicationsCystatin CSudden episodeCare costsTissue inhibitorDiagnostic thresholdMetalloproteinases 2Test utilizationPreponderance of evidenceTraditional markersExpert recommendations
2018
Tocopherols inhibit estrogen-induced cancer stemness and OCT4 signaling in breast cancer
Bak M, Furmanski P, Shan N, Lee H, Bao C, Lin Y, Shih W, Yang C, Suh N. Tocopherols inhibit estrogen-induced cancer stemness and OCT4 signaling in breast cancer. Carcinogenesis 2018, 39: 1045-1055. PMID: 29846560, PMCID: PMC6067126, DOI: 10.1093/carcin/bgy071.Peer-Reviewed Original ResearchConceptsBreast cancer stem cellsBreast cancer developmentCancer stem cellsBreast cancerCancer stemnessTrefoil factorEffect of tocopherolCancer developmentSize of tumorspheresBreast cancer stemnessCell invasionStem cell-like propertiesPutative breast cancer stem cellsCell-like propertiesStem cellsStem cell markersAldehyde dehydrogenase activityMammary progenitor cellsEstrogen effectsProgesterone receptorTranscription factor 4Sex-determining region Y-boxInvasion markersRegion Y-boxTissue inhibitorPericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain
Dave JM, Mirabella T, Weatherbee SD, Greif DM. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Developmental Cell 2018, 44: 665-678.e6. PMID: 29456135, PMCID: PMC5871595, DOI: 10.1016/j.devcel.2018.01.018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Brain BarrierBrainEmbryo, MammalianEndothelium, VascularFemaleHumansIntracranial HemorrhagesMaleMiceMice, Inbred C57BLMice, KnockoutMorphogenesisPericytesProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IReceptors, Transforming Growth Factor betaSignal TransductionTissue Inhibitor of Metalloproteinase-3ConceptsEndothelial morphogenesisReceptor-like kinasesBlood-brain barrierActivin receptor-like kinaseGerminal matrixGerminal matrix hemorrhage-intraventricular hemorrhageMurine embryosEC morphogenesisEndothelial cellsEC hyperproliferationMorphogenesisMatrix metalloproteinase-3Glial precursorsBasement membrane collagenMatrix metalloproteinase activityBBB developmentMutantsVascular stabilityALK5Brain pericytesAbnormal dilationSubstantial therapeutic potentialMetalloproteinase-3Membrane collagenTissue inhibitor
2015
Establishment and Characterization of Rat Portal Myofibroblast Cell Lines
Fausther M, Goree JR, Lavoie ÉG, Graham AL, Sévigny J, Dranoff JA. Establishment and Characterization of Rat Portal Myofibroblast Cell Lines. PLOS ONE 2015, 10: e0121161. PMID: 25822334, PMCID: PMC4378927, DOI: 10.1371/journal.pone.0121161.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsPortal fibroblastsMyofibroblast cell lineLiver fibrosisCell linesAlpha 1Alpha-smooth muscle actinMyofibroblast marker alpha-smooth muscle actinScar-forming myofibroblastsSmooth muscle actinMesenchymal cell markersNTPDase2/CD39L1Lecithin retinol acyltransferaseStellate cellsCollagen alpha 1Cholangiocyte proliferationMetalloproteinases-1Muscle actinTissue inhibitorAdult rat liverCell markersCholangiocarcinoma cellsCulture activationRetinol acyltransferaseFunctional studies
2014
Temporal Regulation of venous Extracellular Matrix Components during Arteriovenous Fistula Maturation
Hall MR, Yamamoto K, Protack CD, Tsuneki M, Kuwahara G, Assi R, Brownson KE, Bai H, Madri JA, Dardik A. Temporal Regulation of venous Extracellular Matrix Components during Arteriovenous Fistula Maturation. The Journal Of Vascular Access 2014, 16: 93-106. PMID: 25262757, PMCID: PMC4405006, DOI: 10.5301/jva.5000290.Peer-Reviewed Original ResearchConceptsExtracellular matrix componentsTemporal regulationECM componentsStructural proteinsMatrix componentsGene microarray analysisMatrix metalloproteinasesRegulatory proteinsMicroarray analysisNon-collagenous proteinsDistinct temporal patternsECM degradationTemporal patternsProteinProtein expressionElastin expressionExpressionMaturationOsteopontin expressionProtease inhibitorsHuman AVF maturationRegulationTissue inhibitorDays of maturationMetalloproteinase-1Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression
Gong Y, Chippada-Venkata U, Oh W. Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Prostate Cancer Progression. Cancers 2014, 6: 1298-1327. PMID: 24978435, PMCID: PMC4190542, DOI: 10.3390/cancers6031298.Peer-Reviewed Original ResearchProstate cancer progressionMatrix metalloproteinase inhibitorsMatrix metalloproteinasesProstate cancerTreatment of metastatic prostate cancerCancer progressionMetastatic prostate cancerHuman prostate cancerGroup of zinc-dependent endopeptidasesMediators of tumor invasionExpression of matrix metalloproteinasesPrognostic implicationsTIMP-1Tumor invasionTissue inhibitorMMP-2Blood expressionZinc-dependent endopeptidasesCancerTissue barriersMetalloproteinase inhibitorsTissue repairMT1-MMPProstateConnective tissue barrier
2013
Posttranslational regulation of tissue inhibitor of metalloproteinase‐1 by calcium‐dependent vesicular exocytosis
Dranoff JA, Bhatia N, Fausther M, Lavoie EG, Granell S, Baldini G, Hickman DA, Sheung N. Posttranslational regulation of tissue inhibitor of metalloproteinase‐1 by calcium‐dependent vesicular exocytosis. Physiological Reports 2013, 1: e00125. PMID: 24400134, PMCID: PMC3871447, DOI: 10.1002/phy2.125.Peer-Reviewed Original ResearchHepatic stellate cellsMyofibroblastic hepatic stellate cellsLiver fibrosisMetalloproteinase-1Tissue inhibitorVesicular exocytosisTIMP-1 releaseLiver myofibroblastsStellate cellsTIMP-1FibrosisCritical mediatorNew targetsInhibitorsPosttranslational regulationFibrinolysisExocytosisMyofibroblastsReleasePlasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion
Mukherjee R, Akar JG, Wharton JM, Adams DK, McClure CD, Stroud RE, Rice AD, DeSantis SM, Spinale FG, Gold MR. Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion. Journal Of Cardiovascular Translational Research 2013, 6: 528-535. PMID: 23722357, DOI: 10.1007/s12265-013-9471-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationBiomarkersC-Reactive ProteinChi-Square DistributionElectric CountershockFibrosisHeart AtriaHumansLogistic ModelsMatrix MetalloproteinasesMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPeptide FragmentsPredictive Value of TestsRecurrenceRisk FactorsTime FactorsTissue Inhibitor of MetalloproteinasesTreatment OutcomeConceptsAF recurrenceMatrix metalloproteinasesMMP-9TIMP-4MMP-3N-terminus pro B type natriuretic peptideHigh-sensitivity C-reactive protein levelsPro-B-type natriuretic peptideTissue inhibitorC-reactive protein levelsB-type natriuretic peptideLevels of MMPsAtrial fibrillation recurrenceNovel biomarker panelAtrial volumeNatriuretic peptideAtrial fibrosisSinus rhythmPredicts RecurrenceBiomarker panelRecurrenceMultivariate analysisPostcardioversionProtein levelsPlasma samples
2012
Simvastatin Decreases Invasiveness of Human Endometrial Stromal Cells1
Sokalska A, Cress A, Bruner-Tran KL, Osteen KG, Taylor HS, Ortega I, Duleba AJ. Simvastatin Decreases Invasiveness of Human Endometrial Stromal Cells1. Biology Of Reproduction 2012, 87: 2, 1-6. PMID: 22492974, PMCID: PMC3406552, DOI: 10.1095/biolreprod.111.098806.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionEndometriosisEndometriumFemaleGene ExpressionHumansHyaluronan ReceptorsHydroxymethylglutaryl-CoA Reductase InhibitorsMatrix Metalloproteinase 2Matrix Metalloproteinase 3MiceMice, NudePolyisoprenyl PhosphatesPrenylationSesquiterpenesSimvastatinStromal CellsTissue Inhibitor of Metalloproteinase-2ConceptsEffect of simvastatinMatrix metalloproteinase-2Metalloproteinase-2Human endometrial stromal cellsEndometrial stromal cellsNude mouse modelConcentration-dependent reductionInhibition of HMGCREffects of GGPPInhibition of geranylgeranylationEndometrial implantsEndometrial stromaSimvastatin treatmentMouse modelAnimal modelsTissue inhibitorTIMP2 mRNASimvastatinDecrease invasivenessDecrease proliferationStromal cellsPresence of GGppCell invasivenessMRNA levelsEndometriosis
2011
Ancylostoma ceylanicum Excretory–Secretory Protein 2 Adopts a Netrin-Like Fold and Defines a Novel Family of Nematode Proteins
Kucera K, Harrison LM, Cappello M, Modis Y. Ancylostoma ceylanicum Excretory–Secretory Protein 2 Adopts a Netrin-Like Fold and Defines a Novel Family of Nematode Proteins. Journal Of Molecular Biology 2011, 408: 9-17. PMID: 21352830, PMCID: PMC3070796, DOI: 10.1016/j.jmb.2011.02.033.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAncylostomaAncylostomatoideaAncylostomiasisAnimalsComplement System ProteinsHelminth ProteinsHumansMatrix MetalloproteinasesMolecular Sequence DataNerve Growth FactorsNetrin-1Protein ConformationProtein FoldingSequence Homology, Amino AcidTissue Inhibitor of MetalloproteinasesTumor Suppressor ProteinsConceptsMatrix metalloproteasesHost immune responseComplement factor C3Nematode proteinsProtein 2Complement-mediated cell lysisHookworm anaemiaMucosal vaccinesImmune responseUseful model organismFactor C3Decoy receptorDisease pathogenesisTissue inhibitorIntestinal attachmentNovel familyAncylostoma ceylanicumImmunoreactive moleculesAdult wormsGlobal healthModel organismsHookwormSequence homologyÅ resolutionHuman parasites185: Impact of acute and chronic inflammatory events on the matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP (TIMP-1) homeostasis in preterm infants with adverse neonatal outcomes
Werner E, Buhimschi I, Han C, Dulay A, Ali U, Thung S, Bahtiyar M, Zhao G, Funai E, Bhandari V, Buhimschi C. 185: Impact of acute and chronic inflammatory events on the matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP (TIMP-1) homeostasis in preterm infants with adverse neonatal outcomes. American Journal Of Obstetrics And Gynecology 2011, 204: s84-s85. DOI: 10.1016/j.ajog.2010.10.201.Peer-Reviewed Original Research
2010
Elevated plasma tissue inhibitor of metalloproteinase‐1 levels predict decreased survival in castration‐resistant prostate cancer patients
Oh W, Vargas R, Jacobus S, Leitzel K, Regan M, Hamer P, Pierce K, Brown‐Shimer S, Carney W, Ali S, Kantoff P, Lipton A. Elevated plasma tissue inhibitor of metalloproteinase‐1 levels predict decreased survival in castration‐resistant prostate cancer patients. Cancer 2010, 117: 517-525. PMID: 20862742, DOI: 10.1002/cncr.25394.Peer-Reviewed Original ResearchConceptsTIMP-1 levelsPlasma TIMP-1 levelsTIMP-1Overall survivalProstate cancerElevated plasma TIMP-1 levelsMetastatic castration-resistant PC patientsCastration-resistant prostate cancer patientsEastern Cooperative Oncology Group performance statusTissue inhibitorCastration-resistant prostate cancerDecreased survivalElevated TIMP-1 levelsCatalytic activity of matrix metalloproteinasesPlasma TIMP-1Castration-resistant PCMedian Follow-UpProstate-specific antigenKaplan-Meier methodPlasma tissue inhibitorProstate cancer patientsActivity of matrix metalloproteinasesCox regression modelsPromotion of angiogenesisEnzyme-linked immunosorbent assay
2007
Upregulation of matrix metalloproteinases and inflammatory mediators are associated with abdominal aortic aneurysm induction in a porcine model
Khare G, Rhee S, Hynecek R, DeRubertis B, Kent K, Faries P. Upregulation of matrix metalloproteinases and inflammatory mediators are associated with abdominal aortic aneurysm induction in a porcine model. The FASEB Journal 2007, 21: a1129-a1129. DOI: 10.1096/fasebj.21.6.a1129-b.Peer-Reviewed Original ResearchAbdominal aortic aneurysmPorcine modelMatrix metalloproteinasesEndovascular treatment strategiesNormal aortic tissueMale Yorkshire swineDays post inductionKey matrix metalloproteinasesCDNA expression profilesAneurysm inductionInflammatory mediatorsGene chip arrayInflammatory cytokinesAortic aneurysmAAA formationLocal perfusionTreatment strategiesAAA pathogenesisMechanical dilationAortic tissueExpression profilesTissue inhibitorAAA tissueYorkshire swineSerine protease levels
2006
Adenosine metabolism and murine strain–specific IL-4–induced inflammation, emphysema, and fibrosis
Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA. Adenosine metabolism and murine strain–specific IL-4–induced inflammation, emphysema, and fibrosis. Journal Of Clinical Investigation 2006, 116: 1274-1283. PMID: 16670768, PMCID: PMC1451205, DOI: 10.1172/jci26372.Peer-Reviewed Original ResearchConceptsIL-4C57BL/6 miceBALB/cAirway fibrosisEosinophilic inflammationAdenosine metabolismEmphysematous alveolar destructionTissue adenosine levelsAdenosine receptor expressionIL-4 inducesAdenosine deaminase activityAlveolar destructionTh1 cytokinesC57BL/6 animalsEmphysematous destructionAdenosine levelsReceptor expressionTg animalsMurine lungMetalloproteinase-2Alveolar remodelingTissue inhibitorFibrosisInflammationPremature deathRole of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling*
Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG. Role of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling*. Journal Of Biological Chemistry 2006, 281: 8161-8168. PMID: 16439363, DOI: 10.1074/jbc.m506770200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar LavageCaspasesCell DeathCollagenDNAEarly Growth Response Protein 1Enzyme InhibitorsFibrosisFlavonoidsImmunoblottingIn Situ Nick-End LabelingInflammationInterleukin-13LungMatrix Metalloproteinase 9MiceMice, Inbred C57BLMice, TransgenicMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Models, BiologicalModels, StatisticalRNARNA, MessengerSTAT6 Transcription FactorTh2 CellsTime FactorsTransforming Growth Factor betaTransforming Growth Factor beta1TransgenesConceptsIL-13Early growth response 1IL-13-induced tissue responsesEgr-1Transgenic IL-13Matrix metalloproteinase-9Wild-type miceResponse 1Th2 inflammationCXC chemokinesMetalloproteinase-9Type miceMetalloproteinase-1Transgenic miceAlveolar remodelingTissue inhibitorInflammationPotent stimulatorImportant stimulatorMiceTissue effectsKey roleTissue responsePathogenesisApoptosis regulator
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