2024
Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3
Yrigoin K, Bernard K, Castaño M, Cleaver O, Sumanas S, Davis G. Enhancing human capillary tube network assembly and maturation through upregulated expression of pericyte-derived TIMP-3. Frontiers In Cell And Developmental Biology 2024, 12: 1465806. PMID: 39544367, PMCID: PMC11560913, DOI: 10.3389/fcell.2024.1465806.Peer-Reviewed Original ResearchTIMP-3Endothelial cellsHuman pericytesPresence of doxycyclineCollagen type IVCo-culture modelIncreasing tube lengthHuman endothelial cellsStabilization networkTissue inhibitorNetwork assemblyPericyte recruitmentCapillary assemblyCo-assemblyType IVUpregulated expressionPericytesCo-CultureTube lengthDoxycycline additionEC-pericyte interactionsTube widthDoxycyclineNetwork of capillary tubesTick-borne infections in children in North America
Taylor-Salmon E, Shapiro E. Tick-borne infections in children in North America. Current Opinion In Pediatrics 2024, 36: 156-163. PMID: 38167816, PMCID: PMC10932821, DOI: 10.1097/mop.0000000000001326.Peer-Reviewed Original Research
2023
Effect of Doxycycline on Progression of Arterial Calcification in the Noninvasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT)
Kim T, Kostiuk V, Olson S, Curci J, Matsumura J, Baxter B, Blackwelder W, Terrin M, Guzman R. Effect of Doxycycline on Progression of Arterial Calcification in the Noninvasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT). Annals Of Vascular Surgery 2023, 104: 1-9. PMID: 37356652, PMCID: PMC10748791, DOI: 10.1016/j.avsg.2023.06.019.Peer-Reviewed Original ResearchAbdominal Aortic Aneurysm Clinical TrialSerum MMP-3MMP-9 levelsArterial calcificationEffect of doxycyclineNon-invasive treatmentMMP-3Clinical trialsTomography scanMatrix metalloproteinasesSmall aortic aneurysmsArtery calcificationBaseline characteristicsPlacebo armCalcium scoreStudy armsAortic aneurysmPreclinical modelsMean changeAbdominal vesselsPatientsIndividual arteriesMatrix degradingDoxycyclineCalcification
2022
Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity
Grada A, Del Rosso J, Moore A, Gold L, Harper J, Damiani G, Shaw K, Obagi S, Salem R, Tanaka S, Bunick C. Reduced blood-brain barrier penetration of acne vulgaris antibiotic sarecycline compared to minocycline corresponds with lower lipophilicity. Frontiers In Medicine 2022, 9: 1033980. PMID: 36569144, PMCID: PMC9773825, DOI: 10.3389/fmed.2022.1033980.Peer-Reviewed Original ResearchAdverse eventsClinical trialsVestibular side effectsBlood-brain barrier penetrationSecond-generation tetracyclineNon-clinical studiesLower ratesH postdosingAcne vulgarisSide effectsMinocyclineBrain samplesPotential associationSarecyclineBarrier penetrationDoxycyclineTrialsLow lipophilicityPenetranceTetracyclineDizzinessVertigoPostdosingRosaceaAcne
2016
Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice
Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6: 32659. PMID: 27619752, PMCID: PMC5020643, DOI: 10.1038/srep32659.Peer-Reviewed Original ResearchConceptsCalcific aortic valve diseaseAortic valve diseaseEffect of doxycyclineWestern dietCAVD progressionMatrix metalloproteinasesValve diseaseMicro-single photon emissionNonselective MMP inhibitorTherapeutic blood levelsLack of effectSingle photon emissionMatrix metalloproteinase inhibitorsGroups of animalsAortic stenosisMedical therapyHyperlipidemic miceEarly diseaseBlood levelsCommon causeTissue analysisMMP activationMMP inhibitionGelatinase activityDoxycyclineDifferential Effects of Azithromycin, Doxycycline, and Cotrimoxazole in Ingested Blood on the Vectorial Capacity of Malaria Mosquitoes
Gendrin M, Yerbanga R, Ouedraogo J, Lefèvre T, Cohuet A, Christophides G. Differential Effects of Azithromycin, Doxycycline, and Cotrimoxazole in Ingested Blood on the Vectorial Capacity of Malaria Mosquitoes. Open Forum Infectious Diseases 2016, 3: ofw074. PMID: 27419152, PMCID: PMC4943539, DOI: 10.1093/ofid/ofw074.Peer-Reviewed Original ResearchIngested bloodMass drug administration programsMosquito lifespanEffect of doxycyclineDrug administration programsMosquito vectorial capacityAntibiotic treatmentMosquito microbiotaPlasmodium infectionBlood meal supplementationInfection loadVectorial capacityGut microbiotaMalaria transmissionAzithromycinMalaria parasitesPlasmodium falciparumDisease eliminationDoxycyclineMalaria vector mosquitoesAntibioticsBlood mealDifferential effectsInfection intensityMicrobiota
2015
Vegetative pyoderma gangrenosum.
Kim R, Lewin J, Hale C, Meehan S, Stein J, Ramachandran S. Vegetative pyoderma gangrenosum. Dermatology Online Journal 2015, 20 PMID: 25526339, DOI: 10.5070/d32012025060.Peer-Reviewed Original ResearchConceptsPyoderma gangrenosumSteroid-sparing immunosuppressantsIgA monoclonal gammopathyPrior surgical siteUrinary protein electrophoresisGangrenosum lesionsIntralesional glucocorticoidsSystemic glucocorticoidsSuperficial variantSystemic diseaseVegetative lesionsMonoclonal gammopathyGangrenosumSurgical siteShort courseLesionsPatientsGlucocorticoidsProtein electrophoresisPrednisoneGammopathyImmunosuppressantsMinocyclineDiseaseDoxycycline
2006
Human Neutrophil Calprotectin Reduces the Susceptibility of Borrelia burgdorferi to Penicillin
Montgomery RR, Schreck K, Wang X, Malawista SE. Human Neutrophil Calprotectin Reduces the Susceptibility of Borrelia burgdorferi to Penicillin. Infection And Immunity 2006, 74: 2468-2472. PMID: 16552081, PMCID: PMC1418918, DOI: 10.1128/iai.74.4.2468-2472.2006.Peer-Reviewed Original ResearchConceptsClearance of spirochetesB. burgdorferiSites of inflammationTherapeutic dosesCalprotectinGrowth of spirochetesLeukocyte componentsNeutrophil calprotectinAntibiotic sensitivitySpirochetal agentLyme diseaseTherapeutic antibioticsBorrelia burgdorferiPenicillin GProtein calprotectinInflammationBurgdorferiSpirochetesDiseaseDoxycyclineDosesClearance
2003
Successful Treatment of Human Granulocytic Ehrlichiosis in Children Using Rifampin
Krause PJ, Corrow CL, Bakken JS. Successful Treatment of Human Granulocytic Ehrlichiosis in Children Using Rifampin. 2003, 112: e252-e253. PMID: 12949322, DOI: 10.1542/peds.112.3.e252.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisYears of ageSuccessful treatmentGranulocytic ehrlichiosisTick-borne infectious diseaseFlu-like illnessTreatment of choiceHospital admissionClinical featuresSerious infectionsInfectious diseasesPhagocytophilum infectionRifampinAnaplasma phagocytophilumPermanent stainingChildrenInfectionTreatmentEhrlichiosisAgeYearsAdmissionIllnessDiseaseDoxycycline
2001
Prophylaxis with Single-Dose Doxycycline for the Prevention of Lyme Disease after an Ixodes scapularis Tick Bite
Nadelman R, Nowakowski J, Fish D, Falco R, Freeman K, McKenna D, Welch P, Marcus R, Agüero-Rosenfeld M, Dennis D, Wormser G. Prophylaxis with Single-Dose Doxycycline for the Prevention of Lyme Disease after an Ixodes scapularis Tick Bite. New England Journal Of Medicine 2001, 345: 79-84. PMID: 11450675, DOI: 10.1056/nejm200107123450201.Peer-Reviewed Original ResearchConceptsDose of doxycyclineTick biteLyme diseaseErythema migransSingle-dose doxycyclinePlacebo-controlled trialFrequent adverse effectsMore frequent adverse effectsEfficacy of treatmentSerum antibody testsNymphal ticksAsymptomatic seroconversionPlacebo groupDoxycycline groupBlood culturesDegree of engorgementExtracutaneous signsI. scapularis ticksAntibody testAntimicrobial treatmentDiseaseAdverse effectsDoxycyclineBiteBorrelia burgdorferiUse of the Tetracycline-controlled Transcriptional Silencer (tTS) to Eliminate Transgene Leak in Inducible Overexpression Transgenic Mice*
Zhu Z, Ma B, Homer R, Zheng T, Elias J. Use of the Tetracycline-controlled Transcriptional Silencer (tTS) to Eliminate Transgene Leak in Inducible Overexpression Transgenic Mice*. Journal Of Biological Chemistry 2001, 276: 25222-25229. PMID: 11331286, DOI: 10.1074/jbc.m101512200.Peer-Reviewed Original ResearchConceptsIL-13Reverse tetracycline transactivatorIL-13 productionTetracycline-controlled transcriptional silencerOverexpression transgenic miceTransgene expressionMucus metaplasiaLung volumeAlveolar enlargementDOX administrationDoxycycline administrationTransgenic miceParental miceMiceCC10 promoterDoxycyclineTetracycline transactivatorBase lineAdministrationPhenotypeVivo
1997
Trospectomycin in acute pelvic inflammatory disease: a preliminary report
Chatwani A, Dandalou V, Harmanli O, Nyirjesy P. Trospectomycin in acute pelvic inflammatory disease: a preliminary report. Infectious Diseases In Obstetrics And Gynecology 1997, 5: 215-218. DOI: 10.1002/(sici)1098-0997(1997)5:3<215::aid-idog4>3.0.co;2-o.Peer-Reviewed Original ResearchAcute pelvic inflammatory diseasePelvic inflammatory diseaseTreatment of womenInpatient treatmentCefoxitin/doxycyclineSingle-agent therapyGroup of patientsSingle-blind studyOverall success rateIntravenous cefoxitinIntravenous doxycyclineOral doxycyclineClinical responseClinical efficacyInflammatory diseasesChlamydia trachomatisSide effectsTrospectomycinPatientsClinical diagnosisDoxycyclineCefoxitinSuccess rateAppropriate culturesTreatmentTrospectomycin in Acute Pelvic Inflammatory Disease: A Preliminary Report
Chatwani A, Dandalou V, Harmanli O, Nyirjesy P. Trospectomycin in Acute Pelvic Inflammatory Disease: A Preliminary Report. Infectious Diseases In Obstetrics And Gynecology 1997, 5: 215-218. PMID: 18476139, PMCID: PMC2364539, DOI: 10.1155/s1064744997000355.Peer-Reviewed Original ResearchAcute pelvic inflammatory diseasePelvic inflammatory diseaseTreatment of womenInflammatory diseasesInpatient treatmentCefoxitin/doxycyclineSingle-agent therapyGroup of patientsSingle-blind studyOverall success rateIntravenous cefoxitinIntravenous doxycyclineOral doxycyclineClinical responseClinical efficacyChlamydia trachomatisSide effectsTrospectomycinPatientsClinical diagnosisDoxycyclineCefoxitinPreliminary reportSuccess rateAppropriate cultures
1996
Control of endemic glycopeptide-resistant enterococci.
Dembry LM, Uzokwe K, Zervos MJ. Control of endemic glycopeptide-resistant enterococci. Infection Control And Hospital Epidemiology 1996, 17: 286-92. PMID: 8727617, DOI: 10.1086/647297.Peer-Reviewed Original ResearchConceptsVancomycin-resistant EnterococcusRenal unitsEradication of carriageVRE stool colonizationCommunity teaching hospitalPatient carriageBarrier precautionsOral doxycyclineFurther patientsStool colonizationGlycopeptide-resistant enterococciCulture surveyTeaching hospitalPatientsStudy periodEnterococcus faeciumEnterococcus gallinarumCarriageRifampinDoxycyclineEnterococcusControl measuresDaysUseful measureHospitalControl of Endemic Glycopeptide-Resistant Enterococci
Dembry L, Uzokwe K, Zervos M. Control of Endemic Glycopeptide-Resistant Enterococci. Infection Control And Hospital Epidemiology 1996, 17: 286-292. DOI: 10.2307/30141928.Peer-Reviewed Original ResearchVancomycin-resistant EnterococcusRenal unitsEradication of carriageVRE stool colonizationCommunity teaching hospitalPatient carriageBarrier precautionsOral doxycyclineFurther patientsStool colonizationGlycopeptide-resistant enterococciCulture surveyTeaching hospitalPatientsStudy periodEnterococcus faeciumEnterococcus gallinarumEnterococcus faecalisCarriageRifampinDoxycyclineEnterococcusControl measuresDaysUseful measure
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