2010
Elevated plasma tissue inhibitor of metalloproteinase‐1 levels predict decreased survival in castration‐resistant prostate cancer patients
Oh W, Vargas R, Jacobus S, Leitzel K, Regan M, Hamer P, Pierce K, Brown‐Shimer S, Carney W, Ali S, Kantoff P, Lipton A. Elevated plasma tissue inhibitor of metalloproteinase‐1 levels predict decreased survival in castration‐resistant prostate cancer patients. Cancer 2010, 117: 517-525. PMID: 20862742, DOI: 10.1002/cncr.25394.Peer-Reviewed Original ResearchConceptsTIMP-1 levelsPlasma TIMP-1 levelsTIMP-1Overall survivalProstate cancerElevated plasma TIMP-1 levelsMetastatic castration-resistant PC patientsCastration-resistant prostate cancer patientsEastern Cooperative Oncology Group performance statusTissue inhibitorCastration-resistant prostate cancerDecreased survivalElevated TIMP-1 levelsCatalytic activity of matrix metalloproteinasesPlasma TIMP-1Castration-resistant PCMedian Follow-UpProstate-specific antigenKaplan-Meier methodPlasma tissue inhibitorProstate cancer patientsActivity of matrix metalloproteinasesCox regression modelsPromotion of angiogenesisEnzyme-linked immunosorbent assay
2007
Elevated plasma TIMP-1 levels predict reduced survival in metastatic hormone-refractory prostate cancer patients
Oh W, Leitzel K, Kantoff P, Regan M, Hamer P, Pierce K, Brown-Shimer S, Carney W, Ali S, Lipton A. Elevated plasma TIMP-1 levels predict reduced survival in metastatic hormone-refractory prostate cancer patients. Journal Of Clinical Oncology 2007, 25: 5143-5143. DOI: 10.1200/jco.2007.25.18_suppl.5143.Peer-Reviewed Original ResearchTIMP-1 levelsPlasma TIMP-1 levelsTime of blood collectionPlasma TIMP-1Androgen deprivation therapyProstate cancer patientsTIMP-1Overall survivalBlood collectionMetastatic hormone-refractory prostate cancer patientsElevated plasma TIMP-1 levelsHormone-refractory prostate cancer patientsCancer patientsCohort of prostate cancer patientsHormone-refractory prostate cancerMedian Follow-UpKaplan-Meier methodHead and neckReduced overall survivalPrognostic biomarker potentialTIMP-1 ELISAReduced survivalIncreased TIMP-1Activity of MMPsInhibition of apoptosis
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