Autoantibody mimicry of hormone action at the thyrotropin receptor
Faust B, Billesbølle C, Suomivuori C, Singh I, Zhang K, Hoppe N, Pinto A, Diedrich J, Muftuoglu Y, Szkudlinski M, Saghatelian A, Dror R, Cheng Y, Manglik A. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature 2022, 609: 846-853. PMID: 35940205, PMCID: PMC9678024, DOI: 10.1038/s41586-022-05159-1.Peer-Reviewed Original ResearchConceptsExtracellular domainMembrane bilayerCryo-electron microscopy structureGraves' diseaseGlycoprotein hormone receptorsTSHR extracellular domainG protein-coupled receptorsSteric clashesThyroid hormone synthesisConformational changesThyrotropin receptorHormone synthesisReceptor activationAutoantibodiesHormone receptorsThyroid hormonesThyrotropinTSHRHormone actionThyroidReceptors
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