2024
Intrathecal Injection of Newborn Mouse for Genome Editing and Drug Delivery.
Lu X, Jiang Y. Intrathecal Injection of Newborn Mouse for Genome Editing and Drug Delivery. Journal Of Visualized Experiments 2024 PMID: 38526075, DOI: 10.3791/65761.Peer-Reviewed Original ResearchConceptsIntrathecal injectionNewborn miceNeonatal pupsInjection of newborn miceReducing systemic side effectsSystemic side effectsPostnatal day 1Local drug concentrationCentral nervous systemDelivery of drugsPotential therapeutic interventionsNeonatal micePreclinical studiesDay 1Newborn pupsSide effectsCerebrospinal fluidDrug concentrationsAdult clinicIntramuscular injectionNervous systemTherapeutic interventionsClinical settingNon-human primatesAccurate delivery
2023
Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function
Vamesu B, Nicola T, Li R, Hazra S, Matalon S, Kaminski N, Ambalavanan N, Kandasamy J. Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function. JCI Insight 2023, 8: e160697. PMID: 36917181, PMCID: PMC10243814, DOI: 10.1172/jci.insight.160697.Peer-Reviewed Original ResearchConceptsUmbilical cord-derived mesenchymal stem cellsNeonatal lung injuryMild bronchopulmonary dysplasiaSevere bronchopulmonary dysplasiaBronchopulmonary dysplasiaLung injuryELBW infantsThyroid hormonesLung homogenatesMitochondrial dysfunctionTotal T4Newborn miceLow birth weight infantsMitochondrial functionNeonatal hyperoxic lung injuryPeroxisome proliferator-activated receptor γ coactivator 1αProliferator-activated receptor γ coactivator 1αHyperoxic lung injuryReceptor γ coactivator 1αLow total T4Murine lung fibroblastsΓ coactivator 1αNeonatal hypothyroxinemiaWeight infantsPulmonary fibrosis
2019
Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function
Wang SB, Xu T, Peng S, Singh D, Ghiassi-Nejad M, Adelman RA, Rizzolo LJ. Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function. Communications Biology 2019, 2: 113. PMID: 30937396, PMCID: PMC6433901, DOI: 10.1038/s42003-019-0355-0.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumClaudin-19Retinal neurogenesisP1 waveOuter nuclear layerRPE signature genesARPE19 cell lineOcular involvementKidney diseaseVisual functionFamilial hypomagnesaemiaNuclear layerBipolar cellsNewborn miceOcular diseasesPigment epitheliumRetinal isomeraseDiseaseMiceHuman induced pluripotent cellsRetinal differentiationSignature genesCell linesNeurogenesisInduced pluripotent cells
2017
Zika Virus Targeting in the Developing Brain
van den Pol AN, Mao G, Yang Y, Ornaghi S, Davis JN. Zika Virus Targeting in the Developing Brain. Journal Of Neuroscience 2017, 37: 2161-2175. PMID: 28123079, PMCID: PMC5338758, DOI: 10.1523/jneurosci.3124-16.2017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntiviral AgentsBrainCell Line, TransformedCells, CulturedDisease Models, AnimalGene Expression Regulation, ViralHumansImmunocompromised HostInterferonsMental DisordersMiceMice, TransgenicNervous System DiseasesNeurogliaNeuronsReceptors, InterferonZika VirusZika Virus InfectionConceptsZika virusPeripheral inoculationZIKV infectionSomatosensory cortexType 1 interferon responseContralateral somatosensory cortexSecond trimester human fetusesEarly neonatal stageDay of birthNormal mouse brainSerious neurological problemsMidline brain regionsDevelopmental mouse modelAstrocyte infectionRNA flavivirusInfected astrocytesCortical thinningOptic tractImmunocompetent miceLateral geniculateRetinal neuronsGlial cellsMouse modelNeurological problemsNewborn mice
2016
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
Nonomura K, Woo S, Chang R, Gillich A, Qiu Z, Francisco A, Ranade S, Liberles S, Patapoutian A. Piezo2 senses airway stretch and mediates lung inflation-induced apnoea. Nature 2016, 541: 176-181. PMID: 28002412, PMCID: PMC5267560, DOI: 10.1038/nature20793.Peer-Reviewed Original ResearchConceptsSensory neuronsAdult miceSensory neurons of adult miceHering-BreuerPiezo2-mediated mechanotransductionNeurons of adult miceVagal sensory neuronsIncreased tidal volumeResponse to lung inflationSleep apnoeaPerinatal mortalityNewborn miceMechanisms of respiratory controlRespiratory distressRespiratory dysfunctionOptogenetic activationNodose ganglionTidal volumeAirway stretchApnoeaNormal breathingMicePiezo2Lung inflationInducible ablation
2012
Transmission of mouse parvovirus to neonatal mice.
Compton SR, Paturzo FX, Macy JD. Transmission of mouse parvovirus to neonatal mice. Journal Of The American Association For Laboratory Animal Science 2012, 51: 797-802. PMID: 23294886, PMCID: PMC3508184.Peer-Reviewed Original Research
2008
Autoimmune syndrome after induction of neonatal tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunity
Merino J, Schurmans S, Wen L, Brighouse G, Luzuy S, Lambert P. Autoimmune syndrome after induction of neonatal tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunity. Clinical & Experimental Immunology 2008, 79: 273-278. PMID: 1968797, PMCID: PMC1534764, DOI: 10.1111/j.1365-2249.1990.tb05190.x.Peer-Reviewed Original ResearchConceptsDonor T cellsF1 donor B cellsDonor B cellsT cell subsetsAutoimmune syndromeF1 cellsT cellsNeonatal toleranceCell subsetsSpleen cellsNewborn miceB cellsBALB/c newborn miceMature donor T cellsDifferent T cell subsetsAutoreactive B cell clonesBALB/c miceLupus-like syndromeDeposits of immunoglobulinsF1 spleen cellsInduction of autoimmunityAnti-Sm antibodiesB cell clonesCTL alloreactivityTolerant mice
2006
Engraftment of Donor‐Derived Epithelial Cells in Multiple Organs Following Bone Marrow Transplantation into Newborn Mice
Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. Engraftment of Donor‐Derived Epithelial Cells in Multiple Organs Following Bone Marrow Transplantation into Newborn Mice. Stem Cells 2006, 24: 2299-2308. PMID: 16794262, DOI: 10.1634/stemcells.2006-0166.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBone Marrow TransplantationCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsFemaleFluorescent Antibody TechniqueHematopoietic Stem Cell TransplantationIn Situ Hybridization, FluorescenceMaleMiceMice, Inbred C57BLMice, Inbred StrainsMice, TransgenicRNA, MessengerY ChromosomeConceptsBone marrow-derived cellsMarrow-derived epithelial cellsBone marrow transplantationNewborn miceEpithelial cellsMarrow transplantationGI tractBone marrow-derived epithelial cellsDonor-derived epithelial cellsDoses of busulfanMarrow-derived cellsEngraftment of donorIrradiated adult recipientsMyeloablative regimenPreparative regimenAdult recipientsDifferent regimensEngrafted miceHematopoietic engraftmentGastrointestinal tractSurvival advantageTherapeutic benefitAdult miceMultiple organsBone marrow
1980
Western Equine Encephalitis Mimicking Herpes Simplex Encephalitis
Bia F, Thornton G, Main A, Fong C, Hsiung GD. Western Equine Encephalitis Mimicking Herpes Simplex Encephalitis. JAMA 1980, 244: 367-369. PMID: 7190194, DOI: 10.1001/jama.1980.03310040049029.Peer-Reviewed Case Reports and Technical NotesConceptsHerpes simplex encephalitisBrain biopsy tissueSimplex encephalitisBrain biopsySevere encephalitisFocal findingsTherapeutic responsePatient's conditionNewborn miceAntiviral agentsBiopsy tissueEncephalitisLaboratory diagnosisWestern equine encephalitisMurine coronavirusHuman illnessEquine encephalitisDiagnostic virologyTissue culturePatientsBiopsyVidarabineIllnessMiceDiagnosis
1971
Cell Interactions in the Graft-versus-Host Response
ASOFSKY R, CANTOR H, TIGELAAR R. Cell Interactions in the Graft-versus-Host Response. 1971, 369-381. DOI: 10.1016/b978-0-12-057550-3.50034-x.Peer-Reviewed Original ResearchThymus cellsBlood lymphocytesHost responseParental strain miceBALB/cAnNCell interactionsDonor of cellsPeripheral bloodFemoral arteryLeukocyte numbersStrain miceBlood leukocytesNewborn miceAdult miceHybrid miceMiceLymphocytesGraftRecovered cellsCellsCombination of cellsDextran solutionCell suspensionsArterySpleen
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