2024
12611 The Thyroid Adapts Remarkably to Overnutrition to Mitigate Hypothyroidism
Rampy J, Manzo A, Hoffsmith K, Loberg M, Wang H, Weiss V, Carrasco N. 12611 The Thyroid Adapts Remarkably to Overnutrition to Mitigate Hypothyroidism. Journal Of The Endocrine Society 2024, 8: bvae163.2092. PMCID: PMC11453901, DOI: 10.1210/jendso/bvae163.2092.Peer-Reviewed Original ResearchThyroid-stimulating hormoneThyroid-stimulating hormone stimulationPathogenesis of obesityThyroid hormonesTH levelsThyroid functionTH availabilityIncreased thyroid-stimulating hormoneMatching energy intakeDiet-induced weight gainSerum TH levelsWeight lossMale C57BL/6J miceER stress-related proteinsHigh-fat dietMild hypothyroidismThyroid impairmentStimulating hormoneFemale miceHypothyroid stateC57BL/6J miceAdrenomedullin 2Whole-body energy balanceVascular changesEnergy intake
2016
A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo
Wong J, Krueger K, Costa M, Aggarwal A, Du H, McLaughlin T, Feldman B. A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo. Science Signaling 2016, 9: ra103. PMID: 27811141, PMCID: PMC8087215, DOI: 10.1126/scisignal.aag0487.Peer-Reviewed Original ResearchConceptsDifferentiation of adipocyte precursor cellsAdipocyte precursor cellsCell activity in vivoAdipose depotsADAMTS1 expressionDiet-induced weight gainAdipose tissueInguinal adipose depotsAdipocyte differentiation programExcess caloric intakeExtracellular protease ADAMTS1Pathogenesis of obesityAdipose tissue hyperplasiaExposure in vitroExpansion of adipose tissueWnt target genesWnt/b-catenin pathwayAdipose tissue homeostasisExpression of ADAMTS1High-fat dietSubcutaneous adipose tissueMouse subcutaneous adipose tissueSubcutaneous adipose depotsCaloric intakeTranscription factors
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