2024
Temporal biomarker concentration patterns during the early course of acute coronary syndrome
Eggers K, Batra G, Lindahl B, Lakic T, Lindbäck J, Budaj A, Cornel J, Giannitsis E, Katus H, Storey R, Becker R, Siegbahn A, Wallentin L. Temporal biomarker concentration patterns during the early course of acute coronary syndrome. Clinical Chemistry And Laboratory Medicine 2024, 62: 1167-1176. PMID: 38341860, DOI: 10.1515/cclm-2023-1253.Peer-Reviewed Original ResearchAcute coronary syndromeST-elevation myocardial infarctionSymptom onsetNSTE-ACSHs-cTnTGDF-15Concentrations of high-sensitivity cardiac troponin TNon-ST-elevation acute coronary syndromeHigh-sensitivity cardiac troponin TPro-B-type natriuretic peptideBiomarker patternsAcute coronary syndrome patientsGrowth differentiation factor 15Cardiac troponin TC-reactive proteinPathophysiological processesBiomarker concentrationsClinically useful informationPlatelet inhibitionNatriuretic peptideHs-cTnICoronary syndromeTroponin TEarly courseAssociated with time
2021
Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children
Greenberg JH, Abraham AG, Xu Y, Schelling JR, Feldman HI, Sabbisetti VS, Ix JH, Jogalekar MP, Coca S, Waikar SS, Shlipak MG, Warady BA, Vasan RS, Kimmel PL, Bonventre JV, Denburg M, Parikh CR, Furth S, Consortium O. Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children. Journal Of The American Society Of Nephrology 2021, 32: 2664-2677. PMID: 34544821, PMCID: PMC8722795, DOI: 10.1681/asn.2021010094.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlbuminuriaAlpha-GlobulinsBiomarkersChemokine CCL2ChildChitinase-3-Like Protein 1CreatinineDisease ProgressionEpidermal Growth FactorFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney TubulesMaleNephritisProspective StudiesRenal Insufficiency, ChronicConceptsUrine KIM-1CKD progressionUrine biomarkersMicroglobulin concentrationsHighest quartileKIM-1MCP-1High riskRapid kidney function declineBiomarker concentrationsEGF concentrationsKidney tubule healthNovel urine biomarkersUrine biomarker concentrationsKidney function declineProgression of CKDUrine creatinine concentrationIdentification of childrenTubular healthMultivariable adjustmentComposite outcomeTubular injuryPrimary outcomeFunction declineStudy enrollment
2019
Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients
Kukova LZ, Mansour SG, Coca SG, de Fontnouvelle CA, Thiessen-Philbrook HR, Shlipak MG, El-Khoury JM, Parikh CR. Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients. The Journal Of Applied Laboratory Medicine 2019, 4: 331-342. PMID: 31659071, DOI: 10.1373/jalm.2018.028621.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsSurgery patientsCardiac surgeryBiomarker concentrationsAcute kidney injuryComparison of urinePlasma biomarker concentrationsImmunoassay methodPostoperative biomarkersPostoperative plasmaPreoperative biomarkersKidney injuryInjury cohortBiomarker discoveryBiomarker endpointsClinical settingCurrent immunoassay methodsBiomarker valuesUrine samplesTranslational researchUrineSpearman correlationPaired samplesPatientsSurgeryA repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Calafat A, Cordero J, Meeker J. A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort. Environmental Health 2019, 18: 28. PMID: 30940137, PMCID: PMC6444601, DOI: 10.1186/s12940-019-0459-5.Peer-Reviewed Original ResearchConceptsUrinary biomarkersAssociated with adverse birth outcomesAdverse birth outcomesPregnant womenBirth outcomesAdverse outcomesSerum hormonesStudy visitsParaben biomarkersThyroid hormonesParaben exposurePercent changeHormoneBiomarker concentrationsMaternal hormonesBiomarkersOutcomesVisitsAssociationExposureGestationRandom interceptPregnancyThyroid
2018
The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environmental Research 2018, 169: 41-51. PMID: 30412856, PMCID: PMC6347499, DOI: 10.1016/j.envres.2018.10.030.Peer-Reviewed Original ResearchConceptsAssociated with gestational ageGestational ageOdds of SGAInfant sexBirth outcomesStudy visitsVisit 1Odds of preterm birthOdds of LGAAssociated with adverse birth outcomesBirthweight z-scoreBiomarker concentrationsAdverse birth outcomesPuerto Rico TestsitePreterm birthPregnant womenBirth weightUrinary biomarker concentrationsExposure biomarkersLogistic regression modelsVisit 3SGADecreased oddsZ-scoreCalculate odds
2017
Urinalysis findings and urinary kidney injury biomarker concentrations
Nadkarni GN, Coca SG, Meisner A, Patel S, Kerr KF, Patel UD, Koyner JL, Garg AX, Philbrook HT, Edelstein CL, Shlipak M, El-Khoury J, Parikh CR, on behalf of the TRIBE-AKI Consortium Investigators. Urinalysis findings and urinary kidney injury biomarker concentrations. BMC Nephrology 2017, 18: 218. PMID: 28683730, PMCID: PMC5499057, DOI: 10.1186/s12882-017-0629-z.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Post-operative samplesKidney injuryUrinalysis findingsUrinary biomarkersBiomarker concentrationsPost-operative AKIPre-operative samplesUrine dipstick testingPost-operative time pointsInjury molecule-1Time pointsRenal tubular damageUrinary biomarker concentrationsUrinary biomarker levelsTRIBE-AKI cohortLiver fatty acidClinical AKIDipstick proteinuriaProteinuria concentrationsUrinary NGALAKI biomarkersTubular damageCardiac surgeryNeutrophil gelatinase
2016
Associations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function
Parikh C, Hall I, Bhangoo R, Ficek J, Abt P, Thiessen-Philbrook H, Lin H, Bimali M, Murray P, Rao V, Schröppel B, Doshi M, Weng F, Reese P. Associations of Perfusate Biomarkers and Pump Parameters With Delayed Graft Function and Deceased Donor Kidney Allograft Function. American Journal Of Transplantation 2016, 16: 1526-1539. PMID: 26695524, PMCID: PMC4844819, DOI: 10.1111/ajt.13655.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsBiomarkersCadaverDelayed Graft FunctionFemaleFollow-Up StudiesHumansHypothermia, InducedKidney Failure, ChronicKidney Function TestsKidney TransplantationMaleMiddle AgedOrgan PreservationPerfusionPrognosisProspective StudiesTime FactorsTissue and Organ ProcurementTissue DonorsConceptsDelayed graft functionHypothermic machine perfusionTransplanted kidneysAllograft functionGraft functionPerfusate biomarkersDeceased donor kidney transplantationKidney allograft functionL-FABP concentrationDonor kidney transplantationHigher NGALKidney transplantationKidney qualityMachine perfusionOrgan qualityBiomarker levelsMost recipientsBiomarker concentrationsPerfusion biomarkersKidneyAdditional studiesBiomarkersEGFRRecipientsMedian resistance
2013
Approach to Cerebrospinal Fluid (CSF) Biomarker Discovery and Evaluation in HIV Infection
Price RW, Peterson J, Fuchs D, Angel TE, Zetterberg H, Hagberg L, Spudich S, Smith RD, Jacobs JM, Brown JN, Gisslen M. Approach to Cerebrospinal Fluid (CSF) Biomarker Discovery and Evaluation in HIV Infection. Journal Of Neuroimmune Pharmacology 2013, 8: 1147-1158. PMID: 23943280, PMCID: PMC3889225, DOI: 10.1007/s11481-013-9491-3.Peer-Reviewed Original ResearchConceptsHIV infectionCentral nervous system infectionSystemic HIV infectionNervous system infectionCNS disease progressionCerebrospinal fluid biomarkersCross-sectional studyInteraction of HIVCSF biomarker studiesCNS infectionsDisease activitySystem infectionAntiretroviral treatmentClinical stagingNeural injuryCSF biomarkersNeurological consequencesFluid biomarkersDisease progressionMore accurate diagnosisNeuropsychological test performanceNovel biomarkersAccurate diagnosisBiomarker concentrationsInfection
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