2025
Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab
Foss F, Kim Y, Scarisbrick J, Akilov O, Ristuccia R, Dwyer K, Wu W, Bagot M. Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab. Journal Of Dermatological Treatment 2025, 36: 2438794. PMID: 39894454, DOI: 10.1080/09546634.2024.2438794.Peer-Reviewed Original ResearchConceptsMogamulizumab-associated rashConcomitant steroid useSezary syndromeAdvanced diseaseMycosis fungoidesSteroid useResponse to mogamulizumabProportion of patientsPercentage of patientsTreatment of patientsConcomitant steroidsRelapsed/refractory patientsLong-term responseMogamulizumabNext treatmentPatient characteristicsPatientsLymphopeniaVorinostatPatient responseFungoidesPFSMycosisSyndromeTreatment
2022
Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome
Zehentmeier S, Lim VY, Ma Y, Fossati J, Ito T, Jiang Y, Tumanov AV, Lee HJ, Dillinger L, Kim J, Csomos K, Walter JE, Choi J, Pereira JP. Dysregulated stem cell niches and altered lymphocyte recirculation cause B and T cell lymphopenia in WHIM syndrome. Science Immunology 2022, 7: eabo3170. PMID: 36149943, PMCID: PMC9614684, DOI: 10.1126/sciimmunol.abo3170.Peer-Reviewed Original ResearchConceptsSecondary lymphoid organsWHIM syndromeMesenchymal stem cellsInterleukin-7B lymphopeniaBone marrowBM mesenchymal stem cellsT cell numbersIL-7 productionT-cell lymphopeniaLymphotoxin beta receptorEarly progenitor stageLymphoid organsCell lymphopeniaMouse modelBeta receptorsB cellsB cell developmentLymphopeniaStromal cellsLeukocyte retentionSyndromeGOF mutationsLymphopoietic activityCritical pathwaysCoagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19
Wang J, Kotagiri P, Lyons PA, Al-Lamki RS, Mescia F, Bergamaschi L, Turner L, Morgan MD, Calero-Nieto FJ, Bach K, Mende N, Wilson NK, Watts ER, Collaboration C, Maxwell PH, Chinnery PF, Kingston N, Papadia S, Stirrups KE, Walker N, Gupta RK, Menon DK, Allinson K, Aitken SJ, Toshner M, Weekes MP, Nathan JA, Walmsley SR, Ouwehand WH, Kasanicki M, Göttgens B, Marioni JC, Smith KGC, Pober JS, Bradley JR. Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19. IScience 2022, 25: 103971. PMID: 35224470, PMCID: PMC8863325, DOI: 10.1016/j.isci.2022.103971.Peer-Reviewed Original ResearchFactor VSuppress T-cell proliferationCOVID-19 lung diseasePeripheral blood mononuclear cellsCOVID-19Severe COVID-19Blood mononuclear cellsT-cell lymphopeniaT-cell inhibitorsT cell proliferationAdaptive immune systemHospitalized patientsRegulatory cellsLung diseaseMononuclear cellsDisease correlateCoagulation factor VImmune systemLeukocytesNeutrophilsFV expressionFactor VaLymphopeniaCellsPatients
2020
SARS-CoV-2: A Storm is Raging
Pedersen SF, Ho YC. SARS-CoV-2: A Storm is Raging. Journal Of Clinical Investigation 2020, 130: 2202-2205. PMID: 32217834, PMCID: PMC7190904, DOI: 10.1172/jci137647.Peer-Reviewed Original ResearchConceptsSevere COVID-19Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2COVID-19Respiratory syndrome coronavirus 2Syndrome coronavirus 2IFN-γ expressionCoronavirus infectious diseaseCytokine levelsCytokine stormRespiratory distressCoronavirus 2Immune therapeuticsUnfavorable outcomeT cellsImmunological characteristicsVaccine designInfectious diseasesLymphopeniaCD4AdmissionDisease
2017
Idiopathic T cell lymphopenia identified in New York State Newborn Screening
Albin-Leeds S, Ochoa J, Mehta H, Vogel BH, Caggana M, Bonagura V, Lehman H, Ballow M, Rubinstein A, Siegel S, Weiner L, Weinberg GA, Cunningham-Rundles C. Idiopathic T cell lymphopenia identified in New York State Newborn Screening. Clinical Immunology 2017, 183: 36-40. PMID: 28694137, PMCID: PMC5736366, DOI: 10.1016/j.clim.2017.07.002.Peer-Reviewed Original ResearchConceptsT-cell receptor excision circlesT-cell lymphopeniaCD3 countsCell lymphopeniaLow T cell receptor excision circlesIdiopathic T-cell lymphopeniaAbsolute CD3 countState referral centerOutcomes of patientsAppropriate laboratory monitoringT cell valuesIdentification of infantsClinical characteristicsMost patientsReferral centerAdditional infantsRetrospective reviewExcision circlesLaboratory monitoringState newborn screeningImmune deficiencyNewborn screeningInfantsLymphopeniaPatients
2009
MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival
Wang X, Chang X, Facchinetti V, Zhuang Y, Su B. MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival. The Journal Of Immunology 2009, 182: 3597-3608. PMID: 19265138, PMCID: PMC2923428, DOI: 10.4049/jimmunol.0803738.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationCell SurvivalCells, CulturedGene Knock-In TechniquesHomeostasisLymphopeniaMAP Kinase Kinase Kinase 3MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Thymus GlandConceptsT cell proliferationT cell homeostasisT cellsCell proliferationPeripheral T cell numbersSelf-peptide MHCTCR stimulationT cell immunityT cell numbersThymic T cell developmentConditional knockout miceCell homeostasisT cell developmentCell immunityActivity of ERK1/2Knockout miceConditional ablationPeptide-MHCP38 MAPKLymphopeniaCell numberSignificant reductionCell developmentSelective roleProliferation
2005
Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients
Schwab SR, Pereira J, Matloubian M, Xu Y, Huang Y, Cyster JG. Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients. Science 2005, 309: 1735-1739. PMID: 16151014, DOI: 10.1126/science.1113640.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde-LyasesAnimalsB-LymphocytesChemotaxis, LeukocyteEnzyme InhibitorsFood Coloring AgentsHematopoietic Stem CellsImidazolesImmunosuppressive AgentsLymphLymph NodesLymphoid TissueLymphopeniaLysophospholipidsMiceMice, Inbred C57BLPyridoxineReceptors, LysosphingolipidRNA InterferenceSphingosineT-LymphocytesThymus GlandVitamin B 6
1986
Effects of Cyclosporine and Cortisone on the Pathogenesis of Primary Infection with Cytomegalovirus in the Guinea Pig
MacGregor M, Lucia H, Vine W, FitzGerald P, Bia F. Effects of Cyclosporine and Cortisone on the Pathogenesis of Primary Infection with Cytomegalovirus in the Guinea Pig. The Journal Of Infectious Diseases 1986, 153: 503-510. PMID: 3005426, DOI: 10.1093/infdis/153.3.503.Peer-Reviewed Original ResearchConceptsPrimary infectionGuinea pigsTissue culture infectious dosesEffect of cyclosporineGuinea pig modelRate of isolationGuinea pig cytomegalovirusOral CsAImmunosuppressive agentsInflammatory responseInfectious dosesViral inclusionsPig modelDay 14Day 0CortisoneCytomegalovirusMinimal inflammatory responseCsALymphopeniaPathogenesisInfectionUntreated controlsAnimalsTissue
1983
Immunodeficiency in Female Sexual Partners of Men with the Acquired Immunodeficiency Syndrome
Harris C, Small C, Klein R, Friedland G, Moll B, Emeson E, Spigland I, Steigbigel N. Immunodeficiency in Female Sexual Partners of Men with the Acquired Immunodeficiency Syndrome. New England Journal Of Medicine 1983, 308: 1181-1184. PMID: 6221192, DOI: 10.1056/nejm198305193082001.Peer-Reviewed Original ResearchConceptsFemale sexual partnersMale patientsImmunodeficiency syndromeSexual partnersProdrome of AIDSSuppressor T cellsAcquired Immunodeficiency SyndromeImmunologic abnormalitiesProdromal illnessBiologic agentsT cellsDrug abusersHealthy adultsSyndromeCurrent outbreakDecreased ratioWomenPatientsHeterosexual menIllnessAbnormalitiesAIDSMenLymphadenopathyLymphopenia
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