2025
Autistic traits in childhood and post‐traumatic stress disorder as young adults: a cohort study
Quinton A, Rumball F, Ronald A, Fisher H, Arseneault L, Happé F, Danese A. Autistic traits in childhood and post‐traumatic stress disorder as young adults: a cohort study. Journal Of Child Psychology And Psychiatry 2025 PMID: 40133042, DOI: 10.1111/jcpp.14163.Peer-Reviewed Original ResearchPost-traumatic stress disorderLifetime PTSD diagnosisChildhood Autism Spectrum TestLifetime trauma exposureAutistic traitsPTSD diagnosisStress disorderTrauma exposureIntelligence quotientTraumatic experiencesDevelopment of post-traumatic stress disorderAssociated with greater reportsTrauma-exposed young peopleTrauma-related psychopathologyTrauma-exposed childrenChildhood traumatic experiencesAssociation of autistic traitsSame-sex twinsEvidence-based treatmentsFamily socioeconomic statusGeneral psychopathologyDiagnosing autistic childrenSocioeconomic statusPsychopathologyAutistic adultsHigh Verbal Intelligence in Juvenile Delinquents: Protective or Risk Factor?
Garcia J, Mattuck S, Kovalenko J, Li N, Shelton M, Quintana D, Grigorenko E. High Verbal Intelligence in Juvenile Delinquents: Protective or Risk Factor? Youth Justice 2025 DOI: 10.1177/14732254251316857.Peer-Reviewed Original ResearchRisk factors of delinquencyFactors of delinquencyJuvenile delinquencyDetained youthDelinquencyVerbal intelligenceJIYProtective factorsYouthOffensesVerbal intelligence quotientAcademic achievement scoresAcademic achievement testFuture behaviorIntelligence quotientJuvenilesAchievement scoresAchievement testGenderRace/ethnicityIntelligenceImportant risk factors
2024
The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores
Salto A, Salum G, Hoffmann M, Santoro M, Zugman A, Pan P, Belangero S, Ito L, Doretto V, Croci M, Brañas M, de Giusti C, Da Silva‐Jr F, Ribeiro S, Miguel E, Leckman J. The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores. JCPP Advances 2024, 5: e12268. PMID: 40060001, PMCID: PMC11889643, DOI: 10.1002/jcv2.12268.Peer-Reviewed Original ResearchAnxiety symptomsIntelligence quotientTrajectory class membershipPolygenic risk scoresTrajectory classesLate adolescenceCourse of anxiety symptomsScreen for Child Anxiety Related DisordersTrajectories of anxiety symptomsBrazilian High-Risk CohortYoung adulthoodEffect of intelligence quotientAnxiety Related DisordersHigh-decreasing classClass membershipLongitudinal studyConfirmatory factor analysisGrowth mixture modelingIncidence of anxiety symptomsInternalizing symptomatologyLow-increasing classHigher IQCognitive abilitiesAnxiety riskFactor analysisComparison of emotional and behavioral regulation between metopic and sagittal synostosis
Almeida M, Alper D, Parikh N, De Baun H, Kammien A, Persing J, Alperovich M. Comparison of emotional and behavioral regulation between metopic and sagittal synostosis. Child's Nervous System 2024, 40: 2789-2799. PMID: 38691155, DOI: 10.1007/s00381-024-06387-8.Peer-Reviewed Original ResearchIntelligence quotientBehavior Rating Inventory of Executive Function-2Wechsler Abbreviated Scale of IntelligenceSocial Responsiveness Scale-2Behavior Rating InventoryWechsler Abbreviated ScaleExecutive function subscalesChild Behavior ChecklistExecutive function scoresScale of IntelligenceWASI-IIBRIEF-2Conners-3Executive functionExternalizing behaviorsBehavior ChecklistBehavioral regulationProblems subscaleSchool ageBehavioral assessmentBehavioral difficultiesScale-2Behavioral outcomesRule-breakingBehavioral differencesCannabis Dependence is Associated with Reduced Hippocampal Subregion Volumes Independently of Sex: Findings from an ENIGMA Addiction Working Group Multi-Country Study
Lorenzetti V, Gaillard A, McTavish E, Grace S, Rossetti M, Batalla A, Bellani M, Brambilla P, Chye Y, Conrod P, Cousijn J, Labuschagne I, Clemente A, Mackey S, Rendell P, Solowij N, Suo C, Li C, Terrett G, Thompson P, Yücel M, Garavan H, Roberts C. Cannabis Dependence is Associated with Reduced Hippocampal Subregion Volumes Independently of Sex: Findings from an ENIGMA Addiction Working Group Multi-Country Study. Cannabis And Cannabinoid Research 2024, 9: e1565-e1578. PMID: 38498015, PMCID: PMC11685300, DOI: 10.1089/can.2023.0204.Peer-Reviewed Original ResearchConceptsNon-dependent cannabis usersCornu ammonis subfield 1Cannabis dependenceCannabinoid type 1Cannabis usersIntelligence quotientENIGMA Addiction Working GroupHippocampal subregion volumesDependent cannabis usersTheories of addictionDentate gyrus volumeNeuroimaging workAddictive behaviorsNeuroimaging studiesCannabis useSubregion volumesHippocampal alterationsCognitive problemsCannabisNeuroscientific theoriesAssociated with alterationsSex differencesIntracranial volumeMale samplesMental healthAssociation of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia
Casey B, Mele L, Peaceman A, Varner M, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Costantine M, Mercer B, Caritis S. Association of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia. American Journal Of Perinatology 2024, 41: e3326-e3332. PMID: 38228158, PMCID: PMC11153033, DOI: 10.1055/s-0043-1778037.Peer-Reviewed Original ResearchUrinary iodine concentrationSubclinical hypothyroidismSubclinical thyroid diseasePregnant patientsIodine statusIodine insufficiencyThyroid diseaseIodine concentrationMaternal urinary iodine concentrationPrimary outcomePlacebo-controlled treatment trialMaternal iodine statusMild iodine insufficiencyIntelligence quotientFull-scale intelligence quotientYears of ageDifferential Ability Scales-IISingleton gestationsDouble-MaskedIdentical placeboLevothyroxine replacementWeeks gestationMaternal urineThyroid screeningSerum thyrotropin
2023
Health literacy correlates with abbreviated full‐scale IQ in adolescent and young adults with sickle cell disease
Bhatt N, Calhoun C, Longoria J, Nwosu C, Howell K, Varughese T, Kang G, Jacola L, Hankins J, King A. Health literacy correlates with abbreviated full‐scale IQ in adolescent and young adults with sickle cell disease. Pediatric Blood & Cancer 2023, 70: e30281. PMID: 36861391, PMCID: PMC10425156, DOI: 10.1002/pbc.30281.Peer-Reviewed Original ResearchConceptsSickle cell diseaseFull-scale intelligence quotientAdequate health literacyHealth literacyCell diseaseNeurocognitive deficitsInadequate health literacyLow health literacyCross-sectional studyDevelopment of interventionsChronic conditionsAdult careHigh school educationSign toolHealth outcomesYounger ageLogistic regressionAge 15Young adultsYoung adulthoodHealthcare decisionsAYAsIntelligence quotientWechsler Abbreviated ScaleDiseaseThe Association between Infant Birth Weight, Head Circumference, and Neurodevelopmental Outcomes
Costantine M, Tita A, Mele L, Casey B, Peaceman A, Varner M, Reddy U, Wapner R, Thorp J, Saade G, Rouse D, Sibai B, Mercer B, Caritis S, Bethesda F. The Association between Infant Birth Weight, Head Circumference, and Neurodevelopmental Outcomes. American Journal Of Perinatology 2023, 41: e1313-e1323. PMID: 36791785, PMCID: PMC10425571, DOI: 10.1055/s-0043-1761920.Peer-Reviewed Original ResearchYears of ageChild intelligence quotientSecondary outcomesBirth weightHead circumferenceNeurodevelopmental outcomesPrimary outcomeGestational ageHypothyroid disordersPopulation nomogramsGestational age birth weightIntelligence quotientHigher Body Mass IndexLGA birth weightSGA birth weightInfant birth weightAdverse neurodevelopmental outcomesBody mass indexLarger head circumferenceFetal growth standardsOdds of childrenDetection of newbornsFetal Growth StudiesAGA neonatesSGA neonates
2022
Virtual Neurocognitive Testing in Craniofacial Surgery
Wu RT, Park KE, Chandler L, Ahmad M, Allam O, Timberlake AT, Persing JA, Alperovich M. Virtual Neurocognitive Testing in Craniofacial Surgery. Plastic & Reconstructive Surgery 2022, 149: 1413-1416. PMID: 35413035, DOI: 10.1097/prs.0000000000009145.Peer-Reviewed Original ResearchConceptsNeurocognitive testingIntelligence quotientNeurocognitive assessment batteryCongenital craniofacial conditionsPerformance intelligence quotientVerbal intelligence quotientLong-term developmental outcomesWord recognitionVisuomotor skillsVisual perceptionMath computationPerson testingAssessment BatteryVisuomotor integrationNeurocognitive assessmentAcademic achievementDevelopmental outcomesSchool-age subjectsSame batteryCraniofacial conditionsPositive experiencesOverall positive experienceInteractive naturePercent of participantsParticipants
2021
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.
Mauras N, Buckingham B, White NH, Tsalikian E, Weinzimer SA, Jo B, Cato A, Fox LA, Aye T, Arbelaez AM, Hershey T, Tansey M, Tamborlane W, Foland-Ross LC, Shen H, Englert K, Mazaika P, Marzelli M, Reiss AL. Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study. Diabetes Care 2021, 44: 983-992. PMID: 33568403, PMCID: PMC7985430, DOI: 10.2337/dc20-2125.Peer-Reviewed Original ResearchConceptsType 1 diabetesBrain volumeControl subjectsTotal brain volume differencesEarly-onset type 1 diabetesAge-matched control subjectsIntelligence quotientCognitive scoresWhite matter volumeBrain volume differencesContinuous glucose monitoringDiabetes groupFull-scale intelligence quotientDiabetes complicationsDiabetes controlTotal brainVerbal intelligence quotientDiabetesMatter volumeSensor glucoseCognitive testingGlucose monitoringMixed-effects modelsBrainGroup differencesIntellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD
Kang N, Ahn Y, Park E, Lee K, Baek H, Kim S, Cho H, Cho M, Shin J, Lee J, Cheong H, Kang H, Park Y, Ha I, Moon D, Han K. Intellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD. Journal Of Korean Medical Science 2021, 36: e138. PMID: 34032031, PMCID: PMC8144594, DOI: 10.3346/jkms.2021.36.e138.Peer-Reviewed Original ResearchConceptsIntelligence quotientKNOW-Ped CKDWechsler Intelligence Scale for ChildrenWechsler Adult Intelligence ScaleAdult Intelligence ScaleCognitive functioning of childrenFull-scale IQFull-scale intelligence quotientInvestigate cognitive impairmentChronic kidney diseaseDuration of chronic kidney diseaseFunctioning of childrenIntellectual functioningIntelligence ScalePostmorbid periodLow intelligenceCognitive functionNeurocognitive impairmentCognitive impairmentMean intelligenceKidney diseasePediatric patientsGrowth failureWechslerPoorer glomerular filtration rate
2020
Comparison of Neurocognitive Outcomes in Postoperative Adolescents with Unilateral Coronal Synostosis.
Wu RT, Gabrick KS, Singh A, Landi N, Taylor JA, Bartlett SP, Persing JA, Alperovich M. Comparison of Neurocognitive Outcomes in Postoperative Adolescents with Unilateral Coronal Synostosis. Plastic & Reconstructive Surgery 2020, 146: 614-619. PMID: 32842112, DOI: 10.1097/prs.0000000000007067.Peer-Reviewed Original ResearchConceptsPerformance intelligence quotientVisual-motor integrationVerbal intelligence quotientIntelligence quotientMean full-scale intelligence quotientMotor integrationLeft-sided patientsRight-side patientsNonsyndromic craniosynostosisLong-term functionLarge population studiesCranial vaultHigh motor coordinationMotor achievementsUnilateral coronal synostosisFull-scale intelligence quotientIndependent predictorsFemale patientsStudy cohortNeurodevelopmental assessmentAverage intelligence quotient scoresMean ageControl subjectsNeurocognitive outcomesIntelligence quotient scoresIntelligence quotient (IQ) in pediatric patients with obsessive-compulsive disorder
Batistuzzo M, de Marco e Souza M, Bernardes E, Requena G, Miguel E, Shavitt R. Intelligence quotient (IQ) in pediatric patients with obsessive-compulsive disorder. Journal Of Obsessive-Compulsive And Related Disorders 2020, 26: 100548. DOI: 10.1016/j.jocrd.2020.100548.Peer-Reviewed Original ResearchObsessive-compulsive disorderIntelligence quotientProcessing speedGroup differencesFull-scale intelligence quotientWechsler Abbreviated ScalePerformance intelligence quotientVerbal intelligence quotientBlock Design TestAbbreviated ScaleIntellectual efficiencyImpaired performanceIQ discrepanciesSubtest scoresPIQ scoresIntellectual quotientOCD patientsIntelligence evaluationVIQAverage rangeDesign testMultiple comparison correctionAdult literatureFSIQLarge sampleSMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis.
Wu RT, Timberlake AT, Abraham PF, Gabrick KS, Lu X, Peck CJ, Sawh-Martinez RF, Steinbacher DM, Alperovich MA, Persing JA. SMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2020, 145: 117e-125e. PMID: 31592950, DOI: 10.1097/prs.0000000000006319.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild BehaviorChild DevelopmentChild, PreschoolCraniosynostosesCraniotomyDevelopmental DisabilitiesDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantIntelligence TestsLoss of Function MutationMalePlastic Surgery ProceduresProspective StudiesSkullSmad6 ProteinTreatment Outcome
2019
Self-reported social impairments predict depressive disorder in adults with autism spectrum disorder
Day TC, McNaughton KA, Naples AJ, McPartland JC. Self-reported social impairments predict depressive disorder in adults with autism spectrum disorder. Autism 2019, 24: 297-306. PMID: 31238701, PMCID: PMC6930361, DOI: 10.1177/1362361319857375.Peer-Reviewed Original ResearchConceptsAutism spectrum disorder groupAutism spectrum disorderAutism symptom severitySocial impairmentSpectrum disorderDisorder groupCo-occurring depressive disorderCognitive abilitiesTypical developmentSymptom severityTypical development groupCo-occurring psychiatric conditionsHigher intelligence quotientCommon co-occurring disordersCo-occurring disordersDepressive disorderCognitive testsDepressive disorder groupLongitudinal designIntelligence quotientStandardized psychiatric interviewPsychiatric interviewPsychiatric conditionsImpairmentAdults
2017
Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience
van Os J, van der Steen Y, Islam M, Gülöksüz S, Rutten B, Simons C. Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine 2017, 47: 2421-2437. PMID: 28436345, DOI: 10.1017/s0033291717000915.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresHealthy comparison subjectsPsychotic disordersAttribution of salienceAffective episodesComparison subjectsIntelligence quotientTotal scorePolygenic riskFirst-degree relativesElevated genetic riskLower intelligence quotientManic episodesHealthy relativesRisk scoreNeurodevelopmental alterationsDepression subscaleLifetime ratesSimilar associationPsychosis riskFloor effectsGenetic riskPositive subscalePsychosis phenotypeDisorders
2016
What grades and achievement tests measure
Borghans L, Golsteyn BH, Heckman JJ, Humphries JE. What grades and achievement tests measure. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 13354-13359. PMID: 27830648, PMCID: PMC5127298, DOI: 10.1073/pnas.1601135113.Peer-Reviewed Original Research
2015
Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis
Iyer NS, Balsamo LM, Bracken MB, Kadan-Lottick NS. Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis. Blood 2015, 126: 346-353. PMID: 26048910, DOI: 10.1182/blood-2015-02-627414.Peer-Reviewed Original ResearchConceptsLong-term neurocognitive functioningAcute lymphoblastic leukemiaCranial radiationNeurocognitive functioningIntelligence quotientChildhood acute lymphoblastic leukemiaContinuous first remissionSurvivors of childhoodDatabase of AbstractsConfidence intervalsHealthy control groupStandard deviation scoreFine motor domainNeurocognitive domainsReviews of EffectsMEDLINE/PubMedFirst remissionFull-scale intelligence quotientPerformance intelligence quotientLymphoblastic leukemiaInformation processing speedDeviation scoreSD scoreModerate impairmentMultiple neurocognitive domainsFetal Growth, Cognitive Function, and Brain Volumes in Childhood and Adolescence
Rogne T, Engstrøm AA, Jacobsen GW, Skranes J, Østgård HF, Martinussen M. Fetal Growth, Cognitive Function, and Brain Volumes in Childhood and Adolescence. Obstetrics And Gynecology 2015, 125: 673-682. PMID: 25730232, DOI: 10.1097/aog.0000000000000694.Peer-Reviewed Original ResearchConceptsFetal growth restrictionGestational age childrenLower performance intelligence quotientGrowth restrictionControl groupBrain volumeCognitive functionPerformance intelligence quotientFetal growthFetal growth restriction groupNon-SGA neonatesGestational age neonatesCerebral magnetic resonanceFetal growth patternsGestational week 25Lower intelligence quotient scoresSmaller brain volumesCerebellar white matter volumeWhite matter volumeFetal ultrasound measurementsRegional brain volumesTotal intracranial volumeBrain volume differencesIntelligence quotientSGA neonates
2010
Hemoglobin, Lead Exposure, and Intelligence Quotient: Effect Modification by the DRD2 Taq IA Polymorphism
Roy A, Hu H, Bellinger D, Mukherjee B, Modali R, Nasaruddin K, Schwartz J, Wright R, Ettinger A, Palaniapan K, Balakrishnan K. Hemoglobin, Lead Exposure, and Intelligence Quotient: Effect Modification by the DRD2 Taq IA Polymorphism. Environmental Health Perspectives 2010, 119: 144-149. PMID: 21205584, PMCID: PMC3018494, DOI: 10.1289/ehp.0901878.Peer-Reviewed Original ResearchConceptsDRD2 Taq IA polymorphismIntelligence quotientIQ pointsAssociated with higher IQDopamine D2 receptorsScale of IntelligenceProtective effect of hemoglobinLog blood leadD2 receptorsDRD2 polymorphismsHigher IQDRD2IA categoriesLead exposureCognitionGeneralized Estimating EquationsSignificant public health issueChildrenIntelligenceEffects of leadAnimal studiesChildren 3DopamineMassARRAY iPLEX platformHigher hemoglobin levels
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