2024
Early-life maturation of the somatosensory cortex: sensory experience and beyond
Nwabudike I, Che A. Early-life maturation of the somatosensory cortex: sensory experience and beyond. Frontiers In Neural Circuits 2024, 18: 1430783. PMID: 39040685, PMCID: PMC11260818, DOI: 10.3389/fncir.2024.1430783.Peer-Reviewed Original ResearchConceptsEarly life experiencesAtypical sensory perceptionLife experiencesPostnatal sensory experienceSensory experienceBehavioral outcomesNeurodevelopmental disordersCortex developmentSubstance exposureSensory circuitsSomatosensory cortexSocial isolationPhysiological changesConcurrent factorsSensory perception
2021
Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation
Falk E, Norman K, Garkun Y, Demars M, Im S, Taccheri G, Short J, Caro K, McCraney S, Cho C, Smith M, Lin H, Koike H, Bateh J, Maccario P, Waltrip L, Janis M, Morishita H. Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation. Science Advances 2021, 7: eabe1527. PMID: 33674307, PMCID: PMC7935362, DOI: 10.1126/sciadv.abe1527.Peer-Reviewed Original ResearchConceptsFrontal neuronsModel of fragile X syndromeMouse model of fragile X syndromeNicotinic cholinergic systemTop-down neuronsTreating cognitive deficitsBehavior in adulthoodNicotinic signalingCircuit maturationFragile X syndromeNicotine regulationCholinergic inputMouse modelIncreased expressionCognitive deficitsCortex developmentCholinergic systemCognitive functionTop-down projectionsX syndromeNeurodevelopmental disordersNeuronsVisual cortexAdolescentsMaturation process
2012
Expression of TRPC6 in Renal Cortex and Hippocampus of Mouse during Postnatal Development
Xu P, Xu J, Li Z, Yang Z. Expression of TRPC6 in Renal Cortex and Hippocampus of Mouse during Postnatal Development. PLOS ONE 2012, 7: e38503. PMID: 22701654, PMCID: PMC3368853, DOI: 10.1371/journal.pone.0038503.Peer-Reviewed Original ResearchConceptsExpression of TRPC6Renal cortexPostnatal developmentEffects of TRPC6Hippocampus of micePostnatal day 1Development of kidneyMouse renal cortexMouse kidney cortexPresent studyLoss of expressionTRPC6 expressionPostnatal maturationMouse hippocampusDay 1HippocampusKidney cortexDecreased expressionTRPC6Cortex developmentWestern blottingCortexMouse kidneyKidneyTRPC family
2002
Long-term dendritic spine stability in the adult cortex
Grutzendler J, Kasthuri N, Gan WB. Long-term dendritic spine stability in the adult cortex. Nature 2002, 420: 812-816. PMID: 12490949, DOI: 10.1038/nature01276.Peer-Reviewed Original ResearchConceptsLayer 5 pyramidal neuronsAxo-dendritic synapsesFilopodia-like dendritic protrusionsPrimary visual cortexVisual cortex developmentDendritic spine stabilityTwo-photon imaging techniquePyramidal neuronsDendritic specializationsAdult cortexYoung miceSpine eliminationAdult miceOne-month intervalsNervous systemTransgenic miceSpine stabilityVisual cortexDendritic protrusionsMammalian brainCortex developmentAdult animalsSpineMiceYoung animals
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