2021
Oral Enrichment of Streptococcus and its Role in Systemic Inflammation Related to Monocyte Activation in Humans with Cocaine Use Disorder
Fu X, Cheng D, Luo Z, Wagner A, Fitting S, Cong X, Xu W, Maas K, Wan Z, Zhu J, Zhou Z, Stoops W, McRae-Clark A, Jiang W. Oral Enrichment of Streptococcus and its Role in Systemic Inflammation Related to Monocyte Activation in Humans with Cocaine Use Disorder. Journal Of Neuroimmune Pharmacology 2021, 17: 305-317. PMID: 34448131, PMCID: PMC8881519, DOI: 10.1007/s11481-021-10007-6.Peer-Reviewed Original ResearchConceptsCocaine use disorderMacrophage-derived chemokineCocaine usersSystemic inflammationMonocyte chemoattractant protein (MCP)-4Use disorderExposure to cocaineMonocyte activation markersMyeloid cell activationActivation-regulated chemokineChronic systemic inflammationIncreased Plasma LevelsPrimary human monocytesNon-usersMIP-3aActivation markersCocaine useSaliva levelsMonocyte activationPlasma levelsProinflammatory cytokinesOral microbiomeOral streptococciCocaineCell activation
2020
Assessing mobile health feasibility and acceptability among HIV-infected cocaine users and their healthcare providers: guidance for implementing an intervention
Brown SE, Krishnan A, Ranjit YS, Marcus R, Altice FL. Assessing mobile health feasibility and acceptability among HIV-infected cocaine users and their healthcare providers: guidance for implementing an intervention. MHealth 2020, 6: 4-4. PMID: 32190615, PMCID: PMC7063267, DOI: 10.21037/mhealth.2019.09.12.Peer-Reviewed Original ResearchMedication adherenceHealthcare providersCocaine useFeasibility of mHealthHIV treatment outcomesCocaine usersCommunity health workersSelf-reported cocaine usePatient-provider relationshipPhone callsPharmacological treatmentText remindersTreatment outcomesHealth workersControl trialFocus groupsMHealth interventionsPatientsHIVMHealth pilotsCost-effective strategyCase managersHealth informationHealth purposesAdherence
2019
Accelerated Intermittent Theta-Burst Stimulation as a Treatment for Cocaine Use Disorder: A Proof-of-Concept Study
Steele VR, Maxwell AM, Ross TJ, Stein EA, Salmeron BJ. Accelerated Intermittent Theta-Burst Stimulation as a Treatment for Cocaine Use Disorder: A Proof-of-Concept Study. Frontiers In Neuroscience 2019, 13: 1147. PMID: 31736689, PMCID: PMC6831547, DOI: 10.3389/fnins.2019.01147.Peer-Reviewed Original ResearchCocaine use disorderTranscranial magnetic stimulationITBS sessionsDorsolateral prefrontal cortexUse disordersCocaine use behaviorCocaine usersIntermittent theta burst stimulationIntermittent theta burst stimulation (iTBS) protocolChronic cocaine usersCocaine-positive urine testsExecutive controlNeural underpinningsTheta burst stimulationCue reactivityResponse inhibitionAccelerated Intermittent Theta Burst StimulationCocaine usePrefrontal cortexDrugs of abuseTheta-burst stimulation protocolEffective treatmentITBSMagnetic stimulationSingle participantRandomized placebo-controlled trial of galantamine in individuals with cocaine use disorder
DeVito EE, Carroll KM, Babuscio T, Nich C, Sofuoglu M. Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder. Journal Of Substance Use And Addiction Treatment 2019, 107: 29-37. PMID: 31757262, PMCID: PMC6918721, DOI: 10.1016/j.jsat.2019.08.009.Peer-Reviewed Original ResearchConceptsCocaine use disorderSignificant treatment group differencesUse disordersEfficacy of galantamineTreatment-seeking cocaine usersCurrent cocaine use disordersGroup differencesCocaine use outcomesSample of individualsTreatment group differencesComorbid opioid use disorderMethadone-maintained individualsMemory capacityAbstinent individualsCocaine useCognitive improvementCognitive outcomesCocaine use reductionCognitive functionUse outcomesCocaine usersGalantamine groupIndividualsDisordersInitial promise
2018
fMRI Stroop and behavioral treatment for cocaine-dependence: Preliminary findings in methadone-maintained individuals
DeVito EE, Kober H, Carroll KM, Potenza MN. fMRI Stroop and behavioral treatment for cocaine-dependence: Preliminary findings in methadone-maintained individuals. Addictive Behaviors 2018, 89: 10-14. PMID: 30240978, PMCID: PMC6374034, DOI: 10.1016/j.addbeh.2018.09.005.Peer-Reviewed Original ResearchConceptsCocaine use disorderStroop effectBehavioral treatmentComputer-based cognitive behavioral therapyColor-word Stroop taskCognitive neuroscience methodsCognitive behavioral therapyCocaine-dependent individualsCocaine abstinenceCognitive controlStroop taskNeuroscience methodsMethadone-maintained individualsTreatment abstinenceLingual gyrusStroopCingulate gyrusUse disordersCocaine usersTreatment mechanismsAbstinenceBetter treatment outcomesPreliminary findingsGyrusParticipants
2017
Assessing Feasibility and Acceptability of mHealth among Underserved HIV+ Cocaine Users and Their Healthcare Providers
Brown S, Krishnan A, Ranjit Y, Marcus R, Altice F. Assessing Feasibility and Acceptability of mHealth among Underserved HIV+ Cocaine Users and Their Healthcare Providers. Iproceedings 2017, 3: e48. DOI: 10.2196/iproc.8676.Peer-Reviewed Original ResearchGroup of HIVText remindersCocaine usersDrug treatment clinicsFeasibility of mHealthHIV treatment outcomesSelf-reported cocaine useRisk of transmissionAcceptability of mHealthPhone callsViral suppressionAntiretroviral medicationsMobile medical unitsUnstable living conditionsHIV statusMedication adherenceSubstance use providersTreatment clinicsTreatment outcomesPharmacological interventionsControl trialHIVAdherence behaviorMHealth interventionsHealth behaviorsAtomoxetine in abstinent cocaine users: Sex differences
DeVito EE, Herman AI, Konkus NS, Zhang H, Sofuoglu M. Atomoxetine in abstinent cocaine users: Sex differences. Data In Brief 2017, 14: 566-572. PMID: 28861456, PMCID: PMC5568877, DOI: 10.1016/j.dib.2017.08.011.Peer-Reviewed Original ResearchAtomoxetine in abstinent cocaine users: Cognitive, subjective and cardiovascular effects
DeVito EE, Herman AI, Konkus NS, Zhang H, Sofuoglu M. Atomoxetine in abstinent cocaine users: Cognitive, subjective and cardiovascular effects. Pharmacology Biochemistry And Behavior 2017, 159: 55-61. PMID: 28716656, PMCID: PMC5573182, DOI: 10.1016/j.pbb.2017.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAdultAffectAtomoxetine HydrochlorideAttentionCocaine-Related DisordersCognitionCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodFemaleHemodynamicsHumansInhibition, PsychologicalMaleMemory, Short-TermMiddle AgedNeuropsychological TestsSex CharacteristicsConceptsCocaine use disorderMeasures of attentionAbstinent cocaine usersSubjective drug effectsHuman laboratory studiesResponse inhibitionCognitive enhancementAbstinent individualsCognitive enhancersBehavioral treatmentAddictive processClinical populationsAtomoxetineCognitive impairmentNorepinephrine transporter inhibitorUse disordersCocaine usersCardiovascular effectsMoodMedication effectsPoor clinical outcomeDose-dependent effectIndividualsDrug effectsMemory
2016
Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence
Hodges SE, Pittman B, Morgan PT. Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence. Sleep 2016, 40: zsw069. PMID: 28364419, PMCID: PMC5806585, DOI: 10.1093/sleep/zsw069.Peer-Reviewed Original ResearchConceptsChronic cocaine usersSleep state misperceptionWeeks of abstinenceTotal sleep timeOccult insomniaCocaine usersState misperceptionSleep onsetSleep timeCocaine-dependent personsInpatient research facilitySleep latencyDiary questionnairesSleep perceptionPolysomnographic sleep recordingsDiary measurementsAbstinenceTreatment studiesFinal awakeningMisperceptionsNight 3Objective worseningParticipantsInsomniaSleep recordingsAttenuated neural response to emotional cues in cocaine-dependence: a preliminary analysis of gender differences
Canterberry M, Peltier MR, Brady KT, Hanlon CA. Attenuated neural response to emotional cues in cocaine-dependence: a preliminary analysis of gender differences. The American Journal Of Drug And Alcohol Abuse 2016, 42: 577-586. PMID: 27441590, PMCID: PMC5495203, DOI: 10.1080/00952990.2016.1192183.Peer-Reviewed Original ResearchConceptsNeural responsesCocaine-dependent individualsMedial prefrontal cortexAnterior cingulate cortexNeural reactivityNegative imageInternational Affective Picture SystemGroup activation differencesDrug-related rewardsEmotional cuesNondrug stimuliEmotional imagesNeutral imagesActivation differencesSalience processingPicture SystemBrain responsesPrefrontal cortexCingulate cortexPolydrug usersFemale usersUnique behavioralStimuliCocaine usersGender differencesRegulating task-monitoring systems in response to variable reward contingencies and outcomes in cocaine addicts
Morie KP, De Sanctis P, Garavan H, Foxe JJ. Regulating task-monitoring systems in response to variable reward contingencies and outcomes in cocaine addicts. Psychopharmacology 2016, 233: 1105-1118. PMID: 26861797, DOI: 10.1007/s00213-015-4191-8.Peer-Reviewed Original ResearchConceptsReward processingTask successConsummatory reward processingEvent-related potentialsSpeeded response taskValue of rewardsMeasures of anhedoniaCocaine usersNeural measuresReward contingenciesPredictive cuesReward motivationReward receiptReward outcomesTask contingenciesResponse taskActive cocaine abusersReward probabilityHedonic toneAnticipatory responsesVulnerability markerReward scheduleMonitoring deficienciesAnhedoniaRewardModafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence
Morgan PT, Angarita GA, Canavan S, Pittman B, Oberleitner L, Malison RT, Mohsenin V, Hodges S, Easton C, McKee S, Bessette A, Forselius E. Modafinil and sleep architecture in an inpatient–outpatient treatment study of cocaine dependence. Drug And Alcohol Dependence 2016, 160: 49-56. PMID: 26777774, PMCID: PMC4767553, DOI: 10.1016/j.drugalcdep.2015.12.004.Peer-Reviewed Original ResearchConceptsUrine toxicology screenModafinil treatmentSlow-wave sleepClinical outcomesOutpatient treatmentToxicology screenUrine screensInpatient settingInpatient treatmentSleep timeCocaine dependencePrimary clinical outcomeWeekly cognitive behavioral therapyCocaine usersImproved clinical outcomesPolysomnographic sleep recordingsChronic cocaine useChronic cocaine usersHigh rateCognitive behavioral therapyCocaine-dependent participantsSleep architectureOutpatient phaseEffective treatmentDays abstinentChapter 21 Sleep and Cocaine
Angarita G, Canavan S, Hodges S, Morgan P. Chapter 21 Sleep and Cocaine. 2016, 220-228. DOI: 10.1016/b978-0-12-800212-4.00021-2.Peer-Reviewed Original ResearchPoor cognitive performanceChronic cocaine usersChapter 21 SleepObjective sleep abnormalitiesCocaine use disorderOccult insomniaCognitive performanceSleep architectureMood dysregulationSleep experiencesCocaine usersAbstinenceSleepSleep abnormalitiesInsomniaCocaineDisordersOutcomesExperienceDysregulationBetter outcomesProfound abnormalities
2015
Cocaine Abuse
Kahn E, Mikhael H, Vadivelu N. Cocaine Abuse. 2015, 143-154. DOI: 10.1007/978-1-4939-1951-2_12.ChaptersSex-Related Differences in Self-Reported Neurocognitive Impairment among High-Risk Cocaine Users in Methadone Maintenance Treatment Program
Shrestha R, Huedo-Medina TB, Copenhaver MM. Sex-Related Differences in Self-Reported Neurocognitive Impairment among High-Risk Cocaine Users in Methadone Maintenance Treatment Program. Substance Use Research And Treatment 2015, 9: sart.s23332. PMID: 25861219, PMCID: PMC4363005, DOI: 10.4137/sart.s23332.Peer-Reviewed Original ResearchSelf-reported neurocognitive impairmentSex-related differencesAdverse health outcomesNeurocognitive impairmentNeuropsychological Impairment ScaleCocaine usersHealth outcomesTreatment programMethadone maintenance treatment programPossible sex-related differencesMaintenance treatment programSubstance abuse treatmentDifferential treatment outcomesNeuropsychological symptomsPatient awarenessTreatment outcomesImpairment ScaleClinical careHigher scoresPrevention strategiesCocaine cravingConfounding variablesSignificant associationGreater impairmentNeurocognitive deficits
2014
Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users
Canavan SV, Forselius EL, Bessette AJ, Morgan PT. Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users. Addictive Behaviors 2014, 39: 1057-1061. PMID: 24642345, PMCID: PMC4026273, DOI: 10.1016/j.addbeh.2014.02.015.Peer-Reviewed Original ResearchConceptsBalloon Analogue Risk TaskBART scoresHealthy participantsCocaine-dependent individualsCocaine dependenceChronic cocaine usersEffects of modafinilCognitive effectsRisk TaskBehavioral measuresChronic cocaine useDependent individualsWake-promoting agentNormalization of riskRisk takingSubstance useCognitive impairmentPreliminary evidenceCocaine usersHigher scoresModafinilParticipantsCocaine useSleep disordersModafinil treatment
2013
Abstinence-related changes in sleep during treatment for cocaine dependence
Angarita GA, Canavan SV, Forselius E, Bessette A, Pittman B, Morgan PT. Abstinence-related changes in sleep during treatment for cocaine dependence. Drug And Alcohol Dependence 2013, 134: 343-347. PMID: 24315572, PMCID: PMC4396819, DOI: 10.1016/j.drugalcdep.2013.11.007.Peer-Reviewed Original ResearchConceptsTotal sleep timeExtended abstinenceOutpatient cognitive behavioral therapyAbstinence-related changesDecreased slow wave sleepInpatient substance abuse treatmentCognitive behavioral therapySleep timeCocaine usersPolysomnographic sleepChronic cocaine usersCocaine-dependent participantsSubstance abuse treatmentThrice weekly urine toxicologyBehavioral therapyWeeks of abstinenceOverall sleep qualityAbuse treatmentDays abstinentDependent participantsREM sleep latencySleep qualityCocaine dependenceSlow-wave sleepAbstinenceError processing in current and former cocaine users
Castelluccio BC, Meda SA, Muska CE, Stevens MC, Pearlson GD. Error processing in current and former cocaine users. Brain Imaging And Behavior 2013, 8: 87-96. PMID: 23949893, PMCID: PMC3925762, DOI: 10.1007/s11682-013-9247-y.Peer-Reviewed Original ResearchConceptsFormer cocaine usersError processingSupramarginal gyrusCocaine usersBOLD responseRight inferior parietal lobuleAspects of impulsivityAbstinent cocaine usersCocaine abuse/dependenceInferior parietal lobuleCocaine-dependent individualsCurrent cocaine usersCognitive compensationNeural differencesPrepotent responsesResponse inhibitionAbuse/dependenceCorrect rejectionsSpecific deficitsBOLD activityTrait measuresMaladaptive behaviorsParietal lobuleAddictive behaviorsNeural activityRobust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task
Patel KT, Stevens MC, Meda SA, Muska C, Thomas AD, Potenza MN, Pearlson GD. Robust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task. Biological Psychiatry 2013, 74: 529-537. PMID: 23778289, PMCID: PMC3775945, DOI: 10.1016/j.biopsych.2013.04.029.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskVentral tegmental areaHealthy subjectsFormer cocaine usersLoss anticipationIncentive delay taskCocaine usersTegmental areaLoss outcomesCurrent cocaine usersDrug useAbnormal brain activation patternsCocaine addictionCurrent usersActivation patternsCocaine-using groupDelay taskLong-term cocaine abstinenceFunctional magnetic resonanceSubstance-induced alterationsBrain activation patternsCircuit abnormalitiesAnterior cingulate activationControl subjectsRisk factors
2012
A single-day paradigm of self-regulated human cocaine administration
Matuskey D, Pittman B, Chen JI, Wanyiri J, Nadim H, Jatlow P, Gueorguieva R, Potenza MN, Morgan PT, Bhagwagar Z, Malison RT. A single-day paradigm of self-regulated human cocaine administration. Pharmacology Biochemistry And Behavior 2012, 103: 95-101. PMID: 22922558, PMCID: PMC3652339, DOI: 10.1016/j.pbb.2012.08.009.Peer-Reviewed Original Research
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