2024
Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses
Espinosa Dice A, Lawn R, Ratanatharathorn A, Roberts A, Denckla C, Kim A, de la Rosa P, Zhu Y, VanderWeele T, Koenen K. Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses. BMC Medicine 2024, 22: 135. PMID: 38523269, PMCID: PMC10962116, DOI: 10.1186/s12916-024-03360-9.Peer-Reviewed Original ResearchConceptsOutcome-wide analysisUK BiobankBias due to unmeasured confoundingPolygenic risk score analysisPolygenic risk scoresPhysical health outcomesLower household incomeDirection of associationImprove causal inferenceRisk score analysisHearing difficultiesHealth behaviorsHealth outcomesHealth themesUnmeasured confoundersSocioeconomic statusDiastolic blood pressureAnalytic sampleTriangulation studySources of biasHousehold incomeRisk scoreTriangulation designChildhood maltreatmentGeneralized linear model
2023
Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank
Jiang R, Noble S, Sui J, Yoo K, Rosenblatt M, Horien C, Qi S, Liang Q, Sun H, Calhoun V, Scheinost D. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank. The Lancet Digital Health 2023, 5: e350-e359. PMID: 37061351, PMCID: PMC10257912, DOI: 10.1016/s2589-7500(23)00043-2.Peer-Reviewed Original ResearchConceptsPopulation-based studyPhysical frailtyHealth-related outcomesBrain structuresMental healthHealth outcomesHealth measuresTotal white matter hyperintensitiesIndicators of frailtySeverity of frailtyLower gray matter volumePoor physical fitnessWhite matter hyperintensitiesGray matter volumeUK BiobankHealth-related measuresPoor mental healthMental health measuresDirection of associationMatter hyperintensitiesUnhealthy lifestyleEarly-life risksPsychiatric disordersNumerous confoundersPreventative strategiesPolygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample
Sato J, Biazoli C, Bueno A, Caye A, Pan P, Santoro M, Honorato‐Mauer J, Salum G, Hoexter M, Bressan R, Jackowski A, Miguel E, Belangero S, Rohde L. Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample. Genes Brain & Behavior 2023, 22: e12838. PMID: 36811275, PMCID: PMC10067387, DOI: 10.1111/gbb.12838.Peer-Reviewed Original ResearchConceptsCingulo-opercular networkDefault mode networkADHD-PRSAttentional networksFunctional segregationAttention-deficit/hyperactivity disorder (ADHD) symptomsAttention-deficit/hyperactivity disorderLarge-scale brain networksADHD polygenic risk scoresHyperactivity disorder symptomsSegregation of networksFunctional network segregationLongitudinal community-based cohortAttentional processesRs-fMRI dataExecutive functionHyperactivity disorderDisorder symptomsBrain networksCommunity-based sampleProbable ADHDADHDNetwork segregationPolygenic risk scoresDirection of association
2022
Temporal associations between depressive features and self-stigma in people with substance use disorders related to heroin, amphetamine, and alcohol use: a cross-lagged analysis
Saffari M, Chang K, Chen J, Chang C, Chen I, Huang S, Liu C, Lin C, Potenza M. Temporal associations between depressive features and self-stigma in people with substance use disorders related to heroin, amphetamine, and alcohol use: a cross-lagged analysis. BMC Psychiatry 2022, 22: 815. PMID: 36544132, PMCID: PMC9768939, DOI: 10.1186/s12888-022-04468-z.Peer-Reviewed Original ResearchConceptsSubstance use disordersFeatures of depressionUse disordersDepression Anxiety Stress ScaleCross-lagged analysisCross-lagged associationsCross-lagged modelsAnxiety Stress ScaleGood fit indicesSubstance use concernsStructural equation modelingSelf-Stigma ScaleDepressive featuresMental health problemsLongitudinal relationshipStress ScaleEquation modelingSubstance useDirection of associationAlcohol useFit indicesUse concernsSocial relationshipsTemporal associationUnacceptable behaviorSpatiotemporal Patterns of Diarrhea Incidence in Ghana and the Impact of Meteorological and Socio-Demographic Factors
Asare EO, Warren JL, Pitzer VE. Spatiotemporal Patterns of Diarrhea Incidence in Ghana and the Impact of Meteorological and Socio-Demographic Factors. Frontiers In Epidemiology 2022, 2: 871232. PMID: 35822109, PMCID: PMC9272077, DOI: 10.3389/fepid.2022.871232.Peer-Reviewed Original ResearchSocio-demographic factorsDiarrhea incidenceHealth insurance schemeSignificant public health problemOverall diarrhea incidencePublic health problemGhana Health ServiceHigh-risk districtsConsiderable financial burdenDirection of associationDiarrhea controlDiarrhoea patternsHealth problemsDiarrheaHealth servicesPotential associationSignificant associationDiarrhea dataIncidence
2021
Associations between posttraumatic stress symptoms, perceived social support and psychological distress among disaster-exposed Chinese young adults: A three-wave longitudinal mediation model
Yuan G, Shi W, Lowe S, Chang K, Jackson T, Hall B. Associations between posttraumatic stress symptoms, perceived social support and psychological distress among disaster-exposed Chinese young adults: A three-wave longitudinal mediation model. Journal Of Psychiatric Research 2021, 137: 491-497. PMID: 33798977, DOI: 10.1016/j.jpsychires.2021.03.036.Peer-Reviewed Original ResearchConceptsPosttraumatic stress symptomsPerceived Social SupportPsychological distressSocial supportStress symptomsAcute posttraumatic stress symptomsThree-wave longitudinal studyLongitudinal mediation modelsLong-term psychological problemsPsychological health outcomesChinese university studentsChinese young adultsMediation modelDirection of associationMediation relationshipPsychological problemsYoung adultsLongitudinal studyUniversity studentsHealth outcomesSocial resourcesDistressSymptomsAggravating effectAssociation
2020
Intermediate and Late Outcomes With PCI vs CABG for Left Main Disease — Landmark Meta-Analysis of Randomized Trials
Akintoye E, Salih M, Olagoke O, Oseni A, Sistla P, Alqasrawi M, Panos A, Panaich S, Sellke F. Intermediate and Late Outcomes With PCI vs CABG for Left Main Disease — Landmark Meta-Analysis of Randomized Trials. Cardiovascular Revascularization Medicine 2020, 23: 114-118. PMID: 32921597, DOI: 10.1016/j.carrev.2020.08.040.Peer-Reviewed Original ResearchConceptsUnprotected left main diseaseLeft main diseaseEXCEL trialLate mortalityCause mortalityDirection of associationRandomized trialsLate outcomesCABGLate MIMain diseaseReasonable alternativePCITrialsSignificant differencesRCTsLower ratesHigh rateMortalityYearsLong termPatientsMixed resultsPRECOMBATStrokeUromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes.
Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes. Transplantation 2020, 105: 876-885. PMID: 32769629, PMCID: PMC8805736, DOI: 10.1097/tp.0000000000003299.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBiomarkersCells, CulturedDelayed Graft FunctionFemaleGlomerular Filtration RateGraft SurvivalHistocompatibility Antigens Class IIHumansKidneyKidney TransplantationMacrophagesMaleMiceMiddle AgedOsteopontinProspective StudiesRisk AssessmentRisk FactorsTime FactorsTissue DonorsUnited StatesUromodulinConceptsGraft failureGraft functionGraft outcomePrimary outcomeMajor histocompatibilityDeath-censored graft failureDeceased donor kidney transplantationCause graft failureImproved graft survivalRecipient graft outcomesKidney graft outcomeGlomerular filtration rateDeceased donor kidneysTime of procurementGraft survivalKidney transplantationDirection of associationDeceased donorsFiltration rateKidney qualityLower riskExtensive injuryDonor urineSimilar associationMouse macrophages
2019
Toward Addiction Prediction: An Overview of Cross-Validated Predictive Modeling Findings and Considerations for Future Neuroimaging Research
Yip SW, Kiluk B, Scheinost D. Toward Addiction Prediction: An Overview of Cross-Validated Predictive Modeling Findings and Considerations for Future Neuroimaging Research. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 748-758. PMID: 31932230, PMCID: PMC8274215, DOI: 10.1016/j.bpsc.2019.11.001.Peer-Reviewed Original ResearchConceptsIndividual differencesBrain-behavior modelsFuture neuroimaging researchLikelihood of replicationEvidence-based treatmentsNeuroimaging researchEffect size estimatesSubstance useDirection of associationAnatomical locusBrain functionTreatment outcomesModeling findingsClinical samplesNovel subjectRelapse rateClinical outcomesPredictive modeling approachUnsuccessful treatmentLeading causeIndividualsClinical settingParticular riskSize estimatesOutcomes
2015
Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease
Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, Traylor M, Anderson CD, Battey TW, Radmanesh F, Deka R, Woo JG, Martin LJ, Jimenez-Conde J, Selim M, Brown DL, Silliman SL, Kidwell CS, Montaner J, Langefeld CD, Slowik A, Hansen BM, Lindgren AG, Meschia JF, Fornage M, Bis JC, Debette S, Ikram MA, Longstreth WT, Schmidt R, Zhang CR, Yang Q, Sharma P, Kittner SJ, Mitchell BD, Holliday EG, Levi CR, Attia J, Rothwell PM, Poole DL, Boncoraglio GB, Psaty BM, Malik R, Rost N, Worrall BB, Dichgans M, Van Agtmael T, Woo D, Markus HS, Seshadri S, Rosand J, Sudlow CL. Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology 2015, 84: 918-926. PMID: 25653287, PMCID: PMC4351667, DOI: 10.1212/wnl.0000000000001309.Peer-Reviewed Original ResearchConceptsDeep intracerebral hemorrhageSmall vessel diseaseCerebral small vessel diseaseIntracerebral hemorrhageWhite matter hyperintensitiesVessel diseaseIschemic strokeSingle nucleotide polymorphismsMatter hyperintensitiesSymptomatic small vessel diseaseSporadic cerebral small vessel diseaseWhite matter hyperintensity volumeLacunar ischemic strokeIschemic stroke patientsPopulation-based studySymptomatic ischemic stroke patientsCOL4A1/COL4A2Common single nucleotide polymorphismsDirection of associationCommon variationStroke patientsHyperintensity volumeSporadic formsHemorrhageCerebrovascular phenotypes
2012
Helicobacter pylori and the risk of Barrett's esophagus: A meta-analysis.
Salami A, Njei B, Ditah I. Helicobacter pylori and the risk of Barrett's esophagus: A meta-analysis. Journal Of Clinical Oncology 2012, 30: 35-35. DOI: 10.1200/jco.2012.30.4_suppl.35.Peer-Reviewed Original ResearchPublication biasIncreased risk of BERisk of Barrett's esophagusEvidence of publication biasIncreased riskAssociation of BESTATA version 11Risk of BEDirection of associationAdjusted risk estimatesRisk of esophageal adenocarcinomaIncreased risk of esophageal adenocarcinomaCase-control studyHelicobacter pylori infectionPooled risk ratioFixed-effects modelEgger's testIdentified articlesRisk estimatesRisk ratioSystematic searchCochrane LibraryMeta-analysisVersion 11Subgroup analysis
2010
HIV Disclosure, Condom Use, and Awareness of HIV Infection Among HIV-Positive, Heterosexual Drug Injectors in St. Petersburg, Russian Federation
Grau LE, White E, Niccolai LM, Toussova OV, Verevochkin SV, Kozlov AP, Heimer R. HIV Disclosure, Condom Use, and Awareness of HIV Infection Among HIV-Positive, Heterosexual Drug Injectors in St. Petersburg, Russian Federation. AIDS And Behavior 2010, 15: 45-57. PMID: 20700645, PMCID: PMC3023022, DOI: 10.1007/s10461-010-9775-z.Peer-Reviewed Original Research
2008
Early versus late intravenous insulin administration in critically ill patients
Honiden S, Schultz A, Im SA, Nierman DM, Gong MN. Early versus late intravenous insulin administration in critically ill patients. Intensive Care Medicine 2008, 34: 881-887. PMID: 18180902, PMCID: PMC2486366, DOI: 10.1007/s00134-007-0978-3.Peer-Reviewed Original ResearchConceptsIntensive insulin therapyHospital mortalityICU admissionEarly therapyEarly intensive insulin therapyMore ventilator-free daysDecreased hospital mortalityLower ICU mortalityShorter ICU stayVentilator-free daysLower hospital mortalityProspective cohort studyShorter hospital stayTertiary teaching hospitalIntravenous insulin administrationPatientsThe studyAdmission diagnosisHospital stayICU mortalityICU stayCohort studyInsulin therapyMedical ICUDirection of associationIll patients
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply