2024
A call to address penicillin allergy labels in patients with hematopoietic stem cell transplants: How to avoid rash decisions
Belmont A, Stone C, Guyer A, Edelman E, Trubiano J. A call to address penicillin allergy labels in patients with hematopoietic stem cell transplants: How to avoid rash decisions. Transplant Infectious Disease 2024, 26: e14350. PMID: 39101669, PMCID: PMC11502247, DOI: 10.1111/tid.14350.Peer-Reviewed Original ResearchHematopoietic stem cell transplantationStem cell transplantationPenicillin allergy labelMultidrug-resistant infectionsPenicillin allergyCell transplantationAllergy labelsAssociated with more severe infectionsReported penicillin allergyRisk-stratify patientsMore severe infectionsPoint-of-care assessmentBeta-lactam antibioticsClinical decision toolTolerate penicillinsAssociated with useDelabel patientsTherapeutic optionsEvaluating patientsSevere infectionsAlternative antibioticsOral challengeClinical care settingsClostridium difficilePatientsFrailty is a predictor for worse outcomes in patients hospitalized with Clostridioides difficile infection
Chaar A, Yoo J, Nawaz A, Rizwan R, Agha O, Feuerstadt P. Frailty is a predictor for worse outcomes in patients hospitalized with Clostridioides difficile infection. Annals Of Gastroenterology 2024, 37: 442-448. PMID: 38974087, PMCID: PMC11226747, DOI: 10.20524/aog.2024.0898.Peer-Reviewed Original ResearchHospital Frailty Risk ScoreHealthcare resource utilizationHigher healthcare utilizationAdministrative billing dataPrimary diagnosis of CDIFrailty Risk ScoreNational Inpatient SampleHigher healthcare resource utilizationIntensive care unit admissionHealthcare utilizationClostridioides difficile</i> infectionFrailty statusDiagnosis of CDIRisk-stratify patientsHigher oddsClostridioides difficile infectionInpatient mortalityPerioperative risk assessmentHospital outcomesBilling dataRisk scoreInpatient SampleFrailtyAssessed differencesHealth implications
2023
Unsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging
Williams M, Bednarski B, Pieszko K, Miller R, Kwiecinski J, Shanbhag A, Liang J, Huang C, Sharir T, Dorbala S, Di Carli M, Einstein A, Sinusas A, Miller E, Bateman T, Fish M, Ruddy T, Acampa W, Hauser M, Kaufmann P, Dey D, Berman D, Slomka P. Unsupervised learning to characterize patients with known coronary artery disease undergoing myocardial perfusion imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2656-2668. PMID: 37067586, PMCID: PMC10317876, DOI: 10.1007/s00259-023-06218-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingCause mortalityTotal perfusion deficitArtery diseaseRisk stratificationPerfusion deficitsHigher Body Mass IndexTomography myocardial perfusion imagingMore diabetes mellitusSPECT myocardial perfusion imagingBetter risk stratificationRisk-stratify patientsBody mass indexREFINE SPECT registrySingle photon emissionDiabetes mellitusMass indexExternal cohortStress imagingMyocardial perfusionPatientsRisk phenotypePerfusion imagingImaging characteristics
2021
The Predictive Role of Model for End‐Stage Liver Disease–Lactate and Lactate Clearance for In‐Hospital Mortality Among a National Cirrhosis Cohort
Mahmud N, Asrani SK, Kaplan DE, Ogola GO, Taddei TH, Kamath PS, Serper M. The Predictive Role of Model for End‐Stage Liver Disease–Lactate and Lactate Clearance for In‐Hospital Mortality Among a National Cirrhosis Cohort. Liver Transplantation 2021, 27: 177-189. PMID: 33025731, PMCID: PMC7880877, DOI: 10.1002/lt.25913.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseHospital mortalityLactate clearanceCirrhosis hospitalizationsMELD-NaLiver diseaseDay 1Predictive roleRetrospective cohort studyIn-Hospital MortalityRisk-stratify patientsVeterans Health AdministrationCirrhosis cohortMELD categoriesGastrointestinal bleedingCohort studyClinical dataLimited cohortStratified analysisLactate levelsHospitalizationHealth AdministrationMELDClinical toolMortality
2020
AGA White Paper: Roadmap for the Future of Colorectal Cancer Screening in the United States
Melson JE, Imperiale TF, Itzkowitz SH, Llor X, Kochman ML, Grady WM, Schoen RE, Burke CA, Shaukat A, Rabeneck L, Ladabaum U, Bresalier R, Spiegel B, Yee J, Wang T, Lieberman D, Komanduri S, Muthusamy VR, Dey N. AGA White Paper: Roadmap for the Future of Colorectal Cancer Screening in the United States. Clinical Gastroenterology And Hepatology 2020, 18: 2667-2678.e2. PMID: 32634626, DOI: 10.1016/j.cgh.2020.06.053.Peer-Reviewed Original ResearchConceptsColorectal cancer screeningCancer screeningBetter risk-stratify patientsMultiple screening modalitiesRisk-stratify patientsNoninvasive screening testAmerican Gastroenterological Association's CenterPersonal risk assessmentCRC morbidityCRC screeningCRC outcomesScreening modalityConsensus conferenceScreening testAssociation centerOutcomesScreeningTesting paradigmSurveillanceMorbidityPatientsRisk assessmentMortalityUptake
2017
Prospective study of a non-restrictive decision rule for acute aortic syndrome
Goldschmiedt J, Levsky J, Bellin E, Mizrachi E, Esses D, Haramati L. Prospective study of a non-restrictive decision rule for acute aortic syndrome. The American Journal Of Emergency Medicine 2017, 35: 1309-1313. PMID: 28427782, DOI: 10.1016/j.ajem.2017.04.014.Peer-Reviewed Original ResearchConceptsAcute aortic syndromeClinical decision ruleEmergency department patientsCT utilization ratesDepartment patientsAortic syndromeCT utilizationMean effective radiation doseRisk-stratify patientsHigh-risk groupDose reduction protocolResults of CTEffective radiation doseQuality improvement measuresAortic surgeryProspective cohortDerivation cohortHistoric cohortStudy cohortProspective studyAcute traumaSafe decreaseDiagnostic yieldPatientsClinical decisionEvaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department
Swenson KE, Dziura JD, Aydin A, Reynolds J, Wira CR. Evaluation of a novel 5-group classification system of sepsis by vasopressor use and initial serum lactate in the emergency department. Internal And Emergency Medicine 2017, 13: 257-268. PMID: 28132131, DOI: 10.1007/s11739-017-1607-y.Peer-Reviewed Original ResearchConceptsInitial serum lactate levelSerum lactate levelsEmergency departmentLactate elevationVasoplegic shockLactate levelsCryptic shockVasopressor useInfected patientsShock mortalityHigh-risk ED patientsGroup mortality rateInitial serum lactateVasopressor-dependent patientsIdentifiable risk factorsSepsis-3 definitionRisk-stratify patientsHigh-risk subgroupsInitial lactate levelProximal phaseVasopressor dependenceVasopressor requirementHospital outcomesED patientsSerum lactate
2014
Validated Contemporary Risk Model of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions: Insights From the National Cardiovascular Data Registry Cath‐PCI Registry
Tsai TT, Patel UD, Chang TI, Kennedy KF, Masoudi FA, Matheny ME, Kosiborod M, Amin AP, Weintraub WS, Curtis JP, Messenger JC, Rumsfeld JS, Spertus JA. Validated Contemporary Risk Model of Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions: Insights From the National Cardiovascular Data Registry Cath‐PCI Registry. Journal Of The American Heart Association 2014, 3: e001380. PMID: 25516439, PMCID: PMC4338731, DOI: 10.1161/jaha.114.001380.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAge FactorsAgedBiomarkersComorbidityCreatinineDecision Support TechniquesFemaleGlomerular Filtration RateHumansKidneyMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsRegistriesRenal DialysisReproducibility of ResultsRisk AssessmentRisk FactorsSeverity of Illness IndexTreatment OutcomeUnited StatesConceptsAcute kidney injuryPercutaneous coronary interventionCardiogenic shockKidney injuryCoronary interventionHeart failureValidation cohortPreventative strategiesRisk of PCIPrior percutaneous coronary interventionAKI prediction modelBaseline renal impairmentConsecutive PCI patientsContemporary risk modelsPrior cerebrovascular diseasePrior heart failureChronic lung diseaseRisk-stratify patientsLocal quality improvement effortsQuality improvement effortsGood discriminationBaseline CKDSTEMI presentationPCI patientsPCI registryDevelopment of a duplex-derived velocity risk prediction model of disease progression in patients with moderate asymptomatic carotid artery stenosis
Hicks CW, Canner JK, Arhuidese I, Glebova NO, Schneider E, Qazi U, Perler B, Malas MB. Development of a duplex-derived velocity risk prediction model of disease progression in patients with moderate asymptomatic carotid artery stenosis. Journal Of Vascular Surgery 2014, 60: 1585-1592. PMID: 25238724, DOI: 10.1016/j.jvs.2014.08.056.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArea Under CurveAsymptomatic DiseasesBlood Flow VelocityCarotid Artery, CommonCarotid Artery, InternalCarotid StenosisChi-Square DistributionDecision Support TechniquesDisease ProgressionFemaleHumansMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProportional Hazards ModelsRegional Blood FlowRetrospective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsUltrasonography, Doppler, DuplexConceptsAsymptomatic carotid artery stenosisICA/CCA ratioCarotid artery stenosisInternal carotid arteryDisease progressionEnd-diastolic velocityPeak systolic velocityRisk prediction modelCCA ratioArtery stenosisSystolic velocityRisk factorsInitial peak systolic velocityProportional hazards regression modelsHigh-risk patientsRisk of progressionRisk-stratify patientsHazards regression modelsSignificant independent predictorsICA/CCACharacteristic curve analysisClinical prediction modelCarotid artery ratioIndependent predictorsDuplex imagingImpact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy)
Lansky AJ, Ng VG, Meller S, Xu K, Fahy M, Feit F, Ohman EM, White HD, Mehran R, Bertrand ME, Desmet W, Hamon M, Stone GW. Impact of Nonculprit Vessel Myocardial Perfusion on Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes Analysis From the ACUITY Trial (Acute Catheterization and Urgent Intervention Triage Strategy). JACC Cardiovascular Interventions 2014, 7: 266-275. PMID: 24650400, DOI: 10.1016/j.jcin.2013.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCardiac CatheterizationCoronary AngiographyCoronary CirculationDouble-Blind MethodElectrocardiographyEmergenciesFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial Perfusion ImagingPercutaneous Coronary InterventionPericardiumPractice Guidelines as TopicPrognosisProspective StudiesSurvival RateTriageUnited StatesConceptsPercutaneous coronary interventionMyocardial blush gradeNSTE-ACS patientsMBG 0/1Myocardial perfusionACUITY trialNonculprit vesselsCulprit vesselCoronary interventionSegment elevation acute coronary syndrome patientsST-segment elevation myocardial infarction (STEMI) patientsElevation acute coronary syndrome patientsOutcomes of PCIAcute Coronary Syndromes AnalysisTIMI flow grade 3Worse baseline clinical characteristicsAcute coronary syndrome patientsElevation myocardial infarction patientsLong-term mortality ratesInfarct-related vesselBaseline clinical characteristicsOutcomes of patientsCoronary syndrome patientsRisk-stratify patientsMyocardial infarction patientsA systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries
Miller A, Rosati S, Suffredini A, Schrump D. A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries. Resuscitation 2014, 85: 724-731. PMID: 24525116, PMCID: PMC4031922, DOI: 10.1016/j.resuscitation.2014.01.028.Peer-Reviewed Original ResearchConceptsActive compression-decompression deviceThoracic wall injuriesPooled data analysisPooled analysisCardiopulmonary resuscitationThoracic injuriesSystematic reviewInclusion criteriaWall injuryRisk-stratify patientsInternational Clinical Trials Registry PlatformWorld Health Organization International Clinical Trials Registry PlatformClinical Trials Registry PlatformPre-clinical studiesIntensive care unitTrials Registry PlatformClinical Trials RegistryNew Zealand Clinical Trials RegistryCurrent Controlled TrialsAtrial repairCase reportBedside ultrasoundIncidence of thoracic injuriesAtrial ruptureWeb of Science
2012
Epidemiology of Myelodysplastic Syndromes
Ma X. Epidemiology of Myelodysplastic Syndromes. The American Journal Of Medicine 2012, 125: s2-s5. PMID: 22735748, PMCID: PMC3394456, DOI: 10.1016/j.amjmed.2012.04.014.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeIncidence of MDSBetter risk-stratify patientsClonal hematopoietic stem cell malignanciesHematopoietic stem cell malignanciesRisk-stratify patientsStem cell malignanciesMore effective treatmentsMDS prognosisDifferent comorbiditiesPrognostic factorsSignificant morbidityEtiologic factorsDisease burdenPoor survivalEffective treatmentCell malignanciesHigh mortalityNew casesHeterogeneous groupComorbiditiesSyndromeDiseaseRecent studiesPotential interactions
2011
Prognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) Trial
Palmerini T, Genereux P, Caixeta A, Cristea E, Lansky A, Mehran R, Dangas G, Lazar D, Sanchez R, Fahy M, Xu K, Stone GW. Prognostic Value of the SYNTAX Score in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage StrategY) Trial. Journal Of The American College Of Cardiology 2011, 57: 2389-2397. PMID: 21658558, DOI: 10.1016/j.jacc.2011.02.032.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCoronary AngiographyCoronary Artery BypassElectrocardiographyEmergency TreatmentFemaleHeparin, Low-Molecular-WeightHirudinsHospital MortalityHumansItalyKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisPeptide FragmentsPrognosisProportional Hazards ModelsProspective StudiesRecombinant ProteinsRisk AssessmentROC CurveSeverity of Illness IndexStatistics, NonparametricSurvival AnalysisTreatment OutcomeTriageConceptsSegment elevation acute coronary syndromesElevation acute coronary syndromePercutaneous coronary interventionAcute coronary syndromeSYNTAX scoreCoronary syndromeCardiac deathACUITY trialIndependent predictorsPredictive valueTarget vessel revascularization rateStable ischemic heart diseaseTriple-vessel coronary diseaseVessel revascularization rateCardiac mortality rateMyocardial infarction ratePre-specified subgroupsRisk-stratify patientsIschemic heart diseaseAngiographic substudySS tertilesInfarction rateRevascularization ratesCoronary interventionCoronary disease
2009
Statistical Models and Patient Predictors of Readmission for Acute Myocardial Infarction
Desai MM, Stauffer BD, Feringa HH, Schreiner GC. Statistical Models and Patient Predictors of Readmission for Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2009, 2: 500-507. PMID: 20031883, DOI: 10.1161/circoutcomes.108.832949.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPatient characteristicsAMI readmissionsReadmission ratesMyocardial infarctionPatient riskOvid Evidence-Based Medicine ReviewsEvidence-Based Medicine ReviewsRelevant English-language studiesRisk-stratify patientsPatient risk stratificationInclusion/exclusion criteriaPublic reportingEnglish-language studiesMedicine ReviewsRisk stratificationPatient predictorsHospital ratesPreventable outcomesReadmissionEligible publicationsExclusion criteriaAMI hospitalizationSystematic reviewRelevant articles
2001
The association between white blood cell count and acute myocardial infarction mortality in patients ≥65 years of age: findings from the cooperative cardiovascular project
Barron H, Harr S, Radford M, Wang Y, Krumholz H. The association between white blood cell count and acute myocardial infarction mortality in patients ≥65 years of age: findings from the cooperative cardiovascular project. Journal Of The American College Of Cardiology 2001, 38: 1654-1661. PMID: 11704377, DOI: 10.1016/s0735-1097(01)01613-8.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionWhite blood cell countBlood cell countWBC countWhite blood cellsYears of ageIndependent predictorsCell countDevelopment of AMIAcute myocardial infarction mortalityHospital clinical eventsLong-term mortalityRisk-stratify patientsCoronary artery diseaseCooperative Cardiovascular Project databaseStrong independent predictorCooperative Cardiovascular ProjectMyocardial infarction mortalityImportant clinical implicationsHospital mortalityArtery diseaseHospital eventsClinical eventsHighest quintileLowest quintile
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