2025
Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study.
Morales D, Bu F, Viernes B, DuVall S, Matheny M, Simon K, Falconer T, Richter L, Ostropolets A, Lau W, Man K, Chattopadhyay S, Mathioudakis N, Minty E, Nishimura A, Sun F, Yin C, Seager S, Chai Y, Zhou J, Lu Y, Reyes C, Pistillo A, Duarte-Salles T, Blacketer C, Schuemie M, Ryan P, Krumholz H, Hripcsak G, Khera R, Suchard M. Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study. Diabetes Care 2025 PMID: 40465422, DOI: 10.2337/dc25-0154.Peer-Reviewed Original ResearchRisk of thyroid tumorThyroid tumorsGLP-1RADPP-4isHazard ratioThyroid malignancyCohort studyIncreased riskSodium-glucose cotransporter 2 inhibitorsElectronic health record databaseGlucagon-like peptide 1 receptor agonistsEstimate hazard ratiosRandom-effects meta-analysisGLP-1 receptor agonistsPeptide 1 receptor agonistsDipeptidyl peptidase 4 inhibitorsThyroid tumor incidenceUsers of SGLT2isHealth record databaseSecond-line treatmentType 2 diabetes mellitusNew-user cohort studyRetrospective cohort studyUsers of sulfonylureasIntention-to-treat
2024
Do relationships between ambient temperature and serious adverse health outcomes vary among users of different antidiabetes drugs? A retrospective cohort study of US Medicaid beneficiaries with type 2 diabetes
Leonard C, Bogar K, Brensinger C, Bilker W, Bell M, Flory J, Shi C, Chen C, Hennessy S. Do relationships between ambient temperature and serious adverse health outcomes vary among users of different antidiabetes drugs? A retrospective cohort study of US Medicaid beneficiaries with type 2 diabetes. BMJ Open 2024, 14: e085139. PMID: 39433419, PMCID: PMC11499775, DOI: 10.1136/bmjopen-2024-085139.Peer-Reviewed Original ResearchConceptsAdverse health outcomesZone Improvement PlanHealth outcomesSudden cardiac arrestMedicaid beneficiariesType 2 diabetesLinear associationResidential zip codeModified Poisson regressionCardiac arrestInverse linear associationPerson-daysUsers of sulfonylureasNon-insulin usersPositive linear associationHealth plan enrollmentRetrospective cohort studyEffect modificationPoisson regressionZip codesHospital presentationHealthcare claimsUS MedicaidCohort studyCalculated age-
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