2025
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren Aged 6 MonthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysis
2024
Improving cefazolin administration for surgical prophylaxis in reported penicillin allergy: A retrospective study of a health system intervention
Belmont A, Son M, Hyman J, You L, Su C, Kashyap N, Topal J, McManus D, Martinello R, Kwah J. Improving cefazolin administration for surgical prophylaxis in reported penicillin allergy: A retrospective study of a health system intervention. Journal Of Allergy And Clinical Immunology Global 2024, 4: 100377. PMID: 39830990, PMCID: PMC11742594, DOI: 10.1016/j.jacig.2024.100377.Peer-Reviewed Original ResearchPenicillin allergy labelHospital-wide guidelinesSurgical site infectionAllergy labelsSurgical patientsSevere allergic reactionsSurgical prophylaxisSite infectionAssociated with increased rates of surgical site infectionRate of surgical site infectionMulti-drug resistant infectionsAllergic reactionsPrevent surgical site infectionsFirst-line antibioticsFirst-line prophylaxisAdministration of cefazolinAssociated with increased ratesRetrospective cohort studyGuideline-directed therapyAdult surgical patientsPre-intervention groupPost-intervention groupPenicillin allergyPerioperative outcomesCefazolin administration
2023
SOMETHING'S FISHY WITH THE FEED: AN IGE-MEDIATED ALLERGIC REACTION TO HUMAN MILK
Halperin-Goldstein S, Soffer G. SOMETHING'S FISHY WITH THE FEED: AN IGE-MEDIATED ALLERGIC REACTION TO HUMAN MILK. Annals Of Allergy Asthma & Immunology 2023, 131: s170. DOI: 10.1016/j.anai.2023.08.523.Peer-Reviewed Original ResearchAssociated with allergen exposureHuman milkAllergic reactionsCase description ARare case reportFood proteinsSkin prick testAllergy to peanutIgE-mediated reactionsIgE-mediated allergic reactionsIntermittent pruritusBreastfed infantsCase reportRespiratory distressPrick testLaboratory evidenceChildren's dietsFood allergyMother's dietAllergen exposureComplementary foodsDiet modificationInduce sensitizationFin fishAllergic symptomatology
2022
Eptacog beta efficacy and safety in the treatment and control of bleeding in paediatric subjects (<12 years) with haemophilia A or B with inhibitors
Pipe S, Hermans C, Chitlur M, Carcao M, Castaman G, Davis J, Ducore J, Dunn A, Escobar M, Journeycake J, Khan O, Mahlangu J, Meeks S, Mitha I, Négrier C, Nowak‐Göttl U, Recht M, Chrisentery‐Singleton T, Stasyshyn O, Vilchevska K, Martinez L, Wang M, Windyga J, Young G, Alexander W, Bonzo D, Macie C, Mitchell I, Sauty E, Wilkinson T, Shapiro A. Eptacog beta efficacy and safety in the treatment and control of bleeding in paediatric subjects (<12 years) with haemophilia A or B with inhibitors. Haemophilia 2022, 28: 548-556. PMID: 35475308, PMCID: PMC9542908, DOI: 10.1111/hae.14563.Peer-Reviewed Original ResearchConceptsInitial dosing regimensControl of bleedingYears of ageEptacog betaBleeding episodesHemophilia ATreatment-related adverse eventsPhase 3 clinical trialsAlternative haemostatic agentModerate bleeding episodesTreat bleeding episodesTreatment of bleedingTreatment success criteriaSuccess proportionRandomised crossover designDosing regimensBeta infusionPaediatric subjectsAdverse eventsBlood productsHaemostatic agentsBleedingEffective treatmentAllergic reactionsNeutralising antibodiesClinical experience with sesame oral immunotherapy and a quality-of-life assessment
You L, Soffer G, Factor J. Clinical experience with sesame oral immunotherapy and a quality-of-life assessment. Journal Of Food Allergy 2022, 4: 1-9. PMID: 39021386, PMCID: PMC11250642, DOI: 10.2500/jfa.2022.4.220003.Peer-Reviewed Original ResearchOral immunotherapyRespiratory reactionsMaintenance therapyGastrointestinal reactionsSesame allergyCutaneous reactionsFood Allergy QualityFurther prospective studiesYears of ageQuality of lifeFood-related anxietyAdverse eventsPatient chartsProspective studyLife QuestionnaireAdverse reactionsAllergic reactionsFemale genderClinical experiencePatientsDietary limitationsTherapyPrivate practiceU.S. populationOdds
2021
Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose
Krantz MS, Kwah JH, Stone CA, Phillips EJ, Ortega G, Banerji A, Blumenthal KG. Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose. JAMA Internal Medicine 2021, 181: 1530-1533. PMID: 34309623, PMCID: PMC8314170, DOI: 10.1001/jamainternmed.2021.3779.Peer-Reviewed Original ResearchPersistent Postoperative Vasoplegia After Ureteronephrectomy Due To Suspected Intravesical Gemcitabine Toxicity
Yan L, Bohorquez MA, Carr ZJ. Persistent Postoperative Vasoplegia After Ureteronephrectomy Due To Suspected Intravesical Gemcitabine Toxicity. A&A Practice 2021, 15: e01537. PMID: 34695040, DOI: 10.1213/xaa.0000000000001537.Peer-Reviewed Case Reports and Technical NotesConceptsIntravesical adjuvant therapyPulmonary embolic phenomenaTreatment of patientsPotential adverse eventsPostoperative vasoplegiaRobotic nephroureterectomyVasopressor supportAdjuvant therapyPostoperative courseAdverse eventsEmbolic phenomenaSupportive managementResuscitative effortsAllergic reactionsCommon causeVasoplegiaGemcitabine toxicityGemcitabinePatientsUreteronephrectomyNephroureterectomyBleedingTherapyInfectionProlonged Anaphylaxis to Pfizer Coronavirus Disease 2019 Vaccine: A Case Report and Mechanism of Action
Frank A, Radparvar S, Manasia A, Bassily-Marcus A, Kohli-Seth R. Prolonged Anaphylaxis to Pfizer Coronavirus Disease 2019 Vaccine: A Case Report and Mechanism of Action. Critical Care Explorations 2021, 3: e0397. PMID: 33834172, PMCID: PMC8021358, DOI: 10.1097/cce.0000000000000397.Peer-Reviewed Original ResearchMessenger RNA-based vaccinesEtiology of anaphylaxisRate of anaphylaxisCritical care managementCenters for Disease Control and PreventionEmergency use authorizationProtracted anaphylaxisDisease Control and PreventionIV steroidsRNA-based vaccinesMechanism of actionSafety profilePatient's anaphylaxisCase reportControl and PreventionRespiratory distressAnaphylactic reactionsClinical trialsEpinephrine infusionCoronavirus diseaseUnique caseAnaphylaxisAllergic reactionsPatientsVaccine prototypeWheat oral immunotherapy
Leeds S, Liu EG, Nowak-Wegrzyn A. Wheat oral immunotherapy. Current Opinion In Allergy And Clinical Immunology 2021, 21: 269-277. PMID: 33840798, DOI: 10.1097/aci.0000000000000743.Peer-Reviewed Original ResearchConceptsWheat oral immunotherapyOral immunotherapyMaintenance dosesSevere reactionsFood allergy epidemiologyLow maintenance dosesNonrandomized clinical trialRisk of reactionSustained unresponsivenessSuccessful desensitizationAdjunct therapeuticsFood allergyTrial protocolClinical trialsAllergic reactionsAllergy epidemiologyHuman trialsSafety outcomesHead comparisonAugmenting factorSmall sample sizeTrialsFood modificationImmunotherapyDoses
2020
Pediatric Hemovigilance and Adverse Transfusion Reactions
Sostin N, Hendrickson JE. Pediatric Hemovigilance and Adverse Transfusion Reactions. Clinics In Laboratory Medicine 2020, 41: 51-67. PMID: 33494885, DOI: 10.1016/j.cll.2020.10.004.Peer-Reviewed Original ResearchConceptsTransfusion reactionsBronchopulmonary dysplasia/chronic lung diseaseChronic lung diseaseNonhemolytic transfusion reactionsAdverse transfusion reactionsIntraventricular hemorrhagePediatric populationLung diseasePulmonary reactionsAllergic reactionsPreventive strategiesHemovigilance systemMale childrenAdult populationChildrenTransfusionHemorrhageNeonatesPathophysiologyPopulationHemovigilancePediatricsDiseaseFlow cytometric identification of T fh 13 cells in mouse and human
Chen JS, Grassmann JDS, Gowthaman U, Olyha SJ, Simoneau T, Berin MC, Eisenbarth SC, Williams A. Flow cytometric identification of T fh 13 cells in mouse and human. Journal Of Allergy And Clinical Immunology 2020, 147: 470-483. PMID: 32709424, PMCID: PMC7854882, DOI: 10.1016/j.jaci.2020.04.063.Peer-Reviewed Original ResearchConceptsIgE antibodiesHigh affinity IgE antibodiesLife-threatening allergic reactionFollicular helper THigh-affinity IgEIgE productionHelper TAllergic reactionsMast cellsSevere reactionsMouse modelCytometric identificationCellular mechanismsBetter therapeuticsAllergyMiceAntibodiesCellsAnaphylaxisIgEPatientsHumansAeroallergensBasophilsPhenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function
Karaca M, Atceken N, Karaca Ş, Civelek E, Şekerel BE, Polimanti R. Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function. Allergy Asthma And Immunology Research 2020, 12: 806-820. PMID: 32638561, PMCID: PMC7347000, DOI: 10.4168/aair.2020.12.5.806.Peer-Reviewed Original ResearchLung functionRespiratory diseaseFat massPulmonary function testsPhenome-wide association studyAllergic respiratory diseasesBody fat massPrevious genome-wide association studyGenome-wide association studiesAsthma comorbidityAdult asthmaAsthma pathogenesisFunction testsPediatric cohortBlood levelsImmune cellsAllergic reactionsMultifactorial etiologyAsthmaAssociation studiesIndividual susceptibilityRisk allelesDiseaseDiscovery Genome-Wide Association StudiesComorbiditiesTopical hemostatic and tissue-sealing agents in gynecologic surgery.
Cullifer RM, Makai G, Pacis M, Huynh T. Topical hemostatic and tissue-sealing agents in gynecologic surgery. Current Opinion In Obstetrics & Gynecology 2020, 32: 285-291. PMID: 32324712, DOI: 10.1097/gco.0000000000000632.Peer-Reviewed Original ResearchConceptsTopical hemostatic agentsGynecologic surgeryPotential complicationsShorter operating room timeHemostatic agent useSmall bowel obstructionBlood-borne pathogensOperating room timeMechanism of actionOvarian cystectomyAbdominal myomectomyBowel obstructionOvarian reserveBlood lossAbscess formationAllergic reactionsAgent useRoom timeSurgery proceduresHemostatic agentsSurgeryEfficacious useSurgical subspecialtiesTopical hemostaticsOperating time
2019
Disorders of the Immune System
Kavathas P, Krause P, Ruddle N. Disorders of the Immune System. 2019, 97-107. DOI: 10.1007/978-3-030-25553-4_6.ChaptersImmune systemImmune dysregulationHypersensitivity reactionsRegulation of autoimmunityMajor health problemHuman immune systemNumber of PIDsAllergic reactionsClinical impactAutoinflammatory diseasesForeign antigensImmune responseImmunodeficiency diseaseImmune functionHealth problemsNongenetic causesAutoimmunityHarmful responsesInborn errorsDiseaseType of disorderGenetic defectsImmunodeficiencyInfectionPredominant feature
2018
ALPHA-GAL ALLERGY; MORE THAN MEAT?
Kaman K, Robertson D. ALPHA-GAL ALLERGY; MORE THAN MEAT? Annals Of Allergy Asthma & Immunology 2018, 121: s115. DOI: 10.1016/j.anai.2018.09.380.Peer-Reviewed Original ResearchMammalian meatHigher fat contentAlpha-galMammalian cell membranesDelayed allergic reactionsFat contentMilk proteinsWhey proteinDelayed urticariaMeatIgE testsMeat ingestionTick exposureAllergic reactionsWheyCase description ADose of whey proteinNegative skin prickCarbohydrate moietyWhey consumptionCell membraneMilkMammalian productsProteinGalactose-alpha-1,3-galactoseDexamethasone-Related Perineal Burning in the Prehospital Setting: A Case Series
Dylla L, Acquisto N, Manzo F, Cushman J. Dexamethasone-Related Perineal Burning in the Prehospital Setting: A Case Series. Prehospital Emergency Care 2018, 22: 655-658. PMID: 29485338, DOI: 10.1080/10903127.2018.1440039.Peer-Reviewed Original ResearchDirect-to-Consumer Broadcast Advertisements for Pharmaceuticals: Off-Label Promotion and Adherence to FDA Guidelines
Klara K, Kim J, Ross JS. Direct-to-Consumer Broadcast Advertisements for Pharmaceuticals: Off-Label Promotion and Adherence to FDA Guidelines. Journal Of General Internal Medicine 2018, 33: 651-658. PMID: 29484575, PMCID: PMC5910340, DOI: 10.1007/s11606-017-4274-9.Peer-Reviewed Original ResearchConceptsDTC adsDiabetes medicationsPresentation of risksLabel promotionPrescription drugsBlood pressure reductionFDA guidelinesBladder dysfunctionDiabetic neuropathyResultsOur sampleChronic conditionsInflammatory conditionsAllergic reactionsLabel usesPrescribers' decisionsUnique drugDrug AdministrationDrug risksDrug efficacyPressure reductionOff-label promotionWeight lossAdvertisement claimsConsumer advertisementsDrugs
2016
Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction
Ambartsumyan L, Flores A, Nurko S, Rodriguez L. Utility of Octreotide in Advancing Enteral Feeds in Children with Chronic Intestinal Pseudo-Obstruction. Pediatric Drugs 2016, 18: 387-392. PMID: 27520652, DOI: 10.1007/s40272-016-0189-x.Peer-Reviewed Original ResearchConceptsOctreotide responseEnteral toleranceAntroduodenal manometryChronic Intestinal Pseudo-ObstructionEfficacy of octreotideIntestinal phase IIIIntestinal Pseudo-ObstructionPresence of ileostomyTPN-dependent childrenTertiary care centerTotal parenteral nutritionMethodsThe study populationLimited effective therapiesHigher median increasePseudo-ObstructionParenteral nutritionEnteral feedsHigh morbidityProspective studyResultsA totalCare centerEffective therapyChallenging disorderAllergic reactionsStudy populationTwo approaches to the clinical dilemma of treating TTP with therapeutic plasma exchange in patients with a history of anaphylactic reactions to plasma
Sidhu D, Snyder EL, Tormey CA. Two approaches to the clinical dilemma of treating TTP with therapeutic plasma exchange in patients with a history of anaphylactic reactions to plasma. Journal Of Clinical Apheresis 2016, 32: 158-162. PMID: 27246502, DOI: 10.1002/jca.21475.Peer-Reviewed Original ResearchConceptsTherapeutic plasma exchangeThrombotic thrombocytopenic purpuraSevere allergic reactionsAnaphylactic reactionsTTP exacerbationTTP remissionTreatment strategiesAllergic reactionsVon Willebrand factor (VWF) cleaving proteasePotential treatment strategyPossible treatment protocolReplacement plasmaAdverse eventsAcute treatmentPlasma exchangeThrombocytopenic purpuraSimilar patientsClinical dilemmaTreatment protocolAllergic riskPatientsDonor plasmaADAMTS-13Plasma productsStandard plasma
2015
Use of Clostridium botulinum toxin in gastrointestinal motility disorders in children
Arbizu RA, Rodriguez L. Use of Clostridium botulinum toxin in gastrointestinal motility disorders in children. World Journal Of Gastrointestinal Endoscopy 2015, 7: 433-437. PMID: 25992183, PMCID: PMC4436912, DOI: 10.4253/wjge.v7.i5.433.Commentaries, Editorials and LettersGastrointestinal motility disordersMotility disordersBotulinum toxin type APatients 12 yearsToxin type AExcessive neural activityTreatment of strabismusBotulinum neurotoxin type AType ANeurotoxin type ABowel perforationPresynaptic releaseTherapeutic applicationsClostridium botulinum toxinSignificant complicationsMinor painCentral originBotulinum toxinGastroenterological conditionsAllergic reactionsParalytic diseaseSignificant paralysisGastrointestinal tractObligate anaerobic bacteriaClinical experience
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