2025
Quality of gastrointestinal surgical oncology care according to insurance status
Butensky S, Kerekes D, Bakkila B, Billingsley K, Ahuja N, Johnson C, Khan S. Quality of gastrointestinal surgical oncology care according to insurance status. Journal Of Gastrointestinal Surgery 2025, 29: 101961. PMID: 39800081, DOI: 10.1016/j.gassur.2025.101961.Peer-Reviewed Original ResearchConceptsMedicare-insured patientsNational Cancer DatabaseAdequate lymphadenectomyNegative marginsCancer DatabaseRetrospective study of adult patientsStudy of adult patientsSurvival analysisInsurance statusReceipt of lymphadenectomyCurative-intent resectionGastrointestinal (GI) cancersIncreased risk of deathMultivariate survival analysisAdequacy of lymphadenectomyCox proportional hazards modelsRisk of deathProportional hazards modelResection marginsSurgical oncology careAdjuvant therapyRetrospective studyAdult patientsBiliary organismsLymphadenectomyPrognostic Factors for Refractory Outcome in Localizing TIO: Experience in a Tertiary Center
Hoong C, Sfeir J, Tebben P, Clarke B. Prognostic Factors for Refractory Outcome in Localizing TIO: Experience in a Tertiary Center. The Journal Of Clinical Endocrinology & Metabolism 2025, dgae911. PMID: 39760693, DOI: 10.1210/clinem/dgae911.Peer-Reviewed Original ResearchRefractory outcomesPredicting cureBaseline biochemistryPredictive of cureChance of cureMarker of cureRenal phosphate wastingSize of tumorYear of diagnosisLevels of FGF23Long-term medical complicationsSurgical tumor marginsUnivariate Cox regressionCulprit tumorsTumor factorsParaneoplastic disordersResection marginsPrognostic factorsFavorable prognosisTertiary centerTumor marginsSurgical removalRetrospective cohortPhosphate wastingFollow-up
2024
Non-dominant, Lesional Frontal Lobe Epilepsy Overlapping with Motor Cortex
Herlopian A. Non-dominant, Lesional Frontal Lobe Epilepsy Overlapping with Motor Cortex. 2024, 469-496. DOI: 10.1007/978-3-031-23828-4_20.Peer-Reviewed Original ResearchFocal cortical dysplasiaCortical dysplasiaIntracranial monitoringPredictors of seizure freedomIctal onset patternsPost-operative outcomesSurgical decision-making processFrontal lobe epilepsySensorimotor functionDysplastic cortexResection marginsSurgical interventionSeizure freedomEpileptiform patternsLobe epilepsyPharmacoresistant epilepsyMotor cortexOnset patternsDysplasiaCortexPatientsCircuit organizationEpileptiformEpilepsyDominant, Lesional Temporal Lobe Epilepsy
Herlopian A. Dominant, Lesional Temporal Lobe Epilepsy. 2024, 849-888. DOI: 10.1007/978-3-031-23828-4_34.Peer-Reviewed Original ResearchHemispheric language dominanceDominant temporal lobe epilepsyLanguage reorganizationLanguage dominanceLinguistic tasksTemporal lobe epilepsyFunctional connectivityResponsive neurostimulationNetwork reorganizationIctal aphasiaLobe epilepsyLong-term effectsCortical stimulationResection marginsCavernous angiomaNeocortical epilepsyPredictive biomarkersIctal tachycardiaTherapeutic effectAphasiaFunctional mappingCortexEpilepsyLanguageHandedness
2023
So Now We Know—Reflections on the Extent of Resection for Stage I Lung Cancer
Detterbeck F, Ely S, Udelsman B, Blasberg J, Boffa D, Dhanasopon A, Mase V, Woodard G. So Now We Know—Reflections on the Extent of Resection for Stage I Lung Cancer. Clinical Lung Cancer 2023, 25: e113-e123. PMID: 38310034, DOI: 10.1016/j.cllc.2023.12.007.Peer-Reviewed Original ResearchStage I lung cancerI lung cancerSublobar resectionRecurrence-free survivalHealthy patientsLung cancerRecent trialsInadequate resection marginsLarge recent trialsAdditional randomized trialsHigh-level evidenceOverall survival differenceExtent of resectionLong-term outcomesLong-term resultsHigh locoregional recurrenceAspects of patientsLesser resectionsLocoregional recurrencePerioperative morbidityIntraoperative detailsLung functionResection extentResection marginsPostoperative changesDoes Length of Extended Resection Beyond Transition Zone Change Clinical Outcome for Hirschsprung Pull-Through?
Ullrich S, Denning N, Holder M, Wittenberg R, Krebs K, Schwan A, Verderber A, Garrison A, Rymeski B, Rosen N, Frischer J. Does Length of Extended Resection Beyond Transition Zone Change Clinical Outcome for Hirschsprung Pull-Through? Journal Of Pediatric Surgery 2023, 59: 86-90. PMID: 37865574, DOI: 10.1016/j.jpedsurg.2023.09.024.Peer-Reviewed Original ResearchConceptsTransition zone pull-throughPrimary pull-throughProximal resection marginFecal incontinence severityPull-throughResection marginsIncontinence severityHypertrophic nervesBowel movementsRetrospective chart review of patientsChart review of patientsPost-operative complication rateChanging clinical outcomeDaytime bowel movementsFaecal incontinence severity scoreVoluntary bowel movementsReview of patientsIncontinence Severity ScorePost-operative complicationsProximal marginRetrospective chart reviewHirschsprung-associated enterocolitisAssociated with increased ratesNormal ganglion cellsExtended resection
2022
The prognostic significance of the circumferential resection margin in esophageal squamous cell carcinoma patients without neoadjuvant treatment
Yang Z, Lin H, Wang Z, Rong L, Zhang X, Wang L, Qin J, Xue X, Li Y, Xue L. The prognostic significance of the circumferential resection margin in esophageal squamous cell carcinoma patients without neoadjuvant treatment. BMC Cancer 2022, 22: 1180. PMID: 36384463, PMCID: PMC9670431, DOI: 10.1186/s12885-022-10276-1.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaEsophageal squamous cell carcinoma patientsRoyal College of Pathologists criteriaRoyal College of PathologistsCRM statusCollege of American PathologistsResection marginsPrognostic factorsPrognostic significancePrognostic valueSquamous cell carcinoma patientsLong-term prognostic significanceCircumferential resection marginCell carcinoma patientsCollege of American Pathologists criteriaSquamous cell carcinomaLymph node metastasisMultivariate survival analysisLong-term survivalPN0 subgroupPN3 subgroupsNeoadjuvant therapyNeoadjuvant treatmentPT3 tumorsTumor distanceEvaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery
Bakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery. JAMA Network Open 2022, 5: e225664. PMID: 35377425, PMCID: PMC8980937, DOI: 10.1001/jamanetworkopen.2022.5664.Peer-Reviewed Original ResearchConceptsGastrointestinal tract cancerNegative resection marginsTract cancerNegative surgical marginsBlack patientsAdequate lymphadenectomyWhite patientsQuality of careRacial disparitiesSurgical resectionResection marginsSurgical marginsSurgical careNational Cancer DatabaseRetrospective cohort studySite of cancerLonger median survivalHealth careStandard of careCommon age rangeSignificant racial disparitiesAdjuvant chemotherapyBiliary resectionAdjuvant therapyAdult patients
2021
Robotic-Assisted Surgery Training (RAST) Program: An Educational Research Protocol.
Castaldi M, Palmer M, Con J, Abouezzi Z, Latifi R, Bergamaschi R. Robotic-Assisted Surgery Training (RAST) Program: An Educational Research Protocol. Surgical Technology Online 2021, 38: 52-55. PMID: 33830493, DOI: 10.52198/21.sti.38.so1428.Peer-Reviewed Original ResearchConceptsRobotic-assisted surgery trainingDistal resection marginOperating roomDundee Ready Education Environment MeasureGeneral surgery residentsResection marginsPrimary endpointDistance of anastomosisRobotic-AssistedCritical landmarksRobotic surgeryOperative timeSurgery residentsNozzle adjustmentSurgery trainingBoom controlRobot instructorTissue handling
2020
Intra-surgical Site Vancomycin Powder Application in Infected Diabetic Heel Ulcers with Calcaneal Osteomyelitis
Brodell J, Oh I. Intra-surgical Site Vancomycin Powder Application in Infected Diabetic Heel Ulcers with Calcaneal Osteomyelitis. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00144. PMCID: PMC8704756, DOI: 10.1177/2473011420s00144.Peer-Reviewed Original ResearchDiabetic heel ulcersVancomycin powder applicationVancomycin powderTotal calcanectomyVancomycin cohortHeel ulcersBone resection marginsCharleston Comorbidity IndexAnkle-brachial indexPeripheral arterial diseaseMulti-drug resistant bacteriaHigh rateASA classInfection surgeryIntrawound vancomycinPreoperative labsCalcaneal osteomyelitisComorbidity indexWound complicationsPatient demographicsSurgical complicationsSystemic antibioticsDiabetic patientsResection marginsRevision amputationEffect of Time to Surgery of Colorectal Liver Metastases on Survival
Chen EY, Mayo SC, Sutton T, Kearney MR, Kardosh A, Vaccaro GM, Billingsley KG, Lopez CD. Effect of Time to Surgery of Colorectal Liver Metastases on Survival. Journal Of Gastrointestinal Cancer 2020, 52: 169-176. PMID: 32086781, PMCID: PMC7900034, DOI: 10.1007/s12029-020-00372-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantColorectal NeoplasmsDisease-Free SurvivalFemaleFollow-Up StudiesHepatectomyHumansKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalPrognosisRetrospective StudiesTime FactorsTime-to-TreatmentYoung AdultConceptsColorectal liver metastasesLong-term OSPostoperative overall survivalOverall survivalLonger TTSLiver metastasesWorse survivalDiagnosis of CLMLong-term survivorsResultsTwo hundred eightyRisk of recurrenceComprehensive cancer centerHigh disease burdenSpecific primary tumorsShorter TTSPerioperative chemotherapyPostoperative chemotherapyPerioperative treatmentResection marginsCancer CenterMetastasis characteristicsInstitutional databasePrimary tumorDisease burdenSimilar survival
2018
Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery
Hu S, Kang H, Baek Y, Fakhri G, Kuang A, Choi H. Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery. Advanced Healthcare Materials 2018, 7: e1800066. PMID: 29719137, PMCID: PMC6105507, DOI: 10.1002/adhm.201800066.Peer-Reviewed Original ResearchConceptsNormal tissuesBrain tumorsCompleteness of surgical resectionDifferentiate cancerous lesionsIncomplete tumor resectionReal-time image guidanceRemoval of normal tissueDecrease surgical complicationsOptical fluorescence imagingMalignant brain tumorsBrain tumor treatmentIntraoperative guidance techniquesImage-guided surgeryMagnetic resonance imagingResidual tumorResection marginsSurgical resectionPrognostic factorsTumor resectionOncologic surgeonsSurgical complicationsResection completenessImage guidanceImage-guidedAdjacent normal tissuesThe importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller J, Kreppel M. The importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1007-1012. PMID: 29709331, DOI: 10.1016/j.jcms.2018.03.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Squamous CellChemoradiotherapyFemaleHumansKaplan-Meier EstimateLymph Node ExcisionLymph NodesLymphatic MetastasisMaleMandibleMiddle AgedMouth NeoplasmsMultivariate AnalysisNeck DissectionNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesRisk AssessmentConceptsOral squamous cell carcinomaSquamous cell carcinomaMandibular infiltrationLocoregional recurrenceCell carcinomaLymph nodesExclusion criteriaTreatment-naive oral squamous cell carcinomaImportance of lymphPathologic N classificationLymph node ratioPositive lymph nodesNegative resection marginsRetrospective chart reviewRisk stratification toolAssessment of prognosisConventional nodalT4b classificationUnresectable diseaseNeoadjuvant chemoradiotherapyPerioperative deathsSynchronous malignanciesChart reviewResection marginsClinicopathological characteristics
2017
Analysis of clinicopathological risk factors for locoregional recurrence of oral squamous cell carcinoma – Retrospective analysis of 517 patients
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller JE, Kreppel M. Analysis of clinicopathological risk factors for locoregional recurrence of oral squamous cell carcinoma – Retrospective analysis of 517 patients. Journal Of Cranio-Maxillofacial Surgery 2017, 45: 1749-1753. PMID: 28823597, DOI: 10.1016/j.jcms.2017.07.012.Peer-Reviewed Original ResearchConceptsCervical lymph nodesClinicopathological risk factorsIndependent risk factorSignificant risk factorsLocoregional recurrenceRisk factorsLymph nodesMultivariate analysisExtracapsular spreadHistological gradingTreatment-naive oral squamous cell carcinomaPossible significant risk factorPositive cervical lymph nodesOral squamous cell carcinomaIndividualized therapy managementPositive lymph nodesNegative resection marginsOverall survival rateSquamous cell carcinomaBinary logistic regression analysisLogistic regression analysisImprovement of therapyMaxillofacial plastic surgeryClinicopathological factorsResection margins
2016
Is Radiotherapy Warranted Following Intrahepatic Cholangiocarcinoma Resection? The Impact of Surgical Margins and Lymph Node Status on Survival
Hammad A, Berger N, Eastwood D, Tsai S, Turaga K, Christian K, Johnston F, Pawlik T, Gamblin T. Is Radiotherapy Warranted Following Intrahepatic Cholangiocarcinoma Resection? The Impact of Surgical Margins and Lymph Node Status on Survival. Annals Of Surgical Oncology 2016, 23: 912-920. PMID: 27654107, DOI: 10.1245/s10434-016-5560-1.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaComorbidityDatabases, FactualFemaleHumansLymphatic MetastasisMaleMargins of ExcisionMiddle AgedNeoplasm GradingNeoplasm StagingNeoplasm, ResidualPropensity ScoreRadiotherapy, AdjuvantRetrospective StudiesSurvival RateConceptsPositive resection marginsLymph node statusResection marginsPredictors of survivalIntrahepatic cholangiocarcinoma resectionIntrahepatic cholangiocarcinomaPropensity score matchingNode statusT stageSurvival outcomesImpact of surgical marginsLymph node negative patientsSurgically resected intrahepatic cholangiocarcinomaNegative predictors of survivalReceipt of RTNegative resection marginsNode negative patientsImpact of radiotherapyNational Cancer DatabaseNode negative diseaseResected intrahepatic cholangiocarcinomaImprove survival outcomesTumor T stageEarly-stage diseaseIntrahepatic cholangiocarcinoma patientsOverall survival and resection margin after hepatectomy for intrahepatic cholangiocarcinoma at academic cancer centers versus community cancer centers.
Berger N, Hammad A, Miura J, Johnston F, Christians K, Tsai S, Turaga K, Gamblin T. Overall survival and resection margin after hepatectomy for intrahepatic cholangiocarcinoma at academic cancer centers versus community cancer centers. Journal Of Clinical Oncology 2016, 34: 339-339. DOI: 10.1200/jco.2016.34.4_suppl.339.Peer-Reviewed Original ResearchCommunity cancer centerAcademic cancer centerOverall survivalIntrahepatic cholangiocarcinomaResection marginsCancer CenterR0 resectionMargin statusRate of negative resection marginsAssociated with improved OSPrognostic factors of survivalAlpha-feto-protein levelNegative resection marginsNational Cancer DatabaseRecurrence-free survivalSurgical resection marginsFactors of survivalKaplan-Meier methodCox multivariate modelPredictors of survivalReadmission ratesAssociated with higher ratesRates of R0Median OSR1/2 resectionRadiotherapy for intrahepatic cholangiocarcinoma: An analysis of the National Cancer Database.
Hammad A, Younan G, Rajeev R, Berger N, Turaga K, Johnston F, Christians K, Gamblin T. Radiotherapy for intrahepatic cholangiocarcinoma: An analysis of the National Cancer Database. Journal Of Clinical Oncology 2016, 34: 379-379. DOI: 10.1200/jco.2016.34.4_suppl.379.Peer-Reviewed Original ResearchPositive resection marginsPredictors of survivalNational Cancer DatabaseResection marginsIntrahepatic cholangiocarcinomaSurgical resectionCancer DatabaseSurgically resected intrahepatic cholangiocarcinomaNegative predictors of survivalPositive predictor of survivalReceipt of RTResection margin statusImpact of radiotherapyResected intrahepatic cholangiocarcinomaKaplan-Meier methodR0 statusNegative marginsLiver resectionImproved survivalRadiotherapyMargin statusResectionMultivariate regression modelFemale sexImpact survival
2015
The evolving role of adjuvant radiotherapy for elderly women with early‐stage breast cancer
Rutter CE, Lester-Coll NH, Mancini BR, Corso CD, Park HS, Yeboa DN, Gross CP, Evans SB. The evolving role of adjuvant radiotherapy for elderly women with early‐stage breast cancer. Cancer 2015, 121: 2331-2340. PMID: 25810128, DOI: 10.1002/cncr.29377.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerER-positive early-stage breast cancerRT useElderly patientsLogistic regression analysisBoost radiotherapyAdjuvant radiotherapyBreast cancerLeukemia Group B (CALGB) 9343 trialPositive early-stage breast cancerNational Cancer Data BaseMultivariable logistic regression analysisAvoidance of radiotherapyLocal control benefitNegative resection marginsYear of diagnosisUse of radiotherapyRegression analysisClinicopathologic covariatesRT detailsOlder patientsOverall survivalHypofractionated radiotherapyResection marginsEvidence-based practice
2013
Dysplasia at the margin? Investigating the case for subsequent therapy in ‘Low-Risk’ squamous cell carcinoma of the oral tongue
Sopka DM, Li T, Lango MN, Mehra R, Liu JC, Burtness B, Flieder DB, Ridge JA, Galloway TJ. Dysplasia at the margin? Investigating the case for subsequent therapy in ‘Low-Risk’ squamous cell carcinoma of the oral tongue. Oral Oncology 2013, 49: 1083-1087. PMID: 24054332, PMCID: PMC4037753, DOI: 10.1016/j.oraloncology.2013.08.001.Peer-Reviewed Original ResearchConceptsDisease-free survivalFox Chase Cancer CenterModerate dysplasiaOverall survivalLocal controlOral tongueSevere dysplasiaMild dysplasiaActuarial local controlInferior local controlKaplan-Meier methodOral tongue cancerWorse local controlSquamous cell carcinomaEarly-stage cancerAdditional therapyMeier methodResection marginsSubsequent therapyEntire cohortTongue cancerCancer CenterCell carcinomaPathology reportsFinal marginsClinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas
Delpech Y, Coutant C, Hsu L, Barranger E, Iwamoto T, Barcenas CH, Hortobagyi GN, Rouzier R, Esteva FJ, Pusztai L. Clinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas. British Journal Of Cancer 2013, 108: 285-291. PMID: 23299541, PMCID: PMC3566807, DOI: 10.1038/bjc.2012.557.Peer-Reviewed Original ResearchConceptsInvasive ductal carcinomaBreast-conserving surgeryNeoadjuvant chemotherapyPure lobular carcinomaLobular carcinomaClinical benefitTumor sizeER-positive invasive ductal carcinomasLower pathological complete response rateResponse ratePathological complete response ratePathological response rateComplete response rateGood clinical responsePathological complete responseType of chemotherapyPositive surgical marginsSurgical resection marginsClinical responseNodal statusComplete responseResection marginsSurgical marginsDuctal carcinomaPositive margins
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