2016
Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma
Correa-Gallego C, Maddalo D, Doussot A, Kemeny N, Kingham T, Allen P, D’Angelica M, DeMatteo R, Betel D, Klimstra D, Jarnagin W, Ventura A. Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. PLOS ONE 2016, 11: e0163699. PMID: 27685844, PMCID: PMC5042503, DOI: 10.1371/journal.pone.0163699.Peer-Reviewed Original ResearchMiR-21MiR-221Plasma miRNAsOverexpression of miR-21Circulating miR-21Circulating plasma miRNAsPlasma expression levelsLevel of microRNA-21MiRNA expressionMicroRNA-21Differentially expressed miRNAsOverexpressed miRNAsUpregulated miRNAsCohort of patientsIntrahepatic cholangiocarcinomaMicroRNA-221Healthy controlsMiRNAsMiRNA expression dataNon-neoplastic liver parenchymaDiscriminatory abilityPrimary intrahepatic cholangiocarcinomaIntrahepatic cholangiocarcinoma patientsCirculating plasma levelsPotential diagnostic markersIs Radiotherapy Warranted Following Intrahepatic Cholangiocarcinoma Resection? The Impact of Surgical Margins and Lymph Node Status on Survival
Hammad A, Berger N, Eastwood D, Tsai S, Turaga K, Christian K, Johnston F, Pawlik T, Gamblin T. Is Radiotherapy Warranted Following Intrahepatic Cholangiocarcinoma Resection? The Impact of Surgical Margins and Lymph Node Status on Survival. Annals Of Surgical Oncology 2016, 23: 912-920. PMID: 27654107, DOI: 10.1245/s10434-016-5560-1.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaComorbidityDatabases, FactualFemaleHumansLymphatic MetastasisMaleMargins of ExcisionMiddle AgedNeoplasm GradingNeoplasm StagingNeoplasm, ResidualPropensity ScoreRadiotherapy, AdjuvantRetrospective StudiesSurvival RateConceptsPositive resection marginsLymph node statusResection marginsPredictors of survivalIntrahepatic cholangiocarcinoma resectionIntrahepatic cholangiocarcinomaPropensity score matchingNode statusT stageSurvival outcomesImpact of surgical marginsLymph node negative patientsSurgically resected intrahepatic cholangiocarcinomaNegative predictors of survivalReceipt of RTNegative resection marginsNode negative patientsImpact of radiotherapyNational Cancer DatabaseNode negative diseaseResected intrahepatic cholangiocarcinomaImprove survival outcomesTumor T stageEarly-stage diseaseIntrahepatic cholangiocarcinoma patients
2015
Chemotherapy for Surgically Resected Intrahepatic Cholangiocarcinoma
Miura J, Johnston F, Tsai S, George B, Thomas J, Eastwood D, Banerjee A, Christians K, Turaga K, Pawlik T, Clark Gamblin T. Chemotherapy for Surgically Resected Intrahepatic Cholangiocarcinoma. Annals Of Surgical Oncology 2015, 22: 3716-3723. PMID: 25777092, DOI: 10.1245/s10434-015-4501-8.Peer-Reviewed Original ResearchConceptsSurgically resected intrahepatic cholangiocarcinomaResected intrahepatic cholangiocarcinomaAdvanced tumor stageLymph node metastasisIntrahepatic cholangiocarcinomaReceipt of chemotherapySurgical marginsTumor stageMedian OSOverall survivalNode metastasisAssociated with receipt of chemotherapyNon-metastatic intrahepatic cholangiocarcinomaAssociated with poor overall survivalInadequate surgical resectionLymph node statusNational Cancer DatabaseHigh-risk featuresPoorly differentiated tumorsBenefit of chemotherapyIntrahepatic cholangiocarcinoma patientsImpact of chemotherapyPoor overall survivalAssociated with receiptN0 diseaseChemotherapy for surgically resected intrahepatic cholangiocarcinoma: Influence of lymph node status on treatment efficacy.
Miura J, Johnston F, Tsai S, George B, Thomas J, Christians K, Turaga K, Pawlik T, Gamblin T. Chemotherapy for surgically resected intrahepatic cholangiocarcinoma: Influence of lymph node status on treatment efficacy. Journal Of Clinical Oncology 2015, 33: 353-353. DOI: 10.1200/jco.2015.33.3_suppl.353.Peer-Reviewed Original ResearchLymph node statusSurgically resected intrahepatic cholangiocarcinomaResected intrahepatic cholangiocarcinomaIntrahepatic cholangiocarcinomaNode statusMedian OSOverall survivalFrequency of lymph node metastasisNon-metastatic intrahepatic cholangiocarcinomaAssociated with shorter OSTime of surgical resectionAssessment of lymph nodesNational Cancer DatabaseLymph node evaluationCurative intent surgeryLog-rank testRate of recurrenceAdvanced tumor stageLymph node metastasisSubgroup of patientsIntrahepatic cholangiocarcinoma patientsReceipt of CTCox proportional hazards modelsProportional hazards modelBenefits of CT
2008
Intrahepatic Cholangiocarcinoma
Endo I, Gonen M, Yopp A, Dalal K, Zhou Q, Klimstra D, D'Angelica M, DeMatteo R, Fong Y, Schwartz L, Kemeny N, O'Reilly E, Abou-Alfa G, Shimada H, Blumgart L, Jarnagin W. Intrahepatic Cholangiocarcinoma. Annals Of Surgery 2008, 248: 84-96. PMID: 18580211, DOI: 10.1097/sla.0b013e318176c4d3.Peer-Reviewed Original ResearchConceptsHilar cholangiocarcinoma patientsIntrahepatic cholangiocarcinoma patientsDisease-specific survivalIntrahepatic cholangiocarcinomaUnresectable diseasePredicted poorer recurrence-free survivalMedian disease-specific survivalMemorial Sloan-Kettering Cancer CenterPoor recurrence-free survivalMultifocal intrahepatic cholangiocarcinomaRecurrence-free survivalMedian Follow-UpRegional nodal involvementTreated with chemotherapyMultiple hepatic tumorsHepatic arterial floxuridineHeavy tobacco useAdvanced hepatic diseaseLong-term survivalStudy periodInflammatory bowel diseaseNodal involvementIntrahepatic cholangiocarcinoma incidenceIntrahepatic diseaseNonoperative therapy
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