2024
Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach
Wei S, Zhang Y, Sowmiyanarayanan S, Yehia Z, Jan I, Yue N, Haffty B, Nie K. Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e341. DOI: 10.1016/j.ijrobp.2024.07.752.Peer-Reviewed Original ResearchBreast cancer patientsRadiation dermatitisSide effectsCancer patientsBreast cancer patients treated with radiationRadiogenomic approachCancer patients treated with radiationRadiation-induced acute toxicityPatients treated with radiationRadiomic featuresSingle nucleotide polymorphismsAcute radiation dermatitisBreast-conserving surgeryRadiation side effectsPeripheral blood samplesTotal radiation dosePersonalized treatment strategiesGenetic statusRadiation therapyMammographic patternsRadiomic texture featuresTherapy side effectsClinical parametersRetrospective studyClinical featuresPre-Operative Boost Results in Low Rates of Re-Excision and Reduced Time from Initial Diagnosis to Completion of Local-Regional Treatment in Breast Cancer Patients
Chakraborty M, Sherwani Z, Yehia Z, Ohri N, Cui T, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Toppmeyer D, Haffty B. Pre-Operative Boost Results in Low Rates of Re-Excision and Reduced Time from Initial Diagnosis to Completion of Local-Regional Treatment in Breast Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s201-s202. DOI: 10.1016/j.ijrobp.2024.07.2265.Peer-Reviewed Original ResearchBreast-conserving surgeryWhole breast irradiationDuctal carcinoma in situRe-excision ratesProspective phase II clinical trialRate of re-excisionPhase II clinical trialRe-ExcisionII clinical trialsHypofractionated regimenWound complicationsPre-operativelyDiagnosis to completionTreated with breast-conserving surgeryClinical trialsInitiation of systemic therapyMedian clinical tumor sizeRisk of wound complicationsIncidence of wound complicationsEarly-stage breast cancerLocal-regional treatmentTumor bed boostClinical tumor sizeNode-positive diseaseCompletion of radiationClinical Outcomes in Breast Cancer Patients with Underlying Germline PALB2 Mutations Treated with Radiation
Shalaby A, Jan I, Ohri N, Yehia Z, Toppmeyer D, Haffty B. Clinical Outcomes in Breast Cancer Patients with Underlying Germline PALB2 Mutations Treated with Radiation. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e331-e332. DOI: 10.1016/j.ijrobp.2024.07.731.Peer-Reviewed Original ResearchBreast-conserving surgeryPALB2 variantsBreast cancer patientsInterpretations of pathogenicityClinical outcomesPathogenic variantsHYPO-RTBreast cancer patients treated with radiationCancer patients treated with radiationCancer patientsRisk of radiation toxicitySentinel lymph node dissectionPatients treated with radiationMedical recordsPALB2 pathogenic variantsContralateral breast cancerExternal beam radiationMedian tumor sizeLymph node dissectionSuppression of cancer developmentGrade 2 fibrosisRecurrence 4 monthsMultigene panel testingDNA double-strand break repairDouble-strand break repairPredicting peripheral neuropathy following neoadjuvant therapy in patients with breast cancer.
Feiger B, Biancalana M, Shelton A, Blenman K, Lustberg M. Predicting peripheral neuropathy following neoadjuvant therapy in patients with breast cancer. Journal Of Clinical Oncology 2024, 42: e12639-e12639. DOI: 10.1200/jco.2024.42.16_suppl.e12639.Peer-Reviewed Original ResearchBreast cancer patientsNeoadjuvant chemotherapyPeripheral neuropathyNeoadjuvant therapyBreast cancerCancer patientsAdministration of neoadjuvant chemotherapyCohort of breast cancer patientsLikelihood of breast-conserving surgeryContrast-enhanced magnetic resonance imagingQuality of lifeDynamic contrast-enhanced magnetic resonance imagingBreast-conserving surgeryReduced tumor burdenTreatment-induced neuropathyOccurrence of neuropathyInduce peripheral neuropathyDensity of blood vesselsPatients' quality of lifeMagnetic resonance imagingAmeliorate neuropathyDCE-MRI dataTumor burdenCumulative toxic effectsIntratumoral vascularity
2023
Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Small W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA. Journal Of Clinical Oncology 2023, 42: 390-398. PMID: 38060195, PMCID: PMC11846025, DOI: 10.1200/jco.23.02270.Peer-Reviewed Original ResearchBreast-conserving surgeryIpsilateral breast eventsEndocrine therapyPostmenopausal patientsBreast cancerCrude rateLower riskBreast cancer-specific survival ratesUnifocal invasive breast cancersYears of ETCancer-specific survival ratesStage I breast cancerHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Omission of radiotherapyYounger postmenopausal patientsPatients age 50Primary end pointBreast conserving surgeryGrowth factor receptor 2I breast cancerInvasive breast cancerRecurrence 5 yearsPatients age 65Single-arm trialRadiotherapy Use and Incidence of Locoregional Recurrence in Patients With Favorable-Risk, Node-Positive Breast Cancer Enrolled in the SWOG S1007 Trial
Jagsi R, Barlow W, Woodward W, Connolly E, Mahtani R, Shumway D, Speers C, Stecklein S, Zeidan Y, Zhang H, Sharma P, Pusztai L, Hortobagyi G, Kalinsky K. Radiotherapy Use and Incidence of Locoregional Recurrence in Patients With Favorable-Risk, Node-Positive Breast Cancer Enrolled in the SWOG S1007 Trial. JAMA Oncology 2023, 9: 1083-1089. PMID: 37410451, PMCID: PMC10326730, DOI: 10.1001/jamaoncol.2023.1984.Peer-Reviewed Original ResearchConceptsInvasive disease-free survivalDisease-free survivalLocoregional recurrenceBreast-conserving surgeryBreast cancerLocoregional therapyCumulative incidenceRecurrence scoreRadiotherapy informationERBB2-negative breast cancerPredictors of LRRRate of LRRSecondary analysisNode-positive breast cancerBreast Recurrence ScoreLimited nodal diseaseLower locoregional recurrenceOmission of chemotherapyAxillary surgeryRadiotherapy receiptEndocrine therapyN1 diseaseNodal diseaseLocoregional treatmentMenopausal status
2022
Risk Assessment in the Molecular Era
Knowlton CA, Jimenez RB, Moran MS. Risk Assessment in the Molecular Era. Seminars In Radiation Oncology 2022, 32: 189-197. PMID: 35688517, DOI: 10.1016/j.semradonc.2022.01.005.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryClinical-pathologic featuresHormone receptor-positive diseaseLow-risk DCIS patientsLow-risk DCISAdjuvant endocrine therapyLocal control rateMajority of patientsSpecific survival outcomesPersonalized risk assessmentMolecular assaysBreast recurrenceDCIS patientsDCIS ScoreRT recommendationsDefinitive surgeryEndocrine therapyPostoperative radiotherapyPositive diseaseDuctal carcinomaSurvival outcomesControl rateInvasive cancerTreatment paradigmBreast cancerLocal Therapy Outcomes and Toxicity From the ATEMPT Trial (TBCRC 033): A Phase II Randomized Trial of Adjuvant Trastuzumab Emtansine Versus Paclitaxel in Combination With Trastuzumab in Women With Stage I HER2-Positive Breast Cancer
Bellon JR, Tayob N, Yang DD, Tralins J, Dang CT, Isakoff SJ, DeMeo M, Burstein HJ, Partridge AH, Winer EP, Krop IE, Tolaney SM. Local Therapy Outcomes and Toxicity From the ATEMPT Trial (TBCRC 033): A Phase II Randomized Trial of Adjuvant Trastuzumab Emtansine Versus Paclitaxel in Combination With Trastuzumab in Women With Stage I HER2-Positive Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2022, 113: 117-124. PMID: 34990776, DOI: 10.1016/j.ijrobp.2021.12.173.Peer-Reviewed Original ResearchConceptsHER2-positive breast cancerBreast-conserving surgeryStage I HER2-positive breast cancerT-DM1 armBreast radiation therapyT-DM1Radiation therapySkin toxicityBreast cancerBCS patientsWBRT patientsInvasive disease-free survival eventsDisease-free survival eventsInvasive disease-free survivalHuman epidermal growth factor receptor 2Phase II Randomized TrialWhole breast radiation therapyEpidermal growth factor receptor 2Adjuvant T-DM1Adjuvant trastuzumab emtansineEfficacy of HER2RT-related toxicityWeeks of therapyAcute skin toxicityAnti-HER2 therapy
2021
Milestone Studies in Breast Cancer Surgery
Chagpar A. Milestone Studies in Breast Cancer Surgery. 2021, 9-17. DOI: 10.1007/978-3-030-73147-2_2.Peer-Reviewed Original ResearchBreast cancer surgeryCancer surgerySentinel node biopsyBreast-conserving surgeryPostoperative cosmetic outcomeBreast cancer managementAxillary dissectionNode biopsyRadical mastectomyLandmark trialsSurgical managementSurgical interventionCosmetic outcomeMargin clearanceBreast cancerCancer managementSurgeryRadiation oncologyMultidisciplinary approachOngoing studiesMilestone studyNumber of advancesMastectomyMorbidityAxilla
2020
Dermatologic toxicities associated with radiation therapy in women with breast cancer
Ramseier JY, Ferreira MN, Leventhal JS. Dermatologic toxicities associated with radiation therapy in women with breast cancer. International Journal Of Women's Dermatology 2020, 6: 349-356. PMID: 33898697, PMCID: PMC8060663, DOI: 10.1016/j.ijwd.2020.07.015.Peer-Reviewed Original ResearchBreast cancerRadiation therapyDermatologic toxicitiesEarly-stage breast cancerRadiation-induced morpheaAdjuvant radiation therapyBreast-conserving surgeryStage breast cancerStandard of careRadiation-induced fibrosisRadiation recallCutaneous toxicityRadiation dermatitisCutaneous sequelaeClinical presentationCutaneous malignanciesPatients' qualityTherapyCancerWomenToxicityMorpheaSequelaePatientsSurgeryThe impact of pattern of tumor response and other post-treatment histologic features on local recurrence in patients treated with neoadjuvant chemotherapy and breast conservation.
Laws A, Pastorello R, Choi J, Kantor O, Grossmith S, Schnitt S, Golshan M, Mittendorf E, King T. The impact of pattern of tumor response and other post-treatment histologic features on local recurrence in patients treated with neoadjuvant chemotherapy and breast conservation. Journal Of Clinical Oncology 2020, 38: 581-581. DOI: 10.1200/jco.2020.38.15_suppl.581.Peer-Reviewed Original ResearchPathologic complete responseResidual invasive diseaseLocal recurrenceNeoadjuvant chemotherapyBreast-conserving surgeryResidual DCISTumor responseResidual diseaseInvasive diseaseBreast pathologic complete responseDetailed pathology reviewAdjuvant endocrine therapyPoor prognostic factorModern systemic therapyTreatment effectsNeoadjuvant trastuzumabRCB scoreEndocrine therapyFree survivalMulticentric diseaseBreast conservationComplete responseLymphovascular invasionMargin statusPrognostic factors
2019
Peer Influence on Physician Use of Shorter Course External Beam Radiation Therapy for Patients with Breast Cancer
Yu JB, Pollack CE, Herrin J, Soulos PR, Zhu W, Xu X, Gross CP. Peer Influence on Physician Use of Shorter Course External Beam Radiation Therapy for Patients with Breast Cancer. Practical Radiation Oncology 2019, 10: 75-83. PMID: 31785370, PMCID: PMC7061062, DOI: 10.1016/j.prro.2019.11.001.Peer-Reviewed Original ResearchConceptsAdjuvant external beam radiation therapyExternal beam radiation therapyPhysician peer groupsPalliative external beam radiation therapyBeam radiation therapyBreast cancerAdjuvant therapyBone metastasesPatient receiptRadiation therapyBreast-conserving surgeryMixed-effects logistic regressionPatient-sharing relationshipsPalliative therapyCancer careMedicare beneficiariesPatientsPhysician useTherapyLogistic regressionShort courseCancerPhysiciansGroup rateMetastasisLong term outcomes of sentinel lymph node biopsy for ductal carcinoma in situ
Hung P, Wang SY, Killelea BK, Mougalian SS, Evans SB, Sedghi T, Gross CP. Long term outcomes of sentinel lymph node biopsy for ductal carcinoma in situ. JNCI Cancer Spectrum 2019, 3: pkz052. PMID: 32337481, PMCID: PMC7049982, DOI: 10.1093/jncics/pkz052.Peer-Reviewed Original ResearchSentinel lymph node biopsyBreast-conserving surgeryBreast cancer mortalityLong-term outcomesDuctal carcinomaCancer mortalityEnd Results-Medicare datasetCompeting-risks survival analysisLymph node biopsyPopulation cohort dataNode biopsyOlder patientsSentinel lymphBreast conservationUS SurveillanceTerm outcomesSurvival analysisDCISPatientsStatistical significanceRoutine performanceBiopsySurgeryCarcinomaRecurrenceA whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk
Klimov S, Miligy I, Gertych A, Jiang Y, Toss M, Rida P, Ellis I, Green A, Krishnamurti U, Rakha E, Aneja R. A whole slide image-based machine learning approach to predict ductal carcinoma in situ (DCIS) recurrence risk. Breast Cancer Research 2019, 21: 83. PMID: 31358020, PMCID: PMC6664779, DOI: 10.1186/s13058-019-1165-5.Peer-Reviewed Original ResearchConceptsDCIS patientsRecurrence riskDuctal carcinomaScreen-detected breast cancerLong-term outcome dataBreast-conserving surgeryUnmet clinical needNottingham University HospitalsPositive predictive valueAdjuvant radiationIpsilateral recurrenceAdditional therapyMethodsThe cohortHazard ratioLocal recurrenceClinicopathological markersClinicopathological variablesPrimary tumorUniversity HospitalLymphocyte regionBreast cancerOutcome dataBenign ductsPredictive valuePatientsLocal–regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial)
Bellon JR, Guo H, Barry WT, Dang CT, Yardley DA, Moy B, Marcom PK, Albain KS, Rugo HS, Ellis M, Wolff AC, Carey LA, Overmoyer BA, Partridge AH, Hudis CA, Krop I, Burstein HJ, Winer EP, Tolaney SM. Local–regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial). Breast Cancer Research And Treatment 2019, 176: 303-310. PMID: 31004299, DOI: 10.1007/s10549-019-05238-4.Peer-Reviewed Original ResearchConceptsHER2-positive breast cancerLocal-regional recurrenceDisease-free survivalEffective anti-HER2 therapyLRR-free survivalAnti-HER2 therapyBreast-conserving surgeryBreast cancerRadiation therapySystemic therapyHormone receptor-positive tumorsProspective multi-institutional studyHER2-negative diseaseHER2-positive diseaseNegative axillary nodesEffective systemic therapyProspective multicenter trialEarly-stage patientsKaplan-Meier methodReceptor-positive tumorsHER2-positive tumorsMulti-institutional studyFuture investigational effortsAdjuvant trastuzumabProtocol therapyPatient-Reported Outcomes and Cosmesis in a Feasibility Study of 4-Dimensional Simulated Image Guided Accelerated Partial Breast Irradiation
Rahimy E, Weidhaas J, Wei W, Lannin D, Horowitz N, Higgins S, Wilson LD, Knowlton C, Moran MS, Young MR, Killelea B, Chagpar A, Yeboa DN, Zelterman D, Evans S. Patient-Reported Outcomes and Cosmesis in a Feasibility Study of 4-Dimensional Simulated Image Guided Accelerated Partial Breast Irradiation. Practical Radiation Oncology 2019, 9: e257-e265. PMID: 30796975, DOI: 10.1016/j.prro.2019.01.013.Peer-Reviewed Original ResearchConceptsPartial breast irradiationDosimetric constraintsBreast irradiationCosmetic outcomePoor cosmesisToxicity gradeBreast cancerKarnofsky performance status scoreTarget volumeAccelerated Partial Breast IrradiationSmaller planning target volumesAcceptable cosmetic outcomeAdverse cosmetic outcomePathologic tumor sizePerformance status scoreI breast cancerBreast-conserving surgeryThree-dimensional conformalDose-volume relationshipPlanning target volumeComputed tomography simulationDaily image guidanceLocoregional recurrencePrimary endpointTumor size
2018
Associations of preoperative breast magnetic resonance imaging with subsequent mastectomy and breast cancer mortality
Wang SY, Long JB, Killelea BK, Evans SB, Roberts KB, Silber AL, Davidoff AJ, Sedghi T, Gross CP. Associations of preoperative breast magnetic resonance imaging with subsequent mastectomy and breast cancer mortality. Breast Cancer Research And Treatment 2018, 172: 453-461. PMID: 30099634, PMCID: PMC6193824, DOI: 10.1007/s10549-018-4919-3.Peer-Reviewed Original ResearchConceptsBreast-conserving surgeryBreast cancer mortalitySubsequent mastectomyCancer mortalityPre-operative MRIBreast cancerSubgroup analysisStage I/II breast cancerEnd Results-Medicare datasetPreoperative breast magnetic resonanceEarly-stage breast cancerMagnetic resonance imaging useReceipt of radiotherapyBreast magnetic resonanceClinical outcomesCox regressionResultsOur sampleImproved outcomesAdjusted ratesMRI useOlder womenLower riskMastectomyImaging useRadiotherapyAssociations Between Sentinel Lymph Node Biopsy and Complications for Patients with Ductal Carcinoma In Situ
Killelea BK, Long JB, Dang W, Mougalian SS, Evans SB, Gross CP, Wang SY. Associations Between Sentinel Lymph Node Biopsy and Complications for Patients with Ductal Carcinoma In Situ. Annals Of Surgical Oncology 2018, 25: 1521-1529. PMID: 29516364, PMCID: PMC5928184, DOI: 10.1245/s10434-018-6410-0.Peer-Reviewed Original ResearchConceptsSentinel lymph node biopsyBreast-conserving surgeryLymph node biopsySLNB useNode biopsyWound infectionDuctal carcinomaUse of SLNBEnd Results-Medicare datasetIncidence of complicationsShort-term complicationsMonths of diagnosisOlder patientsSubsequent mastectomyInitial treatmentResultsOur sampleConsensus guidelinesHigh riskOlder womenComplicationsMultivariate analysisPatientsWomenDCISMastectomySurgical Management of the Breast
Chagpar A. Surgical Management of the Breast. DeckerMed Complex General Surgical Oncology 2018 DOI: 10.2310/7800.16006.Peer-Reviewed Original ResearchSentinel node biopsySurgical managementAxillary dissectionNode biopsyBreast cancerBreast surgical oncologyKey clinical trialsNode-positive diseaseBreast-conserving surgeryCompletion dissectionBreast conservationRadical mastectomyClinical trialsSurgical oncologyRadiation therapyLeading malignancyCancerDissectionMastectomyBiopsyMalignancyKey wordsChemotherapyManagementSurgerySurgical Management of the Breast
Chagpar A. Surgical Management of the Breast. DeckerMed CGSO Case-Based Reviews 2018 DOI: 10.2310/cgso.16006.Peer-Reviewed Original ResearchSentinel node biopsySurgical managementAxillary dissectionNode biopsyBreast cancerBreast surgical oncologyKey clinical trialsNode-positive diseaseBreast-conserving surgeryCompletion dissectionBreast conservationRadical mastectomyClinical trialsSurgical oncologyRadiation therapyLeading malignancyCancerDissectionMastectomyBiopsyMalignancyKey wordsChemotherapyManagementSurgery
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