2016
Is Radiotherapy Warranted Following Intrahepatic Cholangiocarcinoma Resection? The Impact of Surgical Margins and Lymph Node Status on Survival
Hammad A, Berger N, Eastwood D, Tsai S, Turaga K, Christian K, Johnston F, Pawlik T, Gamblin T. Is Radiotherapy Warranted Following Intrahepatic Cholangiocarcinoma Resection? The Impact of Surgical Margins and Lymph Node Status on Survival. Annals Of Surgical Oncology 2016, 23: 912-920. PMID: 27654107, DOI: 10.1245/s10434-016-5560-1.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaComorbidityDatabases, FactualFemaleHumansLymphatic MetastasisMaleMargins of ExcisionMiddle AgedNeoplasm GradingNeoplasm StagingNeoplasm, ResidualPropensity ScoreRadiotherapy, AdjuvantRetrospective StudiesSurvival RateConceptsPositive resection marginsLymph node statusResection marginsPredictors of survivalIntrahepatic cholangiocarcinoma resectionIntrahepatic cholangiocarcinomaPropensity score matchingNode statusT stageSurvival outcomesImpact of surgical marginsLymph node negative patientsSurgically resected intrahepatic cholangiocarcinomaNegative predictors of survivalReceipt of RTNegative resection marginsNode negative patientsImpact of radiotherapyNational Cancer DatabaseNode negative diseaseResected intrahepatic cholangiocarcinomaImprove survival outcomesTumor T stageEarly-stage diseaseIntrahepatic cholangiocarcinoma patientsRadiotherapy for intrahepatic cholangiocarcinoma: An analysis of the National Cancer Database.
Hammad A, Younan G, Rajeev R, Berger N, Turaga K, Johnston F, Christians K, Gamblin T. Radiotherapy for intrahepatic cholangiocarcinoma: An analysis of the National Cancer Database. Journal Of Clinical Oncology 2016, 34: 379-379. DOI: 10.1200/jco.2016.34.4_suppl.379.Peer-Reviewed Original ResearchPositive resection marginsPredictors of survivalNational Cancer DatabaseResection marginsIntrahepatic cholangiocarcinomaSurgical resectionCancer DatabaseSurgically resected intrahepatic cholangiocarcinomaNegative predictors of survivalPositive predictor of survivalReceipt of RTResection margin statusImpact of radiotherapyResected intrahepatic cholangiocarcinomaKaplan-Meier methodR0 statusNegative marginsLiver resectionImproved survivalRadiotherapyMargin statusResectionMultivariate regression modelFemale sexImpact survival
2015
Chemotherapy for Surgically Resected Intrahepatic Cholangiocarcinoma
Miura J, Johnston F, Tsai S, George B, Thomas J, Eastwood D, Banerjee A, Christians K, Turaga K, Pawlik T, Clark Gamblin T. Chemotherapy for Surgically Resected Intrahepatic Cholangiocarcinoma. Annals Of Surgical Oncology 2015, 22: 3716-3723. PMID: 25777092, DOI: 10.1245/s10434-015-4501-8.Peer-Reviewed Original ResearchConceptsSurgically resected intrahepatic cholangiocarcinomaResected intrahepatic cholangiocarcinomaAdvanced tumor stageLymph node metastasisIntrahepatic cholangiocarcinomaReceipt of chemotherapySurgical marginsTumor stageMedian OSOverall survivalNode metastasisAssociated with receipt of chemotherapyNon-metastatic intrahepatic cholangiocarcinomaAssociated with poor overall survivalInadequate surgical resectionLymph node statusNational Cancer DatabaseHigh-risk featuresPoorly differentiated tumorsBenefit of chemotherapyIntrahepatic cholangiocarcinoma patientsImpact of chemotherapyPoor overall survivalAssociated with receiptN0 diseaseChemotherapy for surgically resected intrahepatic cholangiocarcinoma: Influence of lymph node status on treatment efficacy.
Miura J, Johnston F, Tsai S, George B, Thomas J, Christians K, Turaga K, Pawlik T, Gamblin T. Chemotherapy for surgically resected intrahepatic cholangiocarcinoma: Influence of lymph node status on treatment efficacy. Journal Of Clinical Oncology 2015, 33: 353-353. DOI: 10.1200/jco.2015.33.3_suppl.353.Peer-Reviewed Original ResearchLymph node statusSurgically resected intrahepatic cholangiocarcinomaResected intrahepatic cholangiocarcinomaIntrahepatic cholangiocarcinomaNode statusMedian OSOverall survivalFrequency of lymph node metastasisNon-metastatic intrahepatic cholangiocarcinomaAssociated with shorter OSTime of surgical resectionAssessment of lymph nodesNational Cancer DatabaseLymph node evaluationCurative intent surgeryLog-rank testRate of recurrenceAdvanced tumor stageLymph node metastasisSubgroup of patientsIntrahepatic cholangiocarcinoma patientsReceipt of CTCox proportional hazards modelsProportional hazards modelBenefits of CT
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