2025
Classification of recurrence patterns in surgically treated non-small cell lung cancer – A systematic review and a call for standardization
Bonis A, Detterbeck F, Figueroa P, Chen H, Osarogiagbon R, Dell'Amore A, Infante M. Classification of recurrence patterns in surgically treated non-small cell lung cancer – A systematic review and a call for standardization. European Journal Of Surgical Oncology 2025, 51: 110425. PMID: 40907166, DOI: 10.1016/j.ejso.2025.110425.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerLung cancerRecurrence patternsSystematic reviewNodal recurrenceDistant relapseSublobar resectionSurgical marginsIpsilateral lobeTumor recurrenceIpsilateral nodesClinical decision-makingCancer recurrenceContralateral hilumBronchial stumpRecurrencePleural spacePatient outcomesEligibility criteriaPRISMA guidelinesCancerRecurrence definitionEarly detectionPatientsAnatomic Lung Resection Is Associated With Improved Survival Compared With Wedge Resection for Stage IA (≤2 cm) NSCLC
Seder C, Chang S, Towe C, Puri V, Blasberg J, Bonnell L, Fernandez F, Habib R, Kozower B. Anatomic Lung Resection Is Associated With Improved Survival Compared With Wedge Resection for Stage IA (≤2 cm) NSCLC. Journal Of Thoracic Oncology 2025, 20: 1075-1085. PMID: 40132758, PMCID: PMC12328121, DOI: 10.1016/j.jtho.2025.03.042.Peer-Reviewed Original ResearchLung cancer-specific survivalStage IA NSCLCAssociated with improved OSAssociated with improved survivalWedge resectionOverall survivalSublobar resectionLung resectionImproved survivalSociety of Thoracic Surgeons General Thoracic Surgery DatabaseClinical stage IA NSCLCHazard ratioNon-small cell lung cancerGeneral Thoracic Surgery DatabaseCancer-specific survivalEarly stage NSCLCAnatomical lung resectionSecondary end pointsThoracic Surgery DatabaseCell lung cancerLong-term survivalStabilized inverse probabilityClinical trial dataLong-term vital statusResection cohortLobectomy vs Sublobar Resection in The Society of Thoracic Surgeons Database: Importance of Patient Factors and Lymph Node Evaluation
Woodard G, Grau-Sepulveda M, Onaitis M, Udelsman B, David E, Jacobs J, Kosinski A, Blasberg J, Boffa D. Lobectomy vs Sublobar Resection in The Society of Thoracic Surgeons Database: Importance of Patient Factors and Lymph Node Evaluation. The Annals Of Thoracic Surgery 2025, 119: 1071-1081. PMID: 39864772, DOI: 10.1016/j.athoracsur.2025.01.004.Peer-Reviewed Original ResearchNon-small cell lung cancerSublobar resectionCell lung cancerLung cancerNodal upstagingImproved survivalHealthy patientsNode-negative non-small cell lung cancerThe Society of Thoracic Surgeons databaseRandomized trialsSociety of Thoracic Surgeons databaseAssociated with improved survivalEarly-stage lung cancerFewer lymph nodesInferior to survivalSublobar resection groupLymph node resectionThoracic Surgeons databaseLymph node evaluationProspective randomized trialsKaplan-Meier analysisForced expiratory volumeCT1 N0Pathologic upstagingNodal evaluation
2024
High-risk features associated with recurrence in stage I lung adenocarcinoma
Fick C, Dunne E, Vanstraelen S, Toumbacaris N, Tan K, Rocco G, Molena D, Huang J, Park B, Rekhtman N, Travis W, Chaft J, Bott M, Rusch V, Adusumilli P, Sihag S, Isbell J, Jones D. High-risk features associated with recurrence in stage I lung adenocarcinoma. Journal Of Thoracic And Cardiovascular Surgery 2024, 169: 436-444.e6. PMID: 38788834, PMCID: PMC11582076, DOI: 10.1016/j.jtcvs.2024.05.009.Peer-Reviewed Original ResearchCumulative incidence of recurrenceStage I lung adenocarcinomaIncidence of recurrenceClinicopathological featuresStage I LUADCumulative incidenceHighest maximum standardized uptake valueMaximum standardized uptake valueRetrospective analysis of patientsHigh risk of recurrenceHigh riskHistory of lung cancerStage I diseaseStandardized uptake valueVisceral pleural invasionHigh-risk featuresHazard of recurrenceAssociated with recurrenceFeatures associated with recurrenceRisk of recurrenceAnalysis of patientsPrognosis of patientsDay of surgeryR0 resectionSublobar resectionHistopathologic fate of resected pulmonary pure ground glass nodule: a systematic review and meta-analysis
Woo W, Kang D, Jin Y, Kipkorir V, Song S, Moon D, Shin J, Lee S. Histopathologic fate of resected pulmonary pure ground glass nodule: a systematic review and meta-analysis. Journal Of Thoracic Disease 2024, 0: 0-0. PMID: 38505083, PMCID: PMC10944737, DOI: 10.21037/jtd-23-1089.Peer-Reviewed Original ResearchMinimally invasive adenocarcinomaGround-glass nodulesAdenocarcinoma in situAtypical adenomatous hyperplasiaPure ground-glass nodulesInvasive adenocarcinomaMeta-analysisDiagnosis of invasive adenocarcinomaLung cancer screening programAggressive histologic patternCancer screening programLepidic subtypeSublobar resectionBetween-study heterogeneityHistological subtypesInvasive componentPathology reportsPathological diagnosisPooled proportionAdenomatous hyperplasiaHistological outcomesClinical outcomesHistological patternPathological characteristicsGlass nodules
2023
So Now We Know—Reflections on the Extent of Resection for Stage I Lung Cancer
Detterbeck F, Ely S, Udelsman B, Blasberg J, Boffa D, Dhanasopon A, Mase V, Woodard G. So Now We Know—Reflections on the Extent of Resection for Stage I Lung Cancer. Clinical Lung Cancer 2023, 25: e113-e123. PMID: 38310034, DOI: 10.1016/j.cllc.2023.12.007.Peer-Reviewed Original ResearchStage I lung cancerI lung cancerSublobar resectionRecurrence-free survivalHealthy patientsLung cancerRecent trialsInadequate resection marginsLarge recent trialsAdditional randomized trialsHigh-level evidenceOverall survival differenceExtent of resectionLong-term outcomesLong-term resultsHigh locoregional recurrenceAspects of patientsLesser resectionsLocoregional recurrencePerioperative morbidityIntraoperative detailsLung functionResection extentResection marginsPostoperative changesAdvances in Surgical Techniques for Lung Cancer
Udelsman B, Blasberg J. Advances in Surgical Techniques for Lung Cancer. Hematology/Oncology Clinics Of North America 2023, 37: 489-497. PMID: 36964110, DOI: 10.1016/j.hoc.2023.02.006.Peer-Reviewed Original Research
2022
A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 2: systematic review of evidence regarding resection extent in generally healthy patients
Detterbeck FC, Mase VJ, Li AX, Kumbasar U, Bade BC, Park HS, Decker RH, Madoff DC, Woodard GA, Brandt WS, Blasberg JD. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 2: systematic review of evidence regarding resection extent in generally healthy patients. Journal Of Thoracic Disease 2022, 0: 0-0. PMID: 35813747, PMCID: PMC9264068, DOI: 10.21037/jtd-21-1824.Peer-Reviewed Original ResearchNon-randomized comparisonHealthy patientsResection extentIndividual patientsSystematic reviewStage I lung cancerI lung cancerStage I NSCLCCharacteristics of patientsPulmonary function testsLong-term outcomesRisk of recurrenceVideo-Assisted ApproachSublobar resectionWedge resectionRandomized trialsFunction testsLung cancerResidual confoundingEffect modifiersShort-term benefitsLobectomyPatientsPubMed systematic reviewMargin distanceA guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 3: systematic review of evidence regarding surgery in compromised patients or specific tumors
Bade BC, Blasberg JD, Mase VJ, Kumbasar U, Li AX, Park HS, Decker RH, Madoff DC, Brandt WS, Woodard GA, Detterbeck FC. A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation—part 3: systematic review of evidence regarding surgery in compromised patients or specific tumors. Journal Of Thoracic Disease 2022, 0: 0-0. PMID: 35813753, PMCID: PMC9264070, DOI: 10.21037/jtd-21-1825.Peer-Reviewed Original ResearchLimited pulmonary reserveLong-term outcomesResection extentNon-randomized comparisonPulmonary reserveOlder patientsIndividual patientsFavorable tumorsSystematic reviewStage I lung cancerFavorable long-term outcomeI lung cancerScreen-detected tumorsStage I NSCLCCharacteristics of patientsShort-term outcomesLesser resectionsPerioperative mortalityPulmonary functionSublobar resectionWedge resectionPatient selectionRandomized trialsLung cancerResidual confounding
2020
Percutaneous Ablation of Intrathoracic Malignancy
Thakore S, Perez Lozada J. Percutaneous Ablation of Intrathoracic Malignancy. Current Pulmonology Reports 2020, 9: 171-180. DOI: 10.1007/s13665-020-00262-y.Peer-Reviewed Original ResearchStereotactic body radiotherapyPercutaneous ablationImage-guided percutaneous ablationNumber one cancer killerDifferent side effect profilesComparable overall survivalPost-ablation complicationsEarly-stage diseaseSide effect profilePercutaneous ablative therapiesPalliative intentReviewLung cancerMost patientsOverall survivalSublobar resectionSurgical resectionThoracic malignanciesClinical outcomesEffect profileIntrathoracic malignanciesAblative therapyBody radiotherapyLung cancerRadiofrequency ablationAblative techniquesApproach to the Subsolid Nodule
Mase VJ, Detterbeck FC. Approach to the Subsolid Nodule. Clinics In Chest Medicine 2020, 41: 99-113. PMID: 32008632, DOI: 10.1016/j.ccm.2019.11.004.Peer-Reviewed Original Research
2017
Stage I non-small-cell lung cancer: long-term results of lobectomy versus sublobar resection from the Polish National Lung Cancer Registry†
Dziedzic R, Żurek W, Marjański T, Rudziński P, Orłowski TM, Sawicka W, Marczyk M, Polańska J, Rzyman W. Stage I non-small-cell lung cancer: long-term results of lobectomy versus sublobar resection from the Polish National Lung Cancer Registry†. European Journal Of Cardio-Thoracic Surgery 2017, 52: 363-369. PMID: 28402455, DOI: 10.1093/ejcts/ezx092.Peer-Reviewed Original ResearchConceptsStage I NSCLCLung Cancer RegistryWedge resectionCell lung cancerOverall survivalSurvival rateCancer RegistryLung cancerCox proportional hazard ratiosPropensity score-matched analysisProportional hazard ratiosGroup of patientsTreatment of patientsLong-term resultsMethod of resectionLobar resectionHazard ratioSublobar resectionMediastinal lymphadenectomySurgical treatmentPatient groupRetrospective analysisSegmentectomyLobectomyStudy group
2015
Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base
Combs SE, Hancock JG, Boffa DJ, Decker RH, Detterbeck FC, Kim AW. Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base. Journal Of Thoracic Oncology 2015, 10: 316-323. PMID: 25319182, DOI: 10.1097/jto.0000000000000402.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerNational Cancer Data BaseSurgical resectionStage ISCLC patientsSublobar resectionOverall survivalLung cancerIIIA small cell lung cancerFive-year overall survivalAddition of surgeryClinical stage IPatient underwent surgeryPrimary surgical resectionKaplan-Meier methodLikelihood of deathCurative intentComorbidity scoreUnderwent surgeryChemoradiation therapyHazard ratioMetastatic diseaseMultimodality treatmentSelect patientsTreatment regimen
2012
American College of Chest Physicians and Society of Thoracic Surgeons Consensus Statement for Evaluation and Management for High-Risk Patients With Stage I Non-small Cell Lung Cancer
Donington J, Ferguson M, Mazzone P, Handy J, Schuchert M, Fernando H, Loo B, Lanuti M, de Hoyos A, Detterbeck F, Pennathur A, Howington J, Landreneau R, Silvestri G, Surgeons F. American College of Chest Physicians and Society of Thoracic Surgeons Consensus Statement for Evaluation and Management for High-Risk Patients With Stage I Non-small Cell Lung Cancer. CHEST Journal 2012, 142: 1620-1635. PMID: 23208335, DOI: 10.1378/chest.12-0790.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerStage I non-small cell lung cancerHigh-risk patientsCell lung cancerChest PhysiciansTreatment optionsLung cancerAmerican CollegeStereotactic body radiation therapySevere medical comorbiditiesThoracic Oncology NetworkAlternative treatment optionMore indolent tumorsBody radiation therapyRisk-benefit decisionsInterventional riskMedical comorbiditiesNonoperative therapyRespiratory failureInvolved lobeMediastinal lymphProcedural morbidityRegional recurrenceSublobar resectionRadiographic staging
2011
Management of Early Stage Non–Small Cell Lung Cancer in High-Risk Patients
Donington JS, Blasberg JD. Management of Early Stage Non–Small Cell Lung Cancer in High-Risk Patients. Thoracic Surgery Clinics 2011, 22: 55-65. PMID: 22108689, DOI: 10.1016/j.thorsurg.2011.08.018.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerEarly-stage non-small cell lung cancerHigh-risk patientsCell lung cancerLung cancerStage I non-small cell lung cancerStage non-small cell lung cancerPeri-procedural morbidityOperable lung cancerType of resectionRefinement of indicationsAnatomic resectionMediastinal lymphSublobar resectionOncologic efficacyTreatment optionsPreferred treatmentResectionPatientsCancerTreatmentLobectomyLymphMorbidityMortality
2010
Sublobar Resection: A Movement from the Lung Cancer Study Group
Blasberg JD, Pass HI, Donington JS. Sublobar Resection: A Movement from the Lung Cancer Study Group. Journal Of Thoracic Oncology 2010, 5: 1583-1593. PMID: 20879185, DOI: 10.1097/jto.0b013e3181e77604.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerSublobar resectionStage IA non-small cell lung cancerStage I non-small cell lung cancerMulti-institutional phase III trialLung Cancer Study GroupPostoperative lung functionSingle-institution trialLung cancer resectionCancer Study GroupHigh-risk patientsPhase III trialsEarly-stage diseaseInvasive surgical resectionCell lung cancerHigh-risk individualsMultislice computer tomographyRate of survivalPerioperative morbidityIII trialsSurgical resectionCancer resectionLung functionOncologic effectivenessRecurrence rateRobotic Brachytherapy and Sublobar Resection for T1 Non-Small Cell Lung Cancer in High-Risk Patients
Blasberg JD, Belsley SJ, Schwartz GS, Evans A, Wernick I, Ashton RC, Bhora FY, Connery CP. Robotic Brachytherapy and Sublobar Resection for T1 Non-Small Cell Lung Cancer in High-Risk Patients. The Annals Of Thoracic Surgery 2010, 89: 360-367. PMID: 20103299, DOI: 10.1016/j.athoracsur.2009.09.052.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAged, 80 and overBrachytherapyCombined Modality TherapyComorbidityDisease ProgressionFemaleFollow-Up StudiesHealth Status IndicatorsHumansImage Processing, Computer-AssistedIodine RadioisotopesLung NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPneumonectomyPositron-Emission TomographyPostoperative ComplicationsRadiometryRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRadiotherapy, AdjuvantRoboticsTomography, X-Ray ComputedConceptsNon-small cell lung cancerHigh-risk patientsCell lung cancerPlanning target volumeSublobar resectionLung cancerPrescription doseStage IA non-small cell lung cancerTarget volumeT1 non-small cell lung cancerSublobar lung resectionPatients 5 yearsSite of recurrenceIncidence of recurrenceComputed tomography scanBrachytherapy seed placementDa Vinci systemConventional lobectomyPerioperative mortalityLocoregional recurrenceLung resectionSelect patientsLimited resectionResection marginsTumor size
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